检索结果-南通市图书馆

Journal of Environmental Sciences 2010年第9期22卷 1357-1363页

作者： Simonetta Giordano Paola Adamo Valeria Spagnuolo bianca Maria Vaglieco Department of Structural and Functional Biology University of Naples Federico II Department of Soil Plant Environment and Animal Production Sciences University of Naples Federico II Istituto Motori CNR Via Marconi 8 I-80125 Napoli Italy

In the present article we characterized the emissions at the exhaust of a Common Rail （CR） diesel engine, representative of lightduty class, equipped with a catalyzed diesel particulate filter （CDPF） in controlled environment. The downstream exhausts were directly analyzed （for PM, CO, CO/, Oz, HCs, NOx） by infrared and electrochemical sensors, and SEM-EDS microscope; heavy metals were chemically analyzed using mosses and lichens in bags, and glass-fibre filters all exposed at the engine exhausts. The highest particle emission value was in the 7-54 nm size range; the peak concentration rose until one order of magnitude for the highest load and speed. Particle composition was mainly carbonaceous, associated to noticeable amounts of Fe and silica fibres. Moreover, the content of Cu, Fe, Na, Ni and Zn in both moss and lichen, and of A1 and Cr in moss, was significantly increased. Glass-fibre filters were significantly enriched in A1, B, Ba, Cu, Fe, Na, and Zn. The role of diesel engines as source of carbonaceous nanoparticles has been confirmed, while further investigations in controlled environment are needed to test the catalytic muffler as a possible source of silica fibres considered very hazardous for human health.

关键词： common rail diesel engine exhaust and non-exhaust emissions moss and lichen bags particulate matter

The PI3K/Akt/m TOR pathway in ovarian cancer: therapeutic opportunities and challenges

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Cancer 2015年第1期34卷 4-16页

作者： bianca Cheaib Aurélie Auguste Alexandra Leary Gynecological Unit Department of MedicineGustave Roussy Comprehensive Cancer Centre Gynecological Tumor Team Translational Research Laboratory U981 Gustave Roussy Comprehensive Cancer Centre

The phosphatidylinositol 3 kinase(PI3K) pathway is frequently altered in cancer, including ovarian cancer(OC). Unfortunately, despite a sound biological rationale and encouraging activity in preclinical models, trials of first-generation inhibitors of mammalian target of rapamycin(m TOR) in OC have demonstrated negative results. The lack of patient selection as well as resistance to selective m TOR complex-1(m TORC1) inhibitors could explain the disappointing results thus far. Nonetheless, a number of novel agents are being investigated, including dual m TORC1/m TORC2, Akt, and PI3 K inhibitors. Although it is likely that inhibition of the PI3K/Akt/m TOR pathway may have little effect in unselected OC patients, certain histological types, such as clear cell or endometrioid OC with frequent phosphatidylinositol-4,5-biphosphate 3-kinase, catalytic subunit alpha(PIK3CA) and/or phosphatase and tensin homolog(PTEN) alterations, may be particularly suited to this approach. Given the complexity and redundancy of the PI3 K signaling network, PI3 K pathway inhibition may be most useful in combination with either chemotherapy or other targeted therapies, such as MEK inhibitors, anti-angiogenic therapy, and hormonal therapy, in appropriately selected OC patients. Here, we discuss the relevance of the PI3 K pathway in OC and provide an up-to-date review of clinical trials of novel PI3 K inhibitors alone or in combination with cytotoxics and novel therapies in OC. In addition, the challenges of drug resistance and predictive biomarkers are addressed.

关键词： mTOR 信号通路卵巢癌磷脂酰肌醇3激酶 AKT 激素疗法治疗临床试验

A novel paradigm for feedback control in LPBF:layer-wise correction for overhang structures

在线全文

学校读者我要写书评

暂无评论

Advances in Manufacturing 2022年第2期10卷 326-344页

作者： Ema Vasileska Ali Gokhan Demir bianca Maria Colosimo Barbara Previtali Department of Mechanical Engineering Polytechnic University of MilanVia La Masa 120156 MilanItaly

