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Physiologic postoperative presepsin kinetics following primary cementless total hip arthroplasty:A prospective observational study

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World Journal of Orthopedics 2023年第7期14卷 547-553页

作者： Davide Bizzoca Andrea Piazzolla lorenzo Moretti Giovanni Vicenti biagio Moretti Giuseppe Solarino DAI Neuroscienze Organi di Senso e Apparato LocomotoreAOU Consorziale Policlinico di BariBari 70124Italy University of Bari"Aldo Moro" Bari 70124Italy

BACKGROUND Presepsin is an emerging biomarker in the diagnosis of *** the field of orthopaedics,it could be useful in diagnosing and managing periprosthetic joint *** To define the normal postoperative presepsin plasmatic curve,in patients undergoing primary cementless total hip arthroplasty(THA).METHODS Patients undergoing primary cementless THA at our Institute were *** criteria were:Primary osteoarthritis of the hip;urinary catheter time of permanencediseases;chronic kidney diseases;history of recurrent infections or malignant neoplasms;previous surgery in the preceding 12 mo;diabetes mellitus;immunosuppressive drug or corticosteroid *** the patients received the same antibiotic *** the THA were performed by the same surgical and anaesthesia team;total operative time was defined as the time taken from skin incision to completion of skin *** enrollment,anthropometric data,smocking status,osteoarthritis stage according to Kellgren and Lawrence,Harris Hip Score,drugs assumption and comorbidities were *** the patients underwent serial blood tests,including complete blood count,presepsin(PS)and C-reactive protein 24 h before arthroplasty and at 24,48,72 and 96 h postoperatively and at 3,6 and 12-mo *** A total of 96 patients(51 female;45 male;mean age=65.74±5.58)were *** mean PS values were:137.54 pg/mL at baseline,192.08 pg/mL at 24 h post-op;254.85 pg/mL at 48 h post-op;259 pg/mL at 72 h post-op;248.6 pg/mL at 96-h post-op;140.52 pg/mL at 3-mo follow-up;135.55 pg/mL at 6-mo follow-up and 130.11 pg/mL at 12-mo *** two patients(2.08%)a soft-tissue infection was observed;in these patients,higher levels(

关键词： Presepsin Periprosthetic joint infection Total hip arthroplasty Total hip replacement Hip surgery Postoperative care

Anterior vertebral body tethering for idiopathic scoliosis in growing children:A systematic review

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World Journal of Orthopedics 2022年第5期13卷 481-493页

作者： Davide Bizzoca Andrea Piazzolla lorenzo Moretti Giovanni Vicenti biagio Moretti Giuseppe Solarino UOSD Spinal Deformity Centre AOU Consorziale Policlinico di BariBari 70124Italy Department of Biomedical Sciences and Human Oncology University of Bari“Aldo Moro”Bari 70124Italy Orthopaedic and Trauma Unit AUO Consorziale Policlinico di BariBari 70124Italy Department of Basic Medical Sciences Neuroscience and Sense OrgansOrthopaedic and Trauma UnitUniversity of Bari“Aldo Moro”Bari 70124PugliaItaly

BACKGROUND The management of idiopathic scoliosis(IS)in skeletally immature patients should aim at three-dimensional deformity correction,without compromising spinal and chest *** 2019,the US Food and Drug Administration approved the first instrumentation system for anterior vertebral body tethering(AVBT),under a Humanitarian Device Exception,for skeletally immature patients with curves having a Cobb angle between 35°and 65°.AIM To summarize current evidence about the efficacy and safety of AVBT in the management of IS in skeletally immature *** From January 2014 to January 2021,Ovid Medline,Embase,Cochrane Library,Scopus,Web of Science,Google Scholar and PubMed were searched to identify relevant *** methodological quality of the studies was evaluated and relevant data were *** Seven clinical trials recruiting 163 patients were included in the present *** studies out of seven were classified as high quality,whereas the remaining two studies were classified as moderate quality.A total of 151 of 163 AVBT procedures were performed in the thoracic spine,and the remaining 12 tethering in the lumbar *** 117 of 163(71.8%)patients had a nonprogressive curve at skeletal ***-three of 163(14.11%)patients required unplanned revision surgery within the follow-up *** to posterior spinal fusion(PSF)was performed in 18 of 163(11%)*** AVBT is a promising growth-friendly technique for treatment of IS in growing ***,it has moderate success and perioperative complications,revision and conversion to PSF.

