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Bimanual motor skill learning and robotic assistance for chronic hemiparetic stroke: a randomized controlled trial

Neural Regeneration Research 2021年第8期16卷 1566-1573页

作者： Maral Yeganeh Doost benoît herman Adrien Denis Julien Sapin Daniel Galinski Audrey Riga Patrice Laloux benoît Bihin Yves Vandermeeren UCLouvain CHU UCL Namur–site Mont-GodinneDepartment of NeurologyStroke UnitYvoirBelgium UCLouvain Institute of NeuroScience(IoNS)Clinical neuroscience division(NEUR)divisionBrusselsBelgium UCLouvain Louvain BionicsLouvain-la-NeuveBelgium UCLouvain Institute of MechanicsMaterials and Civil Engineering(iMMC)Louvain-la-NeuveBelgium AXINESIS SA WavreBelgique Scientific Support Unit CHU UCL Namur–site Mont-GodinneYvoirBelgium

Using robotic devices might improve recovery post-stroke, but the optimal way to apply robotic assistance has yet to be determined. the current study aimed to investigate whether training under the robotic active-assisted mode improves bimanual motor skill learning(biMSkL) more than training under the active mode in stroke patients. twenty-six healthy individuals(HI) and 23 chronic hemiparetic stroke patients with a detectable lesion on MRI or Ct scan, who demonstrated motor deficits in the upper limb, were randomly allocated to two parallel groups. the protocol included a two-day training on a new bimanual cooperative task, LIFt-tHE-tRAY, under either the active or activeassisted modes(where assistance decreased in a pre-determined stepwise fashion) with the bimanual version of the REAplan? robotic device. the hypothesis was that the active-assisted mode would result in greater biMSkL than the active mode. the biMSkL was quantified by a speed-accuracy trade-off(SAt) before(t1) and immediately after(t2) training on days 1 and 2(t3 and t4). the change in SAt after 2 days of training(t4/t1) indicated that both HI and stroke patients learned and retained the bimanual cooperative task. After 2 days of training, the active-assisted mode did not improve biMSkL more than the active mode(t4/t1) in HI nor stroke patients. Whereas HI generalized the learned bimanual skill to different execution speeds in both the active and active-assisted subgroups, the stroke patients generalized the learned skill only in the active subgroup. taken together, the active-assisted mode, applied in a pre-determined stepwise decreasing fashion, did not improve biMSkL more than the active mode in HI and stroke subjects. Stroke subjects might benefit more from robotic assistance when applied "as-needed." this study was approved by the local ethical committee(Comité d'éthique médicale, CHU UCL Namur, MontGodinne, Yvoir, Belgium;Internal number: 54/2010, Eudra Ct number: NUB B039201317382) on July 1

关键词： bimanual hemiparesis motor learning rehabilitation robotic robotic assistance slacking stroke retention

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Exploiting viral vectors to deliver genome editing reagents in plants

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aBIOtECH 2024年第2期5卷 247-261页

作者： Yilin Shen tao Ye Zihan Li torotwa herman Kimutai Hao Song Xiaoou Dong Jianmin Wan State Key Laboratory of Crop Genetics and Germplasm Enhancement and Utilization Jiangsu Collaborative Innovation Centre for Modern Crop ProductionJiangsu Engineering Research Center for Plant Genome EditingNanjing Agricultural UniversityNanjing 210095China Zhongshan Biological Breeding Laboratory Nanjing 210014China Hainan Seed Industry Laboratory Sanya 572025China State Key Laboratory of Crop Gene Resources and Breeding Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China

Genome editing holds great promise for the molecular breeding of plants,yet its application is hindered by the shortage of simple and effective means of delivering genome editing reagents into *** plant transformation-based methods for delivery of genome editing reagents into plants often involve prolonged tissue culture,a labor-intensive and technically challenging process for many elite crop *** this review,we describe various virus-based methods that have been employed to deliver genome editing reagents,including components of the CRISPR/Cas machinery and donor DNA for precision editing in *** update the progress in these methods with recent successful examples of genome editing achieved through virus-based delivery in different plant species,highlight the advantages and limitations of these delivery approaches,and discuss the remaining challenges.