In laser powder bed fusion(LPBF),it is common practice to select process parameters to achieve high density parts starting from simple geometries such as cubes or ***,additive manufacturing is usually adopted to producevery complex geometries,where parameters should be tuned locally,depending on the local features to be *** fact,geometrical features,such as overhangs,acute corners,and thin walls may lead to over-or under-heating conditions,which may result in geometrical inaccuracy,high roughness,volumetric errors(i.e.,porosity)oreven job failure due to *** work proposes a layer-wise control strategy to improve the geometrical precision of overhanging regions using a coaxial melt pool monitoring *** meltpool images acquired at each layer are used in a controlloop toadapt theprocess parameters locally at the next layer in order to minimize surface *** particular,the laser duty cycle is used as a controllable parameterto correct the energy *** work presents the main architecture of the proposed approach,the control strategy and the experimental procedure that need to be applied to design the control *** layer-wise control strategy was tested on AISI 316L stainless steel using an open LPFB *** results showed that the proposed layer-wise control solution results in a constant melt pool observed via the laser heated area size starting from the second layer onward,leading to a significant improvement in the geometrical accuracy of 5 mm-long bridge geometries.

关键词： Closed-loop control Melt pool monitoring:Defect correction Pulsed-wave emission

Regulating Wnt signaling： a strategy to prevent neurodegeneration and induce regeneration

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Molecular Cell Biology 2014年第1期8卷 1-2页

作者： Guest Editors Kirsten Harvey bianca Marchetti Department of Pharmaco-logy UCL School of PharmacyUniversity College LondonLondon WCIN lAX UK Department of Clinical andMolecular Biomedicine Phar-macology Section MedicalSchool University of Catania95125 Catania Italy 0A51 Institute for Researchand Care on Mental Retarda-tion and Brain Aging (IRCCS) Neurapharmacology Section94018 Tmina Italy

During the past three decades, Wingtess/Int （Wnt）signaling has emerged as an essential regu{ator crucial for neuronal development and maintenance （Inestrosa and Arenas, 201_0）. In addition, Wnt signal- ing was recently shown to be involved in the regula- tion of synaptic function and plasticity, which is critical for learning and memory （Oliva et aL, 2013）. Deregulation of Wnt signaling has been proposed as a key contributor to the pathogenesis of neurode- generative disorders including Alzheimer＇s disease （AD） and Parkinson＇s disease （PD）. This increasing knowledge of the specific roles of Wnt signaling cascades during different stages of life has suggested innovative therapeutic strategies for the treatment of neurodegenerative diseases.

关键词： Wnt 神经元退行性病变信号神经退行性疾病阿尔茨海默氏病再生诱发

Dual Targeting of a Mitochondrial Protein： The Case Study of Cytochrome C1

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular Plant 2011年第4期4卷 679-687页

作者： Anja Rodiger bianca Baudisch Uwe Langner Ralf Bernd Klosgen Institute of Biology--Plant Physiology Martin Luther University Halle-Wittenberg Weinbergweg 10 06120 Halle/Saale Germany

As a result of the endosymbiotic gene transfer, the majority of proteins of mitochondria and chloroplasts is encoded in the nucleus and synthesized in the cytosol as precursor molecules carrying N-terminal transit peptides for the transport into the respective target organelle. In most instances, transport takes place into either mitochondria or chloroplasts, although a few examples of dual targeting into both organelles have been described. Here, we show by a combination of three different experimental strategies that also cytochrome c1 of potato, a component of the respiratory electron transport chain, is imported not only into mitochondria, but also into plastids. In organello import experiments with isolated mitochondria and chloroplasts, which were analyzed in both single and mixed organelte assays, demonstrate that the processing products accumulating after import within the two endosymbiotic organelles are different in size. Dual targeting of cytochrome c1 is observed also in vivo, after biolistic transformation of leaf epidermal cells with suitable reporter constructions. Finally, Western analyses employing cytochrome c1-specific antiserum provide evidence that the protein accumulates in significant amounts in mitochondria and chloroplasts of both pea and spinach. The possible consequences of our findings on the relevance of the dual targeting phenomenon are discussed.

关键词： Protein transport dual targeting cytochrome c1 mitochondria chloroplast.