关键词： Idiopathic scoliosis Spinal growth modulation Anterior spinal instrumentation Curve correction Anterior vertebral body tethering Paediatric spine Growing spine Skeletally immature patients Growth-friendly spinal implants

Total hip arthroplasty following the failure of intertrochanteric nailing:First implant or salvage surgery?

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World Journal of Orthopedics 2023年第10期14卷 763-770页

作者： Giuseppe Solarino Davide Bizzoca Pasquale Dramisino Giovanni Vicenti lorenzo Moretti biagio Moretti Andrea Piazzolla University of Bari Aldo Moro Bari 70154Italy Orthopaedic and Trauma Unit Policlinico di Bari Bari 70124Italy UOSD Vertebral Surgery Policlinico di BariBari 70124Italy

BACKGROUND Proximal femur fractures,including both intracapsular(femoral neck fractures)and extracapsular fractures(intertrochanteric femoral fractures,IFFs),affect around 1.5 million people per year *** failures of intertrochanteric nailing in IFFs could be managed with revision total hip arthroplasty(THA).AIM To describe the surgical complexity and the procedure-related complication rates in patients with trochanteric nailing failure and treated with *** Patients referred to our level I trauma center between April 2012 and July 2018 with failed cephalomedullary nailing following trochanteric fractures were retrospectively *** patients underwent a salvage surgical procedure,i.e.,cephalomedullary nail removal and conversion to *** same surgical and anesthesiology team performed the surgical procedures under spinal *** patients underwent clinical and radiographic follow-ups for at least 24 *** and re-operations were *** Seventy-four patients met the inclusion criteria(male:29;female:45;mean age:73.8-years-old;range:65-89)and were included in the current *** average operative time was 117 min(76-192 min).The average blood loss was 585 mL(430-1720 mL).Among the 74 patients,43(58.1%)required transfusion of three or more blood *** patients died within the 4th d after surgery because of pulmonary embolism,and 1 patient died 9 mo after surgery due to ischemic myocardial *** complication rate in the 71 patients who completed the minimum 24-mo follow-up was 22.5%.In 3 cases out of 71(4.2%)periprosthetic acetabular fracture was observed during the *** of these periacetabular fractures occurred *** intraoperative periprosthetic femur fracture was observed in 5 patients out of 71(7.0%).Four of these patients needed a re-operation to fix the fracture with plates and cerclages;in one of these patients,femoral stem revision was also *** 4 patients ou

关键词： Femoral nailing Total hip arthroplasty Proximal femur fractures Osteoporosis Fragility fractures Geriatric patients Hip traumatology Hip replacement

Clinical and prostate multiparametric magnetic resonance imaging findings as predictors of general and clinically significant prostate cancer risk:A retrospective single-center study

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Current Urology 2023年第3期17卷 147-152页

作者： Matteo Massanova Rebecca Vere Sophie Robertson Felice Crocetto biagio Barone lorenzo Dutto Imran Ahmad Mark Underwood Jonathan Salmond Amit Patel Giuseppe Celentano Jaimin R.Bhatt Department of Urology Queen Elizabeth University HospitalGlasgowUK Department of Neuroscience Reproductive and Odontostomatological SciencesSchool of MedicineUniversity of Naples"FedericoⅡ"NaplesItaly Department of Pathology Queen Elizabeth University HospitalGlasgowUK Department of Radiology Queen Elizabeth University HospitalGlasgowUK

