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Current Medical Science 2018年第6期38卷 1103-1108页

作者： bi-li WU Wen-xi HE Meng KE Xiao-fang SHANG-GUAN Guo-fang HE Rui HUANG Department of Oncology Tongii HospitalTongji Medical CollegeHuazhong Universityof Science and TechnologyWuhan 430030China Department of Pharmacy Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China School of Pharmacy Tongji Medical CollegeHuazhong University of Science and Technology.Wuhan 430030China

Qingkailing (QKL)is a modern preparation exploited according to the traditional Chinese medicine *** becomes the second leading cause of adverse drug events (ADEs)in all traditional Chinese medicine *** safety evaluation and rational use of QKL are of special *** retrospective study used data from Adverse Drug Reaction Monitoring Center of Hubei Province in China from January 2012 to December *** cases induced by QKL were collected and analyzed according to patients'demographics,characteristics of drugs involved,characteristics of ADEs,causality,and outcomes.A total of 1330 qualified ADEs were *** ADEs occurred within 30 min after administration and the 0-10 years old age group had the highest number of *** common ADEs included anaphylactic reaction,dyspnea and *** reactions accounted for 5.19%.Combination with cephalosporin (74/146,50.69%) caused more ADEs than other drugs *** attention should be paid when QKL is used for children,and combination with cephalosporin should be avoided.

关键词： adverse drug event anaphylaxis drug safety Qingkailing

The Coalition Cooperative Game Method and Its Application in Multi-objective Optimization Design

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International Journal of Plant Engineering and Management 2011年第2期16卷 125-128页

作者： li bi-yan School of Mechanical Engineering Anhui University of Technology Maanshan 243002 P.R. China

This paper proposes a multi-objective optimization design method based on the coalition cooperative game theory where the three design goals have been seen as three game players. By calculating the affecting factors and fuzzy clustering, the design variables are divided into different strategic spaces which belong to each player, then it constructs a payoff function based on the coalition mechanism. Each game player takes its own revenue function as a target and obtains the best strategy versus other players. The best strategies of all players consist of the strategy permutation of a round game and it obtains the final game solutions through multi-round games according to the convergence criterion. A multi-objective optimization example of the luff mechanism of compensative sheave block shows the effectiveness of the coalition cooperative game method.

关键词： coalition cooperative game multi-objective optimization fuzzy clustering luff mechanism

Screening and characterization of a novel ruminal cellulase gene(Umcel-1) from a metagenomic library of gayal(Bos frontalis)

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Journal of Integrative Agriculture 2016年第4期15卷 855-861页

作者： li bi-feng ZHU Ya-xin GU Zhao-bing CHEN Yuan LENG Jing GOU Xiao FENG li li Qing XI Dong-mei MAO Hua-ming YANG Shu-li Yunnan Provincial Key Laboratory of Animal Nutrition and Feed Science Yunnan Agricultural University Institute of Microbiology Chinese Academy of Sciences Department of biological Science Huizhou University

Gayal is a rare semi-wild bovine species found in the Indo-China. They can graze grasses, including bamboo leaves, as well as reeds and other plant species, and grow to higher mature live weights than Yunnan Yellow cattle maintained in similar harsh environments. The aim of this study was to identify specific cellulase in the gayal rumen. A metagenomic fosmid library was constructed using genomic DNA isolated from the ruminal contents of four adult gayals. This library contained 38400 clones with an average insert size of 35.5 kb. The Umcel-1 gene was isolated from this library. Investigation of the cellulase activity of 24 random clones led to the identification of the Umcel-1 gene, which exhibited the most potent cellulase activity. Sequencing the Umcel-1 gene revealed that it contained an open reading frame of 942 base pairs that encoded a product of 313 amino acids. The putative gene Umcel-1 product belonged to the glycosyl hydrolase family 5 and showed the highest homology to the cellulase （GenBank accession no. YP_004310852.1 ） from Clostridium lentocellum DSM 5427, with 44% identity and 62% similarity. The Umcel-1 gene was heterologously expressed in Escherichia coil BL21, and recombinant Umcel-1 was purified. The activity of purified recombinant Umcel-1 was assessed, and the results revealed that it hydrolyzed carboxymethyl cellulose with optimal activity at pH 5.5 and 45~C. To our knowledge, this study provides the first evidence for a cellulase produced by bacteria in gayal rumen.

