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On a New Reverse Extended Hardy’s Integral Inequality

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Journal of Mathematical Research and Exposition 2011年第3期31卷 474-478页

作者： bi cheng yang Department of Mathematics Guangdong Education Institute Guangdong 510303 P. R. China

In this paper,a new reverse extended Hardy＇s integral inequality is proved by means of weight coefficients and the technique of real *** particular results are considered.

关键词： Hardy's integral inequality weight function Hlder's inequality.

Comparative study of intracavernous pressure and cavernous pathology after bilateral caver nous n erve crushing and resection in rats

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Asian Journal of Andrology 2020年第6期22卷 629-635页

作者： Meng Li Yi-Ming Yuan bi-cheng yang Sheng-Ji Gu Hui-Xi Li Zhong-cheng Xin Dong Fang Rui-Li Guan Molecular biology Laboratory of Andrology Center Peking University First HospitalPeking UniversityBeijing 100034China

This study aimed to compare the effects of bilateral cavernous nerve crushing(BCNC)and bilateral cavernous nerve resection(BCNR)on intracavernous pressure(ICP)and cavernous pathology in rats and to explore the optimal treatment time for the BCNC and BCNR ***-two male rats aged 12 weeks were randomly divided into three equal groups:Sham(both cavernous nerves exposed only),BCNC(BCN crushed for 2 min),and BCNR(5 mm of BCN resected).Erectile function was then measured at 1 week,3 weeks,and 5 weeks after nerve injury,and penile tissues were harvested for histological and molecular analyses by immunohistochemistry,immuno fluoresce nee,Western blot,and cytokine *** found that erectile function parameters including the maximum,area,and slope of ICP/mean arterial pressure(MAP)significantly decreased after BCNR and BCNC at 1 week and 3 *** 5 weeks,no significant differences were observed in ICP/MAP between the BCNC and Sham groups,whereas the ICP/MAP of the BCNR group remained significantly lower than that of the Sham *** BCNC and BCNR,the amount of neuronal-nitric oxide synthase-positive fibers,smooth muscle cells,and endothelial cells decreased,whereas the amount of collage n III con tent *** pathological cha nges recovered over time,especially in the BCNC *** fin dings demonstrate that BCNC leads to acute and reversible erectile dysfunction,thus treatme nt time should be restricted to the first 3 weeks *** contrast,the self-healing ability of the BCNR model is poor,making it more suitable for long-term treatment research.

关键词： caver nous nerve crushing cavernous nerve resection erectile dysfunction in tracavernous pressure

Therapeutic effects of adipose-derived stem cells-based microtissues on erectile dysfunction in streptozotocin-induced diabetic rats

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Asian Journal of Andrology 2017年第1期19卷 91-97页

作者： Feng Zhou Hua Xin Yong-De Xu Hong-En Lei bi-cheng yang Rui-Li Guan Meng Li Jian-Quan Hou Zhong-cheng Xin Molecular biology Laboratory of Andrology Center Peking University First Hospital Peking University Beijing 100034 China Department of Urology First Affiliated Hospital of Soochow University Soochow University Suzhou 215006 China Department of Ophthalmology Beijing Chao-Yang Hospital Capital Medical University Beijing 100043 China Department of Urology General Hospital of Ningxia Medical University Ningxia Medical University Ningxia 750021 China

This study aimed to explore the therapeutic effects of adipose-derived stem cells （ADSCs）-based microtissues （MTs） on erectile dysfunction （ED） in streptozotocin （STZ）-induced diabetic rats. Fifty-six 8-week-old Sprague-Dawley rats received intraperitoneal injection of STZ （60 mg kg-1）, and 8 weeks later, the determined diabetic rats randomly received intracavernous （IC） injection of phosphate buffer solution （PBS）, ADSCs, or MTs. Another eight normal rats equally got IC injection of PBS. MTs were generated with a hanging drop method, and the injected cells were tracked in ADSC- and MT-injected rats. Four weeks after the treatments, intracavernous pressure （ICP）, histopathological changes in corpus cavernosum （CC）, and functional proteins were measured. Rat cytokine antibody array was used to detect ADSCs or MTs lysate. The results showed that MTs expressed vascular endothelial growth factor （VEGF）, nerve growth factor （NGF）, and tumor necrosis factor-stimulated gene-6 （TSG-6）. MTs injection had a higher retention than ADSCs injection and MTs treatment improved ICP, neuronal nitric oxide synthase （nNOS） expression, smooth muscle, and endothelial contents in diabetic rats, ameliorated local inflammation in CC better. Thus, our findings demonstrate that IC injection of MTs improves erectile function and histopathological changes in STZ-induced diabetic rats and appears to be more promising than traditional ADSCs. The underlying mechanisms involve increased cell retention accompanied with neuroprotection and anti-inflammatory behaviors of the paracrine factors.

