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Genetically predicted fatty liver disease and risk of psychiatric disorders: A mendelian randomization study

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World Journal of Clinical Cases 2024年第14期12卷 2359-2369页

作者： Wei-Ming Xu Hai-fu Zhang Yong-Hang Feng Shuo-Jun Li bi-Yun Xie Department of Medicine The First People's Hospital of FuyangHangzhou 311400Zhejiang ProvinceChina Department of Internal Medicine The First People's Hospital of FuyangHangzhou 311400Zhejiang ProvinceChina

BACKGROUND Non-alcoholic fatty liver disease(NAFLD)and alcohol-related liver disease(Ar-LD)constitute the primary forms of chronic liver disease,and their incidence is progressively increasing with changes in lifestyle *** studies have do-cumented a correlation between the occurrence and development of prevalent mental disorders and fatty *** To investigate the correlation between fatty liver and mental disorders,thus ne-cessitating the implementation of a mendelian randomization(MR)study to elu-cidate this *** Data on NAFLD and ArLD were retrieved from the genome-wide association studies catalog,while information on mental disorders,including Alzheimer's disease,schizophrenia,anxiety disorder,attention deficit hyperactivity disorder(ADHD),bipolar disorder,major depressive disorder,multiple personality dis-order,obsessive-compulsive disorder(OCD),post-traumatic stress disorder(PTSD),and schizophrenia was acquired from the psychiatric genomics consor-tium.A two-sample MR method was applied to investigate mediators in signifi-cant *** After excluding weak instrumental variables,a causal relationship was identified between fatty liver disease and the occurrence and development of some psychia-tric ***,the findings indicated that ArLD was associated with a significantly elevated risk of developing ADHD(OR:5.81,95%CI:5.59-6.03,Pbipolar disorder(OR:5.73,95%CI:5.42-6.05,P=0.03),OCD(OR:6.42,95%CI:5.60-7.36,Pbipolar disorder(OR:55.08,95%CI:3.59-845.51,Pbipolar disorder,OCD,and PTSD,highlighting the significance of preven-tive measures against psy

关键词： Non-alcoholic fatty liver disease Alcohol-related liver disease Psychiatric disorders Mendelian randomization Single nucleotide polymorphisms

Chaiqin Chengqi Decoction as an adjuvant treatment for mild/moderately severe hypertriglyceridemic acute pancreatitis: A retrospective study

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World Journal of Clinical Cases 2024年第11期12卷 1918-1928页

作者： Hai-fu Zhang Ze-Xuan Su Yong-Hang Feng Shuo-Jun Li bi-Yun Xie Department of Internal Medicine The First People's Hospital of FuyangHangzhou 311400Zhejiang ProvinceChina

Hypertriglyceridemia is the third leading cause of acute pancreatitis(AP),and its incidence is *** to its relatively insidious etiology,it is easy to be ignored in the early *** China,Chaiqin Chengqi Decoction(CQCQD)has long been employed for treating *** To evaluate the effectiveness of CQCQD in patients diagnosed with mild/moderately severe hypertriglyceridemic AP(HTG-AP).METHODS In this study,the clinical data of 39 patients with HTG-AP admitted from January 2019 to November 2022 were *** changes of blood lipids,gastrointestinal symptoms,and abdominal pain before and after treatment were analyzed and compared between the two *** Twenty patients were treated with the conventional HTG-AP regimen,and 19 patients were additionally treated with *** receiving treatment,the triglycerides(TG)level of the CQCQD group was lower than that of the CQCQD group(3.14±0.25 mmol/L vs 4.96±0.47 mmol/L,Pfunction of most patients returned to normal,and the acute gastrointestinal injury score was significantly lower than that of the control group(0.11±0.07 vs 0.42±0.11,Pfunction.

