检索结果-南通市图书馆

Danzhi Jiangtang capsule(丹蛭降糖胶囊)reduces renal injury in rats with diabetes induced by high fat diet and streptozotocin via downregulating toll-like receptor 4-nuclear factor-κB pathway and apoptosis

引用

Journal of Traditional Chinese Medicine 2023年第2期43卷 312-321页

作者： XIE Jing bi zheng WANG Sihai SHEN Guoming FANG Zhaohui Department of Endocrinology the First Affiliated Hospital of Anhui University of Traditional Chinese MedicineHefei 230031China Anhui Academic of Traditional Chinese Medicine Diabetes Research Institute Hefei 230031China

OBJECTIVE:To investigate the effect and mechanisms of Danzhi Jiangtang capsule(丹蛭降糖胶囊,DJC)on renal injury in streptozotocin(STZ)-induced diabetes of rats.METHODS:Sprague-Dawley rats were fed with high fat diet for 6 weeks followed by streptozotocin(STZ,35 mg/kg)injection.These rats were then treated with DJC(270,540 and 1080 mg/kg)daily for 8 weeks.RESULTS:A combination of high fat diet and STZ significantly increased blood glucose creatinine,urea nitrogen,and urine albumin in rats.Meanwhile,the glomerular and tubular lesions were observed in rats fed with high fat diet and injected with STZ.These biochemical and pathological changes were significantly attenuated by DJC treatments in a dose-dependent manner.Mechanistically,DJC treatments significantly decreased toll-like receptor 4(TLR4),mitogen-activated protein kinase(MAPK),and nuclear factor-κB(NF-κB)signals in the kidney of rats fed with high fat diet and injected with STZ.Terminal deoxynucleotidyl transferase dU TP nick end labeling staining and caspase-8 levels showed that renal apoptosis was increased in rats fed with high fat diet and injected with STZ,and this was attenuated by DJC treatments.CONCLUSIONS:DJC treatments protect against diabetic kidney disease,and the mechanism may be closely related to downregulation of TLR4/MAPK/NF-κB pathways and apoptosis.This study provides further evidence of using DJC as a potential therapeutic option for diabetic kidney disease.

关键词： diabetic nephropathies inflammation apoptosis toll-like receptor 4 mitogen-activated protein kinase kinases NF-kappa B Danzhi Jiangtang capsule

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

85例低血磷性佝偻病患儿诊断、治疗与随访的回顾性研究

引用

中国当代儿科杂志 2024年第7期26卷 677-682页

作者：李海琦陈秋霞车若琛郑必霞张爱华陈颖南京医科大学附属儿童医院江苏南京210000 南京医科大学附属儿童医院儿科学重点实验室江苏南京210000

目的了解低血磷性佝偻病(hypophosphatemic rickets,HR)患儿的诊断、治疗及并发症情况,探讨疾病疗效评价指标,了解患儿身高增长规律。方法回顾性分析2008年1月—2022年12月于南京医科大学附属儿童医院诊治的85例HR患儿的首诊临床资料及... 详细信息

目的了解低血磷性佝偻病(hypophosphatemic rickets,HR)患儿的诊断、治疗及并发症情况,探讨疾病疗效评价指标,了解患儿身高增长规律。方法回顾性分析2008年1月—2022年12月于南京医科大学附属儿童医院诊治的85例HR患儿的首诊临床资料及5年随访资料。结果85例HR患儿中,男性46例(54%),女性39例(46%);首诊年龄范围为6个月至13岁9个月,中位年龄为2.75岁;平均身高标准差数值为-2.0±1.1。首诊时患儿血磷降低,血碱性磷酸酶(alkaline phosphatase,ALP)升高,99%(84/85)患儿存在下肢畸形,PHEX基因突变阳性率为93%(55/59)。患儿治疗1年后ALP水平及双下肢间距较前明显减低(P<0.05)。患儿身高在治疗后第1年增长最快,为8.23 cm/年;存在青春期身高突增峰速度(peak height velocity,PHV)阶段,持续约2年,男性患儿PHV阶段身高共增长9~20 cm,女性患儿PHV阶段身高共增长10~15 cm。患儿主要并发症为肾钙质沉着及甲状旁腺功能亢进。肾钙质沉着治疗后第1年发生率为55%(22/40),其发生率随病程延长而增加(P<0.001);尿磷/尿肌酐比值升高与肾钙质沉着的风险升高呈正性关联(OR=1.740,P<0.001)。甲状旁腺功能亢进治疗后第1年发生率为64%(27/42)。结论对存在下肢畸形、身材矮小、生长缓慢的儿童,及早进行血磷、血钙、ALP检测及下肢影像学检查有助HR的早期诊断,必要时可结合基因检测确诊。ALP结合骨骼畸形改善及身高年增长情况可作为HR治疗疗效的评价指标。患儿青春期PHV阶段身高总增长小于正常儿童,需密切随访,及时调整治疗方案.

关键词：低血磷性佝偻病诊断治疗随访身高儿童

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

撑开器辅助复位克氏针内固定治疗桡骨远端骨折

引用

临床骨科杂志 2024年第3期27卷 382-385页

作者：谭新欢侯金永毕宏政高祥杨凯山东省文登整骨医院骨、手显微外科二病区山东威海264400

目的探讨撑开器辅助复位克氏针内固定治疗桡骨远端C2型骨折的临床疗效。方法采用撑开器辅助复位克氏针内固定治疗320例桡骨远端C2型骨折患者。记录掌倾角、尺偏角、桡骨高度、骨折愈合及并发症发生情况,根据Gartland-Werley腕关节功能... 详细信息

目的探讨撑开器辅助复位克氏针内固定治疗桡骨远端C2型骨折的临床疗效。方法采用撑开器辅助复位克氏针内固定治疗320例桡骨远端C2型骨折患者。记录掌倾角、尺偏角、桡骨高度、骨折愈合及并发症发生情况,根据Gartland-Werley腕关节功能评分标准评价疗效。结果患者均获得随访,时间12~16个月。骨折临床愈合时间6~8(7.2±1.1)周,骨性愈合时间8~12(9.5±1.6)周。术后4例出现桡神经浅支损伤表现,8例出现针孔周围渗出伴红肿,均未出现骨髓炎、感染、骨折延期愈合或不愈合等并发症。末次随访时,掌倾角、尺偏角及桡骨高度均恢复正常或接近正常,与术后第2天比较差异均无统计学意义(P>0.05)。术后12个月根据Gartland-Werley腕关节评分标准进行疗效评定:优98例,良177例,可34例,差11例,优良率为85.9%。结论撑开器辅助复位克氏针内固定治疗桡骨远端C2型骨折具有操作简便、复位满意、固定牢靠、损伤小、并发症少的优点,腕关节功能恢复满意。

关键词：桡骨远端骨折克氏针内固定

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Inactivation of the Rho-ROCK signaling pathway to promote neurologic recovery after spinal cord injuries in rats

引用

Chinese Medical Journal 2013年第19期126卷 3723-3727页

作者： WU bin-qi bi zheng-gang QI Quan Department of Orthopaedics First Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150001 China

Background After injury,axonal regeneration of the adult central nervous system （CNS） is inhibited by myelin-derived growth-suppressing proteins.These axonal growth inhibitory proteins are mediated via activation of Rho,a small GTP-binding protein.The activated form of Rho,which is bound to GTP,is the direct activator of Rho kinase （ROCK） through serial downstream effector proteins to inhibit axonal regeneration.The objective of this study was to observe the therapeutic effect of inactivation of the Rho-ROCK signaling pathway to promote neurologic recovery after spinal cord injuries in rats.Methods One hundred and twenty adult female Sprague-Dawley rats were randomly divided into three groups.Laminectomies alone were conducted in 40 rats in the sham group.Laminectomies and spinal cord transections were performed in 40 rats in the control group （treated with normal saline administered intraperitoneally）.Laminectomies and spinal cord transections were performed in 40 rats in the fasudil-treated group （treated with fasudil administered intraperitoneally）.Neurologic recovery was evaluated before surgery and 3 days,and 1,2,3,and 4 weeks after surgery using the Basso-Beattie-Bresnahan （BBB） scale of hind limb movement.At the same time,the expression of RhoA mRNA was determined with RT-PCR.Histopathologic examinations and immunofiuorescence staining of NF were performed 1 month after surgery.Results Compared with the control group,the BBB scores of the fasudil-treated group were significantly increased and the expression of RhoA mRNA was significantly decreased.In the fasudil-treated group,a large number of NF-positive regenerating fibers was observed; some fibers crossed the slit of the lesion.Conclusion Inactivation of the Rho-ROCK signaling pathway promotes CNS axonal regeneration and neurologic recovery after spinal cord injuries in rats.

关键词： Rho-ROCK spinal cord injury axonal regeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of crystal morphology of ultrahigh-nickel cathode materials on high temperature electrochemical stability of lithium ion batteries

引用

Journal of Energy Chemistry 2024年第1期88卷 327-335,I0008页

作者： bi Luo Hui Li Haoyu Qi Yun Liu Chuanbo zheng Weitong Du Jiafeng Zhang Lai Chen School of Metallurgy Engineering Jiangsu University of Science and TechnologyZhangjiagang 215600JiangsuChina National Engineering Laboratory for High-Efficiency Recovery of Refractory Nonferrous Metals School of Metallurgy and EnvironmentCentral South UniversityChangsha 410083HunanChina School of Materials Science and Engineering Beijing Key Laboratory of Environmental Science and EngineeringBeijing Institute of TechnologyBeijing 100081China

Higher nickel content endows Ni-rich cathode materials LiNi_(x)Co_yMn_(1-x-y)O_(2)(x>0.6)with higher specific capacity and high energy density,which is regarded as the most promising cathode materials for Li-ion batteries.However,the deterioration of structural stability hinders its practical application,especially under harsh working conditions such as high-temperature cycling.Given these circumstances,it becomes particularly critical to clarify the impact of the crystal morphology on the structure and high-temperature performance as for the ultrahigh-nickel cathodes.Herein,we conducted a comprehensive comparison in terms of microstructure,high-temperature long-cycle phase evolution,and high-temperature electrochemical stability,revealing the differences and the working mechanisms among polycrystalline(PC),single-crystalline(SC)and Al doped SC ultrahigh-nickel materials.The results show that the PC sample suffers a severe irreversible phase transition along with the appearance of microcracks,resulting a serious decay of both average voltage and the energy density.While the Al doped SC sample exhibits superior cycling stability with intact layered structure.In-situ XRD and intraparticle structural evolution characterization reveal that Al doping can significantly alleviate the irreversible phase transition,thus inhibiting microcracks generation and enabling enhanced structure.Specifically,it exhibits excellent cycling performance in pouch-type full-cell with a high capacity retention of 91.8%after 500 cycles at 55℃.This work promotes the fundamental understanding on the correlation between the crystalline morphology and high-temperature electrochemical stability and provides a guide for optimization the Ni-rich cathode materials.

关键词： Single-crystalline Ultrahigh-nickel cathode High-temperature performance Phase evolution

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Influences of the Fresh Air Volume on the Removal of Cough-Released Droplets in a Passenger Car of a High-Speed Train Using CFD

引用

Computer Modeling in Engineering & Sciences 2024年第3期138卷 2727-2748页

作者： Jun Xu Kai bi Yibin Lu TiantianWang Hang Zhang Zeyuan zheng Fushan Shi Yaxin zheng Xiaoying Li Jingping Yang CRRC Changchun Railway Vehicles Co. Ltd.Changchun130062China Key Laboratory of Traffic Safety on Track Ministry of EducationSchool of Traffic&Transportation EngineeringCentral South UniversityChangsha410075China College of Mechanical and Vehicle Engineering Hunan UniversityChangsha410082China

The spread and removal of pollution sources,namely,cough-released droplets in three different areas(front,middle,and rear areas)of a fully-loaded passenger car in a high-speed train under different fresh air flow volume were studied using computational fluid dynamics(CFD)method.In addition,the structure of indoor flow fields was also analysed.The results show that the large eddies are more stable and flow faster in the air supply under Mode 2(fresh air volume:2200m3/h)compared to Mode 1(fresh air volume:1100m3/h).By analysing the spreading process of droplets sprayed at different locations in the passenger car and with different particle sizes,the removal trends for droplets are found to be similar under the two air supply modes.However,when increasing the fresh air flow volume,the droplets in the middle and front areas of the passenger car are removed faster.When the droplets had dispersed for 60s,Mode 2 exhibited a removal rate approximately 1%–3%higher than Mode 1 for small and medium-sized droplets with diameters of 10 and 50μm.While those in the rear area,the situation is reversed,with Mode 1 slightly surpassing Mode 2 by 1%–3%.For large droplets with a diameter of 100μm,both modes achieved a removal rate of over 96%in all three regions at the 60 s.The results can provide guidance for air supply modes of passenger cars of high-speed trains,thus suppressing the spread of virus-carrying droplets and reducing the risk of viral infection among passengers.

关键词： Cough-released pollutants CFD ventilation inside trains supply air volume

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Reviewing electrochemical stability of ionic liquids-/deep eutectic solvents-based electrolytes in lithium-ion,lithium-metal and post-lithium-ion batteries for green and safe energy

引用

Green Energy & Environment 2024年第6期9卷 966-991页

作者： Yu Chen Shuzi Liu Zixin bi zheng Li Fengyi Zhou Ruifen Shi Tiancheng Mu Department of Chemistry and Material Science Langfang Normal UniversityNO.100 Aimin West RoadLangfangHebei065000China Department of Chemistry Renmin University of ChinNO.59 Zhongguancun StreetHaidian DistrictBeijing100872China

Sustainable energy is the key issue for the environment protection,human activity and economic development.Ionic liquids(ILs)and deep eutectic solvents(DESs)are dogmatically regarded as green and sustainable electrolytes in lithium-ion,lithium-metal(e.g.,lithium-sulphur,lithium-oxygen)and post-lithium-ion(e.g.,sodium-ion,magnesium-ion,and aluminum-ion)batteries.High electrochemical stability of ILs/DESs is one of the prerequisites for green,sustainable and safe energy;while easy electrochemical decomposition of ILs/DESs would be contradictory to the concept of green chemistry by adding the cost,releasing volatile/hazardous by-products and hindering the recyclability.However,(1)are ILs/DESs-based electrolytes really electrochemically stable when they are not used in batteries?(2)are ILs/DESs-based electrolytes really electrochemically stable in real batteries?(3)how to design ILs/DESs-based electrolytes with high electrochemical stability for batteries to achieve sustainability and green development?Up to now,there is no summary on this topic,to the best of our knowledge.Here,we review the effect of chemical structure and non-structural factors on the electrochemical stability of ILs/DESs in simulated conditions.More importantly,electrochemical stability of ILs/DESs in real lithium-ion,lithium-metal and post-lithium-ion batteries is concluded and compared.Finally,the strategies to improve the electrochemical stability of ILs/DESs in lithium-ion,lithium-metal and post-lithium-ion batteries are proposed.This review would provide a guide to design ILs/DESs with high electrochemical stability for lithium-ion,lithium-metal and postlithium-ion batteries to achieve sustainable and green energy.

关键词： Green solvents Decomposition Sustainable chemistry Lithium-oxygen batteries Lithium-sulphur batteries Sodium-ion batteries

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Intestinal malrotation complicated with gastric cancer: A case report

引用

World Journal of Clinical Cases 2024年第1期12卷 210-216页

作者： Xiang-Hao Jia Shuai Kong Xin-Xin Gao bi-Cong Cong Chun-Ning zheng School of Clinical Medicine Weifang Medical UniversityWeifang 261053Shandong ProvinceChina Department of Gastrointestinal Surgery Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250000Shandong ProvinceChina

BACKGROUND Intestinal malrotation is a congenital defect of embryonic development caused by various teratogenic factors.In this condition,the intestinal tube,along with the superior mesenteric artery serving as the axis for the counterclockwise movement,is incomplete or abnormally rotated due to incomplete attachment of the mesentery and abnormal intestinal tube position.Such a case is usually asymp-tomatic and thus difficult to detect.Therefore,similar variant malformations are only found during an operation required for other abdominal diseases.CASE SUMMARY An elderly male patient was admitted to the hospital due to gastric cancer.An abdominal computed tomography(CT)scan with contrast revealed that the ascending and descending colon were parallel on the right side of the abdominal cavity,while the sigmoid colon extended into the right iliac fossa,allowing the diagnosis of congenital midgut malrotation.Following thorough preoperative preparation,the patient underwent laparoscopic radical gastrectomy to treat his gastric cancer.Intraoperatively,an exploration of the abdominal cavity uncovered the absence of the transverse colon.The distal colon at the hepatic flexure,along with the ascending colon,extended into the right iliac fossa,where it continued as the sigmoid colon.As planned,the laparoscopic radical gastrectomy was perform-ed,and the patient was discharged from the hospital 7 d after the surgery.CONCLUSION Asymptomatic intestinal malrotation is best detected by CT,requiring no treatment but possibly interfering with the treatment of other diseases.