关键词： adipose-derived stem cells diabetes erectile dysfunction microtissues paracrine factors

An alternative surgical technique for varicoceles:a preliminary experience of the microsurgical spermatic(distal end)-inferior or superficial epigastric vein anastomosis in symptomatic varicoceles associated with perineal pain

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Asian Journal of Andrology 2022年第6期24卷 624-627页

作者： Zi Wan Hai-Ming Cao bi-cheng yang Yong Gao Li Ding Peng Luo Guang-Wen yang Lin Ma Chun-Hua Deng The Andrology Department The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China The Andrology Department The Reproductive Medicine CenterThe Seventh Affiliated HospitalSun Yat-sen UniversityShenzhen 518107China The Reproductive Medicine Center The Key Laboratory for Reproductive Medicine of Guangdong ProvinceThe First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China The Pathology Department The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China The Urology Department Tongren Municipal People's HospitalTongren 554399China The Reproductive Medicine Center The Seventh Affiliated HospitalSun Yat-sen UniversityShenzhen 518107China

Many therapies are effective in treating varicoceles,including dilation of the pampiniform plexus in *** most common method of treatment is *** aimed to assess an alternative technique(microsurgical spermatic[distal end]-superficial or inferior epigastric vein anastomosis)that preserves the normal blood flow pattern for varicocele *** retrospectively analyzed 27 men with varicocele between October 2019 and July *** patients underwent microsurgical spermatic(distal end)-superficial or inferior epigastric vein *** prognosis was reviewed retrospectively with an additional survey conducted 3 months after *** mean±standard deviation of the age was 26.1±7.3 years in patients with microsurgical spermatic(distal end)-superficial or inferior epigastric vein *** maximum diameter of the varicocele vein,perineal pain score,sperm density,and forward movement of sperm improved over 3 months after *** spermatic(distal end)-superficial or inferior epigastric vein anastomosis is a safe and efficient surgical treatment for varicoceles.

关键词： microsurgery pain varicocele vein anastomosis

A Reliable Iteration Algorithm for One-bit Compressive Sensing on the Unit Sphere

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Acta Mathematicae Applicatae Sinica 2024年第3期40卷 801-822页

作者： Yan-cheng LU Ning bi An-hua WAN School of Mathematics Sun Yat-sen UniversityGuangzhou 510275China

The one-bit compressed sensing problem is of fundamental importance in many areas,such as wireless communication,statistics,and so ***,the optimization of one-bit problem coustrained on the unit sphere lacks an algorithm with rigorous mathematical proof of convergence and *** this paper,an iteration algorithm is established based on difference-of-convex algorithm for the one-bit compressed sensing problem constrained on the unit sphere,with iterating formula■,where C is the convex cone generated by the one-bit measurements andη_(1)>η_(2)>1/*** new algorithm is proved to converge as long as the initial point is on the unit sphere and accords with the measurements,and the convergence to the global minimum point of the l_(1)norm is discussed.

关键词： one-bit compressed sensing difference of convex algorithm iteration algorithm ■1-minimization

An improved initial rotor position estimation method using high-frequency pulsating voltage injection for PMSM

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Defence Technology（防务技术） 2024年第3期33卷 19-29页

作者： yang Jiang Ming cheng School of Electrical Engineering Southeast UniversityNanjing 210096China

High frequency pulsating voltage injection method is a good candidate for detecting the initial rotor position of permanent magnet synchronous ***,traditional methods require a large number of filters,which leads to the deterioration of system stability and dynamic *** order to solve these problems,a new signal demodulation method is proposed in this *** proposed new method can directly obtain the amplitude of high-frequency current,thus eliminating the use of filters,improving system stability and dynamic performance and saving the work of adjusting filter *** addition,a new magnetic polarity detection method is proposed,which is robust to current measurement ***,experiments verify the effectiveness of the method.

