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实验医学研究导论

The “Two Camels” of Koussa: A Massive Ferrous Meteorite in Mayo Binka (North-West Region in Cameroon)

丛书名：汉译世界学术名著丛书

1991年

作者：（法）克洛德·贝尔纳（claude bernard）夏康农管光东译

本书论述了实验科学的思想方法,鼓励建设实验方法,研究生命现象,并将这种思想方法升华到哲学理论的高度。

ISBN: (纸本)7100021790

本书论述了实验科学的思想方法,鼓励建设实验方法,研究生命现象,并将这种思想方法升华到哲学理论的高度。

关键词：实验医学学科:研究

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Open Journal of Geology 2015年第9期5卷 649-654页

作者： bernard Njom Aurélien Temenou Tiolo Jacques Bertrand Onana Yanick Nyobe Bayi Augustin Patrice Moussango Ibohn Simon Pierre Mbog Bassong Michel Guy Awana Ateba Madi Boukar Thierry Abou’ou Ango Jean claude Ngoute Belle Koumedjalla Georges Emmanuel Ekodeck Faculté des Sciences Université de Yaoundé I Yaoundé Cameroun Institut de Recherches Géologiques et Minières (I.R.G.M) Yaoundé Cameroun Musée National Cameroun Yaoundé Cameroun

At Koussa in Mayo Binka, a hundred kilometers northeasterly from the town of Bamenda, the Capital of the North-West Region in Cameroon, an enormous block of native iron of several tons in mass is found. The observation of the Southern view of this block let anyone see a configuration which surprisingly recalls two camels in an attitude that these animals generally adopt when they are at rest. This strong resemblance with the attitude of these animals in rest has led the local populations in identifying this enormous metallic block with the name of “the two camels’ couple” or simply stills “the two camels”. The test conducted with the acid let the Neumann figures be revealed the Neumann figures which confirm this metallic block as being a ferrous meteorite or a siderite of the?Hexaedrites?class.

关键词： Koussa Mayo Binka Bamenda Cameroon Neumann Figures PDF’s Hoba Hexaedrites BIF

p53 functional loss,stemness and hepatocellular carcinoma

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Hepatoma Research 2020年第11期6卷 67-84页

作者： claude Caron de Fromentel Massimo Levrero Centre de Recherche en Cancérologie de Lyon INSERM U1052CNRS 5286UniversitéClaude Bernard Lyon 1Centre Léon BérardLyon 69008France Service d’Hépatologie et de Gastroentérologie Hôpital de la Croix-RousseHospices Civils de LyonLyon 69004France Dipartimento di Scienze Cliniche InternisticheAnestesiologiche e Cardiovascolari(SCIAC)Sapienza UniversityRome 00161Italy Center for Life Nano Science Istituto Italiano di TecnologiaSapienza UniversityRome 00161Italy

The tumor suppressor p53 is a key player in the control of genomic integrity and homeostasis in connection with p63 and p73,the two other members of the p53 *** of functional p53 leads to the proliferation and survival of mature cells and progenitor or stem cells that accumulate genetic alterations,thus favoring tumorigenesis.p53 loss of function,observed in a wide variety of human tumor types,is frequently caused by missense mutations more frequently found in the DNA binding domain,but can also be due to the expression of a plethora of viral and cellular negative *** hepatocellular carcinoma(HCC)represents a specific situation,first because the TP53 gene mutations pattern exhibits a“hot spot”rarely found in other tumor types that is linked to Aflatoxin B1 exposure and,second,because many HCCs do not exhibit any TP53 ***,we provide an overview of the current knowledge about the inhibition of p53 functions by the N-terminal(ΔN)truncated forms of the family,and their role in the emergence and maintenance of pre-malignant cells with stem cell characteristics and in HCC *** focus in particular on the Nanog-IGF1R-ΔNp73 axis that is associated with stem-like features in HCC cells and that may provide an attractive new therapeutic target and help to develop new biomarkers for HCC risk stratification,as well as preventive strategies.