关键词： Intestinal malrotation Congenital malformation Gastric cancer Abdominal

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

丹蛭降糖胶囊对db/db小鼠摄食行为及脑摄食中枢α-MSH、AgRP的调节作用研究

引用

长春中医药大学学报 2024年第1期40卷 44-49页

作者：毕正鲁云霞张银玉李金菊周恒吕溪娟方朝晖安徽中医药大学合肥230012 安徽医科大学合肥230031 安徽中医药大学第一附属医院合肥230031

目的观察丹蛭降糖胶囊(DJC)对db/db小鼠摄食行为及脑摄食中枢α-MSH、AgRP的调节作用。方法 db/db组和DJC组各9只db/db小鼠,db/dm组共9只db/dm小鼠,DJC组灌胃DJC混悬液每只630 mg·kg^(-1)·d^(-1),db/db组和db/dm组灌胃等量纯净水,饲... 详细信息

目的观察丹蛭降糖胶囊(DJC)对db/db小鼠摄食行为及脑摄食中枢α-MSH、AgRP的调节作用。方法 db/db组和DJC组各9只db/db小鼠,db/dm组共9只db/dm小鼠,DJC组灌胃DJC混悬液每只630 mg·kg^(-1)·d^(-1),db/db组和db/dm组灌胃等量纯净水,饲养12周。每周检测体质量及食物消耗量;Elisa法检测血清α-MSH、AGRP含量,下丘脑α-MSH、AGRP蛋白含量;qRT-PCR法检测下丘脑α-MSH、AGRP mRNA含量;HE染色观察病理改变;免疫组化法观察下丘脑α-MSH、AGRP表达。结果相较db/dm组,db/db组血清α-MSH、下丘脑α-MSH蛋白、mRNA及免疫组化α-MSH均明显减少(P<0.001),而血清AgRP,下丘脑AgRP蛋白、mRNA及免疫组化AgRP均明显增多(P<0.01,P<0.001);db/db组的体质量及摄食量较db/dm组全饲养周期均明显增高(P<0.001);相较db/db组,DJC组血清α-MSH、下丘脑α-MSH蛋白、mRNA及免疫组化均明显升高(P<0.001),而血清AgRP、下丘脑AgRP蛋白、mRNA及免疫组化均明显减少(P<0.01,P<0.001);DJC组体质量从第8周开始较db/db组明显减轻(P<0.05,P<0.01,P<0.001),摄食量全饲养周期均明显低于db/db组(P<0.05,P<0.01,P<0.001)。结论丹蛭降糖胶囊能够能够通过提高db/db小鼠血清α-MSH、下丘脑α-MSH蛋白、mRNA的含量,减少血清AgRP、下丘脑AgRP蛋白、mRNA的含量,起到改善db/db小鼠的摄食行为,减少摄食量,减轻小鼠体重等作用。

关键词：丹蛭降糖胶囊摄食行为脑摄食中枢 α-黑素细胞刺激素刺鼠相关蛋白

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Interaction of Oblique Waves and A Rectangular Structure with An Opening Near A Vertical Wall

引用

China Ocean Engineering 2017年第2期31卷 220-229页

作者： ZHANG Hong-sheng zheng bi-fang YANG Xiao-yan College of Ocean Science and Engineering Shanghai Maritime University School of Naval Architecture Ocean and Civil EngineeringShanghai Jiao Tong University

With the method of separation of variables and the eigenfunction expansion employed, an analytical solution is presented for the radiation and diffraction of a rectangular structure with an opening near a vertical wall in oblique seas, in which the unknown coefficients are determined by the boundary conditions and matching requirement on the interface. The effects of the width of the opening and the angle of incidence on the hydrodynamic characteristics of a rectangular structure with an opening near a vertical wall are mainly studied. The comparisons of the calculation results with wall-present and with wall-absent are also made. The results indicate that the variation trends of the heave added mass and excitation force with wall-present are almost the same as those with wall-absent, and that the peak values in the former case are obviously larger than those in the latter due to the reflection of the vertical wall.

关键词： wave radiation and diffraction rectangular structure opening oblique incidence vertical wall analytical solution hydrodynamic characteristics comparison

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：