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Methamphetamine and male suicide in the US-Mexico border region

Open Journal of Internal Medicine 2013年第2期3卷 30-33页

作者： Elsa de J. Hernández Fuentes bernardo ng Irma A. González Hernández Department of Sociology Universidad Autónoma de Baja California Mexicali Mexico Sun Valley Behavioral Medical Center Imperial USA

Introduction: Studying the use of psychoactive substances in completed suicide is essential in order to understand its role in the suicide generating stimuli. The most commonly reported substances are alcohol and opioids. Method: This is a retrospective study of completed suicide database of the Forensics Medical office in the city of Mexicali from 1999 to 2005. This is the capital of the Mexican state of Baja California in the US-Mexico border region. Results: Out of 288 suicides, 260 were men, and the most frequent drug found on autopsy was methamphetamine (p ng male (20 - 39 years old), employed in blue-collar jobs, lived in an urban area, found in their homes, and died by hanging. Discussion: Although no causal effect can be drawn, our study results suggest that methamphetamine use may be a risk factor for suicide in this sample.

关键词： Mexican US-Mexico Border Dugs Scide Mthamphetamine

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Sensitivity of a Rapid Mix Test with Combined Synthetic Antigens Derived from Mycobacterium Leprae PGL-1 for Diagnosis and Surveillance of Leprosy

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Open Journal of Immunology 2020年第1期10卷 1-9页

作者： Maria do Perpétuo Socorro Amador Silvestre Maxwell Furtado de Lima Antonio G.P.Pereira Aline Rodrigues bernardo Rafaela Lopes Diniz Pedro Paulo Ferreira Ribeiro Edimílson Domingos da Silva Luana Nepomuceno Gondim Costa Lima Instituto Evandro Chagas Rodovia BR-316km 07AnanindeuaParáBrasil Programa de Desenvolvimento Tecnologico de reativos para diagnostico GPRED-Bio Manguinhos-FioCruzRio de JaneiroBrasil

Introduction: In the Americas, Brazil contributes 91.63% of the total cases and the state of Pará still has high endemia for leprosy. Objective: To analyze the performance of a rapid test for the diagnosis and epidemiological surveillance of leprosy in endemic areas. Methods: The sample consisted of 70 MB multibacillary leprosy (MB) patients, 63 paucibacillary (PB) patients, and 80 intradomiciliary consanguineous contacts (ICSCO) of patients. A rapid test with a 15-minute reading was applied using two prototypes: prototype 1, double test with trisaccharide antigen (NT-P-BSA) at 1a. line (83.2 ng/test) and disaccharide antigen (ND-O-BSA) at 2a. (83.2 ng/test), both with a flow of 0.08 μL/mm with a 10 μC membrane, anti-IgM conjugate with a flow of 0.040 μL/mm and a Tris-Triton and prototype 2 runner buffer with MIX antigen (trisaccharide + disaccharide) in the same concentrations and conditions of prototype 1. Results: The comparison of the MIX test positivity rate and the disaccharide or trisaccharide doublet test across all samples was statistically significant, demonstrating that the MIX test had higher seropositivity rates compared to the ND-O-BSA or NT-P-BSA. It was demonstrated that the MIX test showed a good performance, with 25.39% of the PB patients negative for the disaccharide and trisaccharide duplet test, but positive for MIX. Conclusions: These data suggest the potential for further optimizing the performance by adding other synthetic antigens to the MIX antigens.

关键词： Leprosy Diagnosis Rapid Test

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