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Advances in regional nodal management of early-stage breast cancer

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Chinese Journal of Cancer Research 2024年第2期36卷 215-225页

作者： zhao bi Yongsheng Wang Breast Cancer Center Shandong Cancer Hospital and InstituteShandong First Medical University and Shandong Academy of Medical SciencesJinan 250017China

With the continuous improvement of systemic treatment, reasonable local regional control of early-stage breast cancer can be translated into survival benefits. The optimization of regional nodal management in patients with limited sentinel lymph node(SLN) metastasis needs to be weighed by surgical complications, regional recurrence risk, and lymph node status, as well as other escalating treatment(systemic/radiotherapy) that may result from deescalating surgery. With the effective support and supplementation of systemic therapy and radiotherapy, the management of axillary surgery is developing in a de-escalating trend. The widespread application of neoadjuvant therapy has contributed to optimizing the management of patients with clinically node-negative/imaging nodepositive disease. In clinical practice, it is necessary to consider the residual tumor burden of regional lymph nodes when formulating the optimal irradiation fields in patients with limited positive SLN without axillary lymph node dissection. The combined application of genomic tests and American College of Surgeons Oncology Group Z0011/AMAROS criteria could provide patients with a better strategy of dual de-escalation treatment, which includes the de-escalation of both axillary surgery and systemic treatment. In the era of sentinel lymph node biopsy(SLNB), the regional nodal management of breast cancer should adhere to the concept of “updating ideas, making bold assumptions, and carefully seeking proof”, make full use of the benefits of systemic therapy and radiotherapy to reduce the scope of surgery and complications, and expand the “net benefit” of efficacy and quality of life. This review discusses the optimization of regional nodal management in the era of SLNB, in order to provide reference information for clinicians.

关键词： Breast cancer sentinel lymph node biopsy internal mammary lymph node radiotherapy surgery

bipolar membrane electrodialysis integrated with in-situ CO_(2)absorption for simulated seawater concentrate utilization,carbon storage and production of sodium carbonate

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Journal of Environmental Sciences 2024年第8期142卷 21-32页

作者： Jingtao bi Tianyi chen Yue Xie Ruochen Shen bin Li Mengmeng Sun Xiaofu Guo Yingying zhao School of Chemical Engineering and Technology Hebei University of TechnologyTianjin 300401China Engineering Research Center of Seawater Utilization Technology of Ministry of Education School of Chemical Engineering and TechnologyHebei University of TechnologyTianjin 300401China Hebei Collaborative Innovation Center of Modern Marine Chemical Technology Tianjin 300401China Tianjin Key Laboratory of Chemical Process Safety Tianjin 300130China Shandong Technology Innovation Center of Seawater and Brine Efficient Utilization Weifang 262737China

In the context of carbon capture,utilization,and storage,the high-value utilization of carbon storage presents a significant *** address this challenge,this study employed the bipolar membrane electrodialysis integrated with carbon utilization technology to prepare Na_(2)CO_(3)products using simulated seawater concentrate,achieving simultaneous saline wastewater utilization,carbon storage and high-value production of Na_(2)CO_(3).The effects of various factors,including concentration of simulated seawater concentrate,current density,CO_(2)aeration rate,and circulating flow rate of alkali chamber,on the quality of Na_(2)CO_(3)product,carbon sequestration rate,and energy consumption were *** the optimal condition,the CO_(3)^(2-)concentration in the alkaline chamber reached a maximum of 0.817 mol/L with 98 mol%*** resulting carbon fixation rate was 70.50%,with energy consumption for carbon sequestration and product production of 5.7 k Whr/m^(3)CO_(2)and1237.8 k Whr/ton Na_(2)CO_(3),*** coupling design provides a triple-win outcome promoting waste reduction and efficient utilization of resources.

关键词： bipolar membrane electrodialysis(BMED) Carbon capture Utilization and storage(CCUS) Seawater concentrate Sodium carbonate

Achieving dynamic privacy measurement and protection based on reinforcement learning for mobile edge crowdsensing of IoT

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Digital Communications and Networks 2024年第2期10卷 380-388页

作者： Renwan bi Mingfeng zhao Zuobin Ying Youliang Tian Jinbo Xiong Fujian Provincial Key Laboratory of Network Security and Cryptology College of Computer and Cyber SecurityFujian Normal UniversityFuzhou350117China Guangxi Key Laboratory of Trusted Software Guilin University of Electronic TechnologyGuilin541004China Faculty of Data Science City University of Macao999078MacaoChina State Key Laboratory of Public big Data College of Computer Science and TechnologyGuizhou UniversityGuiyang550025China

With the maturity and development of 5G field,Mobile Edge CrowdSensing(MECS),as an intelligent data collection paradigm,provides a broad prospect for various applications in ***,sensing users as data uploaders lack a balance between data benefits and privacy threats,leading to conservative data uploads and low revenue or excessive uploads and privacy *** solve this problem,a Dynamic Privacy Measurement and Protection(DPMP)framework is proposed based on differential privacy and reinforcement ***,a DPM model is designed to quantify the amount of data privacy,and a calculation method for personalized privacy threshold of different users is also ***,a Dynamic Private sensing data Selection(DPS)algorithm is proposed to help sensing users maximize data benefits within their privacy ***,theoretical analysis and ample experiment results show that DPMP framework is effective and efficient to achieve a balance between data benefits and sensing user privacy protection,in particular,the proposed DPMP framework has 63%and 23%higher training efficiency and data benefits,respectively,compared to the Monte Carlo algorithm.

关键词： Mobile edge crowdsensing Dynamic privacy measurement Personalized privacy threshold Privacy protection Reinforcement learning

High‑Entropy Layered Oxide Cathode Enabling High‑Rate for Solid‑State Sodium‑Ion Batteries

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Nano-Micro Letters 2024年第1期16卷 160-171页

作者： Tianxun Cai Mingzhi Cai Jinxiao Mu Siwei zhao Hui bi Wei zhao Wujie Dong Fuqiang Huang State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050People’s Republic of China State Key Laboratory of Rare Earth Materials Chemistry and Applications College of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871People’s Republic of China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049People’s Republic of China Zhongke Institute of Strategic Emerging Materials Yixing 214213JiangsuPeople’s Republic of China

Na-ion O3-type layered oxides are prospective cathodes for Na-ion batteries due to high energy density and ***,such cathodes usually suffer from phase transitions,sluggish kinetics and air instability,making it difficult to achieve high performance solid-state sodium-ion ***,the high-entropy design and Li doping strategy alleviate lattice stress and enhance ionic conductivity,achieving high-rate performance,air stability and electrochemically thermal stability for Na_(0.95)Li_(0.06)Ni_(0.25)Cu_(0.05)Fe_(0.15)Mn_(0.49)O_(2).This cathode delivers a high reversible capacity(141 mAh g^(−1)at 0.2C),excellent rate capability(111 mAh g^(−1)at 8C,85 mAh g^(−1)even at 20C),and long-term stability(over 85%capacity retention after 1000 cycles),which is attributed to a rapid and reversible O3–P3 phase transition in regions of low voltage and suppresses phase ***,the compound remains unchanged over seven days and keeps thermal stability until 279℃.Remarkably,the polymer solid-state sodium battery assembled by this cathode provides a capacity of 92 mAh g^(−1)at 5C and keeps retention of 96%after 400 *** strategy inspires more rational designs and could be applied to a series of O3 cathodes to improve the performance of solid-state Na-ion batteries.