关键词： gayal ruminal microorganism fosmid library Umcel-I gene gene expression cellulase activity

D-S证据理论的改进算法在时-空信息融合中的应用

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数据采集与处理 2005年第2期20卷 156-160页

作者：李茹李弼程信息工程大学信息工程学院信息科学系郑州450002

研究基于D-S证据理论的时-空信息融合,即多传感器多测量周期的信息融合,给出了三种时-空信息融合的方法:集中式、分布式无反馈和有反馈的融合算法。采用这些传统的时-空信息融合方法时,最终的融合结果会产生概率分配过分集中的现象,而... 详细信息

研究基于D-S证据理论的时-空信息融合,即多传感器多测量周期的信息融合,给出了三种时-空信息融合的方法:集中式、分布式无反馈和有反馈的融合算法。采用这些传统的时-空信息融合方法时,最终的融合结果会产生概率分配过分集中的现象,而且证据冲突时还会产生有悖常理的结果。本文在传统证据理论的合成公式的基础上给出了一个有效的合成规则,并由此提出了改进的融合方法。证据冲突的概率按照各个命题的平均支持程度加权进行分配,从而提高了融合结果的可靠性与合理性。

关键词： D—S证据理论传感器时-空信息融合改进算法

Characteristics of transgenic tomatoes antisensed for the ethylene receptor genes LeERT1 and LeERT2

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Journal of Zhejiang University-Science B(biomedicine & biotechnology) 2006年第7期7卷 591-595页

作者： WANG Zhong-feng YING Tie-jin ZHANG Ying BAO bi-li HUANG Xiao-dan School of biosystem Engineering and Food Science Zhejiang University Hangzhou 310029 China Department of biological and Chemical Engineering Guangxi University of Technology Liuzhou 545006 China

Two stable transformed lines containing antisense LeERT1 or LeERT2 sequences and their hybridized line were investigated to determine the effect of LeERT1 and LeERT2 specificity in the ethylene receptor family in tomato （Lycopersicon esculenturn Mill.） on ethylene signaling. The transgenic line alel containing antisense LeER T1 displayed shorter length of seedling grown in the dark and adult plant in the light, severe epinastic petiole, and accelerated abscission of petiole explant and senescence of flower explant, compared with its wild type B 1. The transgenic line ale2 containing antisense LeERT2 also exhibited shorter hypocotyls and slightly accelerated abscission. The phenotypes of cross line dale of LeERT1 and LeERT2 were close to alel in many aspects. These results suggested that LeERT1 probably plays a relatively important role in ethylene signaling of tomato growth and development.

关键词： Antisense transformation Ethylene receptor Ethylene response Tomato

Forward Simulation of Viscoelastic Wave Equation in Thin-lnterbedded Reservoir Model

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石油地球物理勘探 2009年第A2期44卷 106-113页

作者： Di Bang-rang Pei Zheng-lin Xia Ji-zhuang Wang Hui bi li-fei CNPC Key Lab of Geophysical Prospecting China University of Petroleum Beijing 100083 China Beijing North lintai Petroleum Technology Co. Ltd Beijing 100192 China Institute for Geophysical Research of SINOPEC Shengli Oilfield Co. Ltd Dongying Shandong Province 257022 China

Characterization of Changes and Driver Microbes in Gut Microbiota During Healthy Aging Using A Captive Monkey Model

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Genomics, Proteomics & bioinformatics 2022年第2期20卷 350-365页

