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自由生活的橙腹田鼠中是否有配偶选择?来自野外数据的证据(英文)

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动物学报 2004年第4期50卷 527-534页

作者： Lowell L.GETZ betty mcguire Theresa PIZZUTO Department of Animal Biology University of Illinois505 S.Goodwin Ave.UrbanaIL 61801USA Department of Biological SciencesSmith CollegeNorthamptonMA 01063USADepartment of EntomologyClemson UniversityClemsonSC 29634USA

使用在长期研究橙腹田鼠的社会组织中收集的数据 ,我们研究了该物种配对的形成和解体。大多数在春季形成的配对包括了各公社群 (包括至少两个同性个体的群 )过冬后的生存者。无论雌、雄个体是否来自相同或不同的的公社群 ,配对的个体都... 详细信息

使用在长期研究橙腹田鼠的社会组织中收集的数据 ,我们研究了该物种配对的形成和解体。大多数在春季形成的配对包括了各公社群 (包括至少两个同性个体的群 )过冬后的生存者。无论雌、雄个体是否来自相同或不同的的公社群 ,配对的个体都不是同一家庭的成员。春秋季形成的新配对 ,通常包括一直在研究地游荡的无亲缘关系的个体。所以 ,我们的野外数据表明 ,橙腹田鼠避免与家庭成员配对 ;但是没证据表明自由生活的橙腹田鼠以体重为基础来进行配偶选择 ,也没证据表明在野外或半自然的实验室条件下 ,雌性个体偏好有性经历的雄性个体。在我们研究的种群中 ,配对分离的个体都具有一个特征 ,即分离前的繁殖成功率比未分离的配对个体低。在任何特定的时间内 ,由于雌、雄性个体的潜在配偶的数量有限 ,所以 ,几乎没有个体有机会同时比较两个或更多潜在配偶的特征。结果表明 :我们所研究的种群中的配对是机会主义式的。

关键词：橙腹田鼠配偶选择种群繁殖

自由生活橙腹田鼠的社会组织和婚配制度(英文)

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动物学报 2005年第2期51卷 178-186页

作者： Lowell L.GETZ betty mcguire C.Sue CARTER Department of Animal Biology University of Illinois505S.GoodwinAve.UrbanaIL61801USADepartment of Biological SciencesSmith CollegeNorthamptonMA01063USADepartment of PsychiatryUniversity of Illinoisat Chicago1601W.TaylorSt.ChicagoIL60612USA

在美国伊利诺伊州中东部地区对橙腹田鼠(Microtus ochrogaster) 进行的广泛研究基础上, 我们对该鼠的社会组织和婚配制度进行了总结。橙腹田鼠的基本社会组织由最初的雌雄配偶或者单一的雌鼠(常为一对配偶的幸存者) 与留居的后代和非亲... 详细信息

在美国伊利诺伊州中东部地区对橙腹田鼠(Microtus ochrogaster) 进行的广泛研究基础上, 我们对该鼠的社会组织和婚配制度进行了总结。橙腹田鼠的基本社会组织由最初的雌雄配偶或者单一的雌鼠(常为一对配偶的幸存者) 与留居的后代和非亲缘成体的同居群组成。留居的后代占了原始繁殖单位之外的70%。另外, 直到至少两个留居后代达到成年后, 多数(80%) 的非亲缘个体才加入家族群。因此, 同居群的形成是以高水平的留居为基础的。雌雄配偶表现出与行为单配制有关的特征, 包括共享一个巢穴和家域, 雄性保卫配偶, 以及双亲行为(修饰, 拥抱和衔回幼鼠)。同居群的成员也保卫领域。

关键词：橙腹田鼠社会组织婚配制度同居群单配制

鼠类种群动态:食物资源影响力的实验评估(英文)

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兽类学报 2006年第2期26卷 114-122页

作者： Lowell L. Getz Arpat Ozgul Madan K. Oli Joyce E. Hofmann betty mcguire Department of Animal Biology University of Illinois 2113 Lynwood Drive Champaign IL 61821 USA Department of Wildlife Ecology and Conservation University of Florida 110 Newins-Ziegler Hall Gainesville FL 32611 USA Illinois Natural History Survey 607 E. Peabody Drive Champaign IL 81820 USA Department of Ecology and Evolutionary Biology Cornell UniversityCorson Hall Ithaca NY 14853 USA

本研究在美国伊利诺斯州中东部测定了中等食物质量(莓系属的牧草)和低食物质量(高杆草牧场)栖息地内橙腹田鼠(Microtusochrogaster)和草原田鼠(***)种群对附加食物的响应。在中等食物质量栖息地内投放附加食物,橙腹田鼠种群的波动幅度... 详细信息

