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A combined nanotherapeutic approach targeting farnesoid X receptor,ferroptosis,and fibrosis for nonalcoholic steatohepatitis treatment

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2228-2246页

作者： Jiangtao fu Pingping Zhang Zhiguo Sun Guodong Lu Qi Cao Yiting Chen Wenbin Wu Jiabao Zhang Chunlin Zhuang Chunquan sheng Jiajun Xu Ying Lu Pei Wang The Center for Basic Research and Innovation of Medicine and Pharmacy(MOE) School of PharmacyNaval Medical UniversityShanghai 200433China National Demonstration Center for Experimental Pharmaceutical Education Naval Medical University/Second Military Medical UniversityShanghai 200433China Department of Diving and Hyperbaric Medicine Naval Special Medical CenterNaval Medical UniversityShanghai 200433China

Obeticholic acid(OCA),a farnesoid X receptor(FXR)agonist with favorable effects on fatty and glucose metabolism,has been considered the leading candidate drug for nonalcoholic steatohepatitis(NASH)***,its limited effectiveness in resolving liver fibrosis and lipotoxicity-induced cell death remains a major ***,a newly recognized form of cell death characterized by uncontrolled lipid peroxidation,is involved in the progression of *** oxide(NO)is a versatile biological molecule that can degrade extracellular *** this study,we developed a PEGylated thiolated hollow mesoporous silica nanoparticles(MSN)loaded with OCA,as well as a ferroptosis inhibitor liproxsatin-1 and a NO donor S-nitrosothiol(ONL@MSN).biochemical analyses,histology,multiplexed flow cytometry,bulk-tissue RNA sequencing,and fecal 16S ribosomal RNA sequencing were utilized to evaluate the effects of the combined nanoparticle(ONL@MSN)in a mouse NASH *** with the OCA-loaded nanoparticles(O@MSN),ONL@MSN not only protected against hepatic steatosis but also greatly ameliorated fibrosis and ***@MSN also displayed enhanced therapeutic actions on the maintenance of intrahepatic macrophages/monocytes homeostasis,inhibition of immune response/lipid peroxidation,and correction of microbiota *** findings present a promising synergistic nanotherapeutic strategy for the treatment of NASH by simultaneously targeting FXR,ferroptosis,and fibrosis.

关键词： Nonalcoholic steatohepatitis Nanotherapy Farnesoid X receptor Ferroptosis Fibrosis Obeticholic acid S-Nitrosothiol Liproxstatin-1

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江苏省沿海地区小麦品种更替与演变分析

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植物遗传资源学报 2015年第6期16卷 1179-1187页

作者：张巧凤吴纪中颜伟付必胜蔡士宾江苏省农业科学院粮食作物研究所/江苏省种质资源保护与利用研究中心南京210014

对江苏省沿海地区12个县市(滨海县、大丰市、东台市、赣榆县、灌云县、海安县、海门市、启东市、如东县、射阳县、通州市、响水县)8个时间节点(1975年、1980年、1985年、1990年、1995年、2000年、2005年、2010年)的小麦种植面积、总产... 详细信息

对江苏省沿海地区12个县市(滨海县、大丰市、东台市、赣榆县、灌云县、海安县、海门市、启东市、如东县、射阳县、通州市、响水县)8个时间节点(1975年、1980年、1985年、1990年、1995年、2000年、2005年、2010年)的小麦种植面积、总产量、品种种类和数量及重要农艺性状的变化等进行了全面普查,对普查数据进行整理分析,结果如下:(1)江苏省沿海地区小麦植面积呈现波动减少的趋势。(2)小麦总产量和平均单产均呈现逐渐提高的趋势,在总产提高的过程中,单产的平均贡献率远大于面积的平均贡献率,优异小麦品种的推广是平均单产提高的决定因素。随着时间的推移,单产提高的难度越来越大,其对总产的贡献率逐渐下降。(3)对江苏省沿海地区小麦品种的演变分析发现:1淮北淮南麦区的小麦品种均大致经历了4次品种更新,地方品种已经全部被改良品种取代,主推品种始终以江苏省自主选育的品种为主,且随着时间的推移,占主推品种的比重越来越高;在淮北麦区,对其影响较大的外省市主要是山东省和河南省的小麦品种。2综合性状好、适应性广的品种维持时间长,推广面积大。3株高的降低,千粒重、穗粒数及穗长的增加均对小麦品种的单产提高起到了一定的促进作用,培育兼抗多种病害的小麦品种可能是今后小麦育种需要关注的重要方向。

