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Expression of matrix metalloproteinase-11 is increased under conditions of insulin resistance

World Journal of Diabetes 2017年第9期8卷 422-428页

作者： biagio arcidiacono Eusebio Chiefari Anna Elisa Laria Sebastiano Messineo Francesco Luciano Bilotta Domenico Britti Daniela Patrizia Foti Anna Foryst-Ludwig Ulrich Kintscher Antonio Brunetti Department of Health Sciences University"Magna Gr█cia"of Catanzaro Institute of Phar-macology Center for Cardiovascular Research

AIM To investigate matrix metalloproteinase-11(MMP-11) expression in adipose tissue dysfunction, using in vitro and in vivo models of insulin *** Culture of mouse 3T3-L1 preadipocytes were induced to differentiation into mature 3T3-L1 adipocytes. Cellular insulin resistance was induced by treating differentiated cultured adipocytes with hypoxia and/or tumor necrosis factor(TNF)-α, and transcriptional changes were analyzed in each condition thereafter. For the in vivo studies, MMP-11 expression levels were measured in white adipose tissue(WAT) from C57BL/6J mice that underwent low fat diet or high-fat feeding in order to induce obesity and obesity-related insulin resistance. Statistical analysis was carried out with GraphP ad Prism *** MMP-11 m RNA expression levels were significantly higher in insulin resistant 3T3-L1 adipocytes compared to control cells(1.46±0.49vs0.83±0.21, respectively;P<0.00036). The increase in MMP-11 expression was observed even in the presence of TNF-α alone(3.79±1.11vs1±0.17, P<0.01) or hypoxia alone(1.79±0.7vs0.88±0.1, P<0.00023). The results obtained in in vitro experiments were confirmed in the in vivo model of insulin resistance. In particular, MMP-11 m RNA was upregulated in WAT from obese mice compared to lean mice(5.5±2.8vs1.1±0.7, respectively; P<3.72E-08). The increase in MMP-11 levels in obese mice was accompanied by the increase in typical markers of fibrosis, such as collagen type Ⅵ alpha 3(Col6_α3), and fibroblast-specific protein *** Our results indicate that dysregulation of MMP-11 expression is an early process in the adipose tissue dysfunction, which leads to obesity and obesity-related insulin resistance.

关键词： Metalloproteinase-11 Insulin resistance Type 2 diabetes Fibrosis Hypoxia Tumor necrosis factor-α Inflammation

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Hydroelectric and Hydrogen Storage Systems for Electric Energy Produced from Renewable Energy Sources

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Energy Engineering 2024年第10期121卷 2719-2741页

作者： Saif Serag Adil Echchelh biagio Morrone Department of Engineering Universitàdella Campania“Luigi Vanvitelli”Aversa(CE)81031Italy Laboratory of Electronics Treatment Information Mechanic and EnergeticUniversity of Ibn TofailKenitra14000Morocco

Renewable energy sources are essential formitigating the greenhouse effect and supplying energy to resource-scarce ***,their intermittent nature necessitates efficient storage solutions to enhance system efficiency and manage energy *** paper investigates renewable and clean storage systems,specifically examining the storage of electricity generated from renewable sources using hydropower plants and hydrogen,both of which are highly efficient and promising for future energy production and *** study utilizes extensive literature data to analyze the impact of various parameters on the cost per kWh of electricity production in hybrid renewable systems incorporating hydropower and hydrogen storage *** indicate that these hybrid systems can store electricity efficiently and cost-effectively,with production costs ranging from 0.126 to 0.3$/kWh for renewablehydropower systems and 0.118 to 0.42$/kWh for renewable-hydrogen systems,with expected cost reductions over the next decade due to technological advancements and increased market *** novelty of this study lies in its comprehensive comparison of hybrid renewable systems integrating hydropower and hydrogen storage,providing detailed cost analysis and future *** identifies key parameters influencing the cost and efficiency of these systems,offering insights into optimizing storage solutions for renewable ***,this research underscores the potential of hybrid systems to reduce dependency on fossil fuels,particularly during peak demand periods,and emphasizes the importance of seasonal and geographic considerations in selecting energy *** study highlights the importance of policy support and investment in hybrid renewable systems and calls for further research into optimizing these systems for different seasonal and geographic ***,the integration of renewable energy sources with hydropower and hydrogen storage offers a promising pathwa

关键词： Energy storage hydropower hydrogen renewable energy hybrid system

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Nonlinear response of a multidirectional negative-stiffness isolation system via semirecursive multibody dynamic approach

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International Journal of Mechanical System Dynamics 2024年第3期4卷 258-277页