作者： Zhi-Yuan Wei Jun-Hua Rao Ming-Tian Tang Guo-An Zhao Qi-Chun li li-Ming Wu Shao-Qiang liu bi-Hai li Bai-Quan Xiao Xing-Yin liu Jian-Huan Chen Guangdong Key Laboratory of Animal Conservation and Resource Utilization Guangdong Public Laboratory of Wild Animal Conservation and UtilizationInstitute of ZoologyGuangdong Academy of SciencesGuangzhou 510260China Laboratory of Genomic and Precision Medicine Wuxi School of MedicineJiangnan UniversityWuxi 214122China Joint Primate Research Center for Chronic Diseases Jiangnan University and Institute of ZoologyGuangdong Academy of SciencesWuxi School of MedicineJiangnan UniversityWuxi 214122China Department of Pathogen-Microbiology Division Nanjing Medical UniversityNanjing 211166China

Recent population studies have significantly advanced our understanding of how age shapes the gut ***,the actual role of age could be inevitably confounded due to the complex and variable environmental factors in human populations.A well-controlled environment is thus necessary to reduce undesirable confounding effects,and recapitulate age-dependent changes in the gut microbiota of healthy *** we performed 16S rRNA gene sequencing,characterized the age-associated gut microbial profiles from infant to elderly crab-eating macaques reared in captivity,and systemically revealed the lifelong dynamic changes of the primate gut *** the most significant age-associated taxa were mainly found as commensals such as Faecalibacterium,the abundance of a group of suspicious pathogens such as Helicobacter was exclusively increased in infants,underlining their potential role in host ***,topology analysis indicated that the network connectivity of gut microbiota was even more agedependent than taxonomic diversity,and its tremendous decline with age could probably be linked to healthy ***,we identified key driver microbes responsible for such age-dependent network changes,which were further linked to altered metabolic functions of lipids,carbohydrates,and amino acids,as well as phenotypes in the microbial *** current study thus demonstrates the lifelong age-dependent changes and their driver microbes in the primate gut microbiota,and provides new insights into their roles in the development and healthy aging of their hosts.

关键词： Age-dependent change Non-human primate Healthy gut microbiota Network connectivity Driver microbe

Effect of an Airbag-selective Portal Vein Blood Arrester on the liver after Hepatectomy:A New Technique for Selective Clamping of the Portal Vein

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Current Medical Science 2024年第2期44卷 380-390页

作者： Ce-xiong FU Xiao-ri QIN Jin-song CHEN Jie ZHONG Yu-xu XIE bi-dan li Qing-qing FU Fang li Jin-fang ZHENG Department of Hepatobiliary and Pancreatic Surgery Hainan General HospitalHainan Affiliated Hospital of Hainan Medical UniversityHaikou 570311China University of South China Hengyang 421001China Department of Gastroenterology Gastroenterology Endoscopy CenterHainan General HospitalHainan Affiliated Hospital of Hainan Medical UniversityHaikou 57031lChina Center of Clinical Laboratory Hainan General HospitalHainan Affiliated Hospital of Hainan Medical UniversityHaikou 570311China Department of Radiology Hainan General HospitalHainan Affiliated Hospital of Hainan Medical UniversityHaikou 570311China

Objective:A novel technique was explored using an airbag-selective portal vein blood arrester that circumvents the need for an intraoperative assessment of anatomical variations in patients with complex intrahepatic space-occupying ***:Rabbits undergoing hepatectomy were randomly assigned to 4 groups:intermittent portal triad clamping(PTC),intermittent portal vein clamping(PVC),intermittent portal vein blocker with an airbag-selective portal vein blood arrester(APC),and without portal blood occlusion(control).Hepatic ischemia and reperfusion injury were assessed by measuring the 7-day survival rate,blood loss,liver function,hepatic pathology,hepatic inflammatory cytokine infiltration,hepatic malondialdehyde levels,and proliferating cell nuclear antigen ***:liver damage was substantially reduced in the APC and PVC *** APC animals exhibited transaminase levels similar to or less oxidative stress damage and inflammatory hepatocellular injury compared to those exhibited by the PVC *** was significantly higher in the control group than in the other *** APC group had less bleeding than the PVC group because of the avoidance of portal vein skeletonization during ***,more operative time was saved in the APC group than in the PVC ***,the total 7-day survival rate in the APC group was higher than that in the PTC ***:Airbag-selective portal vein blood arresters may help protect against hepatic ischemia and reperfusion injury in rabbits undergoing partial *** technique may also help prevent liver damage in patients requiring hepatectomy.