关键词： Hypertriglyceridemic acute pancreatitis Chinese medicine Chaiqin Chengqi Decoction Serum lipid Triglycerides

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多指标席位分配模型及其应用

数理统计与管理 2009年第4期28卷 660-665页

作者：付必胜杨益民张华广东南海广播电视大学广东南海528200 北京工商大学数理系北京100037

将经典席位分配模型推广,建立了多指标席位分配模型,它是一个有界整数变量非线性规划模型。将模型转化为非线性连续规划模型,因而可用各种具有良好收敛性和收敛速度的求解非线性连续规划的算法求解。给出多指标席位分配模型的一个简单... 详细信息

将经典席位分配模型推广,建立了多指标席位分配模型,它是一个有界整数变量非线性规划模型。将模型转化为非线性连续规划模型,因而可用各种具有良好收敛性和收敛速度的求解非线性连续规划的算法求解。给出多指标席位分配模型的一个简单有效的算法。最后实例说明多指标席位分配模型应用更加合理、更加广泛。

关键词：经典席位分配模型有界整数变量非线性规划多指标席位分配模型

Effect of Ti Particles on the Microstructure and Mechanical Properties of AZ91 Magnesium Matrix Composites

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Acta Metallurgica Sinica(English Letters) 2024年第3期37卷 513-524页

作者： Lu Xiao Ting-Ting Liu Yue Chu Bo Song Jie Zhao Xian-Hua Chen Kai-Hong Zheng fu-sheng Pan College of Materials Science and Engineering Chongqing UniversityChongqing 400044China lntelligent Manufacturing and Automobile School Chongqing College of Electronic EngineeringChongqing 401331China School of Materials and Energy Southwest UniversityChongqing 400715China Science and Technology Research Institute of CNNC 404 Co.LTD Gansu 735100China Institute of New Materials Guangdong Academy of SciencesGuangzhou 510650China

Spherical micro-Ti particle(TiP)-reinforced AZ91 magnesium alloy composites were fabricated by semi-solid stirring assisted ultrasonic vibration,which were then subjected to hot *** microstructure results showed that the addition of Ti particles refined the grain size and decreased the texture intensity of the as-extruded AZ91 *** Al3Ti phase with a thickness of 100 nm formed at the Ti/Mg interface,which had a non-coherent relationship with the magnesium *** as-extruded 1 vol.%TiP/AZ91 composite exhibited the best comprehensive mechanical properties,with yield strength,ultimate tensile strength,and elongation at break of 366 MPa,456 MPa,and 14.6%,respectively,which were significantly higher than those of the AZ91 ***,the addition of Ti particles can improve the strength and ductility of the AZ91 alloy,demonstrating the value of magnesium matrix composites for commercial applications.

关键词： Magnesium matrix composites Ti particles Interface Mechanical properties

Comparison of immune responses and intestinal flora in epicutaneously sensitized BALB/c or C57BL/6 mouse models of food allergy

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Food Science and Human Wellness 2024年第2期13卷 668-680页

作者： Gang Yu Yuhao Jiang Shuifeng Zhang Pengpeng Liu Shunyu Wang Huadong sheng Yanbo Wang Qiaozhi Zhang Linglin fu Food Safety Key Laboratory of Zhejiang Province School of Food Science and BiotechnologyZhejiang Gongshang UniversityHangzhou 310018China Zhejiang Fangyuan Test Group Co. Ltd.Hangzhou 310018China Key Laboratory of biosafety Detection for Zhejiang Market Regulation Hangzhou 310018China Zhejiang Liziyuan Food Co. LtdJinhua 321031China

Cutaneous exposure to food allergens through a disrupted skin barrier is recognized as an important cause of food allergy,and the cutaneous sensitized mouse model has been established to investigate relevant allergic ***,the role of different genetic backgrounds of mice on immune responses to food allergens upon epicutaneous sensitization is largely *** this study,two strains of mice,i.e.,the BALB/c and C57BL/6 mice,were epicutaneously sensitized with ovalbumin on atopic dermatitis(AD)-like skin lesions,followed by intragastric challenge to induce IgE-mediated food *** outcomes were measured as clinical signs,specific antibodies and cytokines,and immune cell subpopulations,as well as changes in intestinal barrier function and gut *** showed that both strains of mice exhibited typical food-allergic symptoms with a Th2-skewed *** C57BL/6 mice,rather than the BALB/c mice,were fitter for establishing an epicutaneously sensitized model of food allergy since a stronger Th2-biased response and severer disruptions in the intestinal barrier and gut homeostasis were *** study provides knowledge for selecting an appropriate mouse model to study food-allergic responses associated with AD-like skin lesions and highlights the role of genetic variations in the immune mechanism underlying pathogenesis of food allergy.

