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OsRFPH2-10,a RING-H2 Finger E3 Ubiquitin Ligase,Is Involved in Rice Antiviral Defense in the Early Stages of Rice dwarf virus Infection

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Molecular Plant 2014年第6期7卷 1057-1060页

作者： Lifang Liu Lian Jin Xiahe Huang Yongtao Geng Feng Li Qingqing Qin Rui Wang Shaoyi Ji Shanshan Zhao Qi Xie Chunhong Wei Can Xie biao ding Yi Li The State Key Laboratory of Protein and Plant Gene Research College of Life SciencesPeking UniversityBeijing 100871People’s Republic of China Peking-Yale Joint Center for Plant Molecular Genetics and Agrobiotechnology College of Life SciencesPeking UniversityBeijing 100871People’s Republic of China Institute of Genetics and Developmental Biology Chinese Academy of SciencesBeijing 100101People’s Republic of China Department of Molecular Genetics and Center for RNA Biology The Ohio State UniversityColumbusOH 43210USA

Dear Editor,Rice dwarf virus(RDV),a member of the Phytoreoviurs genus,is transmitted to rice(Oryza sativa)plants by leaf-hopper(Nephotettix cincticeps)in a propagative *** by RDV results in severe stunting growth pheno-types and a dramatic reduction in grain *** genome of RDV is composed of 12-segmented double-stranded RNAs(S1-S12 based on their migration rates in agarose gel electro-phoresis).The 12 segments encode seven structural proteins(P1,P2,P3,P5,P7,P8,and P9 as the products of Sl,S2,S3,S5,S7,S8,and S9,respectively)and five nonstructural proteins(Pns4,Pns6,Pnsl0,Pns11,and Pns12 as the products of S4,S6,S10,S11,and S12,respectively).The outer capsid protein P2 is essential for RDV infection of insects and thus influences transmission of RDV by the insect vector(Omura et al.,1998;Zhou et al.,2007).P2 also contributes to the dwarf phenotype of infected rice by interfering with gibberellic acid synthesis(Zhu et al.,2005).When RDV-infected rice plants were main-tained via vegetative propagation for several years without insect transmission,they regained normal growth height due to loss of RDV P2 and Pnsl0 proteins(Pu et al.,2011).

关键词： RICE -- Disease & pest resistance RESEARCH RICE -- Diseases & pests UBIQUITIN ligases PLANT viruses PLANT proteins PLANT cells & tissues PHENOTYPE ANTIVIRAL agents

A List of Insects on Stored Traditional Chinese Medicinal (TCM) Materials in Anhui Province of China

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Plant Diseases and Pests 2012年第5期3卷 16-18页

作者： Shuanglin JIANG Yuntao JI Changqing QU Tongfu MA biao ding School of Life Science Fuyang Teachers College

[ Objective ] The paper was to ascertain the insects on the stored traditional Chinese medicinal （TCM） materials in Anhui Province of China, so as to control pests on stored TCM materials effectually. [ Method] The insects on stored TCM materials in 17 regions of Anhui Province were investigated from 2009 to 2012 and 873 kinds of insect samples on TCM materials were collected. [ Result] Investigation showed that a total of 94 species of insects on stored TCM materials belonging to 38 families, 9 orders in Anhui Province had been identified, among which 81 species of pests belonged to 31 families, 5 orders, and 13 species of natu- ral enemies belonged to 7 families, 4 orders ; additionally, 24 species of insects were newly recorded in Anhui Province. The distribution and hosts of 94 species of insects were also described. [ Conclusion] The results could provide scientific basis for controlling pests of the stored traditional Chinese medicinal materials in An- hui Province.

关键词： Traditional Chinese medicinal Insect Storage Anhui Province

非高斯杂波下基于子空间的距离扩展目标检测器

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电子学报 2017年第6期45卷 1342-1348页

作者：简涛廖桂生何友丁彪海军航空工程学院信息融合研究所西安电子科技大学雷达信号处理重点实验室

在辅助数据缺失的非高斯杂波背景下,采用两步法设计策略研究了距离扩展目标检测方法.首先,在杂波纹理分量已知的条件下,对待检测数据进行高斯化,利用高斯背景下杂波协方差矩阵和目标散射点幅度的合适估计,建立检验统计量.其次,利用待检... 详细信息

在辅助数据缺失的非高斯杂波背景下,采用两步法设计策略研究了距离扩展目标检测方法.首先,在杂波纹理分量已知的条件下,对待检测数据进行高斯化,利用高斯背景下杂波协方差矩阵和目标散射点幅度的合适估计,建立检验统计量.其次,利用待检测数据在信号子空间正交补上的正交投影,估计杂波纹理分量,提出了基于子空间的距离扩展目标自适应检测器,并证明了其对杂波纹理分量的恒虚警率(CFAR,Constant False Alarm Rate)特性.仿真结果表明,在典型非高斯背景下,所提检测器的CFAR特性和检测性能均优于对比检测器;另外,阵元数、目标距离单元数或杂波尖峰的增加,能不同程度改善检测性能.