关键词： hepatectomy portal vein hepatic damage selective clamping

Improvement of the Injection and Transport Characteristics of Electrons in Organic light-Emitting Diodes by Utilizing a NaC1 N-Doped Layer

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Chinese Physics Letters 2014年第4期31卷 178-181页

作者： XIAO Zhi-Hui WU Xiao-Ming HUA Yu-lin WANG li bi Wen-Tao BAI Juan-Juan MU Xue YIN Shou-Gen School of Materials Science and Engineering Tianjin University of Technology Tianjin 300384Key Laboratory of Display Materials and Photoelectric Devices .Ministry of Education Tianjin 300384 Tianjin Key Laboratory of Photoelectric Materials and Devices Tianjin 300384

The injection and transport characteristics of electrons are enhanced by using sodium chloride （NaC1） as an n-type dopant doped into a 4, 7-diphnenyl-1, lO-phe-nanthroline （Bphen） electron-transporting layer, which improves the performance of organic light-emitting diodes （OLEDs）. Meanwhile, a NaCl-doped Bphen layer can effectively influence electrical characteristics of the devices, and significantly improve the current and power efficiency. The turn-on voltage and the operation voltage of the optimal device are decreased drastically from 6.5 V and 10.8 V to 3.3 V and 5 V, respectively, compared with those of the reference device. The maximum current efficiency and power efficiency of the optimal device are 7.0 cd/A and 4.4 Im/W at the current density of 16.70 mA/cm~, which are about I. 7 and 4 times higher than those of the reference device, respectively. Moreover, the enhancement of the injection and transport ability for electrons is attributed not only to the reduced energy barrier between A1 cathode and Bphen, but also to the increased mobility of electrons by the doping effect of NaCl. Therefore, both the electron injection and transport ability are enhanced, which improve the carrier balance in OLEDs and lead to the better device efficiency.

关键词： Layer Improvement performance

Effect of Zn, Cu and Ni addition on microstructure and mechanical properties of ascast Mg-Dy alloys

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China Foundry 2016年第1期13卷 54-58页

作者： Guang-li bi Xiao-mei Luo Jing Jiang Yong-gang Zhang Jian-ji Xu Jie-ming Chen Yuan-dong li Ying Ma State Key Laboratory of Advanced Processing and Recycling of Nonferrous Metals Lanzhou University of Technology Key Laboratory of Nonferrous Metal alloys and Processing Ministry of Education Lanzhou University of Technology

This paper presents some research information on the effects of Zn, Cu and Ni on the microstructure and mechanical properties of as-cast Mg-2Dy(at.%) alloys. The Mg-2Dy alloy is composed of α-Mg and Mg24Dy5 phases. With the addition of 0.5at.%Zn, 0.5at.%Cu and 0.5at.%Ni, respectively, besides α-Mg, the long period stacking order(LPSO) phases containing Zn, Cu, and Ni precipitated in the α-Mg interdentritic boundary. The addition of Ni effectively refined the dendrite arm spacing. The as-cast Mg-2Dy-0.5Ni alloy exhibited the best tensile strengths and elongation. The better mechanical properties were mainly attributed to small secondry dendrite arm spacing(SDAS) and high volume fraction of LPSO phases.

关键词： Mg-Dy-Zn(Cu,Ni) alloys LPSO phase microstructure mechanical properties