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Chinese-version Bt Cotton: How to Get the Benefi ts from IPR

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分子植物育种 2007年第2期5卷 296-297页

作者： x.j. Fang HITAR Consultancy in CropScience Beijing 100080 China

Chinese scientists started to fully synthesize the Bacillus thuringiensis (Bt) Cry1A gene in 1991. By the end of 1992, biotechnology Research Institute of Chinese Academy of Agricultural Sciences (BRI-CAAS) success-

关键词：中国生物技术农业科学黄萎病镰刀霉棉花

Enhancing Ulcerative Colitis Diagnosis:A Multi-Level Classification Approach with Deep Learning

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Computer Modeling in Engineering & Sciences 2024年第7期140卷 1129-1142页

作者： Hasan j.Alyamani Department of Information Systems Faculty of Computing and Information Technology in RabighKing Abdulaziz UniversityJeddah21589Saudi Arabia

The evaluation of disease severity through endoscopy is pivotal in managing patients with ulcerative colitis,a condition with significant clinical ***,endoscopic assessment is susceptible to inherent variations,both within and between observers,compromising the reliability of individual *** study addresses this challenge by harnessing deep learning to develop a robust model capable of discerning discrete levels of endoscopic disease *** initiate this endeavor,a multi-faceted approach is embarked *** dataset is meticulously preprocessed,enhancing the quality and discriminative features of the images through contrast limited adaptive histogram equalization(CLAHE).A diverse array of data augmentation techniques,encompassing various geometric transformations,is leveraged to fortify the dataset’s diversity and facilitate effective feature extraction.A fundamental aspect of the approach involves the strategic incorporation of transfer learning principles,harnessing a modified ResNet-50 *** augmentation,informed by domain expertise,contributed significantly to enhancing the model’s classification *** outcome of this research endeavor yielded a highly promising model,demonstrating an accuracy rate of 86.85%,coupled with a recall rate of 82.11%and a precision rate of 89.23%.

关键词： Ulcerative colitis deep learning CLAHE transfer learning geometric transformations

SCFD1 in amyotrophic lateral sclerosis: reconciling a genetic association with in vivo functional analysis

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Neural Regeneration Research 2024年第6期19卷 1201-1202页

作者： Ruben j.Cauchi Centre for Molecular Medicine and biobanking Biomedical Sciences BuildingDepartment of Physiology and Biochemistry Faculty of Medicine and Surgery University of Malta

Amyotrophic lateral sclerosis(ALS) is a neurodegenerative disease characterized by progressive loss of upper and lower motor neurons,resulting in muscle weakness and spasticity,eventually leading to death due to respiratory *** by our group of a casecontrol cohort from an isolated island population have found that genetics plays a significant role in disease etiology(Farrugia Wismayer et al.,2023).

关键词： PROTEIN SLY1

Intelligent Machine Learning Based Brain Tumor Segmentation through Multi-Layer Hybrid U-Net with CNN Feature Integration

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Computers, Materials & Continua 2024年第4期79卷 1301-1317页

作者： Sharaf j.Malebary Department of Information Technology Faculty of Computing and Information TechnologyKing Abdulaziz UniversityP.O.Box 344Rabigh21911Saudia Arabia

Brain tumors are a pressing public health concern, characterized by their high mortality and morbidity ***, the manual segmentation of brain tumors remains a laborious and error-prone task, necessitatingthe development of more precise and efficient methodologies. To address this formidable challenge, we proposean advanced approach for segmenting brain tumorMagnetic Resonance Imaging (MRI) images that harnesses theformidable capabilities of deep learning and convolutional neural networks (CNNs). While CNN-based methodshave displayed promise in the realm of brain tumor segmentation, the intricate nature of these tumors, markedby irregular shapes, varying sizes, uneven distribution, and limited available data, poses substantial obstacles toachieving accurate semantic segmentation. In our study, we introduce a pioneering Hybrid U-Net framework thatseamlessly integrates the U-Net and CNN architectures to surmount these challenges. Our proposed approachencompasses preprocessing steps that enhance image visualization, a customized layered U-Net model tailoredfor precise segmentation, and the inclusion of dropout layers to mitigate overfitting during the training ***, we leverage the CNN mechanism to exploit contextual information within brain tumorMRI images,resulting in a substantial enhancement in segmentation *** experimental results attest to the exceptionalperformance of our framework, with accuracy rates surpassing 97% across diverse datasets, showcasing therobustness and effectiveness of our approach. Furthermore, we conduct a comprehensive assessment of ourmethod’s capabilities by evaluating various performance measures, including the sensitivity, jaccard-index, andspecificity. Our proposed model achieved 99% accuracy. The implications of our findings are profound. Theproposed Hybrid U-Net model emerges as a highly promising diagnostic tool, poised to revolutionize brain tumorimage segmentation for radiologists and clinician