Background:To evaluate the predictive values of Prostate Imaging Reporting and Data System version 2(PI-RADS v2),prostate-specific antigen(PSA)level,PSA density(PSAD),digital rectal examination findings,and prostate volume,individually and in combination,for the detection of prostate cancer(Pca)in biopsy-naïve ***:We retrospectively analyzed 630 patients who underwent transrectal systematic prostate biopsy following prostate multiparametric magnetic resonance imaging.A standard 12-core biopsy procedure was *** and multivariate analyses were performed to determine the significant predictors of clinically significant cancer but not ***:The median age,PSA level,and PSAD were 70 years,8.6 ng/mL,and 0.18 ng/mL/mL,respectively.A total of 374(59.4%)of 630 patients were biopsy-positive for Pca,and 241(64.4%)of 374 were diagnosed with clinically significant Pca(csPCa).The PI-RADS v2 score and PSAD were independent predictors of Pca and *** PI-RADS v2 score of 5 regardless of the PSAD value,or PI-RADS v2 score of 4 plus a PSAD ofdiagnostic tool before performing prostate *** with a PI-RADS v2 score of<3 and PSAD of<0.3 ng/mL/mL could potentially avoid a prostate biopsy.

关键词： Prostate cancer Prostate Imaging Reporting and Data System score Multiparametric magnetic resonance imaging Transrectal ultrasound Prostate biopsy Prostate-specific antigen density

Optimization of transdisciplinary management of elderly with femur proximal extremity fracture:A patient-tailored plan from orthopaedics to rehabilitation

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World Journal of Orthopedics 2021年第7期12卷 456-466页

作者： Alessandro de Sire Marco Invernizzi Alessio Baricich lorenzo Lippi Antonio Ammendolia Federico Alberto Grassi Massimiliano Leigheb Department of Medical and Surgical Sciences University of Catanzaro“Magna Graecia”Catanzaro 88100Italy Physical Medicine and Rehabilitation Department of Health SciencesUniversity of Piemonte OrientaleNovara 28100Italy Infrastruttura Ricerca Formazione Innovazione Azienda Ospedaliera SS.Antonio e Biagio e Cesare ArrigoAlessandria 15121Italy Orthopaedics and Traumatology Unit Department of Health SciencesUniversity of Piemonte OrientaleNovara 28100Italy

Fractures of femur proximal extremity(FFPE)are the most common fragility fractures requiring hospitalization,with a high risk of mortality,low independence in the activities of daily living and severe consequences on healthrelated quality of *** for surgery has a key role in the management of elderly patients with FFPE as recommended by the Australian and New Zealand guidelines and the National Institute for Health and Care Excellence *** surgery(within 48 h from hospital admission)allows significant benefits in terms of lower rates of postoperative complications and risk of death and can provide better functional ***,time for surgery could be considered as a comorbidity *** choice between conservative or surgical approach surprisingly seems to be still not strongly supported by available literature,but it seems that both 30 d and 1 year risk of mortality is higher with the conservative treatment rather than with *** light of these considerations,the optimization of FFPE management care is mandatory to improve functional outcomes and to reduce sanitary *** it is widely accepted that transdisciplinary approach to patients suffering from FFPE is mandatory to optimize both short-term and long-term outcomes,the feasibility of a comprehensive approach in clinical practice is still a *** particular,the large variability of figures involved could be considered both a resource and an additional disadvantage taking into account the difficulty to coordinate multidisciplinary approach covering care in all ***,the aim of the present article was to summarize current evidence supporting transdisciplinary management of patients with FFPE,highlighting the benefits,feasibility and limitations of this approach.

关键词： Transdisciplinary management Elderly Femur fracture Hip fracture Rehabilitation Pathway

CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen biagio di Micco Ran ding Siqin dingl Yadong ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise