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中华医学会第十七次全国儿科学术大会

作者：朱丽李明燕邵洁 betsy lozoff 赵正言浙江大学医学院附属儿童医院儿童保健科美国密西根大学人类生长发育中心

目的自主性(内源性)眨眼是无外源性刺激条件下产生的眨眼,与中枢多巴胺系统的活动度密切相关。对婴儿至成人的研究发现,随年龄增加,自主眨眼次数增加,反映了中枢多巴胺神经通路的成熟过程。但早产儿自主性眨眼的发育状况尚未见研究报道...

目的自主性(内源性)眨眼是无外源性刺激条件下产生的眨眼,与中枢多巴胺系统的活动度密切相关。对婴儿至成人的研究发现,随年龄增加,自主眨眼次数增加,反映了中枢多巴胺神经通路的成熟过程。但早产儿自主性眨眼的发育状况尚未见研究报道。本研究通过观察不同出生胎龄的早产儿在矫正年龄6周龄和9月龄时的自主性眨眼,以此来探讨早产儿在生后早期的眨眼率及中枢多巴胺系统的发育状况。方法本研究共纳入205例6周龄婴儿进行随访研究,按不同出生胎龄分为早产组(出生胎龄:31-36周)和足月组(出生胎龄:39-40周)。其中早产组按照胎龄又分为两个亚组:早期早产组(出生胎龄:31-33周)和晚期早产组(出生胎龄:34-36周)。148例婴儿在9月龄参与了随访。分别于6周龄和9月龄(早产儿按照矫正年龄,足月儿按照生理年龄)时应用5分钟眨眼测试来评估早产儿和足月儿在6周龄和9月龄时的眨眼率,通过眨眼率的变化来反映中枢多巴胺系统的活动。结果 1.6周龄时,早期早产组婴儿的眨眼率低于足月儿(p0.05)。回归模型发现:早产儿在矫正年龄6周龄时,出生胎龄越大,其自主眨眼率越高。性别间比较,发现早产儿与足月儿的眨眼率均无性别差异(p>0.05)。2.9月龄时,早期早产儿、晚期早产儿与足月儿的眨眼率均无明显差异(p>0.05),且胎龄与眨眼率无明显相关性。性别间眨眼率比较未见差异(p>0.05)。结论 1.早产儿中枢多巴胺系统发育随胎龄增加而渐成熟;但胎龄对眨眼率及中枢多巴胺系统的影响会随着年龄增长而逐渐消失。2.早产儿的中枢多巴胺系统在发育过程中可能出现了"追赶性生长"。3.早产儿中枢多巴胺系统的发育不受性别影响。

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婴儿早期脑干听觉通路发育的研究

婴儿早期脑干听觉通路发育的研究

Post-fire regeneration dynamics in whitebark pine(Pinus albicaulis) forests in Wind River and Absaroka Mountains,Wyoming, USA

2012年江浙沪儿科学术年会暨浙江省医学会儿科学分会学术年会、儿内科疾病诊治新进展国家级学习班

作者：李明燕朱丽邵洁赵正言 betsy lozoff 浙江大学医学院附属儿童医院美国密西根大学儿童生长发育中心

目的利用脑干听觉诱发电位(Auditory Brainstem Response,ABR)探测足月婴儿早期脑干听觉通路的发育轨迹。方法共纳入126名出生胎龄(gestational age,GA)为37～41周的6周龄婴儿进行ABR测试,其中107名于9月龄时接受了第二次随访测试。根... 详细信息

目的利用脑干听觉诱发电位(Auditory Brainstem Response,ABR)探测足月婴儿早期脑干听觉通路的发育轨迹。方法共纳入126名出生胎龄(gestational age,GA)为37～41周的6周龄婴儿进行ABR测试,其中107名于9月龄时接受了第二次随访测试。根据胎龄分为:早期足月组(37-38周龄)和足月组(39-41周龄)。结果6周龄时,早期足月组婴儿的Ⅲ、Ⅴ波潜伏期及Ⅰ-Ⅲ、Ⅰ-Ⅴ波峰间期明显长于足月组婴儿

关键词：听觉通路浙江大学医学院附属儿童医院峰间期

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Journal of Forestry Research 2015年第3期26卷 719-733页

作者： Jennifer G.Klutsch betsy A.Goodrich William R.Jacobi Department of Bioagricultural Sciences and Pest Management Colorado State University Ft. CollinsCO 80523-1177 USA Department of Renewable Resources University of Alberta 442 Earth Science BuildingEdmonton AB T6G 2E3 Canada School of Forestry Northern Arizona University PO Box 15018 Flagstaff AZ 86011 USA

Whitebark pine （Pinus albicaulis） populations are in decline across the species＇ range due to historic wildfire exclusion, mountain pine beetle （Dendroctonus ponderosae, MPB） outbreaks, and an invasive fungal pathogen causing the disease white pine blister rust （Cronartium ribicola, WPBR）. Despite reliance on stand- replacing fires, information on whitebark pine regeneration occurrence is limited and the trajectory of future forests is largely unknown in some areas of the range. Regeneration densities were assessed in burned and adjacent non-burned areas at six high elevation locations in northwest Wyoming where stand-replacing fires occurred 8-32 years before thesurveys. In these locations at the eastern extent of the species range, we assessed what site factors were associ- ated with regeneration success. Whitebark pine regen- eration density was greater and seedlings were older in non-burned compared to burned areas. Within burns, north aspects had more regeneration than south aspects. Potential seed source densities and other species＇ regeneration were positively related to whitebark p^ne regeneration densities in burned areas. South facing slopes or grass covered areas may have either delayed or no regeneration of whitebark pine without the help of artificial planting.

