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Expression of mir-15/107 Family MicrorNAs in Human Tissues and Cultured rat Brain Cells

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Genomics, Proteomics & Bioinformatics 2014年第1期12卷 19-30页

作者： Wang-Xia Wang robert J.Danaher Craig S.Miller joseph r.Berger Vega G.Nubia bernard S.Wilfred Janna H.Neltner Christopher M.Norris Peter T.Nelson Sanders-Brown Center on Aging University of KentuckyLexingtonKY 40536USA College of Dentistry University of KentuckyLexingtonKY 40536USA Department of Neurology University of KentuckyLexingtonKY 40536USA Department of Pathology University of KentuckyLexingtonKY 40536USA Department of Molecular and Biomedical Pharmacology University of KentuckyLexingtonKY 40536USA

The mir-15/107 family comprises a group of 10 paralogous microrNAs （mirNAs）,sharing a 5＇ AGCAGC *** mirNAs have overlapping *** order to characterize the expression of mir-15/107 family mirNAs,we employed customized TaqMan Low-Density micro-fluid PCr-array to investigate the expression of mir-15/107 family members,and other selected mirNAs,in 11 human tissues obtained at autopsy including the cerebral cortex,frontal cortex,primary visual cortex,thalamus,heart,lung,liver,kidney,spleen,stomach and skeletal ***-103,mir-195 and mir-497 were expressed at similar levels across various tissues,whereas mir-107 is enriched in brain *** also examined the expression patterns of evolutionarily conserved mir-15/107 mirNAs in three distinct primary rat brain cell preparations （enriched for cortical neurons,astrocytes and microglia,respectively）.In primary cultures of rat brain cells,several members of the mir-15/107 family are enriched in neurons compared to other cell types in the central nervous system （CNS）.In addition to mature mirNAs,we also examined the expression of precursors （pri-mirNAs）.Our data suggested a generally poor correlation between the expression of mature mirNAs and their *** summary,we provide a detailed study of the tissue and cell type-specific expression profile of this highly expressed and phylogenetically conserved family of mirNA genes.

关键词： mir-16 mir-424 mir-503 mir-15 Normalization Target prediction

Assessment of Pollution Levels of Suspended Particulate Matter on an Hourly and a Daily Time Scale in West African Cities: Case Study of Ouagadougou (Burkina Faso)

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Journal of Geoscience and Environment Protection 2020年第11期8卷 119-138页

作者： Issoufou Ouarma bernard Nana Kayaba Haro Antoine Béré Jean Koulidiati Laboratoire de Physique et de Chimie de l’Environnement (LPCE) Université Joseph KI-ZERBO Ouagadougou Burkina Faso Institut Des Sciences (IDS) Ouagadougou Burkina Faso Institut de recherche en Sciences Appliquées et Technologie (IrSAT) Centre National de la Recherche Scientifique et Technologique (CNRST) Ouagadougou Burkina Faso

In Western countries, research works on air quality have reinforced in recent years because of the links between the level of particulate pollution in numerous cities and the appearing of various health disorders including cardio-respiratory pathologies, acute bronchopneumonia, lung cancer, etc. In sub-Saharan Africa countries, particularly Burkina Faso, there is very few similar research. In the present work, the pollution levels of airborne particle in the city of Ouagadougou have been assessed through two campaigns of in situ measurements of suspended particulate matter concentrations. These measurements which have concerned PM1, PM2.5 and PM10 were performed using a portable device (AErOCET531S) at nine sites in 2018 and at ten sites in 2019. These sites are located on roadside, administrative services, secondary education establishments and outlying districts. The results show that: 1) the PM1 concentrations values presented no significant variation between days, seasons or sampling sites;2) the 24-hour PM2.5 concentrations often exceeding WHO recommended concentrations and, 3) the 24-hour PM10 concentrations exceed WHO recommended concentrations regardless of the season or the sampling site. In indeed, the average 24-hour concentrations are 20 ± 4, 87 ± 16 and 951 ± 266 μg·m−3 for the PM1, PM2.5 and PM10, respectively. They are 17 ± 3, 29 ± 5 and 158 ± 43 μg·m−3, respectively, in 2018 dry season and, 12 ± 1, 22 ± 9 and 187 ± 67 μg·m−3, respectively, in 2019 rainy season.