关键词： Plant genome engineering Genome editing CRISPR/Cas Virus-based delivery

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Preparation of Regenerated Silk Fibroin Hybrid Fibers with Hydrogen Peroxide Sensing Properties by Wet Spinning

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Journal of Renewable Materials 2024年第6期12卷 1043-1055页

作者： Song Lu Jianjun Guo Richard Ansah herman Xinyi Wu Lin Ma Guohua Wu College of Biotechnology Jiangsu University of Science and TechnologyZhenjiang212100China College of Agriculture Anshun UniversityAnshun561000China

Silk is widely used in the production of high-quality *** the same time,the amount of silk textiles no longer in use and discarded is increasing,resulting in significant waste and *** issue is of great concern in many countries where silk is *** peroxide as a naturally occurring compound is an important indicator of detection in both biology and the *** study aims to develop a composite fiber with hydrogen peroxide-sensing properties using discarded silk *** achieve this goal,firstly,polydopamine(PDA)was used to encapsulate the ZnFe_(2)O_(4) NPs to achieve the improvement of dispersion,and then regenerated silk fibroin(RSF)and PDA@ZnFe_(2)O_(4)/RSF hybrid fibers are prepared by wet *** has shown that PDA@ZnFe_(2)O_(4)/RSF demonstrates exceptional sensitivity,selectivity,and stability in detecting hydrogen peroxide,while maintaining high mechanical ***,the complete hybridization of PDA@ZnFe_(2)O_(4) with silk fibroin not only results in the combination of the durability of silk fibroin and PDA@ZnFe_(2)O_(4)’s rigidity,ensuring a reliable service life,but also makes PDA@ZnFe_(2)O_(4)/RSF exhibit excellent catalytic activity and ***,the composite fiber exhibits exceptional mechanical properties and reliable hydrogen peroxide sensing capabilities,making it a promising material for biological and medical applications.

关键词： Regenerated silk fibroin modified zinc ferrite nanoparticles composite fiber hydrogen peroxide sensor wet spinning

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Introducing a 2^nd Universal Space-time Constant Can Explain the Observed Age of the Universe and Dark Energy

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World Journal of Mechanics 2024年第2期14卷 9-22页

作者： herman A. van Hoeve Hulst Netherlands

the purpose of this paper is to introduce new theoretical concepts as opposed to accepting the existence of dark entities, such as dark energy. this research sought to introduce a 2nd universal space-time constant, besides having a finite speed constant (speed of light in vacuum c). A finite universal age constant b is introduced. Namely, this paper shows that the changes in the Earth’s anomalistic year duration over time support the hypothesis of the age of the universe correlating with a maximum number of orbital revolutions constant. Neglecting the gravitational influence of other cosmological entities in the proximity of the Earth, the constant maximum number of revolutions is herewith determined solely by the Earth’s orbital revolutions around the Sun. the value of the universal age constant b is calculated to be around 13.8 billion orbital revolutions, derived out of an equation related to the changes in the Earth’s anomalistic year duration over time and the so-called Hubble tension. the above-mentioned calculated value b correlates well with the best fit to measured data of the cosmic microwave background radiation (CMBR) by the Planck spacecraft, the age of the observed universe is measured to be approximately 13.787 ± 0.020 billion years (2018 final data release). Developing a theory with this 2nd universal space-time constant b, being covariant with respect to the Lorentz transformations when time spans are large, gives results such as: A confirmation of the measured CMBR value of 13.787 ± 0.020 billion years. Correlating well with the observed expansion rate of the universe (dark energy). the universe’s expansion accelerating over the last four to five billion years.

关键词： Anomalistic Year Orbital Revolution Hubble tension Age of the Universe Cosmological Constant Dark Energy Cosmic Microwave Background

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Epigenetic silencing schlafen-11 sensitizes esophageal cancer to AtM inhibitor

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2060-2073页

作者： Jing Zhou Mei-Ying Zhang Ai-Ai Gao Cheng Zhu tao He James G herman Ming-Zhou Guo School of Medicine NanKai UniversityTianjin 300071China Department of Gastroenterology and Hepatology The First Medical CenterChinese PLA General HospitalBeijing 100853China Departments of Pathology Characteristic Medical Center of The Chinese People’s Armed Police ForceTianjin 300162China the Hillman Cancer Center University of Pittsburgh Cancer InstitutePittsburghPA 15213United States National Key Laboratory of Kidney Diseases Chinese PLA General HospitalBeijing 100853China

BACKGROUND targeting DNA damage response(DDR)pathway is a cutting-edge *** has been reported that Schlafen-11(SLFN11)contributes to increase chemosensitivity by participating in ***,the detailed mechanism is *** to investigate the role of SLFN11 in DDR and the application of synthetic lethal in esophageal cancer with SLFN11 *** to reach the purpose,eight esophageal squamous carcinoma cell lines,142 esophageal dysplasia(ED)and 1007 primary esophageal squamous cell carcinoma(ESCC)samples and various techniques were utilized,including methylationspecific polymerase chain reaction,CRISPR/Cas9 technique,Western blot,colony formation assay,and xenograft mouse *** Methylation of SLFN11 was exhibited in 9.15%of(13/142)ED and 25.62%of primary(258/1007)ESCC cases,and its expression was regulated by promoter region ***11 methylation was significantly associated with tumor differentiation and tumor size(both Pt associations were observed between promoter region methylation and age,gender,smoking,alcohol consumption,tNM stage,or lymph node *** DNA damaged model induced by low dose cisplatin,SLFN11 was found to activate non-homologous end-joining and AtR/CHK1 signaling pathways,while inhibiting the AtM/CHK2 signaling *** silencing of SLFN11 was found to sensitize the ESCC cells to AtM inhibitor(AZD0156),both in vitro and in *** SLFN11 is frequently methylated in human *** of SLFN11 is sensitive marker of AtM inhibitor in ESCC.