关键词： Brain tumor Hybrid U-Net CLAHE transfer learning MRI images

The quasi-Gramian solution of a non-commutative extension of the higher-order nonlinear Schr?dinger equation

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Communications in Theoretical Physics 2024年第3期76卷 51-61页

作者： H W A Riaz j Lin Department of Physics Zhejiang Normal UniversityJinhua 321004China

The nonlinear Schr?dinger(NLS)equation,which incorporates higher-order dispersive terms,is widely employed in the theoretical analysis of various physical *** this study,we explore the non-commutative extension of the higher-order NLS *** treat real or complex-valued functions,such as g_(1)=g_(1)(x,t)and g_(2)=g_(2)(x,t)as non-commutative,and employ the Lax pair associated with the evolution equation,as in the commutation *** derive the quasi-Gramian solution of the system by employing a binary Darboux *** soliton solutions are presented explicitly within the framework of *** visually understand the dynamics and solutions in the given example,we also provide simulations illustrating the associated ***,the solution can be used to study the stability of plane waves and to understand the generation of periodic patterns within the context of modulational instability.

关键词： integrable systems Darboux transformation solitons

THE INVESTIGATION ON THE RHEOLOGICAL BEHAVIOR OF SEMI-SOLID ALUMINUM ALLOY DURING DIE CASTING

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Acta Metallurgica Sinica(English Letters) 2002年第6期15卷 511-516页

作者： x.j. Yang and j.Liu School of Mechanic & Electronic Engineering, Nanchang University, jiangxi 330029, China School of Mechanic & Electronic Engineering, Shanghai University, Shanghai 200072, China School of Mechanic & Electronic Engineering Nanchang University Shanghai University

Under the condition of die casting and reheating temperature of 570-580 degC, the rheological behavior of semi-solid aluminum alloy (A356) is pseudoplasticity at the shearrate of 2x10^-1x10^4s^(-1), and also shows dil... 详细信息

关键词： shear rate apparent viscosity viscosity model thixocasting

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有限域上的正规元与不可约多项式

数学学报（中文版） 2024年第4期67卷 624-633页

作者：曹炜李卫华徐碧云闽南师范大学数学与统计学院漳州363000 福建省粒计算及其应用重点实验室漳州363000 宁波大学数学与统计学院宁波315211

设F_(q)为q阶有限域,F_(q)^(n)为F_(q)的n次扩域.设α∈F_(q)^(n),若{α,α^(q),...,α^(q^(n-1))}构成F_(q)^(n)/F_(q)的一组基,称α为F_(q)^(n)/F_(q)的正规元.正规元可用来加速有限域上的算术运算,因而在编码和密码中具有重要应用.正规元的极小多项式一定是非零迹的不可约多项式,但反之未必成立.本文利用线性化多项式给出了关于该问题的一组充分必要条件,推广了已知结论.

关键词：有限域正规元线性化多项式不可约多项式

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青藏高原及其周边奥陶纪综合地层、生物群与古地理演化

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中国科学：地球科学 2024年第4期54卷 992-1025页

作者：方翔甄勇毅王光旭魏鑫陈中阳梁艳武学进李文杰李超詹仁斌张元动现代古生物学和地层学国家重点实验室中国科学院南京地质古生物研究所南京210008 Geological Survey of New South Wales W.B.Clarke Geoscience CentreNSW 2753Australia 中国科学院大学北京100049

青藏高原奥陶系代表该地区未变质沉积地层的最古老记录,是解读该地区早期地质历史和生物演化的关键层段.青藏高原地区奥陶系底部地层存在不同程度的缺失,但具有下奥陶统弗洛阶、中奥陶统达瑞威尔阶,以及上奥陶统桑比阶、凯迪阶和赫南特... 详细信息