关键词：江苏省沿海小麦品种

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2023年中国钛白粉行业的现状、未来及发展

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钢铁钒钛 2024年第1期45卷 1-3页

作者：毕胜钛白粉产业技术创新战略联盟江苏常州213016

总结了2023年中国钛白粉行业的各项运行数据,包括产能、产量、市场表观需求量、产能集中度等,分析了近期钛白粉产能增长趋势及相应钛矿原料供求关系的变化。指出,2023年钛白粉产量、产能继续保持增长趋势,产能集中度进一步提高;同时,现... 详细信息

总结了2023年中国钛白粉行业的各项运行数据,包括产能、产量、市场表观需求量、产能集中度等,分析了近期钛白粉产能增长趋势及相应钛矿原料供求关系的变化。指出,2023年钛白粉产量、产能继续保持增长趋势,产能集中度进一步提高;同时,现有生产商规模进一步扩大,业外加盟项目的增加,以及随着新能源材料产业的兴起导致的钛白粉产能增加,这些将加剧钛矿供需矛盾,市场前景和行业面貌堪忧,各方应高度关注和及时调整。对钛白粉行业未来的持续健康发展提出了建议,呼吁关注和积极应对近期出台的新一轮产业政策。

关键词：钛白粉产能产量

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Coexistence of adeno-associated virus 2 with adenovirus 18 or herpesvirus may be associated with severe lingual papillomatosis in an immunocompromised individual

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Virologica Sinica 2024年第4期39卷 705-707页

作者： Jie-Mei Yu Ze-Yin Liang Yuan-Hui fu Xiang-Lei Peng Yan-Peng Zheng Yu-Jun Dong Jin-sheng He College of Life Sciences and bioengineering Beijing Jiaotong UniversityBeijing100044China Department of Hematology Peking University First HospitalBeijing100034China

Dear Editor,Patients undergoing allogeneic hematopoietic stem cell transplantation(HSCT)often experience a significant reduction in immune function due to factors such as severe lymphopenia,immunosuppressive treatment,and the development of graft-versus-host disease,rendering them more susceptible to severe infections(Sahin et al.,2016).Traditional diagnostic approaches are limited in sensitivity,speed,and assay targets,thus failing short of meeting the diagnostic demands(Qu et al.,2022).However,next-generation sequencing(NGS)has greatly improved the accuracy and efficiency of diagnosing various diseases(Schuler et al.,2022),and has been widely utilized for pathogen detection in samples from HSCT patients(Armstrong et al.,2019;Peng et al.,2021).In this study,we employed viral metagenomics analysis using high-throughput sequencing on fecal and tissue samples from a patient with HSCT experiencing severe lingual papillomatosis.

关键词： al. papilloma rendering

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Constructing core@shell structured photothermal nanosphere with thin carbon layer confined Co-Mn bimetals for pollutant degradation and solar interfacial water evaporation

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Rare Metals 2024年第4期43卷 1686-1701页

作者： Hong-Yang Zhu Meng-Ting Liu Gang Wang Rong-Rong Du Hong-Yao Zhao Hao Lu Shi-Qi Yang sheng Tang Zeng-Jing Guo Jun Yang Cheng-Zhang Zhu fu Yang School of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiang212003China School of Chemistry and Chemical Engineering Liaocheng UniversityLiaocheng252000China School of Material Science and Engineering Jiangsu University of Science and TechnologyZhenjiang212003China School of Environmental Science and Engineering Nanjing Tech UniversityNanjing210009China