关键词： Recruitment Age structure White pineblister rust - Mountain pine beetle Restoration

Pandemic COVID-19:Current status and challenges of antiviral therapies

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Genes & Diseases 2020年第4期7卷 502-519页

作者： Winglam Chan betsy He Xiong Wang Ming-Liang He Department of Biomedical Sciences City University of Hong KongHong KongChina Rensselaer Polytechnic Institute TroyNYUSA CityU Shenzhen Research Institute NanshanShenzhenChina

The pandemic COVID-19,caused by a new coronavirus SARS-CoV-2 infection,has infected over 12 million individuals and caused more than 55,200 death ***,there is no specific drug to treating this *** we summarized the mechanisms of antiviral therapies and the clinic findings from different *** chemotherapies have been conducted by in multiple cohorts in different *** FDA has fast approved remdesivir for treating COVID-19,it only speeds up recovery from COVID-19 with mildly reduced *** chloroquine was suggested a potential drug against SARS-CoV-2 infection due to its in vitro antiviral effects,it is imperative high-quality data from worldwide clinical trials are necessitated for an approved *** terms of hydroxychloroquine(HCQ)therapy,although WHO has stopped all the clinic trials due to its strong side-effects in COVID patients,large scale clinical trials with a long-term outcome follow-up may warrant HCQ and azithromycin combination in combating the *** plasma(CP)therapy suggested its safety use in SARS-CoV-2 infection;but both CP immunotherapy and NK cellular therapy must be manufactured and utilized according to scrupulous ethical and controlled conditions to guarantee a possible role of these products of human *** research should be conducted to define the exact mechanism of SARS-CoV-2 pathogenesis,suitable animal models or ex vivo human lung tissues aid in studying replication,transmission and spread of the novel viruses,thereby facilitating highly effective therapies.

关键词： Chloroquine Convalescent plasma therapy COVID-19 Hydroxychloroquine Ivermectin Natural killer cell therapy Remdesivir SARS-CoV-2

Design of a Novel Exoskeleton with Passive Magnetic Spring Self-locking and Spine Lateral Balancing

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Journal of Bionic Engineering 2024年第1期21卷 236-255页

作者： Jhon F.Rodríguez-León betsy D.M.Chaparro-Rico Daniele Cafolla Francesco Lago Eduardo Castillo-Castañeda Giuseppe Carbone Centro de Investigacion en Ciencia Aplicada y Tecnologia Avanzada Unidad Querétaro MecatronicaInstituto Politécnico NacionalCerro Blanco 14176090 Colinas del CimatarioQuerétaroMexico Department of Mechanical Energy and Management EngineeringUniversity of CalabriaVia P.Bucci Cubo 46 C87036 RendeItaly Faculty of Science and Engineering Department of Computer ScienceSwansea UniversitySwanseaUK CESTER University of Cluj-NapocaCluj-NapocaRomania

This paper proposes a new upper-limb exoskeleton to reduce worker physical *** proposed design is based on a novel PRRRP(P-Prismatic;R-Revolute)kinematic chain with 5 passive Degrees of Freedom(DoF).Utilizing a magnetic spring,the proposed mechanism includes a specially designed locking mechanism that maintains any desired task *** proposed exoskeleton incorporates a balancing mechanism to alleviate discomfort and spinal torsional effects also helping in limb weight *** paper reports specific models and simulations to demonstrate the feasibility and effectiveness of the proposed *** experimental characterization is performed to validate the performance of the mechanism in terms of forces and physical strain during a specific application consisting of ceiling-surface drilling *** obtained results preliminarily validate the engineering feasibility and effectiveness of the proposed exoskeleton in the intended operation task thereby requiring the user to exert significantly less force than when not wearing it.

关键词： Assistive mechanism Exoskeleton Locking mechanism Bionic robot

What Makes Apple Golden

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国际经济合作 2008年第3期 1-1页

作者： betsy Morrish

The mass market is supposed to bedead, but you would never know it from Apple. In February the iTunes Store be-came the second-largest music retailer inthe U.S., right behind Wal-Mart. The i-Pod is to music players wh... 详细信息

关键词：苹果公司音乐软件音乐手机市场开拓美国

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Pumpkins Abound

小学生时代（大嘴英语） 2021年第10期 16-19页

作者： betsy Blake Susan Miller(图) 不详

Pumpkins on the back porch,A pumpkin at the *** on the countertop,The table,and the floor.A pumpkin on the garden gate And two under the tree.A pumpkin in the window And a pumpkin on me!