关键词： Schlafen-11 Esophageal squamous cell carcinoma DNA methylation Synthetic lethality AZD0156

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Assessment of the effectiveness of weight-adjusted antibiotic administration,for reduced duration,in surgical prophylaxis of primary hip and knee arthroplasty

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World Journal of Orthopedics 2024年第2期15卷 170-179页

作者： tosan Okoro Michael Wan takura Darlington Mukabeta Ella Malev Marketa Gross Claudia Williams Muhammad Manjra Jan herman Kuiper John Murnaghan Department of Arthroplasty Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Foundation TrustOswestry SY107AGUnited Kingdom School of Medicine Keele UniversityStaffordshire ST55BGUnited Kingdom St Joseph’s Health Centre Unity Health TorontoToronto M6R 1B5Canada Department of Arthroplasty The Royal London HospitalBarts Health NHS TrustLondon E11BBUnited Kingdom Department of Arthroplasty Sunnybrook Holland Orthopaedic and Arthritis CentreToronto M4Y 1H1Canada Institute for Science and technology in Medicine Keele UniversityStaffordshire ST51BGUnited Kingdom

BACKGROUND Prophylactic antibiotics have significantly led to a reduction in the risk of postoperative surgical site infections(SSI)in orthopaedic *** aim of using antibiotics for this purpose is to achieve serum and tissue drug levels that exceed,for the duration of the operation,the minimum inhibitory concentration of the likely organisms that are *** antibiotics reduce the rate of SSIs in lower limb arthroplasty from between 4%and 8%to between 1%and 3%.Controversy,however,still surrounds the optimal frequency and dosing of antibiotic *** to evaluate the impact of introduction of a weight-adjusted antibiotic prophylaxis regime,combined with a reduction in the duration of administration of post-operative antibiotics on SSI incidence during the 2 years following primary elective total hip and knee arthroplasty MEtHODS Following ethical approval,patients undergoing primary total hip arthroplasty(tHA)/total knee arthroplasty(tKA)with the old regime(OR)of a preoperative dose[cefazolin 2 g intravenously(IV)],and two subsequent doses(2 h and 8 h),were compared to those after a change to a new regime(NR)of a weight-adjusted preoperative dose(cefazolin 2 g IV for patientstients>120 kg)and a post-operative dose at 2 *** primary outcome in both groups was SSI rates during the 2 years *** A total of n=1273 operations(tHA n=534,tKA n=739)were performed in n=1264 *** was no statistically significant difference in the rate of deep(OR 0.74%(5/675)vs NR 0.50%(3/598);fishers exact test P=0.72),nor superficial SSIs(OR 2.07%(14/675)vs NR 1.50%(9/598);chi-squared test P=0.44)at 2 years *** propensity score weighting and an interrupted time series analysis,there was also no difference in SSI rates between both groups[RR 0.88(95%CI 0.61 to 1.30)P=0.46].CONCLUSION A weight-adjusted regime,with a reduction in number of post-operative doses had no adverse impact on S

关键词： Antibiotics Weight-adjusted Hip and knee arthroplasty Surgical site infection

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Lab results of COVID-19 patients:Omicron vs delta variants

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World Journal of Virology 2024年第2期13卷 71-77页

作者： Dana Avraham Amir herman Gal Shaham Arkady Shklyar Elina Sulim Maria Oulianski Orthopedic Department Kaplan Medical CenterRehovot 7661041Israel Department of Medicine Lithuanian University of Health SciencesKaunas 44307Lithuania Emergency Department Kaplan Medical CenterRehovot 7661041Israel

BACKGROUND the coronavirus disease 2019(COVID-19)virus has been a world-known pan-demic since February *** variances had been established;the most common variants in Israel were omicron and *** to analyze and compare laboratory values in the"omicron"and"delta"variants of the coronavirus by conducting follow-up examinations and laboratory audits on COVID-19 patients admitted to our *** A retrospective study,two groups,50 patients in each *** examined positive for COVID-19 were divided into groups according to the common variant at the given *** reviewed demographic data and laboratory results such as complete blood count and full chemistry,including electrolytes and coagulation *** the mean age was 52%,66.53±21.7 were *** significance was found comparing laboratory results in the following disciplines:Blood count,hemo-globin,and lymphocytes(P=0.41,P=0.87,P=0.97).Omicron and delta variants have higher neutrophil counts,though they are not significantly different(P=0.38).Coagulation tests:Activated paritial thromoplastin test and international normalized ratio(P=0.72,P=0.68).We found no significance of abnormality for all *** the study compares laboratory results of blood tests between two variants of the COVID-19 virus–omicron and *** found no significance between the *** results show the need for further research with larger data as well as the need to compare all COVID-19 variants.