关键词：宽带雷达距离扩展目标正交补子空间恒虚警率辅助数据

Effects of alcohol on H3K9 acetylation in mouse preimplantation embryos

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Zoological Research 2015年第1期36卷 54-58页

作者： Fang ding Li CHEN Yong LIU Feng-Rui WU biao ding Wen-Yong LI Rong WANG School of Life Science Anhui University Hefei 230601 China School of biological and food engineering Fuyang Teachers College Fuyang 236037 China Key Laboratory of Embryo Development and Reproductive Regulation in Anhui Fuyang 236037 China

It is well known that excessive long-term alcohol consumption is harmful, especially in pregnant women. In the present study, the Kunming white mouse was used as an animal model and indirect immunofluorescence was performed to analyze the toxic effects of alcohol on early pre-implantation embryos. H3K9 acetylation immunofluorescence could not be detected in MII oocytes. H3K9 acetylation levels in the treatment group were higher than in the control group during the morula stage, and contrary to results during the blastocyst stage. Other stages showed no obvious differences for in vivo embryos. For in vitro embryos, almost no difference was found between the two experimental groups across all stages, and both groups showed increasing H3K9 acetylation levels（except at the 2-cell stage）. This study shows that H3K9 acetylation levels in early pre-implantation embryos are notably impacted by excessive alcohol ingestion by females. These data are the first step in understanding the epigenetic mechanism of alcohol toxicity in early preimplantation mouse embryos.

关键词： alcohol implantation pregnant contrary notably indirect epigenetic women Alcohol Kunming

A controlled study of positron-emission-tomography and positron-emission-tomography/computed tomography in differential diagnosis of solitary pulmonary nodules—report of 60 cases

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Chinese Medical Journal 2005年第18期118卷 1572-1576页

作者： ding Qi-yong HUA Yan-qing ZHANG Guo-zhen ZHAO Jun GUAN Yi-hui GE Xiao-jun MAO ding-biao ZUO Chuan-tao Department of Radiology Huadong Hospital Shanghai 200040China PET Center of Huashan Hospital Shanghai 200235 China

The differential diagnosis of solitary pulmonary nodules （SPNs） remains a challenge. It is acknowledged that combining positron-emission tomography （PET） and computed tomography （CT） offers the most reliable noninvasive method for the diagnosis of SPNs. Since Townsend et al1 developed integrated PET/CT in 1999, this technique has increasingly been introduced into clinical practice. To date, nuclear medicine physicians have usually undertaken PET/CT diagnosis, but the question is surfacing as how to make full use of the information of CT image to improve the accuracy of SPN diagnosis. To answer this question, we performed a retrospective study on 60 patients with SPNs.

关键词： solitary pulmonary nodule·differential diagnosis·positron-emission tomography/tomography X-ray computed

经皮冠状动脉介入治疗老年患者焦虑、抑郁情绪与睡眠质量及生活质量的相关性

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上海交通大学学报（医学版） 2018年第9期38卷 1085-1091页

作者：刘霞丁飚章雅青上海交通大学护理学院上海200025 上海交通大学医学院附属新华医院护理部上海200092 上海交通大学附属第六人民医院护理部上海200235

目的·探讨接受经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)的老年患者焦虑、抑郁情绪与睡眠质量及生活质量的相关性。方法·选取在上海交通大学医学院附属新华医院和上海交通大学附属第六人民医院住院行PCI术的297... 详细信息

目的·探讨接受经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)的老年患者焦虑、抑郁情绪与睡眠质量及生活质量的相关性。方法·选取在上海交通大学医学院附属新华医院和上海交通大学附属第六人民医院住院行PCI术的297例老年患者为研究对象,采用一般资料调查表、综合医院焦虑抑郁量表(hospital anxiety and depression scale,HADS)、匹兹堡睡眠质量指数量表(Piusburgh sleep quality index,PSQI)和健康调查量表(12-item short form health survey version 2.0,SF-12v2)对其在出院前1日进行问卷调查,3份量表均回顾性调研入院前1个月的主观感受。对焦虑、抑郁得分与睡眠质量和生活质量得分做Spearman相关分析,生活质量影响因素的分析采用多元线性回归法。结果·PCI老年患者中21.5%被评估为焦虑阳性,22.2%被评估为抑郁阳性,高于国内综合医院就诊患者的焦虑、抑郁水平(均P=0.000)。患者睡眠质量总分的平均分为(6.50±3.46)分,高于国内常模水平(P=0.000)。患者生活质量总分的平均分为(132.20±30.83)分,生理总评分均分为(60.44±17.58)分,心理总评分均分为(71.76±15.96)分。相关性分析表明,焦虑、抑郁评分与睡眠质量总分均呈正相关(P=0.026,P=0.027),与生活质量总分及生理总评分和心理总评分均呈负相关(均P=0.000)。PCI老年患者焦虑、抑郁评分与生活质量得分的线性回归方程有意义(P=0.000,R^2=0.246)。结论·PCI老年患者最近1个月的焦虑、抑郁情绪发生率高,睡眠情况差。焦虑或抑郁情绪越明显,睡眠质量和生活质量越差。应重视焦虑、抑郁情绪与睡眠质量和生活质量的相关性,改善患者的负性情绪,提高其睡眠质量和生活质量。