关键词： Initial position detection Signal demodulation algorithm Magnetic polarity detection Filter elimination

Recent Advances in Deciphering the Mechanisms and biological Functions of DNA Demethylation

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Chinese Journal of Chemistry 2024年第6期42卷 645-651页

作者： yang Feng Sheng-Jun Chen bi-Feng Yuan Key Laboratory of Aquatic Product Processing Ministry of Agriculture and Rural AffairsNational R&D Center for Aquatic Product ProcessingSouth China Sea Fisheries Research InstituteChinese Academy of Fishery SciencesGuangzhouGuangdong510300 China School of Public Health Research Center of Public HealthRenmin Hospital of Wuhan UniversityWuhan UniversityWuhanHubei430071 China

5-Methylcytosine (5mC) is a dynamic and reversible epigenetic modification in genomic DNA of higher *** has been well-established that the demethylation of 5mC occurs through the ten-eleven translocation (TET)-mediated oxidation of 5mC followed by thymine DNA glycosylase (TDG)-initiated base excision repair (BER).Recent findings also have identified an alternative pathway of DNA *** this pathway,TET enzymes directly oxidize 5mC to form 5-formylcytosine (5fC) or 5-carboxylcytosine (5caC).These modified bases can undergo direct deformylation or decarboxylation,***,DNA demethylation can also occur through the deamination of 5mC and 5hmC,resulting in the production of thymine and 5-hydroxymethyluracil (5hmU),*** DNA demethylation pathways possess critical functional implications and roles in biological *** Recent Advances article will focus on the studies of mechanisms and biological functions of DNA demethylation,shedding light on the reversible nature of the epigenetic modification of 5mC.

关键词： Epigenetics DNA DNA methylation 5-Methylcytosine Demethylation Mechanisms biological functions C—C bond cleavage Mass spectrometry

Analysis of multi-objective optimisation method for main insulation structure configuration scheme of valve-side winding of ultra-high voltage converter transformer considering multi-field coupling

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High Voltage 2024年第2期9卷 296-308页

作者： Lijun yang Zhidong cheng Li cheng Ruijin Liao State Key Laboratory of Power Transmission Equipment Technology School of Electrical EngineeringChongqing UniversityChongqingChina

Because DC conductivities of oil-paper materials can be easily affected by electric field and temperature,the electrical properties under electro-thermal coupling of oil-paper materials should be considered when optimising the insulation structure of valve-side winding of the converter *** on the finite element multi-physical field coupling simulation,the multi-objective optimisation of main insulation structure of valve-side winding is carried *** view of the high time consuming of multi-physical field calculation and the actual needs of an insulation structure optimisation,the Kriging method and technique for order preference by similarity to the ideal solution(TOPSIS)method are introduced,and combines them with NSGA-II to obtain a joint algorithm that can be used for the optimisation of insulation structure of the converter *** using the joint algorithm of multi-objective optimisation,the insulation structure configuration scheme of valve-side winding is *** can be seen from the experiment result that,on the one hand,the joint algorithm adopted can obtain the insulation structure configuration scheme that meets the design *** the other hand,when facing the configuration scheme optimisation under multi-field coupling,the computational time required by this method is only 0.15%of that required by original genetic algorithm.

关键词： converter insulation coupling

Deflagration and detonation induced by shock wave focusing at different Mach numbers

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Chinese Journal of Aeronautics 2024年第2期37卷 249-258页

作者： Zezhong yang Jun cheng Bo ZHANG School of Aeronautics and Astronautics Shanghai Jiao Tong UniversityShanghai 200240China

Shock wave focusing is an effective way to create a hot spot or a high-pressure and hightemperature region at a certain place,showing its unique usage in detonation initiation,which is beneficial for the development of detonation-based *** flame propagation behavior after the autoignition induced by shock wave focusing is crucial to the formation and self-sustaining of the detonation *** this study,wedge reflectors with two different angles(60°and 90°)and a planar reflector are employed,and the Mach number of incident shock waves ranging from 2.0 to 2.8 is utilized to trigger different flame propagation *** pressure transducers and the high-speed schlieren imaging system are both employed to investigate the shock-shock collision and ignition *** results reveal a total of four flame propagation modes:deflagration,DDT(Deflagration-to-Detonation Transition),unsteady detonation,and direct *** detonation wave formed in the DDT and unsteady detonation mode is only approximately 75%-85%of the Chapman-Jouguet(C-J)speed;meanwhile,the directly induced detonation wave speed is close to the C-J *** waves,which are strong evidence for the existence of detonation waves,are discovered in *** usage of wedge reflectors significantly reduces the initial pressure difference ratio needed for direct detonation *** also provide a practical method for differentiating between detonation and deflagration modes,which involves contrasting the speed of the reflected shock wave with the speed of the theoretically nonreactive reflected shock *** findings should serve as a reference for the detonation initiation technique in advanced detonation propulsion engines.

关键词： Deflagration Detonation Hydrogen Ignition Shock wave focusing