作者： Wei Dai biagio Carboni Giuseppe Quaranta Yongjun Pan Walter Lacarbonara College of Mechanical and Vehicle Engineering Chongqing UniversityChongqingChina Department of Structural and Geotechnical Engineering Sapienza University of RomeRomeItaly

This paper investigates an innovative negative-stiffness device(NSD)that modifies the apparent stiffness of the supported structure for seismic *** NSD comprises a lower base on the bottom and a cap on the top,together with a connecting rod,vertical movable wall,and compressed elastic spring,as well as circumferentially arranged,pretensioned external ropes,and inclined shape memory *** configuration can deliver negative stiffness and energy dissipation in any direction within the horizontal plane.A numerical model of the device is developed through a two-step semirecursive method to obtain the force–displacement characteristic *** a model is first validated through comparison with the results obtained via the commercial software ***,a large parametric study is performed to assess the role and the influence of each design variable on the overall response of the proposed *** guidelines are drawn from this analysis to guide the system design and optimization.

关键词： multibody system negative stiffness semirecursive approach seismic protection vibration isolation

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Solid pseudopapillary tumor of the pancreas:A systematic review of clinical,surgical and oncological characteristics of 1384 patients underwent pancreatic surgery

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Hepatobiliary & Pancreatic Diseases International 2024年第4期23卷 331-338页

作者： Gennaro Mazzarella Edoardo Maria Muttillo Diego Coletta biagio Picardi Stefano Rossi Simone Rossi Del Monte Vito Gomes Irnerio Angelo Muttillo Division of General and Emergency Surgery San Filippo Neri Hospital00136 RomeItaly Department of Surgery“Pietro Valdoni” Sapienza University of RomeViale del Policlinico 15500161 RomeItaly Surgical and Medical Department of Translational Medicine Sant’Andrea HospitalSapienza University of Rome00185 RomeItaly Department of Surgical Sciences Umberto I University HospitalSapienza University of Rome00136 RomeItaly Department of General Surgery Ospedali Riuniti Marche Nord61121 PesaroItaly Department of Pathology San Filippo Neri Hospital00136 RomeItaly

Background:Pancreatic solid pseudopapillary tumors(SPTs)are rare clinical entity,with low malignancy and still unclear *** account for less than 2%of exocrine pancreatic *** study aimed to perform a systematic review of the main clinical,surgical and oncological characteristics of pancreatic *** sources:MEDLINE/PubMed,Web of Science and Scopus databases were systematically searched for the main clinical,surgical and oncological characteristics of pancreatic SPTs up to April 2021,in accordance with the preferred reporting items for systematic reviews and meta-analyses(PRISMA)*** endpoints were to analyze treatments and oncological ***:A total of 823 studies were recorded,86 studies underwent full-text reviews and 28 met inclusion ***,1384 patients underwent pancreatic *** age was 30 years and 1181 patients(85.3%)were *** most common clinical presentation was non-specific abdominal pain(52.6%of cases).Mean overall survival was 98.1%.Mean recurrence rate was 2.8%.Mean follow-up was 4.2 ***:Pancreatic SPTs are rare,and predominantly affect young women with unclear *** resection is the gold standard of treatment achieving good oncological impact and a favorable prognosis in a yearly life-long follow-up.

关键词： Frantz’s tumor Pancreas Pancreatic neoplasms Pancreatic surgery Solid pseudopapillary tumor

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Statistical Analysis of Abilities to Give Consent to Health Data Processing

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Applied Mathematics 2024年第8期15卷 508-542页

作者： Antonella Massari biagio Solarino Paola Perchinunno Angela Maria D’Uggento Marcello Benevento Viviana D’Addosio Vittoria Claudia De Nicolò Samuela L’Abbate Department of Economics Management and Business Law University of Bari Aldo Moro Bari Italy Institute of Legal Medicine Department of Interdisciplinary Medicine University of Bari Aldo Moro Bari Italy Department of Economics and Finance University of Bari Aldo Moro Bari Italy

The recent pandemic crisis has highlighted the importance of the availability and management of health data to respond quickly and effectively to health emergencies, while respecting the fundamental rights of every individual. In this context, it is essential to find a balance between the protection of privacy and the safeguarding of public health, using tools that guarantee transparency and consent to the processing of data by the population. This work, starting from a pilot investigation conducted in the Polyclinic of Bari as part of the Horizon Europe Seeds project entitled “Multidisciplinary analysis of technological tracing models of contagion: the protection of rights in the management of health data”, has the objective of promoting greater patient awareness regarding the processing of their health data and the protection of privacy. The methodology used the PHICAT (Personal Health Information Competence Assessment Tool) as a tool and, through the administration of a questionnaire, the aim was to evaluate the patients’ ability to express their consent to the release and processing of health data. The results that emerged were analyzed in relation to the 4 domains in which the process is divided which allows evaluating the patients’ ability to express a conscious choice and, also, in relation to the socio-demographic and clinical characteristics of the patients themselves. This study can contribute to understanding patients’ ability to give their consent and improve information regarding the management of health data by increasing confidence in granting the use of their data for research and clinical management.