关键词：经皮冠状动脉介入治疗老年人焦虑抑郁睡眠质量生活质量

Apopotic gene Bax expression in carotid plaque

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Neuroscience Bulletin 2006年第1期22卷 58-62页

作者： Bao-Zhong MEN ding-biao ZHOU Huai-Yin SHI Xiao-Ming ZHANG Department of Neurosurgery the General Hospital of PLA Beijing 100853 China Department of Pathology the General Hospital of PLA Beijing 100853 China

The expression of BAX in carotid atherosclerosis and its regulation is far from defined. Objectives To investigate BAX expression in stable/fibrous and instable/vulnerable carotid plaque and its clinical significance. Methods 25 cases of carotid plaque specimens obtained from endarterectomy were divided into two groups, stable/fibrous 14 cases, vulnerable/instable 11 cases; aortic artery and its branches from hepatic transplantation donors 6 case as control The expression of proapoptotic BAX was detected by immunohistochemistry （IHC）, in situ hybridization （ISH） and in situ TdT dUTP nick end labeling （TUNEL）. Results 5 cases of BAX （＋） were detected by ICH and ISH, 4 case of TUNEL （＋） were detected by TUNEL in stable/fibrous carotid plaque , while 10 cases were BAX （＋）by IHC（P 〈 0.05 ） , 11 case by ISH and 9 case by TUNEL were detected in instable/vulnerable carotid plaque （P 〈0.01 ）, respectively. The intensity of BAX （＋） cells by IHC and ISH was 8.63±2.62 and 10.32 ± 3.12 in fibrous plaques,whereas 122 ±21.64 and 152 ± 23.35 in vulnerable plaques, respectively. No expression of BAX was found in controlled group. Conclusion The higher expression of Bax in vulnerable carotid plaque may be one mechanisms in molecular pathogenesis of carotid atherosclerosis which affect plaque stability and be the cause of higher incidence of stroke than fibrous carotid plaques, the regulation of BAX expression in different stage of atherosclerosis may provide targets in gene therapy for carotid atherosclerosis.

关键词： carotid artery atherosclerosis apoptosis BAX gene

大长径比固体火箭发动机旋转发射过程装药结构完整性分析

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北京理工大学学报 2013年第9期33卷 906-910页

作者：丁彪张春龙邱欣海军航空工程学院飞行器工程系山东烟台264001

以某防空导弹大长径比双推力固体火箭发动机装药为研究对象,为全面分析导弹旋转发射出筒过程中承受的各类载荷,采用基于三维黏弹性有限元法,对发动机点火出筒过程应力-应变场进行了数值计算.结果表明,内压载荷、轴向过载及角加速度过载... 详细信息

以某防空导弹大长径比双推力固体火箭发动机装药为研究对象,为全面分析导弹旋转发射出筒过程中承受的各类载荷,采用基于三维黏弹性有限元法,对发动机点火出筒过程应力-应变场进行了数值计算.结果表明,内压载荷、轴向过载及角加速度过载是影响装药结构安全的主要载荷因素,装药的凸台后端面是危险部位,悬臂段的轴向过度伸长可能造成通道阻塞现象,可引发内压剧升甚至壳体破坏的危险.提出改进装药工装,防止微裂纹的出现;设置有效的装药悬臂段固定支撑机构;优化发动机燃气通道燃通比等方法优化发动机结构.

关键词：大长径比发动机旋转发动机结构完整性载荷分析有限元法

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关于颈动脉内膜切除的若干问题

中华外科杂志 2009年第6期47卷 401-403页

作者：周定标解放军总医院神经外科北京100853

1951年美国神经外科医师Spence首次成功实施颈动脉内膜切除（carotid endarterectomy，CEA）。半个多世纪以来，该手术已成为颈动脉粥样硬化性狭窄有效的治疗方法之一。特别是20世纪90年代初，以“北美症状性颈动脉内膜切除试验”（Nort... 详细信息

1951年美国神经外科医师Spence首次成功实施颈动脉内膜切除（carotid endarterectomy，CEA）。半个多世纪以来，该手术已成为颈动脉粥样硬化性狭窄有效的治疗方法之一。特别是20世纪90年代初，以“北美症状性颈动脉内膜切除试验”（North American symptomatic carotid endarterectomy trial，NASCET）、“欧洲颈动脉外科试验”（European carotid surgery trial，ECST）和“无症状颈动脉粥样硬化研究”（asymptomatic carotid atherosclerosis study。ACAS）等为代表的大规模多中心随机试验结果公布后，CEA在缺血性脑血管病治疗中的地位已毋庸置疑。当然，在CEA的相关问题探讨中，也有若干不同意见。笔者根据自己开展CEA20余年的体会，结合文献，就某些问题谈些看法，供读者参考。

关键词：颈动脉内膜切除颈动脉粥样硬化性狭窄多中心随机试验 surgery 神经外科医师脑血管病治疗颈动脉外科治疗方法