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The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

Neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer M.Colón-Mercado Aranza I.Torrado-Tapias Iris K.Salgado Jose M.Santiago Samuel e.Ocasio Rivera dina P.Bracho-Rincon Luis H.Pagan Rivera Jorge d.Miranda department of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National Institutes of Health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of Neurobiology San JuanPRUSA

In addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous stud.e. showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor modulator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a moderate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von Frey monofilaments and the“up-down method”to evaluate mechanical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and.e.citatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain eAAT-1/GLAST eAAT-2/GLT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury trauma

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effects of Nitrogen on the Competitiveness of echinochloa colona and Amaranthus viridis with direct-seeded Rice

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Journal of Agricultural Science and Technology 2010年第2期4卷 14-19页

作者： B.S. Chauhan d.e. Johnson Crop and.e.vironmental Sciences division International Rice Research Institute Los Banos 4031 Philippines

Information on weed competitiveness responses to ad.e. nitrogen （N） is required to assist with the development of appropriate fertilizer management strategies where weed competition is anticipated. A greenhouse study was conducted to examine the effects of four N rates on the competitive ability ofechinochloa colona and Amaranthus viridis grown together with direct-seeded rice. Rice and.e.ch weed species were grown in a replacement series design at ad.e. N rates of 0, 50, 100, and 150 kg ha1. Replacement series diagrams for relative yield showed that competitive ability ofe. colona increased with ad.e. soil N. Values of weed aggressivity index for e. colona also significantly increased with the addition of N in the soil. In the absence of ad.e. N, A. viridis was more competitive than rice but this relationship slightly changed as N was ad.e.. However, values of weed aggressivity index of were statistically similar at all N rates. The results suggest that the competitiveness ofe. colona increased with ad.e. soil N, and A. viridis unchanged by soil N levels. Both weed species were different in their response to higher N levels. Information gained in this study could be used to demonstrate the importance of effective weed and fertilizer management.

关键词： Amaranthus viridis direct-seeded rice echinochloa colona nitrogen weed

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Three-dimensional models:from cell culture to Patient-derived Organoid and its application to future liposarcoma research

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Oncology Research 2025年第1期33卷 1-13页

作者： SAYUMI TAHARA SYd.e. ReNTSCH FeRNANdA COSTAS CASAL de FARIA PATRICIA SARCHeT ROMA KARNA FedeRICA CALORe RAPHAeL e.POLLOCK department of Surgery Division of Surgical OncologyThe James Comprehensive Cancer CenterThe Ohio State University Wexner Medical CenterColumbusOH 43210USA department of Cancer Biology and Genetics The James Comprehensive Cancer CenterThe Ohio State University Wexner Medical CenterColumbusOH 43210USA

Liposarcoma is one of the most common soft tissue sarcomas,however,its occurrence rate is still rare compared to other *** to its rarity,in vitro experiments are an essential approach to elucidate liposarcoma *** cell culture-based research(2d cell culture)is still playing a pivotal role,while several shortcomings have been recently under *** vivo,mouse models are usually adopted for pre-clinical analyses with expectations to overcome the issues of 2d cell ***,they do not fully recapitulate human dedifferentiated liposarcoma(ddLPS)***,three-dimensional(3d)culture systems have been the recent research focus in the cell biology field with the expectation to overcome at the same time the disadvantages of 2d cell culture and in vivo animal models and fill in the gap between *** the liposarcoma rarity,we believe that 3d cell culture techniques,including 3d cell cultures/co-cultures,and Patient-derived tumor Organoids(PdOs),represent a promising approach to facilitate liposarcoma investigation and.e.ucidate its molecular mechanisms and.e.fective therapy *** this review,we first provide a general overview of 3d cell cultures compared to 2d cell *** then focus on one of the recent 3d cell culture applications,Patient-derived Organoids(PdOs),summarizing and discussing several PdO ***,we discuss the current and future applications of PdOs to sarcoma,particularly in the field of liposarcoma.