Photothermal material applied in environmental governance has attracted growing *** combining the Stober method and dopamine-triggered coating strategy,Co-Mn precursor was in situ incorporated into the poly dopamine(PDA)layer over the surface of silica ***,a unique photothermal nanosphere with SiO_(2)core and thin carbon layer and dual Co-Mn oxides shell was allowed to form by sequential heat treatment in the inert atmosphere(SiO_(2)@CoMn/C).The bimetallic fraction of Co/Mn in the carbon layer and post-treatment calcination temperature was comprehensively tuned to optimize the peroxymonosulfate(PMS)activation performance of the *** state of bimetallic species was studied including their physical distribution,chemical valence,and interplay by various ***,Co oxides appear as dominant monodispersed nanoparticles(~10 nm),while Mn with cluster-like morphology is observed to uniformly distribute over thin-layer carbon and adhered to the surface of SiO_(2)nanospheres(~250 nm).The calcined temperature could tune the oxidized state of Co species,leading to the optimization of the catalytic performance of introduced dual metal *** a result,this obtained optimal catalyst integrated the advantages of exposed bimetallic CoMn species and N-doped thin carbon to deliver excellent catalytic PMS activation performance and photothermal synergetic catalytic mineralization ability for diversiform *** reactions condition controls and anion interference studies were conducted to identify the adaptability of the optimal ***,the application of solar-driven interfacial water evaporation using optimal SiO_(2)@Co_3Mn_1/C-600 catalyst was explored,showing a high water evaporation rate of 1.48 kg·m^(-2)·h^(-1)and an efficiency of 95.2%,further revealing a comprehensive governance functionality of obtained material in the complex pollution condition.

关键词： Photothermal Peroxymonosulfate(PMS)activation bimetallic synergy Water evaporation Advanced oxidation process

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Molecular solid solution of lanthanide-titanium-oxo clusters with enhanced photocatalytic hydrogen evolution

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Science China Chemistry 2024年第2期67卷 529-535页

作者： Rong Chen Chao-Long Chen Hui Zhang Zi-Han Wang fu-Li Sun Ming-Hao Du Gui-Lin Zhuang Cheng Wang La-sheng Long Lan-Sun Zheng Xiang-Jian Kong Collaborative Innovation Centre of Chemistry for Energy Materials State Key Laboratory of Physical Chemistry of Solid Surfaces and Department of Chemistry College of Chemistry and Chemical EngineeringXiamen UniversityXiamen361005China College of Chemical Engineering Zhejiang University of TechnologyHangzhou310032China

Molecular solid solutions of metal clusters containing different metal centers with well-defined structures can accurately regulate the HOMO-LUMO gap,but are rarely ***,a series of colorless lanthanide-titanium-oxo clusters Ln_(2)Ti_4(μ_(2)-O)_(2)(μ_(3)-O)_4(Piv)_(10)(THF)_(2)(Ln_(2)Ti_4,Ln = Eu,Gd,Tb,and Ce,HPiv = pivalic acid) were synthesized by the reaction of pivalic acid with Ln(Ac)_(3) and titanium *** light yellow crystal of cluster solid solutions Eu_(2)Ti_(4-x)Cd_(x),containing a mixture of Eu_(2)Ti_4 and Eu_(2)Ti_(3)Cd,was obtained by in situ doping Cd^(2+) and S^(2–).Eu_(2)Ti_(3.92)Cd_(0.08) displays efficient photocatalytic hydrogen evolution activity without a co-catalyst,which is up to 2.6 times that of Eu_(2)Ti_*** time-resolved transient absorption spectroscopy and spin-polarized density functional calculations showed that the enhanced photocatalytic performance of Eu_(2)Ti_(4-x)Cd_(x) can be attributed to the narrower HOMO-LUMO gap and lower LUMO position than that of Eu_(2)Ti_*** studyprovides an in situ doping method to realize the simple preparation of cluster solid solution.

关键词： molecular solid solution lanthanide-titanium-oxo clusters photocatalytic hydrogen evolution

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Efficient and Stable Inverted Perovskite Solar Modules Enabled by Solid-Liquid Two-Step Film Formation

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Nano-Micro Letters 2024年第9期16卷 571-582页

作者： Juan Zhang Xiaofei Ji Xiaoting Wang Liujiang Zhang Leyu bi Zhenhuang Su Xingyu Gao Wenjun Zhang Lei Shi Guoqing Guan Abuliti Abudula Xiaogang Hao Liyou Yang Qiang fu Alex K.‑Y.Jen Linfeng Lu Graduate School of Science and Technology Hirosaki University3‑BunkyochoHirosaki 036‑8561Japan Department of Materials Science and Engineering Department of ChemistryHong Kong Institute for Clean EnergyCity University of Hong Kong KowloonHong Kong 999077People’s Republic of China The Interdisciplinary Research Center Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210People’s Republic of China Shanghai Synchrotron Radiation Facility(SSRF) Zhangjiang LabShanghai Advanced Research InstituteChinese Academy of SciencesShanghai201204People’s Republic of China JINNENG Clean Energy Technology Ltd. Jinzhong 030300ShanxiPeople’s Republic of China Hangzhou Zhongneng Photoelectricity Technology Co. Ltd.Hangzhou 310018People’s Republic of China College of Chemical Engineering and Technology Taiyuan University of TechnologyTaiyuan 030024People’s Republic of China Institute of Regional Innovation Hirosaki University3‑BunkyochoHirosaki 036‑8561Japan