关键词： Privacy Health Data Consent Cluster Analysis Logit

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Exergy Analysis of Organic Rankine Cycles with Zeotropic Working Fluids

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Fluid Dynamics & Materials Processing 2023年第3期19卷 593-601页

作者： Antonio Mariani Davide Laiso biagio Morrone Andrea Unich Department of Engineering DI Universitàdella Campania“Luigi Vanvitelli”Aversa(CE)Caserta81031Italy

Waste heat recovery is one of the possible solutions to improve the efficiency of internal combustion *** of wasting the exhaust stream of an energy conversion system into the environment,its residual energy content can be usefully recovered,for example in Organic Rankine Cycles(ORC).This technology has been largely consolidated in stationary power plants but not yet for mobile applications,such as road transport,due to the limitations in the layout and to the constraints on the size and weight of the ORC *** ORC system installed on the exhaust line of a bus powered by a natural gas spark ignition engine has been *** thermal power available at engine exhaust has been evaluated by measuring gas temperature and mass flow rate during real driving *** waste thermal power has been considered as heat input for the ORC plant simulation.A detailed heat exchanger model has been developed because it is a crucial component for the ORC *** exergy analysis of the ORC was performed comparing different working fluids:R601,R1233zd(E)and two zeotropic blends of the two organic pure *** model allowed the evaluation of the ORC produced energy over the driving cycle and the potential benefit on the engine efficiency.

关键词： Organic Rankine Cycle zeotropic mixtures exergy analysis waste heat recovery engine efficiency internal combustion engine

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Biological and Pollution Aerosols on Snow and Ice--Interplay between the Atmosphere and the Cryosphere

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Journal of Earth Science 2023年第6期34卷 1951-1956页

作者： Zhiwen Dong Hongchen Jiang Giovanni Baccolo biagio Di Mauro Krzysztof Zawierucha State Key Laboratory of Cryosphere Sciences Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China State Key Laboratory of Biogeology and Environmental Geology China University of GeosciencesWuhan 430078China Laboratory of Environmental Chemistry Paul Scherrer InstitutVilligen 5234Switzerland Institute of Polar Sciences National Research Council of ItalyMilan 20121Italy Department of Animal Taxonomy and Ecology Faculty of BiologyAdam Mickiewicz UniversityPoznan 61-614Poland

1 BACKGROUND The cryosphere covers a relevant portion of the Earth’s surface,playing a major role for terrestrial and marine biomes(Bosson et al.,2023;Sands et al.,2023;Anesio et al.,2017).Glacierets,glaciers and ice sheets represent together 10%of the global land surface,while the annual average maximum of snow cover during the winter accounts for up to 49%of the Northern Hemisphere’s surface (Qin,2017).Aerosols are another major component of the Earth system,playing pivotal roles in the biogeochemical cycles and in the Earth radiative mass balance (Bellouin et al.,2020;Carslaw et al.,2010).A complex network of interactions links aerosols and glaciers.

关键词： Atmosphere Earth winter

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Peripheral clonal selection shapes the human γδ T-cell repertoire

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Cellular & Molecular Immunology 2017年第9期14卷 733-735页

作者： biagio Di Lorenzo Julie Déchanet-Merville Bruno Silva-Santos Instituto de Medicina Molecular Faculdade de MedicinaUniversidade de Lisboa1649-028 LisbonPortugal Instituto Superior Tecnico Universidade de Lisboa1649-028 LisbonPortugal ImmunoConcept CNRS UMR 5164Equipe Labelisée Ligue Contre le CancerUniversity of BordeauxF-33000 BordeauxFrance

γδT cells are often placed at the interface between innate and adaptive *** cells share T-cell receptor(TCR)rearrangements and memory functions1 in common with theirαβT-cell counterparts but differ in terms of the... 详细信息

关键词： Figure kinetics selection

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Physiologic postoperative presepsin kinetics following primary cementless total hip arthroplasty:A prospective observational study

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World Journal of Orthopedics 2023年第7期14卷 547-553页