关键词： Urban Air Pollution PM1 PM2.5 PM10 AErOCET Ouagadougou

Simulation and Evaluation of Dust Emission with Polair3D-SIrEAM Model over West Africa Focused on Ouagadougou (Burkina Faso)

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Journal of Environmental Protection 2019年第1期10卷 80-102页

作者： bernard Nana Oumar Sanogo Issoufou Ouarma Antoine Béré Jean Koulidiati Laboratoire de Physique et de Chimie de l’Environnement (LPCE) Université Ouaga I Professeur Joseph KI-ZERBO Ouagadougou Burkina Faso Institut des Sciences (IDS) Ouagadougou Burkina Faso Institut de recherche en Sciences Appliquées et Technologies Centre National de la Recherche Scientifique et Technologique Ouagadougou Burkina Faso

The study of air pollution is recent in West Africa. There is a lack of data on air pollution. However, some studies conducted in West Africa show that air quality is a concern. Population growth and massive vehicles imports are contributing to the deterioration of this air quality. In this work, we present the modelling of desert aerosols using a CTM Polair3D-SIrEAM. The objective is to evaluate the ability of Polair3D-SIrEAM to reproduce observations of PM10 and Aerosol Optical Thicknesses (AOT). A simulation with Polair3D-SIrEAM was carried out in West Africa, focused on Ouagadougou (Burkina Faso) for 2007. The model of Marticorena and Bergametti (1995), MB95, was used to estimate desert aerosols emissions. The total emission of dust modelled is 52.2 Tg. For the evaluation of PM10, the simulated averages remained within the same orders of magnitude as the observed averages. Correlations are low in all the observation sites. The other indicators are similar to those found by Schmechtig et al. (2011). Performance criteria of Boylan and russel (2006) are met for the observation sites of Ouagadougou and Ilorin (Nigeria). For the AOTs, the correlations are significantly improved, in particular, at the sites of Ouagadougou and Ilorin. Performance criteria of Boylan are met for all observation sites. However, the performance goals are only achieved for Ouagadougou and Ilorin.

关键词： Air Pollution Dust Emission Modelling PM10 Aerosol Optical Thickness Polair3D-SIrEAM

Utility of the low-accelerating-dose regimen in 182 liver recipients with recurrent hepatitis C virus

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World Journal of Gastroenterology 2015年第20期21卷 6236-6245页

作者： Kieron BL Lim Hamid r Sima M Isabel Fiel Viktoriya Khaitova John T Doucette Maria Chernyiak Jawad Ahmad Nancy bach Charissa Chang Priya Grewal Leona Kim-Schluger Lawrence Liu joseph Odin Ponni Perumalswami Sander S Florman Thomas D Schiano Division of Liver Diseases Icahn School of Medicine at Mount Sinai Division of Gastroenterology and Hepatology National University Center for Organ TransplantationNational University Hospital Lillian and Henry M Stratton-Hans Popper Department of Pathology Icahn School of Medicine at Mount Sinai recanati-Miller Transplantation Institute Icahn School of Medicine at Mount Sinai Department of Preventive Medicine Icahn School of Medicine at Mount Sinai

