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Boosting hydrocarbon conversion via Cu-doping induced oxygen vacancies on CeO2 in CO2 electroreduction

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Journal of Energy Chemistry 2025年第1期100卷 66-76页

作者： lei Xue Tong shi Chenhui Han Heng Zhang Fenrong Liu Haorun Li Yan Wang Xiaojun Gu Shanghong Zeng Inner Mongolia Key Laboratory of Chemistry and Physics of Rare Earth Materials School of Chemistry and Chemical Engineering Inner Mongolia University State Key Laboratory of Coal Conversion Institute of Coal Chemistry Chinese Academy of Sciences Institute of Catalysis Department of Chemistry Zhejiang University National Key Laboratory of Baiyunobo Rare Earth Resource Research and Comprehensive Utilization Baotou Research Institute of Rare Earths

Conversion of CO2back to hydrocarbons is the most direct way of closing the“carbon cycle”,and its significance is further enlarged if this process is driven by renewable energies such as ***,precisely controlling the product selectivity towards hydrocarbons against the competitive hydrogen evolution remains challenging,especially for Cu-based ***,we report a novel defect engineering strategy,by which Cu-doping-induced oxygen vacancies on CeO2nanorods were effectively created,with adjustable vacancy/Cu *** resulting optimum catalyst shows up to 79% catalytic current density to hydrocarbons （excluding CO）,with 49% faradaic efficiency to *** and density functional theory unveil that the ratio between oxygen vacancy and Cu affects significantly the formation of*CHO and activation of H2O,which leads to the following deep hydrogenation to *** findings may spur new insights for designing and developing more controllable chemical process relevant to CO2utilization.

关键词： Oxygen vacancy Hydrocarbon production Reaction mechanism

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胎儿生长受限的围分娩期监测

中国实用妇科与产科杂志 2019年第4期35卷 403-407页

作者：毕石磊张丽姿陈敦金广州医科大学附属第三医院妇产科广东省产科重大疾病重点实验室广东广州510150 南方医科大学南方医院妇产科广东广州510515

文章以国内外指南、临床研究及专家共识为基础,阐述胎儿生长受限是胎儿生长体重低、临床上伴有胎盘以及脐带血流异常,介绍了围产期采用彩色多普勒各项指标检测的意义,以及各指标的临床应用价值,探讨了降低胎儿生长受限的围分娩期不良结... 详细信息

文章以国内外指南、临床研究及专家共识为基础,阐述胎儿生长受限是胎儿生长体重低、临床上伴有胎盘以及脐带血流异常,介绍了围产期采用彩色多普勒各项指标检测的意义,以及各指标的临床应用价值,探讨了降低胎儿生长受限的围分娩期不良结局相关措施。

关键词：胎儿生长受限小于胎龄儿多普勒超声

基础与临床研究成果转化——降低胎盘植入性疾病患者严重并发症发生率

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中国实用妇科与产科杂志 2024年第10期40卷 961-963页

作者：陈敦金张丽姿毕石磊广州医科大学附属第三医院妇产科广东广州510530 广东省妇产疾病临床医学研究中心广东广州510530 广东省产科重大疾病重点实验室广东广州510530 广东省母胎医学工程技术研究中心广东广州510530 粤港澳母胎医学高校联合实验室广东广州510530

胎盘植入性疾病(placenta accreta spectrum,PAS)是一种严重的妊娠并发症,其特征是胎盘绒毛外滋养层细胞异常侵入子宫肌层,根据侵入深度,分为粘连型胎盘植入(placenta crete)、植入型胎盘植入(placenta increta)以及穿透型胎盘植入(plac... 详细信息

胎盘植入性疾病(placenta accreta spectrum,PAS)是一种严重的妊娠并发症,其特征是胎盘绒毛外滋养层细胞异常侵入子宫肌层,根据侵入深度,分为粘连型胎盘植入(placenta crete)、植入型胎盘植入(placenta increta)以及穿透型胎盘植入(placenta percreta)[1]。近40年来,随着全球剖宫产率从10%上升至30%,PAS的发病率相较之前增加了10倍[2]。

关键词：胎盘植入性疾病蜕膜组织异常滋养层细胞过度侵袭免疫调节失衡分子诊断技术

Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun Zhao De-En Xu Ming-lei Wu Ji-Chuan Liu Zi-Ling shi Quan-Hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

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前置胎盘合并胎盘植入的认识及处理

中国实用妇科与产科杂志 2020年第2期36卷 107-110页

作者：张丽姿毕石磊陈敦金王志坚南方医科大学南方医院妇产科 510515 广州医科大学附属第三医院妇产科广东省产科重大疾病重点实验室广东广州510150

随着高龄孕产妇、剖宫产率升高,前置胎盘合并胎盘植入的发生率逐年增加,常导致产后出血、子宫切除,严重时甚至危及孕产妇生命。进一步厘清前置胎盘合并胎盘植入的发病机制,结合患者的高危因素,充分利用产前影像学检查,提高诊断准确性,... 详细信息

随着高龄孕产妇、剖宫产率升高,前置胎盘合并胎盘植入的发生率逐年增加,常导致产后出血、子宫切除,严重时甚至危及孕产妇生命。进一步厘清前置胎盘合并胎盘植入的发病机制,结合患者的高危因素,充分利用产前影像学检查,提高诊断准确性,及时转诊,由经验丰富的医疗团队对高危及明确诊断患者进行术前及术中多学科评估和管理,个体化治疗,减少严重并发症的发生。

关键词：前置胎盘胎盘植入

Effect of algal flocculation on dissolved organic matters using cationic starch modified soils

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Journal of Environmental Sciences 2016年第7期28卷 177-184页