青藏高原奥陶系代表该地区未变质沉积地层的最古老记录,是解读该地区早期地质历史和生物演化的关键层段.青藏高原地区奥陶系底部地层存在不同程度的缺失,但具有下奥陶统弗洛阶、中奥陶统达瑞威尔阶,以及上奥陶统桑比阶、凯迪阶和赫南特阶,可划分为喜马拉雅、冈底斯-察隅、羌塘-昌都、松潘-甘孜、喀喇昆仑-昆仑-阿尔金等地层区,并可与周边的滇缅马、印支、柴达木-祁连、塔里木-天山和扬子区(西缘)等地层区进行综合地层对比.笔石、牙形刺和头足类是青藏高原地区奥陶系最常见的、据以构建该地区生物地层框架的化石门类.青藏高原奥陶纪生物群具有鲜明的生物古地理区系特色,其中头足类在早-中奥陶世以珠角石类繁盛为特征,显示与华北板块具有密切亲缘关系,但到晚奥陶世则以喇叭角石和直角石类繁盛为特征,表现出与华南的密切关系.青藏高原的奥陶纪多门类动物群及其生物古地理演化,为冈瓦纳东北缘地区的奥陶纪古板块重建提供了重要依据.西藏南部喜马拉雅地体、拉萨地体及周边的滇缅马地体在寒武纪晚期-奥陶纪早期经历了库尔加克运动,这次影响深远的构造热事件造成了奥陶纪地层与下伏基底地层之间的角度不整合接触关系,这一间断面在青藏高原大部分地区存在.西藏南部中奥陶统发育鲕粒灰岩和暖水生物群,指示当时位于赤道附近的低纬度地带.喜马拉雅地体及滇缅马地体的上奥陶统普遍发育大套具有网纹结构的海相碳酸盐岩红层,可与华南扬子区的同期地层进行对比,二者可能具有相同或相似的成因背景.奥陶纪末全球性冰期与海平面下降事件也造成了滇西和缅甸掸邦等地区普遍缺失凯迪晚期地层,对青藏高原的申扎和聂拉木等地区也有较大影响.

关键词：奥陶系年代地层岩石地层生物地层生物古地理生物和地质事件

Sulforaphane Attenuates CD36-mediated Platelet Hyperreactivity through Modulating cAMP/PKA/NOx2 Signaling in Hyperlipidemic Conditions

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Food Science and Human Wellness 2024年

作者： Weiqi Li Chunting Wu xinyu Zhou xinhui Huang Chunmei Zhang Yongjie Ma jinqiu Hu xiaoyan bi junyu Ma Mengyao Li Dong Lu Liang Hu jiahua Fan Fuli Ya Department of Nutrition， School of Public Health， Dali University Department of Laboratory Teaching Center， School of Public Health， Dali University Department of Health Management， Gem Flower xi'an Changqing Staff Hospital Shanghai Frontiers Science Center of TCM Chemical biology， Institute of Interdisciplinary Integrative Medicine Research， Shanghai University of Traditional Chinese Medicine School of Integrative Medicine， Shanghai University of Traditional Chinese Medicine School of Public Health， Sun Yat-sen University Institute of Translational Medicine for Metabolic Diseases， Dali University

Hyperlipidemia is a risk factor for clinically significant thrombotic events in cardiovascular diseases. Platelet reactivity in hyperlipidemic conditions is enhanced when platelet scavenger receptor CD36 recognizes oxidized lipids in oxidized low-density lipoprotein (ox-LDL) particles， a process that induces atherothrombosis. Sulforaphane (SFN) is a dietary isothiocyanate enriched in cruciferous vegetables and exerts multiple biological activities. The current study sought to investigate the efficacy of SFN on platelet hyperreactivity under hyperlipidemic conditions in vitro and in vivo. Using a series of platelet functional assays in human platelets in vitro， we demonstrated that SFN attenuated ox-LDL-increased platelet aggregation and activation (surface CD62P expression). Mechanistically， studies using pharmacological inhibitors clarified that these inhibitory effects of SFN were mainly modulated by down-regulating CD36-mediated activation of Src kinases， leading to enhanced activation of cAMP/PKA signaling， and resultant inhibition of NAD phosphate oxidase 2 (NOx2)-dependent generation of reactive oxygen species (ROS). Moreover， 12-week supplementation of SFN-enriched broccoli sprout extract (BSE， 0.06% diet) in hyperlipidemic C57BL/6j mice also decreased platelet hyperreactivity. Studies using pharmacological inhibitors of CD36， PKA and NOx2 showed that the efficacy of BSE supplementation was mainly through modulating CD36-mediated the cAMP/PKA/NOx2 signaling. Thus， through modulating the cAMP/PKA/NOx2 pathway and attenuating CD36-mediated platelet hyperreactivity， SFN may play important protective roles in atherothrombosis under hyperlipidemic conditions.

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