本研究在美国伊利诺斯州中东部测定了中等食物质量(莓系属的牧草)和低食物质量(高杆草牧场)栖息地内橙腹田鼠(Microtusochrogaster)和草原田鼠(***)种群对附加食物的响应。在中等食物质量栖息地内投放附加食物,橙腹田鼠种群的波动幅度高于对照样地,但同类型食物质量栖息地内,种群平均密度和波动模式无显著的差异。仅在低等食物质量的高杆草栖息地内,投放附加食物可导致草原田鼠的种群密度高于对照样地。附加食物不直接影响两种栖息地内橙腹田鼠的成活率或成熟率,在中等食物质量栖息地中投放附加食物,繁殖活跃的成熟雌性个体比例及雄性成体的体重高于对照。附加食物不影响莓系属牧草内草原田鼠,也不能影响该动物在高杆草环境中的存活率。然而,投放附加食物,可缩短低等食物质量栖息地内草原田鼠的成熟期,提高繁殖活跃雌性的比例和迁入个体比例,增加并引起雄性个体体重增加。据此,本研究证明食物资源在橙腹田鼠和草原田鼠种群动态中只起极小的作用。

关键词：数量统汁食物资源橙腹田鼠草原田鼠附加食物

橙腹田鼠中延缓性密度依赖效应和种群波动(英文)

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动物学报 2004年第1期50卷 1-8页

作者： Lowell L.GETZ Laura E.SIMMS Joyce E.HOFMANN betty mcguire Department of Animal Biology University of Illinois 505 S.Goodwin Ave Urb anaDepartment of PhysicsAugsburg College2211 Riverside Ave MinneapolisIllinois Natural History Survey 607 E. Peabody Dr. ChampaignDepartment of Biological Sciences Smith College Northampton IL61801USAMN 55406USAIL81820USAMA01063 USA.

检验了延迟的密度依赖对橙腹田鼠 (Microtusochrogaster)一个波动种群的生存和生殖的影响 ,研究持续了 63个月 ,取样间隔为 3 5天。在研究期间 ,该种群的密度经历了 4次波动 ,每次波动的高峰都在 11月至次年 1月 ,种群数量在冬季下降... 详细信息

检验了延迟的密度依赖对橙腹田鼠 (Microtusochrogaster)一个波动种群的生存和生殖的影响 ,研究持续了 63个月 ,取样间隔为 3 5天。在研究期间 ,该种群的密度经历了 4次波动 ,每次波动的高峰都在 11月至次年 1月 ,种群数量在冬季下降。生存和生殖都有负面的密度依赖效应 ,最大效应具有 2个月的时滞。种群存活率增长对种群密度最大的正面效应具有 2个月的时滞 ,而对与增加生殖则有 3个月的时滞。内部因素和冬季都可能推延对生殖的密度依赖效应 ,但是本文未能检验这些内部因素的影响。季节性影响看来与对生存的延缓性密度依赖效应无关。负面的延缓性密度依赖效应对生存和生殖的净作用可能在于减少。

关键词：橙腹田鼠密度依赖效应种群波动种群存活率

Mitophagy and cGAS-STING crosstalk in neuroinflammation

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3327-3361页

作者： Xiaogang Zhou Jing Wang Lu Yu Gan Qiao Dalian Qin betty Yuen-Kwan Law Fang Ren Jianming Wu Anguo Wu Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia MedicaKey Laboratory of Medical Electrophysiology of Ministry of EducationSchool of PharmacySouthwest Medical UniversityLuzhou 646000China State Key Laboratory of Quality Research in Chinese Medicine Macao University of Science and TechnologyMacao SAR 999078China Chongqing Key Laboratory of Sichuan-Chongqing Co-construction for Diagnosis and Treatment of Infectious Diseases Integrated Traditional Chinese and Western Medicine Chongqing Traditional Chinese Medicine HospitalChongqing 400021China

Mitophagy,essential for mitochondrial health,selectively degrades damaged *** is intricately linked to the cGAS-STING pathway,which is crucial for innate *** pathway responds to mitochondrial DNA and is associated with cellular stress *** review explores the molecular details and regulatory mechanisms of mitophagy and the cGAS-STING *** critically evaluate the literature demonstrating how dysfunctional mitophagy leads to neuroinflammatory conditions,primarily through the accumulation of damaged mitochondria,which activates the cGAS-STING *** activation prompts the production of pro-inflammatory cytokines,exacerbating *** review emphasizes the interaction between mitophagy and the cGAS-STING *** mitophagy may suppress the cGAS-STING pathway,offering protection against ***,impaired mitophagy may activate the cGAS-STING pathway,leading to chronic ***,we explored how this interaction influences neurodegenerative disorders,suggesting a common mechanism underlying these *** conclusion,there is a need for additional targeted research to unravel the complexities of mitophagy-cGAS-STING interactions and their role in *** review highlights potential therapies targeting these pathways,potentially leading to new treatments for neuroinflammatory and neurodegenerative *** synthesis enhances our understanding of the cellular and molecular foundations of neuroinflammation and opens new therapeutic avenues for neurodegenerative disease research.