AIM: To describe our experience using a low-acceleratingdose regimen(LADr) with pegylated interferon alpha-2a and ribavirin in treatment of hepatitis C virus(HCV) recurrence. METHODS: From 2003, a protocolized LADr strategy was employed to treat liver transplant(LT) recipients with recurrent HCV at our institution. Medical records of 182 adult patients with recurrent HCV treated with LADr between 1/2003 and 1/2011 were reviewed. Histopathology from all post-LT liver biopsies were reviewed in a blinded fashion. Paired recipient and donor IL28 B status were assessed. A novel technique was employed to ascertain recipient and donor IL28B(rs12979860) Gt data using DNA extracted from archival FFPE tissue from explanted native livers and donor gallbladders respectively. The primary endpoint was SVr; secondary endpoints examined include(1) patient and graft survival;(2) effect of anti-viral therapy on liver histology(fibrosis and inflammation);(3) incidence of on-treatment development of ACr, CDr, or PCH;(4) association of recipient and donor IL28 B genotype with SVr; and(5) incidence of antiviral therapy-associated adverse events(anemia, leukopenia, thrombocytopenia, depression) and hepatic ***: The overall SVr rate was 38%(29% Gt1, 67% Gt2, 86% Gt3 and 58% Gt4). HCV Gt(P r age(P = 0.003), cytomegalovirus mismatch(P = 0.001), baseline serum bilirubin(P = 0.002), and baseline viral load(P = 0.04) were independent predictors for SVr. SVr rates were significantly higher in the recipient-CC/donor-non CC pairs(P = 0.007). Neither baseline fibrosis nor change in fibrosis stage after anti-viral therapy were associated with SVr. Fibrosis progressed in 72% of patients despite SVr. Median graft survival was 91 mo. Five-year patient survival was superior in patients who achieved SVr(97% vs 82%, P = 0.001). Pre-treatment ALP ≥ 150 U/L(P = 0.01), total bilirubin ≥ 1.5 mg/d L(P = 0.001) and creatinine ≥ 2 mg/d L(P = 0.001) were independently associated

关键词： Hepatitis C recurrence Liver transplant Low accelerating dose regimen Peginterferon α-2a IL28B

High Prevalence of Hepatitis B Virus Infection Compared to Human Immunodeficiency Virus among Blood Donors in Bangui

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Open Journal of Gastroenterology 2020年第6期10卷 137-143页

作者： Serges Magloire Camengo Police bernard Bessanguem Eveline Mofini Benoît Elowa Georges Service Peggy Guéréndo Armelo Thibaut Yangba Kalebanga Nathalie Philomène Boua-Akélélo Tolmbaye Sem Fiacre Odilon joseph roger Molowa Kobendo Department of Hepatogastroenterology and Internal Medicine of “Amitié Sino-Centrafraine” University Hospital Center Bangui Central African Republic Department of Internal Medicine “Maman Elisabeth Domitien” University Hospital Center Bimbo Central African Republic Department of Venerology Dermatology National University Hospital Center Bangui Central African Republic

Introduction: Hepatitis B Virus (HBV) and Human Immunodeficiency Virus (HIV) infection is a public health problem worldwide, particularly in sub-Saharan Africa. Objective: to compare the epidemiological, clinical and biological characteristics of chronic HBV and HIV infection in blood donors at the National Center for Blood Transfusion (NCBT) in Bangui. Patients and Methods: This was an 8-month analytical cross-sectional study from August 10, 2011 to April 9, 2012. During this study, we consecutively enrolled consenting blood donors of both sexes in which the search for HBsAg and HIV infection was carried out. Results: During the study period, 850 blood donors were collected. HBsAg was found in 142 donors (16.7%), of whom 55 blood donors (6.5%) were coinfected with HIV. On the other hand, HIV serology was positive in 77 blood donors (9.1%) including 55 co-infected (6.5%) with HBV. In order to better compare the risk factors, we have not included HIV-HBV coinfected patients. Only 795 blood donors were selected for the risk factor study. There were 87 cases of HBsAg positive (10.9%) and 22 cases of HIV positive (2.8%). The average age of HIV and HBV infected patients was 25.7 and 26.2 years

Impact of Improved Cookstoves on the Level of Household Exposure to CO and PM_2.5 in Sub-Saharan Cities: The Case of the City of Ouagadougou

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Open Journal of Air Pollution 2023年第2期12卷 50-66页

作者： Lucmane Koala Kayaba Haro Ousmane Coulibaly bernard Nana Issoufou Ouarma Edwige Ouedraogo Tizane Daho Oumar Sanogo Antoine Béré Laboratoire de Physique et de Chimie de l’Environnement (LPCE) Université Joseph KI-ZERBO Ouagadougou Burkina Faso Institut de recherche en Sciences Appliquées et Technologie (IrSAT) Centre National de la Recherche Scientifique et Technologique (CNRST) Ouagadougou Burkina Faso Institut Des Sciences (IDS) Ouagadougou Burkina Faso