关键词： p53 family p53 functional inactivation ΔNp73 hepatic progenitor cells cancer stem cells Nanog hepatocellular carcinoma

Control of Crystal Size Distribution in Batch Crystallization Processes Governed by Partial Differential Equations

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Control of Crystal Size Distribution in Batch Crystallizatio...

Epstein-Barr病毒相关疾病的IgG/Z抗体检测

第三十届中国控制会议

作者： ZHANG Kun,XU Cheng-Zhong Universite de Lyon,Laboratoire d''Automatique et de Genie des Procedes,Universite claude bernard Lyon 1 43 Boulevard du 11 novembre 1918,F-69622,Villeurbanne Cedex-France

＜正＞The paper deals with the simulation of batch crystallization processes and their crystal size distribution controllability by temperature *** dynamic of crystallization processes under consideration is governed by hyperbolic partial differential *** propose simulating the processes of one size variable using the method of *** turns out that the method of characteristics has no numerical diffusion as compared to the finite difference *** a desired crystal size distribution,we investigate its reachability from the null initial condition（*** seeding） by controlling the temperature. Some checkable criterion is established to determine if a desired crystal size distribution is *** it is reachable, an admissible temperature control is constructed to steer the states to the desired distribution in finite *** construction is developed based on the discretized model and applied for the original model described by partial differential *** ensure a desirable distribution to be reached,we add an output feedback control law to correct possible errors given rise to by uncertainty of parameters.

关键词： Infinite-Dimensional System Controllability Method of Characteristics Balance Population Equation Batch Crystallization Crystal Size Distribution

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病毒学报 1992年第3期8卷 218-222页

作者：曾毅 Jean-claude Nicolas Guy Schwaab Guy de The bernard Clausse Thomas Tursz Irene Joab 中国预防医学科学院病毒学研究所法国Rothschild医院法国Gustave Roussy肿瘤研究所法国巴斯德研究所

血清中Epstein-Barr病毒(EBV)的IgG/Z抗体对鼻咽癌和传染性单核细胞增多症是较特异的,其阳性率分别为85.7％和84％。50％的伯基特淋巴瘤病人亦有IgG/Z抗体。正常人则没有,但有IgG/VCA等抗体,表明IgG/Z抗体在初次感染后是容易消失的。Z... 详细信息

血清中Epstein-Barr病毒(EBV)的IgG/Z抗体对鼻咽癌和传染性单核细胞增多症是较特异的,其阳性率分别为85.7％和84％。50％的伯基特淋巴瘤病人亦有IgG/Z抗体。正常人则没有,但有IgG/VCA等抗体,表明IgG/Z抗体在初次感染后是容易消失的。Z抗原与EBV复制相关,故IgG/Z抗体对鼻咽癌不仅有诊断意义,还可能有预后的意义。

关键词：鼻咽肿瘤 EB病毒抗体 IgG/Z

新生期大白鼠皮下注射谷氨酸单钠对成年后下丘脑α-促黑素细胞激素神经元免疫反应性的影响

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解剖学杂志 1989年第2期12卷 79-82页

作者：张景行 Valatx J L Lucione L Jouvet M 安徽医科大学生理教研室法国里昂克劳伯尔纳大学实验医学研究所

本文用免疫组化方法研究了新生期大白鼠注射谷氨酸单钠(MSG)对成年后下丘脑α-促黑素细胞激素(α-MSH)免疫反应神经元的影响,结果显示MSG处理以后下丘脑弓状核区α-MSII免疫反应神经元减少甚至完全消失,但不影响下丘脑背外侧区的α-MSH... 详细信息