作者： Davide Bizzoca Andrea Piazzolla Lorenzo Moretti Giovanni Vicenti biagio Moretti Giuseppe Solarino DAI Neuroscienze Organi di Senso e Apparato LocomotoreAOU Consorziale Policlinico di BariBari 70124Italy University of Bari"Aldo Moro" Bari 70124Italy

BACKGROUND Presepsin is an emerging biomarker in the diagnosis of *** the field of orthopaedics,it could be useful in diagnosing and managing periprosthetic joint *** To define the normal postoperative presepsin plasmatic curve,in patients undergoing primary cementless total hip arthroplasty(THA).METHODS Patients undergoing primary cementless THA at our Institute were *** criteria were:Primary osteoarthritis of the hip;urinary catheter time of permanence<24 h;peripheral venous cannulation time of permanence<24 h;no postoperative homologous blood transfusion administration and hospital stay≤8 *** criteria were:The presence of other articular prosthetic replacement or bone fixation devices;chronic inflammatory diseases;chronic kidney diseases;history of recurrent infections or malignant neoplasms;previous surgery in the preceding 12 mo;diabetes mellitus;immunosuppressive drug or corticosteroid *** the patients received the same antibiotic *** the THA were performed by the same surgical and anaesthesia team;total operative time was defined as the time taken from skin incision to completion of skin *** enrollment,anthropometric data,smocking status,osteoarthritis stage according to Kellgren and Lawrence,Harris Hip Score,drugs assumption and comorbidities were *** the patients underwent serial blood tests,including complete blood count,presepsin(PS)and C-reactive protein 24 h before arthroplasty and at 24,48,72 and 96 h postoperatively and at 3,6 and 12-mo *** A total of 96 patients(51 female;45 male;mean age=65.74±5.58)were *** mean PS values were:137.54 pg/mL at baseline,192.08 pg/mL at 24 h post-op;254.85 pg/mL at 48 h post-op;259 pg/mL at 72 h post-op;248.6 pg/mL at 96-h post-op;140.52 pg/mL at 3-mo follow-up;135.55 pg/mL at 6-mo follow-up and 130.11 pg/mL at 12-mo *** two patients(2.08%)a soft-tissue infection was observed;in these patients,higher levels(

关键词： Presepsin Periprosthetic joint infection Total hip arthroplasty Total hip replacement Hip surgery Postoperative care

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Anterior vertebral body tethering for idiopathic scoliosis in growing children:A systematic review

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World Journal of Orthopedics 2022年第5期13卷 481-493页

作者： Davide Bizzoca Andrea Piazzolla Lorenzo Moretti Giovanni Vicenti biagio Moretti Giuseppe Solarino UOSD Spinal Deformity Centre AOU Consorziale Policlinico di BariBari 70124Italy Department of Biomedical Sciences and Human Oncology University of Bari“Aldo Moro”Bari 70124Italy Orthopaedic and Trauma Unit AUO Consorziale Policlinico di BariBari 70124Italy Department of Basic Medical Sciences Neuroscience and Sense OrgansOrthopaedic and Trauma UnitUniversity of Bari“Aldo Moro”Bari 70124PugliaItaly

BACKGROUND The management of idiopathic scoliosis(IS)in skeletally immature patients should aim at three-dimensional deformity correction,without compromising spinal and chest *** 2019,the US Food and Drug Administration approved the first instrumentation system for anterior vertebral body tethering(AVBT),under a Humanitarian Device Exception,for skeletally immature patients with curves having a Cobb angle between 35°and 65°.AIM To summarize current evidence about the efficacy and safety of AVBT in the management of IS in skeletally immature *** From January 2014 to January 2021,Ovid Medline,Embase,Cochrane Library,Scopus,Web of Science,Google Scholar and PubMed were searched to identify relevant *** methodological quality of the studies was evaluated and relevant data were *** Seven clinical trials recruiting 163 patients were included in the present *** studies out of seven were classified as high quality,whereas the remaining two studies were classified as moderate quality.A total of 151 of 163 AVBT procedures were performed in the thoracic spine,and the remaining 12 tethering in the lumbar *** 117 of 163(71.8%)patients had a nonprogressive curve at skeletal ***-three of 163(14.11%)patients required unplanned revision surgery within the follow-up *** to posterior spinal fusion(PSF)was performed in 18 of 163(11%)*** AVBT is a promising growth-friendly technique for treatment of IS in growing ***,it has moderate success and perioperative complications,revision and conversion to PSF.

关键词： Idiopathic scoliosis Spinal growth modulation Anterior spinal instrumentation Curve correction Anterior vertebral body tethering Paediatric spine Growing spine Skeletally immature patients Growth-friendly spinal implants

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