检索结果-南通市图书馆

Corrigendum to"A novel FGFR1 inhibitor CYY292 suppresses tumor progression,invasion,and metastasis of glioblastoma by inhibiting the Akt/GSK3β/snail signaling axis"[Genes&Diseases 11(2024)479-494]

在线全文

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第3期11卷 485-490页

作者： Yanran bi Ruiling Zheng jiahao Hu Ruiqing Shi junfeng Shi Yutao Wang Peng Wang Wenyi jiang Gyudong Kim Zhiguo Liu xiaokun Li Li Lin School of Pharmaceutical Science Wenzhou Medical UniversityWenzhou 325035China College of Pharmacy and Research Institute of Drug Development Chonnam National UniversityGwangju 61186Republic of Korea Department of Dermatology Wenzhou Hospital of Integrated Traditional Chinese and Western MedicineWenzhou 325000China Zhejiang Lab for Regenerative Medicine Oujiang LaboratoryWenzhou 325035China

The authors regret that in Figure 3C,the Western Blot(WB)image representing GAPDH levels was mistakenly chosen as the same image for ERK(indicated by the red dotted-line rectangle).We have attached the original WB strip for GAPDH to demonstrate that this was an unintentional error in image ***,we noticed that the Transwell images in the two upper panels of the right column in Figure 4j are misleading due to errors in image *** have attached the original data to show that this was also an unintentional *** assure you that these two corrections do not alter the scientificconclusionof thearticle.

关键词： GSK3β invasion metastasis

Analysis of ancient mass extinction recoveries in marine environments: generating strategies for managing outcomes of the current mass extinction

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

National Science Review 2024年第1期11卷 8-10页

作者： David j.Bottjer Department of Earth Sciences University of Southern California

The defining feature of a mass extinction and its associated recovery is the global amount of extinction that occurred[1]. However, there is finer-scale detail to the story, as seen in the ongoing modern mass extinction(the sixth mass extinction), which exhibits variable effects among marine ecosystems and environments, and hence geographic areas [1].

关键词：

Global weirding at mass extinction horizons

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

National Science Review 2024年第1期11卷 10-12页

作者： Gregory j.Retallack Department of Earth Sciences University of Oregon

A strong motivation for studying mass extinctions is understanding how current climatic and biodiversity crises will affect creatures living on land such as ourselves. Perhaps the question is: how bad can it get? In that case, terrestrial Permian-Triassic mass extinctions are an irresistible worst-case scenario [1].

关键词：

PREPARATION OF NANOMETER ZINC OxIDE BY EVAPORATION METHOD

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Acta Metallurgica Sinica(English Letters) 2002年第6期15卷 499-504页

作者： A.A.A. Saleh, x.j. Zhai, Y.C. Zhai and Y. FuSchool of Materials and Metallurgy, Northeastern University, Shenyang 110004, China School of Materials and Metallurgy Northeastern University

Nanometer ZnO particles were synthesized by evaporating of zinc powders of averageparticle size of 370μm studied by xRD, TEM and electron diffraction. The particleswere formed by the oxidation of evaporated zinc vapor in the air. It was found that the particles range from 70 to 100nm in average particle size. The effect of experimental parameters was investigated, the increase of the air flow-rates reduced the average particle size, while increasing the evaporation temperature and the amount of metal charged increased the average particle size. TEM of the particles collected showed that the crystal habits of particles have a tetrapod-like of wurtzite structure consists of four needle crystals. It was found by electron diffraction that all particles were single crystal.

关键词： evaporation method nanometer ZnO needle or tetrapod

Pien Tze Huang Inhibits Migration and Invasion of Hepatocellular Carcinoma Cells by Repressing PDGFRB/YAP/CCN2 Axis Activity

在线全文

学校读者我要写书评

暂无评论

Chinese journal of Integrative Medicine 2024年第2期30卷 115-124页

作者： LUO Zhi-yi TIAN Qi CHENG Niang-mei LIU Wen-han YANG Ye CHEN Wei ZHANG xiang-zhi ZHENG xiao-yuan CHEN Ming-sheng ZHUANG Qiu-yu ZHAO bi-xing LIU Cong-sheng LIU xiao-long LI Qin WANG Ying-chao The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province Mengchao Hepatobiliary Hospital of Fujian Medical UniversityFuzhou(350025)China Fujian Pien Tze Huang Enterprise Key Laboratory of Natural Medicine Research and Development Zhangzhou Pien Tze Huang Pharmaceutical Co.Ltd.ZhangzhouFujian Province(363099)China College of biological Science and Engineering and Mengchao Med-x Center Fuzhou UniversityFuzhou(350116)China Department of Internal Medicine Mengchao Hepatobiliary Hospital of Fujian Medical UniversityFuzhou(350025)China