本文用免疫组化方法研究了新生期大白鼠注射谷氨酸单钠(MSG)对成年后下丘脑α-促黑素细胞激素(α-MSH)免疫反应神经元的影响,结果显示MSG处理以后下丘脑弓状核区α-MSII免疫反应神经元减少甚至完全消失,但不影响下丘脑背外侧区的α-MSH神经元群。文中还讨论了这两群α-MSH神经元的生理作用。

关键词：谷氨酸单钠弓状核 α-MSH

The comparison study of diagnostics of light filaments in air

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Science China(Physics,Mechanics & Astronomy) 2006年第2期49卷 228-235页

作者： HAO Zuoqiang1, ZHANG Jie1, YU Jin2, ZHENG Zhiyuan1, YUAN Xiaohui1,3, ZHANG Zhe1, LI Yutong1, WANG Zhaohua1, LING Weijun1 & WEI Zhiyi11. Laboratory of Optical Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100080, China 2. Laboratoire de Spectrométrie Ionique et Moléculaire,UMR CNRS 5579,Université claude bernard-Lyon 1,43, Bd. du 11 Novembre 1918, F-69622 Villeurbanne Cedex, France 3. State Key Laboratory of Transient Optics Technology, Xi’an Institute of Optics and Precision Mechanics, Chinese Academy of Sciences, Xi’an 710068, China Laboratory of Optical Physics Institute of Physics Chinese Academy of Sciences Beijing China Laboratoire de Spectrométrie Ionique et Moléculaire Villeurbanne Cedex France State Key Laboratory of Transient Optics Technology Xi’an Institute of Optics and Precision Mechanics Chinese Academy of Sciences Xi’an China

Long plasma channels in air induced by femtosecond laser pulses are inves-tigated using three different methods, including the cross-section imaging, resistivity measuring and acoustic diagnostics. These methods are based on different properties of the light filaments. A comparison of the three diagnostics shows that the imaging method is the most precise one in studying the filaments distribution and evolution, that the sono-graphic method is the most convenient approach to detecting long plasma channels by detecting the acoustic wave generation, and that the resistivity measurement can only be applied for giving a rough estimate. The diagnostics of filaments allow us to choose ap-propriate detecting methods and provide further insight into the dynamic evolution of the light filaments in air.

关键词： plasma channels filaments cross-section imaging resistivity measurement acoustic diagnostics.

Role of immunosuppression and tumor differentiation in predicting recurrence after liver transplantation for hepatocellular carcinoma: A multicenter study of 412 patients

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World Journal of Gastroenterology 2006年第45期12卷 7319-7325页

作者： Thomas Decaens Franoise Roudot-Thoraval Solange Bresson-Hadni Carole Meyer Jean Gugenheim Francois Durand Pierre-Henri bernard Olivier Boillot Philippe Compagnon Yvon Calmus Jean Hardwigsen Christian Ducerf Georges Philippe Pageaux Sébastien Dharancy Olivier Chazouillères Daniel Cherqui Christophe Duvoux Service d'Hépatologie et de Gastroentérologie AP-HP Hpital Henri Mondor Créteil Unité INSERM 581 France Département de Santé Publique AP-HP Hpital Henri Mondor Créteil France Service d’Hépatologie Hpital Jean Minjoz Besanon France Service de Transplantation Hpital HautefeuilleStrasbourg France Service de Chirurgie Digestive Hpital L’Ar-chet 2 Nice France Service d’Hépatologie AP-HP Hpital Beau-jon Clichy France Service d’Hépatologie et de Gastroentéro-logie H?pital Pellegrin Bordeaux France Service de Chirurgie Digestive Hpital Edouard Herriot Lyon France Service de Chirurgie Digestive Hpital Ponchaillou Rennes France Service de Chirurgie Digestive AP-HP HpitalCochin Paris France Service de Chirurgie Digestive Hpital laConception Marseille France Service de Chirurgie Digestive Hpital de laCroix Rousse Lyon France Fédération Médico-Chirurgicale deMaladies de l’Appareil Digestif Hpital Saint-Eloi MontpellierFrance Service d’Hépatologie et de Gastroentérologie H?pital Claude Huriez Lille France Service d’Hépatologie AP-HP Hpital SAntoine Paris France Service de Chirurgie Générale et Digestive APHP Hopital Henri Mondor Créteil France