A considerable efficiency gap exists between large-area perovskite solar modules and small-area perovskite solar *** control of forming uniform and large-area film and perovskite crystallization is still the main obstacle restricting the efficiency of *** this work,we adopted a solid-liquid two-step film formation technique,which involved the evaporation of a lead iodide film and blade coating of an organic ammonium halide solution to prepare perovskite *** method possesses the advantages of integrating vapor deposition and solution methods,which could apply to substrates with different roughness and avoid using toxic solvents to achieve a more uniform,large-area perovskite ***,modification of the NiO_(x)/perovskite buried interface and introduction of Urea additives were utilized to reduce interface recombination and regulate perovskite *** a result,a large-area perovskite film possessing larger grains,fewer pinholes,and reduced defects could be *** inverted PSM with an active area of 61.56 cm^(2)(10×10 cm^(2)substrate)achieved a champion power conversion efficiency of 20.56%and significantly improved *** method suggests an innovative approach to resolving the uniformity issue associated with large-area film fabrication.

关键词： Inverted perovskite solar cells Perovskite solar modules Two-step film formation Crystallization Defect passivation

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Pangenome and multi-tissue gene atlas provide new insights into the domestication and highland adaptation of yaks

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Journal of Animal Science and biotechnology 2024年第5期15卷 1832-1850页

作者： Daoliang Lan Wei fu Wenhui Ji Tserang‑Donko Mipam Xianrong Xiong Shi Ying Yan Xiong Peng sheng Jiangping Ni Lijun Bai Tongling Shan Xiangdong Kong Jian Li Ministry of Education of Key Laboratory of Qinghai‑Tibetan Plateau Animal Genetic Resource and Utilization Southwest Minzu UniversityChengduChina College of Animal&Veterinary Sciences Southwest Minzu UniversityChengduChina Institute of Qinghai‑Tibetan Plateau Southwest Minzu UniversityChengduChina Jiguang Gene biotechnology Co. Ltd.NanjingChina Chengdu Genepre Technology Co. Ltd.ChengduChina Shanghai Veterinary Research Institute Chinese Academy of Agricultural SciencesShanghaiChina

Background The genetic diversity of yak,a key domestic animal on the Qinghai-Tibetan Plateau(QTP),is a vital resource for domestication and breeding *** study presents the first yak pangenome obtained through the de novo assembly of 16 yak *** We discovered 290 Mb of nonreference sequences and 504 new *** pangenome-wide presence and absence variation(PAV)analysis revealed 5,120 PAV-related genes,highlighting a wide range of variety-specific genes and genes with varying frequencies across yak *** component analysis(PCA)based on binary gene PAV data classified yaks into three new groups:wild,domestic,and ***,we pro-posed a‘two-haplotype genomic hybridization model'for understanding the hybridization patterns among breeds by integrating gene frequency,heterozygosity,and gene PAV data.A gene PAV-GWAS identified a novel gene(Bos-Gru3G009179)that may be associated with the multirib trait in Jinchuan ***,an integrated transcrip-tome and pangenome analysis highlighted the significant differences in the expression of core genes and the muta-tional burden of differentially expressed genes between yaks from high and low *** analysis across multiple species revealed that yaks have the most unique differentially expressed m RNAs and lnc RNAs(between high-and low-altitude regions),especially in the heart and lungs,when comparing high-and low-altitude *** The yak pangenome offers a comprehensive resource and new insights for functional genomic studies,supporting future biological research and breeding strategies.