关键词： Neuroinflammation Mitophagy cGAS-STING Innate immunity Mitochondrial DNA Crosstalk Therapeutic avenues Neurodegenerative diseases

种间竞争对同域分布田鼠种群动态的影响(英文)

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动物学报 2007年第5期53卷 800-811页

作者： Lowell L.GETZ Arpat OZGUL Madan K.OLI Joyce E.HOFMANN betty mcguire Department of Animal Biology University of Illinois Department of Wildlife Ecology and Conservation University of Florida Illinois Natural History Survey Department of Ecology and Evolutionary Biology Cornell University

我们对美国伊利诺斯州中东部的蓝草和高草牧场共生的橙腹田鼠(Microtus ochrogaster)和草原田鼠(Microtus pennsylvanicus)开放种群进行了去除实验,以测定潜在的种间竞争。在蓝草草原,橙腹田鼠和草原田鼠的种群密度不因另一种的存在而... 详细信息

我们对美国伊利诺斯州中东部的蓝草和高草牧场共生的橙腹田鼠(Microtus ochrogaster)和草原田鼠(Microtus pennsylvanicus)开放种群进行了去除实验,以测定潜在的种间竞争。在蓝草草原,橙腹田鼠和草原田鼠的种群密度不因另一种的存在而受抑制;同时,另一种存在的情况下,相互间对月存活率、青年鼠位置的持久性生殖或迁入鼠数量没有负面影响,尽管在高草草原,草原田鼠似乎对橙腹田鼠的种群密度有强烈影响,并限制了迁入鼠的数量,但是雌橙腹田鼠的存活率、青年鼠的持久性和生殖活动的比例不因草原田鼠的存在而受影响。总之,在此研究地点,种间竞争没有对橙腹田鼠和草原田鼠共存种群的动态起到驱动作用。

关键词：田鼠橙腹田鼠草原田鼠种群统计种间竞争

Activation of autophagy by Citri Reticulatae Semen extract ameliorates amyloid-beta-induced cell death and cognition deficits in Alzheimer’s disease

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Neural Regeneration Research 2024年第11期19卷 2467-2479页

作者： Yong Tang Jing Wei Xiao-Fang Wang Tao Long Xiaohong Xiang Liqun Qu Xingxia Wang Chonglin Yu Xingli Xiao Xueyuan Hu Jing Zeng Qin Xu Anguo Wu Jianming Wu Dalian Qin Xiaogang Zhou betty Yuen-Kwan Law Dr.Neher’s Biophysics Laboratory for Innovative Drug Discovery State Key Laboratory of Quality Research in Chinese MedicineMacao University of Science and TechnologyMacao Special Administrative RegionChina Sichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica Southwest Medical UniversityLuzhouSichuan ProvinceChina Eye School and Key Laboratory of Sichuan Province Ophthalmopathy Prevention&Cure and Visual Function Protection of Chengdu University of TCM ChengduSichuan ProvinceChina School of Basic Medical Sciences Southwest Medical UniversityLuzhouSichuan ProvinceChina Department of Ophthalmology The Affiliated Hospital of Southwest Medical UniversityLuzhouSichuan ProvinceChina Department of Neurology The First People’s Hospital of NeijiangNeijiangSichuan ProvinceChina

Amyloid-beta-induced neuronal cell death contributes to cognitive decline in Alzheimer’s *** Reticulatae Semen has diverse beneficial effects on neurodegenerative diseases,including Parkinson’s and Huntington’s diseases,however,the effect of Citri Reticulatae Semen on Alzheimer’s disease remains *** the current study,the anti-apoptotic and autophagic roles of Citri Reticulatae Semen extract on amyloid-beta-induced apoptosis in PC12 cells were first *** Reticulatae Semen extract protected PC12 cells from amyloid-beta-induced apoptosis by attenuating the Bax/Bcl-2 ratio via activation of *** addition,Citri Reticulatae Semen extract was confirmed to bind amyloid-beta as revealed by biolayer interferometry in vitro,and suppress amyloid-beta-induced pathology such as paralysis,in a transgenic Caenorhabditis elegans in vivo ***,genetically defective Caenorhabditis elegans further confirmed that the neuroprotective effect of Citri Reticulatae Semen extract was *** importantly,Citri Reticulatae Semen extract was confirmed to improve cognitive impairment,neuronal injury and amyloid-beta burden in 3×Tg Alzheimer’s disease *** revealed by both in vitro and in vivo models,these results suggest that Citri Reticulatae Semen extract is a potential natural therapeutic agent for Alzheimer’s disease via its neuroprotective autophagic effects.