Fatality in Kikuchi-Fujimoto disease: A rare phenomenon

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2017年第2期5卷 35-39页

作者： bianca Barbat Ruby Jhaj Daniyeh Khurram Providence-Providence Park Hospital

Kikuchi-Fujimoto disease(KFD), also known as histiocytic necrotizing lymphadenitis, is an uncommon condition, typically characterized by lymphadenopathy and fevers. It usually has a benign course; however, it may progress to fatality in extremely rare occasions. The diagnosis is made via lymph node biopsy and histopathology. Our patient was a young female who presented with shortness of breath, fever, and malaise. Physical examination revealed significant cervical and axillary lymphadenopathy. Chest X-ray displayed multilobar pneumonia. She required intubation and mechanical ventilation for progressive respiratory distress. Histopathology of lymph nodes demonstrated variable involvement of patchy areas of necrosis within the paracortex composed of karyorrhectic debris with abundant histiocytes consistent with KFD. After initial stabilization, the patient's condition quickly deteriorated with acute anemia, thrombocytopenia and elevated prothrombin time, partial prothrombin time, and D-dimer levels. Disseminated intravascular coagulopathy(DIC) ensued resulting in the patient's fatality. DIC in KFD is not well understood, but it is an important cause of mortality in patients with aggressive disease.

关键词： Kikuchi-Fujimoto disease Disseminated intravascular coagulopathy Histiocytic necrotizing lymphadenitis Lymphadenopathy Fatality

In an interconnected world: joint research priorities for the environment, agriculture and infectious disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Infectious Diseases of Poverty 2014年第1期3卷 15-17页

作者： bianca Brijnath Colin D Butler Anthony J McMichael Department of General Practice School of Primary Health CareMonash UniversityBuilding 1270 Ferntree Gully RoadNotting HillVictoria 3168Australia Faculty of Health University of CanberraCanberraAustralia National Centre for Epidemiology and Population Health Australian National UniversityCanberraAustralia

In 2008 the UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases(TDR)commissioned ten think-tanks to work on disease-specific and thematic reference groups to identify top research priorities that would advance the research agenda on infectious diseases of poverty,thus contributing to improvements in human *** first of the thematic reference group reports-on environment,agriculture and infectious diseases of poverty-was recently *** this article we review,from an insider perspective,the strengths and weaknesses of this thematic reference group report and highlight key messages for policy-makers,funders and researchers.

关键词： Agriculture Environment Infectious disease Research priorities TDR

The role of Epstein-Barr virus in multiple sclerosis:from molecular pathophysiology to in vivo imaging

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2019年第3期14卷 373-386页

作者： Yi Guan Dejan Jakimovski Murali Ramanathan bianca Weinstock-Guttman Robert Zivadinov Buffalo Neuroimaging Analysis Center Department of Neurology Jacobs School of Medicine and Biomedical Sciences University at BuffaloState University of New York Jacobs Comprehensive MS Treatment and Research Center Department of Neurology Jacobs School of Medicine and Biomedical SciencesUniversity at Buffalo State University of New York Department of Pharmaceutical Sciences State University of New York Center for Biomedical Imaging at Clinical Translational Science Institute University at Buffalo State University of New York

Multiple sclerosis(MS) is a disease of the central nervous system characterized by inflammation, demyelination, and neuronal damage. Environmental and genetic factors are associated with the risk of developing MS, but the exact cause still remains unidentified. Epstein-Barr virus(EBV), vitamin D, and smoking are among the most well-established environmental risk factors in MS. Infectious mononucleosis, which is caused by delayed primary EBV infection, increases the risk of developing MS. EBV may also contribute to MS pathogenesis indirectly by activating silent human endogenous retrovirus-W. The emerging B-cell depleting therapies, particularly anti-CD20 agents such as rituximab, ocrelizumab, as well as the fully human ofatumumab, have shown promising clinical and magnetic resonance imaging benefit. One potential effect of these therapies is the depletion of memory B-cells, the primary reservoir site where EBV latency occurs. In addition, EBV potentially interacts with both genetic and other environmental factors to increase susceptibility and disease severity of MS. This review examines the role of EBV in MS pathophysiology and summarizes the recent clinical and radiological findings, with a focus on B-cells and in vivo imaging. Addressing the potential link between EBV and MS allows the better understanding of MS pathogenesis and helps to identify additional disease biomarkers that may be responsive to B-cell depleting intervention.