Objective:To investigate the effects of Pien Tze Huang(PZH) on the migration and invasion of HCC cells and underlying molecular ***:Cell counting kit-8(CCK-8) was applied to evaluate the cell viabilities of SMMC-7721,SK-Hep-1,C3A and HL-7702(6 × 10^(3)cells/well) co-incubated with different concentrations of PZH(0,0.2,0.4,0.6,0.8 mg/mL) for 24 ***,wound healing assay,CCK-8and Annexin V-FITC/PI staining were conducted to investigate the effects of PZH on the migration,invasion,proliferation and apoptosis of SK-Hep-1 and SMMC-7721 cells(650 μg/mL for SK-Hep-1 cells and 330 μg/mL for SMMC-7721 cells),*** vivo,lung metastasis mouse model constructed by tail vein injection of HCC cells was used for evaluating the anti-metastasis function of ***-Hep-1 cells(10^(6)cells/200 μL per mice) were injected into B-NDG mice via tail *** 8 mice were randomly divided into PZH and control groups,4 mice in each *** 2-d inoculation,mice in the PZH group were administered with PZH(250 mg/kg,daily) and mice in the control group received only vehicle(PBS) from the 2nd day after xenograft to day *** analysis based on RNA-seq was subsequently used for deciphering anti-tumor mechanism of *** real-time polymerase chain reaction(qRT-PCR) and Western blot were applied to verify RNA-seq *** reporter assay was performed to examine the transcriptional activity of yes-associated protein(YAP).Results:PZH treatment significantly inhibited the migration,invasion,proliferation and promoted the apoptosis of HCC cells in vitro and in vivo(Pbited the expressions of platelet derived growth factor receptor beta(PDGFRB),YAP,connective tissue growth factor(CCN2),N-cadherin,vimentin and matrix metallopeptidase 2(MMP2,P<0.01).Meanwhile,the phosphorylatio

关键词： PienTzeHuang hepatocellular carcinoma RNA-seq Hippo yes-associated protein

INVESTIGATION OF WO3-DOPED TiO2 FILM COMPOSITE PHOTOCATALYST

在线全文

学校读者我要写书评

暂无评论

Acta Metallurgica Sinica(English Letters) 2004年第3期17卷 263-268页

作者： Q.F. Meng K.R. Liu L. jiang Q. Han j.S. Chen x.j. Wei School of Materials & Metallurgy Northeastern University Shenyang 110004 ChinaSchool of Materials & MetallurgyNortheastern University Shenyang 110004 ChinaSchool of Materials & MetallurgyNortheastern University Shenyang 110004 ChinaSchool of Materials & MetallurgyNortheastern University Shenyang 110004 ChinaSchool of Materials & MetallurgyNortheastern University Shenyang 110004 ChinaSchool of Materials & MetallurgyNortheastern University Shenyang 110004 China

The nano--crystal composite WO_3-TiO_2 photocatalyst was prepared by ultrasonic as-sisted sol--gel process. The effects of various factors, such as the crystal form, thesubstrates, the pH, the dissolved oxygen and the ultrasonic on the photocatalytic ac-tivity were investigated in view of the photodegradation of Rhodamine B. The resultsshow that the crystal form of WO_3-TiO_2 film with highest photocatalytic activity isrutile. The introduction of ultrasonic to the course of preparation can accelerate thedeposit time of the sol and increase the photocatalytic activity significantly in view ofthe highest photodegradation of Rhodamine B being 72.7% in 5 hours. The poroustitanium plate is the most suitable substrate in four kinds of investigated materials.Meanwhile the smaller the pH and the higher the concentration of the dissolved oxygenin the solution is, the higher the photodegradation is.