关键词： Alzheimer’s disease amyloid-beta apoptosis autophagy Caenorhabditis elegans Citri Reticulatae Semen

Trial characteristics and treatment effect estimates in randomized controlled trials of Chinese herbal medicine: A meta-epidemiological study

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Journal of Integrative Medicine 2024年第3期22卷 223-234页

作者： betty H.Wang Ya-li Lin Yin-yan Gao Jin-lu Song Lang Qin Ling-qi Li Wen-qi Liu Claire C.W.Zhong Mary Y.Jiang Chen Mao Xiao-bo Yang Vincent C.H.Chung Irene X.Y.Wu Jockey Club School of Public Health and Primary Care the Chinese University of Hong KongHong Kong 999077China Xiangya School of Public Health Central South UniversityChangsha 410006Hunan ProvinceChina School of Chinese Medicine the Chinese University of Hong KongHong Kong 999077China School of Public Health Southern Medical UniversityGuangzhou 510080Guangdong ProvinceChina State Key Laboratory of Dampness Syndrome of Chinese Medicine the Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Chinese Medicine Syndrome Research Team the Second Affiliated HospitalGuangzhou University of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome Guangzhou 510120Guangdong ProvinceChina Hunan Provincial Key Laboratory of Clinical Epidemiology Central South UniversityChangsha 410006Hunan ProvinceChina

Background:Previously published meta-epidemiological studies focused on Western medicine have identified some trial characteristics that impact the treatment effect of randomized controlled trials(RCTs).Nevertheless,it remains unclear if similar associations exist in RCTs on Chinese herbal medicine(CHM).Further,Chinese medicine-related characteristics have not been explored ***:To investigate trial characteristics related to treatment effect estimates on CHM *** strategy:This meta-epidemiological study searched 5 databases for systematic reviews on CHM treatment published between January 2011 and July *** criteria:An eligible systematic review should only include RCTs of CHM and conduct at least one *** extraction and analysis:Two reviewers independently conducted data extraction on general characteristics of systematic reviews,meta-analyses and included *** also assessed the risk of bias of RCTs using the Cochrane risk of bias tool.A two-step approach was used for data *** ratio of odds ratios(ROR) and difference in standardized mean differences (dSMD) with 95%confidence interval (CI) were applied to present the difference in effect estimates for binary and continuous outcomes,***:Ninety-one systematic reviews,comprising 1338 RCTs were *** binary outcomes,RCTs incorporated with syndrome differentiation (ROR:1.23;95%CI:[1.07,1.39]),adopting Chinese medicine formula (ROR:1.19;95%CI:[1.03,1.34]),with low risk of bias on incomplete outcome data (ROR:1.29;95%CI:[1.06,1.52]) and selective outcome reporting (ROR:1.12;95%CI:[1.01,1.24]),as well as a trial size≥100 (ROR:1.23;95%CI:[1.04,1.42]) preferred to show larger effect *** for continuous outcomes,RCTs with Chinese medicine diagnostic criteria (dSMD:0.23;95%CI:[0.06,0.41]),judged as high/unclear risk of bias on allocation concealment (dSMD:-0.70;95%CI:[-0.99,-0.42]),with low risk of bias on incomplete outcome data (dSMD:0.30

关键词： Chinese herbal medicine Randomized controlled trial Risk of bias Meta-epidemiological study Effect estimates

Imaging and endoscopic tools in pediatric inflammatory bowel disease: What’s new?

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World Journal of Clinical Pediatrics 2024年第1期13卷 7-13页

作者： Alexandra S Hudson Ghassan T Wahbeh Hengqi betty Zheng Department of Pediatrics University of WashingtonSeattleWA 98109United States

Pediatric inflammatory bowel disease(IBD)is a chronic inflammatory disorder,with increasing incidence and prevalence *** have been recent advances in imaging and endoscopic technology for disease diagnosis,treatment,and *** ultrasound,including transabdominal,transperineal,and endoscopic,has been emerging for the assessment of transmural bowel inflammation and disease complications(e.g.,fistula,abscess).Aside from surgery,IBD-related intestinal strictures now have endoscopic treatment options including through-the-scope balloon dilatation,injection,and needle knife stricturotomy and new evaluation tools such as endoscopic functional lumen imaging *** transnasal endoscopy may have a role in patients with upper gastrointestinal Crohn’s disease or those with IBD with new upper gastrointestinal *** to dysplasia screening in pediatric patients with longstanding colonic disease or primary sclerosing cholangitis hold promise with the addition of virtual chromoendoscopy and ongoing research in the field of artificial intelligence-assisted endoscopic *** intelligence and machine learning is a rapidly evolving field,with goals of further personalizing IBD diagnosis and treatment selection as well as *** review summarized these advancements,focusing on pediatric patients with IBD.

关键词： Intestinal ultrasound Endoscopy Inflammatory bowel disease Pediatrics Imaging