关键词： pump floor Pump

Prevalence and Individual-Level Determinants of Uptake of Three or More Doses of Sulphadoxine-Pyrimethamine for Intermittent Preventive Treatment of Malaria in Pregnancy in Busia County, Kenya

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Open Journal of Epidemiology 2024年第3期14卷 405-418页

作者： Anne Nduta Miatu betsy Rono Cheriro Kamija Samuel Phiri School of Public Health Department of Environmental Health and Disease Control Jomo Kenyatta University of Agriculture and Technology Nairobi Kenya School of Global and Public Health Kamuzu University of Health Sciences Blantyre Malawi

Background: Malaria in pregnancy causes maternal anemia, low birth weight, intrauterine growth retardation, and preterm deliveries. In malaria-endemic regions in Kenya, percentage of pregnant women hospitalized with malaria reach up to 60%. WHO recommends at least three doses of sulphadoxine pyrimethamine for Intermittent Preventive Treatment of Malaria in Pregnancy (IPTp) antenatally. This study sought to ascertain the prevalence and individual-level factors influencing the uptake of IPTp-SP3+. Methods: A facility-based cross-sectional study at Busia County Referral Hospital. 384 mothers were consecutively sampled at the maternity unit during delivery. Semi-structured questionnaires were used to collect data. Odds ratio (OR) and adjusted OR were used to determine statistical significance of individual factors influencing uptake of three or more IPTp-SP. Results: 43.0% of participants took IPTp-SP3+. Individual factors that affected the uptake of IPTp-SP3+ included starting ANC visits in the first trimester (adjusted odds ratio (aOR) = 2.1, 95% CI: 1.23 – 3.67, p = 0.046), having more than four ANC visits (aOR = 3.1, 95% CI: 1.49 – 6.50, p = 0.002), having a higher monthly income (aOR = 2.6, 95% CI: 1.24 – 5.36, p = 0.012), being aware of the advantages of IPTp-SP medications (aOR = 3.7, 95% CI: 1.40 – 9.74, p = 0.008), and having a positive attitude toward ANC services (aOR = 3.2, 95% CI: 1.61 – 6.31, p = 0.001). Conclusion: Less than half of the pregnant mothers are complyingIPTp-SP3+. There should be aggressive efforts by the County and National Ministries of Health promoting initiation of ANC attendance early and attendance of all the recommended eight visits together with ensuring availability of the drugs.

关键词： Malaria in Pregnancy Antenatal Clinic Intermittent Prevention of Malaria in Pregnancy Dosage Uptake Sulphadoxine-Pyrimethamine and Individual Level Factors

Water quality impacts of small-scale hydromodification in an urban stream in Connecticut, USA

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Ecological Processes 2018年第1期7卷 106-115页

作者： Bin Zhu Daniel S.Smith Anthony P.Benaquista Dylan M.Rossi betsy M.Kadapuram Man Lok Yu Andrew S.Partlow Nathan R.Burtch Department of Biology University of Hartford200 Bloomfield AvenueWest HartfordCT 06117USA College of Marine and Environmental Sciences James Cook University1 James Cook DriveTownsvilleQLD 4811Australia Department of Geography and Environmental Planning Towson University8000 York RoadTowsonMD 21252USA

Introduction:Construction activities in and along urban streams increase the sediment input into surface waters,causing an overall decline in water quality and aquatic *** this case study,we investigate the water quality impacts of local hydromodification in an urban stream(discharge 0.4 m^(3)/s).At the site of interest,workers removed a stream crossing consisting of an embankment with culverts and replaced it with a small bridge(single span of 25 m)in an effort to improve flow ***:Water samples were taken at four sites along the North Branch Park River in Connecticut,Northeastern United *** and dissolved oxygen(DO)were measured in situ,and nitrate and total phosphorus(TP)were measured in the *** macroinvertebrate samples were also collected and analyzed for taxon richness and Shannon-Weaver species *** were compared between upstream and downstream sites and before,during,and after *** used one-way ANOVA combined with the post hoc Turkey test to derive statistical ***:During construction,turbidity increased temporarily by 60.9%[from 2.48 Nephelometric Turbidity Units(NTU)over ambient to 4.00 NTU].Once construction was completed,DO increased locally from 11.0 to 13.0 mg/*** macroinvertebrate taxon richness and species diversity declined by 61.6 and 32.6%respectively,with no recovery observed in the year following *** quality was only affected within 50 m *** and TP concentrations were ***:Small-scale hydromodification temporarily increased the turbidity as a result of increased sediment input,approaching the maximum level for clean water(5 NTU).Benthic macroinvertebrate communities declined in the immediate downstream vicinity of construction but are expected to recover soon given that turbidity recovered to pre-construction levels,and DO *** outcomes emphasize that environmental assessment is important not

关键词： Urban streams Pollution Hydrologic services Water quality Benthic macroinvertebrates North Branch Park River