关键词： Food allergy Mouse models Epicutaneous sensitization Th2 response Gut microbiota

Normal sperm head morphometric reference values in fertile Asian males

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Asian Journal of Andrology 2024年第3期26卷 315-320页

作者： Ye-Lin Jia Ying-bi Wu Lin Yu Yan Zheng Ting-Ting Yang Yan-Yun Wang bin Zhou Lin Zhang fu-Ping Li Laboratory of Andrology West China Second University Hospital Human Sperm BankChengdu 610000China Laboratory of Molecular Translational Medicine Center for Translational MedicineChengdu 610061China Key Laboratory of birth Defects and Related Diseases of Women and Children(Sichuan University) Ministry of EducationChengdu 610061China NHC Key Laboratory of Chronobiology West China Second University HospitalSichuan UniversityChengdu 610000China

Sperm head morphology is crucial for male factor infertility diagnosis and assessment of male reproductive *** are available to analyze sperm head morphology,but they are limited by poor methodology comparability and *** study aimed to explore comprehensive and new normal morphometric reference values for spermatozoa heads infertile Asian *** automated sperm morphology analysis system captured 23152 stained spermatozoa from confirmed *** these samples,1856 sperm head images were annotated by three experienced laboratory technicians as“normal”.Weemployed 14 novel morphometric features to describe sperm head size(head length,head width,length/width ratio,and girth),shape(ellipse intersection over union,girth intersection over union,short-axis symmetry,and long-axis symmetry),area(head,acrosome,postacrosomal areas,and acrosome area ratio),and degrees of acrosome and nuclear *** straight-forwardmethod for the morphometric analysis of sperm by accurate visual measurements is clinically *** measured parameterspresent valuable information to establish morphometric reference intervals for normal sperm heads in fertile Asian *** detailed measurement data will be valuable for interlaboratory comparisons and technician *** vitro fertilizationand andrology laboratory technicians can use these parameters to perform objective morphology evaluation when assessing malefertilization potential.

关键词： fertile Asian males head morphometric reference value normal spermatozoa

Anti-epileptic and Neuroprotective Effects of Ultra-low Dose NADPH Oxidase Inhibitor Dextromethorphan on Kainic Acid-induced Chronic Temporal Lobe Epilepsy in Rats

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Neuroscience Bulletin 2024年第5期40卷 577-593页

作者： Jing-Jing Yang Ying-Xin Liu Yan-Fang Wang bi-Ying Ge Ying Wang Qing-Shan Wang sheng Li Jian-Jie Zhang Ling-Ling Jin Jau-Shyong Hong sheng-Ming Yin Jie Zhao College of Basic Medical Sciences Dalian Medical UniversityDalian116044China Department of Neurology The First Affiliated Hospital of Dalian Medical UniversityDalian116011China National and Local Joint Engineering Research Center for Drug Research and Development of Neurodegenerative Diseases Dalian116044China School of Public Health Dalian Medical UniversityDalian116044China Neurobiology Laboratory National Institute of Environmental Health SciencesNational Institutes of HealthResearch Triangle ParkDurhamNC27709USA

Neuroinflammation mediated by microglia and oxidative stress play pivotal roles in the development of chronic temporal lobe epilepsy(TLE).We postulated that kainic acid(KA)-Induced status epilepticus triggers microglia-dependent inflammation,leading to neuronal damage,a lowered seizure threshold,and the emergence of spontaneous recurrent seizures(SRS).Extensive evidence from our laboratory suggests that dextromethorphan(DM),even in ultra-low doses,has anti-inflammatory and neuroprotective effects in many animal models of neurodegenerative *** results showed that administration of DM(10 ng/kg per day;subcutaneously via osmotic minipump for 4 weeks)significantly mitigated the residual effects of KA,including the frequency of SRS and seizure *** addition,DM-treated rats showed improved cognitive function and reduced hippocampal neuronal *** found suppressed microglial activation-mediated neuroinflammation and decreased expression of hippocampal gp91^(phox) and p47^(phox) proteins in KA-induced chronic TLE ***,even after discontinuation of DM treatment,ultra-low doses of DM continued to confer long-term anti-seizure and neuroprotective effects,which were attributed to the inhibition of microglial NADPH oxidase 2 as revealed by mechanistic studies.