关键词： ultrasonic sol-gel process photocatalytic photodegradation

青藏高原及其周边侏罗纪综合地层、生物群与古地理演化

在线全文

学校读者我要写书评

暂无评论

中国科学：地球科学 2024年第4期54卷 1211-1243页

作者：李建国饶馨牟林崔肖辉李鑫罗辉刘培学中国科学院南京地质古生物研究所中国科学院生物演化与环境卓越创新中心南京210008 中国科学院大学南京学院南京211135

侏罗纪是青藏高原构造演化的重要阶段,它结束了古特提斯构造演化,即将迎来印度板块的向北漂移和新特提斯的消减.地层时代是地质历史重建的基础.本文对近年来所取得的一些地层学、古生物新发现和新进展进行了综合和梳理,为青藏高原侏罗... 详细信息

侏罗纪是青藏高原构造演化的重要阶段,它结束了古特提斯构造演化,即将迎来印度板块的向北漂移和新特提斯的消减.地层时代是地质历史重建的基础.本文对近年来所取得的一些地层学、古生物新发现和新进展进行了综合和梳理,为青藏高原侏罗系建立了一个新的多重地层划分对比和时代框架.该框架包括巴颜喀拉、羌塘、拉萨-冈底斯和藏南喜马拉雅四个分区.其中,综合生物地层框架得到了很大的补充和细化,包括了一系列在青藏高原侏罗系中常见并在国际侏罗系划分对比中具有重要作用的化石门类,如海相的菊石、双壳、腕足、放射虫、有孔虫和沟鞭藻以及陆相的孢子花粉和轮藻等.通过菊石标准分子或特征属种,建立了该生物地层框架与国际地层委员会2020年侏罗纪地质年表(GTS 2020)的标准分带的对比.以此为基础,建立了青藏高原主要区块间侏罗系的横向对比.生物群对比揭示,侏罗纪时拉萨-冈底斯区与羌塘区的关系比与藏南喜马拉雅更紧密,它们总体属于东特提斯洋北缘海区同一个特征相似的生物地理区系,不太支持雅鲁藏布江缝合带特提斯是弧后小盆地的观点.综合地层、生物和沉积特征,研究认为,班公湖-怒江特提斯在晚三叠世开始张裂,可能在早侏罗世晚期已有初始洋壳增生形成;中侏罗世晚期班公湖-怒江洋发展至顶峰,随后开始收缩,羌塘地块向南俯冲与拉萨-冈底斯地块发生碰撞和拼合.

关键词：生物地层年代地层特提斯雅鲁藏布缝合带班公湖-怒江缝合带

由超拍电子伏特加速器产生的超高能伽马射线气泡

在线全文

学校读者我要写书评

暂无评论

Science Bulletin 2024年第4期69卷 449-457页

作者： LHAASO Collaboration Zhen Cao Chuandong Gao Cong Li Ruo-Yu Liu Ruizhi Yang 不详 Key Laboratory of Particle Astrophyics&Experimental Physics Division&Computing Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China TIANFU Cosmic Ray Research Center ChengduChina Institute of Frontier and Interdisciplinary Science Shandong UniversityQingdao 266237China School of Astronomy and Space Science Nanjing UniversityNanjing 210023China University of Science and Technology of China Hefei 230026China

We report the detection of aγ-ray bubble spanning at least 100deg2 in ultra-high energy(UHE)up to a few PeV in the direction of the star-forming region Cygnus x,implying the presence super PeVatron(s)accelerating protons to at least 10 PeV.A log-parabola form with the photon indexΓ(E)=(2.71±0.02)+(0.11±0.02)×log10(E/10 TeV)is found fitting the gamma-ray energy spectrum of the bubble *** sources,“hot spots”correlated with very massive molecular clouds,and a quasi-spherical amorphousγ-ray emitter with a sharp central brightening are observed in the *** the core of~0.5°,spatially associating with a region containing massive OB association(Cygnus OB2)and a microquasar(Cygnus x-3),as well as previously reported multi-TeV sources,an enhanced concentration of UHEγ-rays is observed with 2 photons at energies above 1 *** general feature of the bubble,the morphology,and the energy spectrum,are reasonably reproduced by the assumption of a particle accelerator in the core,continuously injecting protons into the ambient medium.

关键词： Cosmic rays γ-rays Interstellar medium Star cluster

Decoding the genetic program of micronucleus formation: linking chromosomal instability to human disease

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第7期9卷 2840-2842页

作者： jörg Fahrer Division of Food Chemistry and Toxicology Department of ChemistryRPTU Kaiserslautern-Landau67663 KaiserslauternGermany

A recent study by Adams and colleagues published in Nature unveiled more than one hundred genes that are involved in micronucleus formation,1 which is a biomarker for genomic instability and associated with aging,cancer,and other disorders.2 As an outstanding achievement,the authors identified DSCC1(DNA Replication And Sister Chromatid Cohesion 1)as a critical gene protecting against early developmental defects,genomic instability,reduced proliferative capacity,cohesinopathy-related phenotypes,and tumor development in vivo.

关键词： chromosomal linking Replication