关键词： High-and low-altitude Novel genes Pangenome PAV-GWAS Yak

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Efficacy of hepatic arterial infusion chemotherapy and its combination strategies for advanced hepatocellular carcinoma:A network meta-analysis

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3672-3686页

作者： Shun-An Zhou Qing-Mei Zhou Lei Wu Zhi-Hong Chen Fan Wu Zhen-Rong Chen Lian-Qun Xu bi-LingGan Hao-sheng Jin Ning Shi Department of General Surgery Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510000Guangdong ProvinceChina Department of Geriatrics Ganzhou Hospital-Nanfang HospitalSouthern Medical UniversityGanzhou 341000Jiangxi ProvinceChina Guangdong Cardiovascular Institute Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510000Guangdong ProvinceChina Department of Liver Surgery Peking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100730China

BACKGROUND With the rapid progress of systematic therapy for hepatocellular carcinoma(HCC),therapeutic strategies combining hepatic arterial infusion chemotherapy(HAIC)with systematic therapy arised increasing ***,there have been no systematic review comparing HAIC and its combination strategies in the first-line treatment for advanced *** To investigate the efficacy and safety of HAIC and its combination therapies for advanced *** A network meta-analysis was performed by including 9 randomized controlled trails and 35 cohort studies to carry out our *** outcomes of interest comprised overall survival(OS),progression-free survival(PFS),tumor response and adverse *** ratios(HR)and odds ratios(OR)with a 95% confidence interval(CI)were calculated and agents were ranked based on their ranking *** HAIC outperformed Sorafenib(HR=0.55,95%CI:0.42-0.72;HR=0.51,95%CI:0.33-0.78;OR=2.86,95%CI:1.37-5.98;OR=5.45,95%CI:3.57-8.30;OR=7.15,95%CI:4.06-12.58;OR=2.89,95%CI:1.99-4.19;OR=0.48,95%CI:0.25-0.92,respectively)and transarterial chemoembolization(TACE)(HR=0.50,95%CI:0.33-0.75;HR=0.62,95%CI:0.39-0.98;OR=3.08,95%CI:1.36-6.98;OR=2.07,95%CI:1.54-2.80;OR=3.16,95%CI:1.71-5.85;OR=2.67,95%CI:1.59-4.50;OR=0.16,95%CI:0.05-0.54,respectively)in terms of efficacy and ***+lenvatinib+ablation,HAIC+ablation,HAIC+anti-programmed cell death 1(PD-1),and HAIC+radiotherapy had the higher likelihood of providing better OS and PFS outcomes compared to HAIC ***+TACE+S-1,HAIC+lenvatinib,HAIC+PD-1,HAIC+TACE,and HAIC+sorafenib had the higher likelihood of providing better partial response and objective response rate outcomes compared to ***+PD-1,HAIC+TACE+S-1 and HAIC+TACE had the higher likelihood of providing better complete response and disease control rate outcomes compared to HAIC *** HAIC proved more effective and safer than sorafenib and ***,combined with other interventions,HAIC showed imp

关键词： Hepatic arterial infusion chemotherapy Hepatocellular carcinoma Network meta-analysis Interventional therapy Systemic treatment

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A small D-A molecule with highly heat-resisting room temperature phosphorescence for white emission and anti-counterfeiting

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结构化学 2024年第3期43卷 3-9页

作者： Kun Zhang Ni Dan Dan-Dan Ren Ruo-Yu Zhang Xiaoyan Lu Ya-Pan Wu Li-Lei Zhang Hong-Ru fu Dong-sheng Li College of Materials and Chemical Engineering China Three Gorges UniversityYichang443002PR China College of Chemistry and Chemical Engineering Luoyang Normal UniversityLuoyang471934PR China College of Chemistry and Chemical Engineering Luoyang Normal UniversityLuoyang471934PR China College of Materials and Chemical Engineering China Three Gorges UniversityYichang443002PR China

Achieving high heat-resisting room temperature phosphorescence(RTP)performance and robust white emission from pure small molecules is a meaningful but challenging ***,a simple donor-acceptor(D-A)molecule,9-(1H-benzotriazol-1-ylmethyl)-9H-carbazole(CzBtrz),was *** simple molecule not only exhibits multiple emissions including white light,thermally activated delayed fluorescence(TADF)and ultralong RTP with a lifetime of 988.54 ms at 545 nm,but also shows superhigh heat-resisting phosphorescence property which can maintain stability in a large temperature region from 77 to 350 K(ΔT=273 K),exceeding those of other RTP ***,this molecule shows the time-evolved dynamic *** experimental and theoretical an-alyses from CzBtrz crystal demonstrate that the intramolecular charge transfer(ICT)interaction and molecular stacking play an important role in the generation of ***,this work provides an efficient strategy to design ultrahigh heat-resistant RTP,ultralong RTP and single-phased white-light emitting materials.

关键词： Ultralong RTP TADF D-A molecule Heat-resisting White light

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