作者： Wenqing shi lei bi Gang Pan Research Center for Eco-Environmental Sciences Chinese Academy of Sciences School of Animal Rural and Environmental Sciences Nottingham Trent University

Modified soils（MSs） are being increasingly used as geo-engineering materials for the sedimentation removal of cyanobacterial blooms. Cationic starch（CS） has been tested as an effective soil modifier, but little is known about its potential impacts on the treated *** study investigated dissolved organic matters in the bloom water after algal removal using cationic starch modified soils（CS-MSs）. Results showed that the dissolved organic carbon（DOC） could be decreased by CS-MS flocculation and the use of higher charge density CS yielded a greater DOC reduction. When CS with the charge density of 0.052, 0.102 and0.293 meq/g were used, DOC was decreased from 3.4 to 3.0, 2.3 and 1.7 mg/L, *** excitation–emission matrix fluorescence spectroscopy and UV254 analysis indicated that CS-MS exhibits an ability to remove some soluble organics, which contributed to the DOC reduction. However, the use of low charge density CS posed a potential risk of DOC increase due to the high CS loading for effective algal removal. When CS with the charge density of 0.044 meq/g was used, DOC was increased from 3.4 to 3.9 mg/L. This study suggested, when CS-MS is used for cyanobacterial bloom removal, the content of dissolved organic matters in the treated water can be controlled by optimizing the charge density of CS. For the settled organic matters, other measures（e.g., capping treatments using oxygen loaded materials） should be jointly applied after algal flocculation.

关键词： Cyanobacterial bloom Cationic starch Modified soil Charge density Dissolved organic carbon

Single-cell omics: experimental workflow, data analyses and applications

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li Dongqing Sun Shaliu Fu lei Gu Xin Shao Qinqin Wang Xin Dong bin Duan Feiyang Xing Jun Wu Minmin Xiao Fangqing Zhao Jing-Dong J.Han Qi Liu Xiaohui Fan Chen Li Chenfei Wang Tieliu shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for bioinformatics and Computational biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

Comparative study of galectin-3 and B-type natriuretic peptide as biomarkers for the diagnosis of heart failure

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Journal of Geriatric Cardiology 2014年第1期11卷 79-82页

作者： Qiu-Sheng YIN bing shi Lan Dong lei bi Department of Geriatric Cardiology General Hospital of Be~jing Command of PLA Beijing 100700 China

Background Heart failure （HF） is a common disease with complex pathophysiological causes. The diagnosis of HF commonly relies on comprehensive analyses of medical history and symptoms, and results from echocardiography and biochemical tests. Galectin-3, a rela-tively new biomarker in HF, was approved by the US Food and Drug Administration in 2010 as a marker in the stratification of risk for HF. We assessed galectin-3 as a biomarker for HF diagnosis in patients with preserved ejection fraction （pEF） and compared its performance with that of B-type natriuretic peptide （BNP）. Methods Thirty-five pEF patients with HF （HFpEF group） and 43 pEF patients without HF （control group） were enrolled. Plasma levels of galectin-3 and BNP in HFpEF and control subjects were determined. Sensitivity, specificity, pre dictive values, and accuracy of galectin-3 and BNP as markers for HF diagnosis were calculated and compared. Results Levels of galec- tin-3 and BNP were 23.09 ±6.97 ng/mL and 270.46 ± 330.41 pg/mL in the HFpEF group, and 16.74 ± 2.75 ng/mL and 59.94 ± 29.93 pg/mL in the control group, respectively. Differences in levels of galectin-3 and BNP between the two groups were significant （P 〈 0.01）. As a bio- marker for HF diagnosis in study subjects, galectin-3 showed sensitivity and specificity of 94.3% and 65.1%, respectively, at a cutoff value of 17.8 ug/mL. BNP showed sensitivity and specificity of 77.1% and 90.7%, respectively, at a cutoff value of 100 pg/mL. Galectin-3 was a significantly more sensitive （P 〈 0.05） but less specific （P 〈 0.01） biomarker compared with BNP. Differences in positive predictive value, negative predictive value, and accuracy between galectin-3 and BNP markers were not significant （P 〉 0.05）. Areas under the receiver operating characteristic curve （95% confidence interval） were 0.891 （0.808-0.974） and 0.896 （0.809-0.984） for galectin-3 and BNP, respec- tively, with no significant difference between the two values （P 〉 0.05）. Conclusions The leve

关键词： Heart failure Preserved ejection fraction Galectin-3 B-type natriuretic peptide Diagnosis

Attitude stabilization of rigid spacecraft implemented in backstepping control with input delay

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Journal of Systems Engineering and Electronics 2017年第5期28卷 955-962页

作者： Xianting bi Xiaoping shi Control and Simulation Center Harbin Institute of Technology

A backstepping method is used for nonlinear spacecraft attitude stabilization in the presence of external disturbances and time delay induced by the actuator. The kinematic model is established based on modified Rodrigues parameters (MRPs). Firstly, we get the desired angular velocity virtually drives the attitude parameters to origin, and then backstep it to the desired control torque required for stabilization. Considering the time delay induced by the actuator, the control torque functions only after the delayed time, therefore time compensation is needed in the controller. Stability analysis of the close-loop system is given afterwards. The infinite dimensional actuator state is modeled with a first-order hyperbolic partial differential equation (PDE), the L-2 norm of the system state is constructed and is proved to be exponentially stable. An inverse optimality theorem is also employed during controller design. Simulation results illustrate the efficiency of the proposed control law and it is robust to bounded external disturbances and time delay mismatch.

关键词： backstepping input delay partial differential equation (PDE) inverse optimality