关键词： Temporal lobe epilepsy Dextromethorphan NADPH oxidase Ultra-low dose

Enhancing thermoelectric performance in P-type Mg_(3)Sb_(2)-based Zintls through optimization of band gap structure and nanostructuring

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Journal of Materials Science & Technology 2024年第3期170卷 25-32页

作者： Yi-bo Zhang Ji-sheng Liang Chengyan Liu Qi Zhou Zhe Xu Hong-bo Chen fu-cong Li Ying Peng Lei Miao Guangxi Key Laboratory of Information Material Engineering Research Center of Electronic Information Materials and DevicesMinistry of EducationSchool of Material Science and EngineeringGuilin University of Electronic TechnologyGuilin 541004China Guangxi Key Laboratory for Relativity Astrophysics Center on Nanoenergy ResearchGuangxi Key Laboratory of Processing for Nonferrous Metal and Featured MaterialsSchool of Physical Science&TechnologyGuangxi UniversityNanning 530004China Guangxi Key Laboratory of Precision Navigation Technology and Application Guilin University of Electronic TechnologySchool of Information and CommunicationGuilin 541004China

P-type Mg_(3)Sb_(2)-based Zintls have attracted considerable interest in the thermoelectric(TE)field due to their environmental friendliness and low ***,compared to their n-type counterparts,they show relatively low TE performance,limiting their application in TE *** this work,we simultaneously introduce bi alloying at Sb sites and Ag doping at Mg sites into the Mg_(3)Sb_(2)to coopera-tively optimize the electrical and thermal properties for the first time,acquiring the highest ZT value of∼0.85 at 723 K and a high average ZT of 0.39 in the temperature range of 323-723 K in sample Mg_(2.94)Ag_(0.06)Sb_(1.9)bi_(0.1).The first-principle calculations show that the codoping of Ag and bi can shift the Fermi level into the valence band and narrow the band gap,resulting in the increased carrier concentration from 3.50×10^(17)cm^(-3)in the reference Mg 3 Sb 0.9 bi 0.1 to∼7.88×10^(19)cm^(-3)in sample Mg 2.94 Ag 0.06 Sb 0.9 bi *** a result,a remarkable power factor of∼778.9μW m^(-1)K^(-2)at 723 K is achieved in sample Mg 2.94 Ag 0.06 Sb 0.9 bi ***,a low lattice thermal conductivity of∼0.48 W m^(-1)K^(-1)at 723 K is also obtained with the help of phonon scattering at the distorted lattice,point defects,and nano-precipitates in sample Mg 2.94 Ag 0.06 Sb 0.9 bi *** synergistic effect of using the multi-element co-doping/-alloying to optimize electrical properties in Mg_(3)Sb_(2)holds promise for further improving the TE performance of Zintl phase materials or even others.

关键词： Thermoelectric materials Band engineering Nanostructuring P-type Mg_(3)Sb_(2) Ag and bi Co-doping

Wettability and corrosion behavior between alkaline slag from sodium smelting of vanadium-titanium magnetite and refractory substrates

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Journal of Iron and Steel Research International 2024年第6期31卷 1399-1410页

作者： Fei Zhao Zhi-wei bian Hong-xin Zhao De-sheng Chen Zhang-fu Yuan Yu-lan Zhen Li-na Wang Tao Qi Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing 100083China National Engineering Research Center of Green Recycling for Strategic Metal Resources Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China Hebei Zhongke Tongchuang Vanadium&Titanium Technology Co. Ltd.Hengshui 053000HeheiChina

The sodium smelting of vanadium-titanium magnetite can achieve the comprehensive utilization of Fe,V,and ***,the generation of alkaline slag during this process may cause damage to refractory *** wettability and corrosion behavior of alkaline slag on three types of refractory(MgO-C,SiC,and high alumina refractory)substrates were investigated at temperatures up to 1200℃.The effects of duration on the wettability of molten slag on SiC substrates were also *** showed that the high alumina refractory exhibited better wettability with the molten slag than the others,and thus,it is easier to be *** results of scanning electron microscopy coupled with energy dispersive spectroscopy showed that MgO-C and high alumina refractory substrates were severely *** was a visible and regular interfacial reaction layer between the slag and SiC refractory substrate,which was produced by the redox reaction between the metal oxides in the slag and the SiC refractory *** the increase in holding time,the interface layer expands and silico-ferrite phases are generated at the *** redox reaction between Fe_(2)O_(3) and SiC substrate is the main reason for the *** comparing the differences in wettability and corrosion behavior between the alkaline slag from sodium smelting of vanadium-titanium magnetite and MgO-C,SiC and high alumina refractories,it is concluded that SiC refractory has good corrosion resistance to the *** oxides in the slag accelerate the oxidation rate of SiC refractory.

关键词： Wettability Corrosion Alkaline slag-Contact angle Vanadium-titanium magnetite Refractory