关键词： High-entropy High-rate performance Li-TM interaction Air stability O3 layered oxide cathode

A modified 3D mean strain energy density criterion for predicting shale mixed-mode I/III fracture toughness

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第7期16卷 2411-2428页

作者： Kun Zheng Chaolin Wang Yu zhao Jing bi Haifeng Liu College of Civil Engineering Guizhou UniversityGuiyang550025China State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China

The fracture toughness of rocks is a critical fracturing parameter in geo-energy exploitation playing a significant role in fracture mechanics and hydraulic *** edge-notched disk bending(ENDB)specimens are employed to measure the entire range of mixed-modeⅠ/Ⅲfracture toughness of Longmaxi *** theoretically interpret the fracture mechanisms,this research first introduces the detailed derivations of three established fracture *** distinguishing the volumetric and distortional strain energy densities,an improved three-dimensional mean strain energy density(MSED)criterion is *** the critical volumetric to distortional MSED ratio decreases,the transition from tensiondominated fracture to shear-dominated fracture is *** results indicate that both peak load and applied energy increase significantly with the transition from pure mode I(i.e.,tension)to pure modeⅢ(i.e.,torsion or tearing)since mode-Ⅲcracking happens in a twisted manner and mode-Ⅰcracking occurs in a coplanar *** macroscopic fracture signatures are consistent with those of triaxial hydraulic *** average ratio of pure mode-Ⅲfracture toughness to pure mode-Ⅰfracture toughness is 0.68,indicating that the obtained mode-Ⅲfracture resistance for a tensionbased loading system is apparent rather than *** to the three mainstream fracture criteria,the present fracture criterion exhibits greater competitiveness and can successfully evaluate and predict mixed-modeⅠ/Ⅲfracture toughness of distinct materials and loading methods.

关键词： Longmaxi shale Hydraulic fracturing Fracture mechanisms Fracture criteria Mixed-mode I/III fracture toughness Edge-notched disk bending

Structure-regulated fluorine-containing additives to improve the performance of perovskite solar cells

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Nano Research 2024年第7期17卷 6080-6086页

作者： Peiya chen Xiaoman bi Hao Yan Yingjie zhao Yihao Liu Zhuo Huang Qian Xiao Yongpeng Yang Shasha Zhang Yiqiang Zhang Yanlin Song Henan Institute of Advanced Technology College of ChemistrySchool of Materials Science and EngineeringZhengzhou UniversityZhengzhou 450001China Key Laboratory of Green Printing CAS Research/Education Center for Excellence in Molecular SciencesInstitute of ChemistryChinese Academy of Sciences(ICCAS)Beijing Engineering Research Center of Nanomaterials for Green Printing TechnologyNational Laboratory for Molecular Sciences(BNLMS)Beijing 100190China

Perovskite solar cells(PSCs)have seen remarkable progress in recent years,largely attributed to various additives that enhance both efficiency and *** these,fluorine-containing additives have garnered significant interest because of their unique hydrophobic properties,effective defect passivation,and regulation capability on the crystallization ***,a targeted structural approach to design such additives is necessary to further enhance the performance of ***,fluoroalkyl ethylene with different fluoroalkyl chain lengths(CH_(2)CH(CF_(2))nCF_(3),n=3,5,and 7)as liquid additives is used to investigate influences of fluoroalkyl chain lengths on crystallization regulation and defect *** findings indicate that optimizing the quantity of F groups plays a crucial role in regulating the electron cloud distribution within the additive *** optimization fosters strong hydrogen bonds and coordination effects with FA+and uncoordinated Pb^(2+),ultimately enhancing crystal quality and device ***,1H,1H,2H-perfluoro-1-hexene(PF_(3))with the optimal number of F presents the most effective modulation effect.A PSC utilizing PF_(3)achieves an efficiency of 24.05%,and exhibits exceptional stability against humidity and thermal *** work sheds light on the importance of tailored structure designs in additives for achieving high-performance PSCs.

关键词： perovskite solar cells fluorine number additive structure crystallization regulation defect passivation

Insights into the role of oxygen-containing functional groups on carbon surface in water–electricity generation

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Nano Research 2024年第7期17卷 6645-6653页

作者： Wan Xue Zongbin zhao Honghui bi Bolun Zhang Xuzhen Wang Jieshan Qiu State Key Laboratory of Fine Chemicals Liaoning Key Laboratory for Energy Materials and Chemical EngineeringSchool of Chemical EngineeringDalian University of TechnologyDalian 116024China State Key Laboratory of Fine Chemicals Liaoning Key Laboratory for Energy Materials and Chemical EngineeringSchool of ChemistryDalian University of TechnologyDalian 116024China State Key Laboratory of Chemical Resource Engineering College of Chemical EngineeringBeijing University of Chemical TechnologyBeijing 100029China

A deep understanding of the electricity generation mechanism from the interaction between water molecules and carbon material surfaces is attractive for next-generation water-based energy conversion and storage ***,an asymmetric generator was assembled based on functionalized carbon nanotubes films to investigate the relative contribution from various oxygen functional groups on carbon surface to the water-electrical *** and calculations demonstrate that the electricity mainly originates from the water molecule adsorption by carboxyl groups and dissociation of functional groups on carbon surface,which leads to the formation of electrical double layers at *** device allows the electricity generation with a variety of water sources,such as deionized water,tap water,as well as *** particular,the generator based on carboxyl carbon nanotubes can induce a voltage of over 200 mV spontaneously in natural seawater with the power density of about 0.11 mW·g^(−1).High voltages can be achieved easily through the series-connection strategy to power electronic products such as a liquid crystal *** work reveals the dominant role of carboxyl groups in carbon-based water–electricity conversion and is expected to offer inspiration for the preparation of carbon materials with high electrical performance.

关键词： electricity generation water adsorption dissociation carboxyl groups carbon nanotubes

Longitudinal gut fungal alterations and potential fungal biomarkers for the progression of primary liver disease

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Science China(Life Sciences) 2024年第6期67卷 1183-1198页

作者： Shiman Jiang Lvwan Xu Yanfei chen Zheyue Shu Longxian Lv Yuxi zhao Kefan bi Sisi Yang Qiangqiang Wang Lanjuan Li State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesNational Medical Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Liver disease,a major health concern worldwide,is a serious and progressive ***,we not only established a mouse model of DEN+CCl4-induced primary liver disease but also collected clinical human samples to investigate longitudinal alterations in the gut *** liver disease advanced,gut integrity was disrupted,and the mycobiota was disturbed in the mouse *** metabolites associated with hepatocellular carcinoma(HCC)differed from those associated with the cirrhotic phase as follows:levels of stercobilin and aflatoxin B1 dialcohol were reduced,while levels of triterpenoids,bafilomycin A1,and DHEA were increased in the HCC *** abundance of the phylum Chytridiomycota increased as the chronic liver disease progressed and was then replaced by the phylum Ascomycota in *** on the results from clinical human samples,the genus Candida(Ascomycota)(in humans)and the genus Kazachstania(Ascomycota)(in mice)occupied a dominant position in the HCC group,while other fungi were *** increased abundance of *** and depletion of *** may be hallmarks of the progression of liver cirrhosis to early ***,the administration of *** and *** in the LC-HCC progression could accelerate or retard the progression of ***,gut fungi have the potential to serve as a noninvasive clinical biomarker and even a treatment method.

关键词： gut mycobiome liver disease longitudinal studies hepatocarcinogenesis fungal biomarker

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Low-rank spectral estimation algorithm of learning Markov model

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Frontiers of Mathematics in China 2024年第3期19卷 137-155页

作者： Yongye zhao Shujun bi Department of Basic Courses Guangzhou Maritime UniversityGuangzhou 510725China Department of Mathematics South China University of TechnologyGuangzhou 510640China

This paper proposes a low-rank spectral estimation algorithm of learning Markov ***,an approximate projection algorithm for the rank-constrained frequency matrix set is proposed,and thereafter its local Lipschitzian error bound ***,we propose a low-rank spectral estimation algorithm for estimating the state transition frequency matrix and the probability matrix of Markov model by applying the approximate projection algorithm to correct the maximum likelihood estimation of the frequency matrix,and prove that there is only a multiplying constant difference in estimation errors between the low-rank spectral estimation and the maximum likelihood estimation under appropriate ***,numerical comparisons with the prevailing maximum likelihood estimation,spectral estimation,and rank-constrained maxi-mum likelihood estimation show that the low-rank spectral estimation algorithm is effective.

关键词： Markov model low-rank spectral estimation error bound approximate projection