AIM： To assess pre-orthotopic liver transplantation （OLT） factors that could be evaluated pre-operatively or controlled post-operatively associated with hepatocellular carcinoma （HCC） recurrence and disease-free survival after liver transplantation （LT）.METHODS： Four hundred and twelve patients transplanted for HCC between 1988 and 1998 in 14 French centers, who survived the postoperative period were studied. Kaplan Meier estimates were calculated for 24 variables potentially associated with recurrence of HCC. Uni- and multivariate analyses were conducted to identify independent predictors of recurrence. RESULTS： Overall 5-year disease-free survival was 57.1%. By univariate analysis, variables associated with disease-free survival were： presence of cirrhosis （P = 0.001）, etiology of liver disease （P = 0.03）, α fetoprotein level （〈 200, 200 to 2000, or 〉 2000; P 〈 0.0001）, y-GT activity （N, N to 2N or 〉 2N; P = 0.02）, the number of nodules （1, 2-3 or ≥ 4; P = 0.02）, maximal diameter of the largest nodule （〈 3 cm, 3 to 5 cm or 〉 5 cm; P 〈 0.0001）, the sum of the diameter of the nodules （〈 3 cm, 3 to 5 cm, 5 to 10 cm or 〉10 cm; P 〈 0.0001）, bilobar location （P = 0.01）, preoperative portal thrombosis （P 〈 0.0001）, peri-operative treatment of the tumor （P = 0.002） and chemoembolization （P = 0.03）, tumor differentiation （P = 0.01）, initial type of calcineurin inhibitor （P = 0.003）, the use of antilymphocyte antibodies （P = 0.02）, rejection episodes （P = 0.003） and period of LT （P 〈 0.0001）. By multivariate analysis, 6 variables were independently associated with HCC recurrence： maximal diameter of the largest nodule （P 〈 0.0001）, time of LT （P 〈 0.0001）, tumor differentiation （P 〈 0.0001）, use of anti-lymphocyte antibody （ATG） or anti-CD3 antibody （OKT3）（P = 0.005）, preoperative portal thrombosis （P = 0.06） and the number of nodules （P = 0.06）. CONCLUSION： This study identifies immunosuppression, through the use of ATG or OKT3, as a predictive factor of tumor recur

关键词： Immunosuppression Hepatocellular carcinoma Tumor differentiation Liver transplantation

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纳米复合彩色薄膜的制备

同济大学学报（自然科学版） 2004年第9期32卷 1247-1251页

作者：侯艳芳沈军吴广明 J.Mugnier 同济大学波耳固体物理研究所上海200092 法国里昂第一大学发光材料物理与化学实验室里昂69622

以正硅酸乙酯、乙醇、生物染色剂为主要原料 ,通过溶胶 -凝胶法制备了掺有有机染料的SiO2 溶胶 ,利用提拉法在普通玻璃上成功镀制了均匀透明、色泽丰富的彩色涂层 ,该涂层颜色在高温下会彻底分解消失 ,实现了玻璃的可回收利用 .运用光... 详细信息

以正硅酸乙酯、乙醇、生物染色剂为主要原料 ,通过溶胶 -凝胶法制备了掺有有机染料的SiO2 溶胶 ,利用提拉法在普通玻璃上成功镀制了均匀透明、色泽丰富的彩色涂层 ,该涂层颜色在高温下会彻底分解消失 ,实现了玻璃的可回收利用 .运用光谱分析、扫描探针显微镜研究了薄膜的结构 ,以及工艺参数对薄膜在可见光区光谱性能的影响 .

关键词：纳米复合溶胶-凝胶法生物染色剂彩色薄膜