关键词： Cell culture Liposarcoma Patient-derived Organoid(PdO) Spheroid Three-dimensional(3d)cell culture

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Merging bound states in the continuum in an open acoustic resonator

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 124-131页

作者： Lujun Huang Bin Jia Artem S.Pilipchuk Sibo Huang Chen Shen Almas F.Sad.e.v Yong Li And.e. e.Miroshnichenko School of Physics and.e.ectronic Sciences East China Normal University Institute of Acoustics Tongji University L.V.Kirensky Institute of Physics department of Mechanical engineering Rowan University School of engineering and Technology University of New South Wales at Canberra

Bound states in the continuum （BICs） are perfectly localized resonances despite embedding in the continuum ***,an isolated BIC is very sensitive to the structure ***,we report merging acoustic BICs in a single open resonator,robust against the structure *** find that both symmetry-protected BIC and Friedrich-Wintgen BIC are sustained in a single coupled waveguide-resonator *** varying the height and length of the resonator,these two BICs move toward.e.ch other and merge into a single one at a critical *** to an individual BIC,the merged BIC is robust against fabrication error because its Q-factor is proportional to ΔL-4,whereΔL embod.e. the structure *** essence of this extraordinary phenomenon is perfectly explained by the two-and three-level approximations of the effective nonHermitian ***,we present direct experimental demonstrations of the moving and merging of BICs in a coupled 3d waveguide-resonator,which are evidenced by the vanishing of the linewidth of Fano resonance in the transmission *** results may find.e.citing applications in designing high-quality acoustic sources,sensors and filters.

关键词： acoustic resonances bound state in the continuum high-Q resonances

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High level arsenic resistance in bacteria present in biooxidation tanks used to treat gold-bearing arsenopyrite concentrates:A review

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中国有色金属学会会刊：英文版 2008年第6期18卷 1311-1318页

作者： d.e.RAWLINGS department of Microbiology University of StellenboschPrivate Bag X1

在连续流动的、搅动的坦克过程使用到金忍受的毒砂集中的对待的微生物引起的协会变得在很多年适应了砷的高集中。主导的微生物， Acidithiobacillus caldus 和 Leptospirillum ferriphilum，被发现包含砷抵抗基因的二个集合。艺术基因... 详细信息

在连续流动的、搅动的坦克过程使用到金忍受的毒砂集中的对待的微生物引起的协会变得在很多年适应了砷的高集中。主导的微生物， Acidithiobacillus caldus 和 Leptospirillum ferriphilum，被发现包含砷抵抗基因的二个集合。艺术基因的一个集合在所有是在场的不管他们是否是，种孤立高度砷抵抗。艺术基因的第二个集合在象 Tn21 一样 transposons 上是在场的并且在测试的所有紧张被发现那被使适应了砷的高集中。在在场的砷抵抗 transposons 在。caldus 和 L。ferriphilum 为他们密切相关，却足够地不同独立地被获得了而非从一个细菌被传递了给其它。transposons 在 escherchia coli 是置换地活跃的并且被显示比测试这是可能的定位 chromosomally 的艺术基因授与砷抵抗的高水平。相同的 Transposons 包含砷抵抗基因或仔细与从 L 的 transposon 有关。ferriphilum，原来在南非发现，也在两 L 被发现。ferrooxidans 和 L。ferriphilum 从南美洲和欧洲孤立。一个 arsB 基因大美人在。caldus 被两个都表明了 chromosomal 艺术基因的能力授与砷抵抗的底层在的相应再结合生产在。caldus 和为猛烈异种的创造的一个基因系统的发展。

关键词：砷电阻因子转座子微生物毒砂

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Clickers and d.e. Learning： An Oxymoron？

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Computer Technology and Application 2013年第1期4卷 69-78页

作者： danielle Morin Jennifer d.e. Thomas Robert Cassidy John Molson School of Business Concordia University Montreal QC H3G 1M8 Canada Seidenberg School of Computer Science and Information Systems Pace University New York NY 10038 USA department of Psychology Faculty of Arts and Science Concordia University Montreal QC H4B 1R6 Canada

The use of clicker technology as a tool for promoting learning, let along d.e. learning, is hotly debated and has its proponents and opponents. With the question still open, this paper examines the use of this technology in fostering critical thinking and other higher-order learning and team-building skills, in the context of two entry-level psychology courses. The results obtained indicate that from the perspectives of both the student and the instructor, the integration of this technology was positively perceived to enhance the learning process and the acquisition of these skills. It would seem these concepts are, after all, not antithetical.

关键词： Clickers critical thinking technology and learning higher-order skills.

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加拿大选核算实践

加拿大选核算实践

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1983年

作者：（加）d.e.皮克特等

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Cr-Si-V合金和标准C-Mn钢轨钢脱氢的试验室试验

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钢铁钒钛 1989年第3期10卷 97-107页

作者： Parsons d.e. 郭新春加拿大

当热轧钢轨钢中的氢原子扩散到空隙中,变成分子氢,氢气的压力超过临界值时,在钢轨钢中就会形成发裂.在温度低于200℃时,会产生裂纹.钢水实行真空脱气处理或将热轧钢轨放在保温的缓冷坑内进行缓慢控制冷却,可以把氢脱到“安全”的数值,... 详细信息

当热轧钢轨钢中的氢原子扩散到空隙中,变成分子氢,氢气的压力超过临界值时,在钢轨钢中就会形成发裂.在温度低于200℃时,会产生裂纹.钢水实行真空脱气处理或将热轧钢轨放在保温的缓冷坑内进行缓慢控制冷却,可以把氢脱到“安全”的数值,即低于引起裂纹的临界浓度.但是,对防止比较软的标准的C-Mn钢轨钢产生裂纹有效的冷却条件,却根本不适用于比较硬的优质合金钢轨。因此,拟定了Cr-Si-V合金钢轨和标准C-Mn钢轨的脱氢试验计划,以便研究一种计算冷却条件的方法,在这种冷却条件下将浓度已知的,但浓度比较高的氢降到安全的数值,对模拟轨头的热轧钢板进行了等温和控制冷却的试验.根据其他的长时间试验,得到了空隙吸收氢的估计值。推导出一些公式,根据这些公式,可以计算将已知浓度的氢减少的控制冷却条件。钢轨生产厂可以应用类似的方法。

关键词： Cr-Si-V合金 C-Mn钢轧钢脱氢

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3000化学习题精解

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作者： (美)d.e.戈德堡

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Na_2O-TeO_2系统中的一个新晶相

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无机材料学报 2002年第3期17卷 465-469页

作者：朱冬梅周万城 Ray C.S. day d.e. 西北工业大学凝固技术国家重点实验室西安710072 Ceramic

在Ｎａ２Ｏ－ＴｅＯ２系统中发现了一个未知的新晶相,探索了该晶相的确切成分和形成条件,并根据实验结果,对现有的相图作了相应的修改．该晶相的具体成分为Ｎａ２Ｏ·８ＴｅＯ２．此晶相在３３０℃下能稳定存在,当温度达到或高于３４０... 详细信息

在Ｎａ２Ｏ－ＴｅＯ２系统中发现了一个未知的新晶相,探索了该晶相的确切成分和形成条件,并根据实验结果,对现有的相图作了相应的修改．该晶相的具体成分为Ｎａ２Ｏ·８ＴｅＯ２．此晶相在３３０℃下能稳定存在,当温度达到或高于３４０℃时则分解成Ｎａ３Ｏ·４ＴｅＯ２和ＴｅＯ２两个晶相．

关键词： Na2O-TeO2系统亚碲酸钠相图晶相玻璃

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