Air pollution is one of the major global threats to human health. In Burkina Faso, more than 80% of the population uses solid fuels as the main source of cooking energy. This paper reports a comparative study on the exposure of household to the carbon monoxide (CO) and particulate matter (PM2.5) emitted by improved cookstoves (ICS) or traditional cookstoves (TCS). A cross-sectional study was conducted in the city of Ouagadougou for 4 months during the rainy season (July to October) in households with an outdoor kitchen. The investigation involved 92 households where air pollutants, such as PM2.5 and CO were measured with Indoor Air Pollution Meters (IAP meter). These measurements were focused on the concentration levels of the pollutants during cooking. The results of this study show high levels of PM2.5 and CO for all type of stoves. Wood stoves led to higher PM2.5 and lower CO emissions than charcoal stoves. ICS reduce emissions of indoor air pollutants compared to TCS. This reduction raised up to 82% for PM2.5 and 37% for CO. The analysis of the data measured with the student test (t-test) shows that there is a statistically significant difference between the average values of the concentrations of the pollutants emitted with the TCS compared to ICS, except for CO emissions measured on multi-pot sizes cookstoves (MM). This study shows that the concentrations of indoor air pollutants are very high regardless of the type of cookstoves used. The CO exposure obtained varies from 119.10 to 362.72 μg/m3 for 15-minute and 10.83 - 55.11 μg/m3 for 1-hour exposure. The exposure in PM2.5 varies from 4762 to 16,257 μg/m3 for 15-minute and 106.63 to 1597 μg/m3 for 1-hour of exposure. It was noted that the CO exposure levels obtained over 15-minute of exposure are 1.36 to 4.15 times higher than the WHO recommendation and 1.8 times higher for an exposure time of one hou

关键词： Biomass Cookstove Particulate Matters Carbon Monoxide

2D Modeling of Solar Cell p-n radial Junction: Study of Photocurrent Density and Quantum Efficiency in Static Mode under Monochromatic Illumination

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Smart Grid and renewable Energy 2020年第12期11卷 191-200页

作者： raguilignaba Sam Alain Diasso bernard Zouma François Zougmoré Département de Physique UFR/ST Université Nazi Boni Bobo Dioulasso Burkina Faso Laboratoire de Matériaux et Environnement Département de Physique UFR/SEA Université Joseph Ki-Zerbo Ouagadougou Burkina Faso Laboratoire d’Energies Thermique renouvelables (L.E.T.r.E) Université Joseph Ki-Zerbo Ouagadougou Burkina Faso

A theoretical study of a polysilicon solar cell with a radial junction in static regime under monochromatic illumination is presented in this paper. The junction radial solar cell geometry is illustrated and described. The carriers’ diffusion equation is established and solved under quasi-neutral base assumption with boundaries conditions and Bessel equations. New analytical expressions of electrons and holes photocurrent density and quantum efficiency are found. The wavelength and structural parameters (base radius, base thickness and wavelength) influences on photocurrent density and quantum efficiency are carried out and examined.

关键词： Grain Geometry Photocurrent Density Quantum Efficiency radial Junction

2D Modeling of Solar Cell radial Junction: Study of Carriers Charge Density and Photocurrent Density in Static Mode under Monochromatic Illumination

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Energy and Power Engineering 2020年第10期12卷 568-577页

作者： Moussa Ouédraogo raguilignaba Sam Alain Diasso bernard Zouma François Zougmoré Laboratoire de Maté riaux d’H&eacute liophysique et Environnement (LaMHE) D&eacute partement de Physique UFR/ST Universit&eacute Nazi Boni Bobo Dioulasso Burkina Faso Laboratoire de Maté riaux et Environnement D&eacute partement de Physique UFR/SEA Universit&eacute joseph Ki-Zerbo Ouagadougou Burkina Faso Laboratoire d’Energies Thermique renouvelables (L.E.T.r.E) Universit&eacute joseph Ki-Zerbo Ouagadougou Burkina Faso

A theoretical study of a polysilicon solar cell with a radial junction in static regime under monochromatic illumination is presented in this paper. The junction radial solar cell geometry is illustrated and described. The carriers’ diffusion equation is established and solved under quasi-neutral base assumption with boundaries conditions and Bessel equations. New analytical expressions of electrons and holes density and photocurrent are found. The wavelength and structural parameters (base radius, emitter thickness) influences on charge carriers density and photocurrent are shown and examined.

关键词： Electrons Density Holes Density Holes Photocurrent radial Junction