关键词： Epstein-Barr virus multiple sclerosis meningeal inflammation magnetic resonance imaging leptomeningeal contrast enhancement mononucleosis human endogeneous retrovirus-W B-cells

Epidemiology and Clinical Features of Mycobacterium avium Complex Pulmonary Disease in a Brazilian Amazon Cohort

在线全文

学校读者我要写书评

暂无评论

Advances in Microbiology 2024年第6期14卷 287-302页

作者： Jose Tadeu Colares Monteiro Adriana Rodrigues Barretto Ruan Seguin Azevedo Quaresma bianca Miranda Gouveia Ismari Perini Furlaneto Victória Menezes da Costa Yan Corrêa Rodrigues Layana Rufino Ribeiro Ricardo J. de Paula Souza e Guimarães Alex Brito Souza Ana Roberta Fusco da Costa Karla Valéria Batista Lima Joao de Barros Barreto University Hospital Federal University of Par Belm Brazil Center for Biological and Health Sciences Ph.D. Program in Parasitic Biology in the Amazon Region (PPGBPA) State University of Par (UEPA) Belm Brazil Department of Medicine Centro Universitrio do Par CESUPA Belm Brazil Bacteriology and Mycology Section Evandro Chagas Institute (SABMI/IEC) Ministry of Health Ananindeua Brazil Geoprocessing Laboratory Evandro Chagas Institute/SVSA/MS Ananineua Brazil

The incidence of Mycobacterium avium complex pulmonary disease (MACPD) has been globally increasing. The present study aims to provide a comprehensive analysis of clinical characteristics and treatment response among patients in the Amazon region of Brazil and conduct a retrospective cohort study at a prominent referral hospital in the State of Par, Brazil, from 2012 to 2020. The M. avium group represented 58.9% of cases, followed by M. intracellulare (35.7%), M. colombiense (3.6%), and M. chimaera (1.8%). The majority of patients (73.2%) were female and with an average age of 63 years. Primary clinical manifestations included persistent cough and sputum production. The Charlson comorbidity index (CCI) averaged 2.47, with 36.3% of patients having a CCI score equal to higher than 3. Notably, over 70% of patients had received treatment for pulmonary tuberculosis before initiating treatment for MAC infection. The fibrocavitary radiologic form was the most prevalent (55.4%), frequently exhibiting a bilateral distribution (53.6%). Antimicrobial susceptibility revealed a significant prevalence of MAC resistance to drugs in the therapeutic regimen. Despite this, most of the patients experienced clinical improvement (50%). In conclusion, this study highlights a higher prevalence of MAC infections among middle-aged women, with a history of pulmonary tuberculosis treatment and presenting the fibrocavitary radiological form was predominant.

关键词： MACDP Nontuberculous Mycobacteria Mycobacterium avium Lung Disease

3D bioprinting:current status and trends-a guide to the literature and industrial practice

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bio-Design and Manufacturing 2022年第1期5卷 14-42页

作者： Silvia Santoni Simone G.Gugliandolo Mattia Sponchioni Davide Moscatelli bianca M.Colosimo Department of Mechanical Engineering Politecnico di MilanoVia La Masa120156 MilanItaly Department of Chemistry Materials and Chemical Engineering“Giulio Natta”Politecnico di MilanoPiazza Leonardo da Vinci3220133 MilanItaly

The multidisciplinary research field of bioprinting combines additive manufacturing,biology and material sciences to cre-ate bioconstructs with three-dimensional architectures mimicking natural living *** high interest in the possibility of reproducing biological tissues and organs is further boosted by the ever-increasing need for personalized medicine,thus allowing bioprinting to establish itself in the field of biomedical research,and attracting extensive research efforts from companies,universities,and research institutes *** this context,this paper proposes a scientometric analysis and critical review of the current literature and the industrial landscape of bioprinting to provide a clear overview of its fast-changing and complex *** scientific literature and patenting results for 2000-2020 are reviewed and critically analyzed by retrieving 9314 scientific papers and 309 international patents in order to draw a picture of the scientific and industrial landscape in terms of top research countries,institutions,journals,authors and topics,and identifying the technology hubs *** review paper thus offers a guide to researchers interested in this field or to those who simply want to under-stand the emerging trends in additive manufacturing and 3D bioprinting.

关键词： Additive manufacturing 3D bioprinting Biofabrication Organ-on-a-chip Tissue engineering