关键词： COVID-19 Coronavirus Omicron variant Delta variant

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Antibiotic Resistance Profile of Enterococcus faecalis and Enterococcus faecium Isolates from Urine and Pleural Fluid in two Hospitals of Cameroon

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Open Journal of Medical Microbiology 2024年第1期14卷 39-49页

作者： Cécile Ingrid Djuikoue Farid Wega Grace Yemina Kombeu Cedric Seugnou Nana Christiane Possi Kiyang Lussabella Pohoko Medzam Erica Megane Noubissi Makougoum Nellie Mbianga Nkuigoua herman Koyouo tagne Mérimé Joël tchinda talokou Yvonne Valérie Yolande Mavoungou Ashu Michel Agbor Microbiology Department of the Faculty of Health Sciences of the Université des Montagnes Bangangté Cameroon Faculty of Medicine and Pharmaceutical Sciences University of Douala Douala Cameroon Microbiology Department of the Faculty of Health Sciences of Institut Universitaire du Golf de Guinée Douala Cameroon Centre Hospitalier Dominicain St Martin de Porres Yaoundé Cameroun Faculté des Sciences de la Santé Université Marien Ngouabi Brazzaville République du Congo

Enterococcus faecalis and Enterococcus faecium rank among the leading causes of nosocomial bacteremia and urinary tract infections. they often persist on hospital surfaces due to their ability to withstand adverse environmental conditions (low or high temperatures, high pH, and high salinity). the global Enterococcus faecalis-Enterococcus faecium ratio is currently shifting towards Enterococcus faecium. Enterococci present variable levels of resistance to certain families of antibiotics. this is the case for aminoglycosides, beta-lactams and cephalosporins. In 2017, WHO ranked Enterococci among priority pathogens for research and development of new antibiotics. the objective of our study was to determine the antibiotic resistance profile of Enterococcus faecalis and Enterococcus faecium isolates from urine and pleural fluid in two hospitals in Cameroon. this cross-sectional and analytic study was carried out between June to August 2023 on hospitalized and day patients in which a cytobacteriological test of urine and pleural fluid was done. the samples were inoculated on CLED Agar for urine and on Chocolate + polyvitex and blood agar (prepared from Columbia agar) for pleural fluid samples and incubated at 37℃ for 18 to 24 hours. Identification of isolates was carried out using the API 20 StREP micro gallery (Biomerieux, France) and tested for antimicrobial susceptibility. the data on socio-demographical and potential risk factors were recorded using self-administered questionnaires and data from laboratory analyses of the specimen were collected in a data capture sheet. Potential risk factors associated with the presence of Enterococci, were evaluated using the logistic regression in univariate and multivariate analysis. P value t. A total of 511 patients were recruited who were predominantly females. Enterococcus spp were isolated in 27.79% of our samples with Enterococcus faecalis mostly encountered. Enterococcus spp showed a high

关键词： Enterococcus faecalis Enterococcus faecium Healthcare-Associated Infections Antimicrobial Resistance Cameroon

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Quo vadis? Bioengineered polysaccharide-based hydrogel scaffolds for damaged central nervous system recovery and regeneration

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Neural Regeneration Research 2022年第7期17卷 1478-1480页

作者： Isadora C.Carvalho herman S.Mansur Center of Nanoscience Nanotechnology and Innovation-CeNano2IDepartment of Metallurgical and Materials EngineeringFederal University of Minas GeraisBelo HorizonteMGBrazil

Impairments in the central nervous system(CNS)are a prevalent cause of life-long disabilities worldwide,representing serious health,social,and economic concerns(Doblado et al.,2021).During the last decades,with the population eldering and the increase in the life span,we have experienced an increase in CNS-related disorders,like stroke and neurodegenerative diseases(Jarrin et al.,2021).

关键词： al. diseases system

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Effective Force Stabilising technique for the Immersed Boundary Method

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Communications in Computational Physics 2023年第1期33卷 349-366页

作者： Arnab Ghosh Alessandro Gabbana herman Wijshoff Federico toschi Department of Applied Physics and Science Education Eindhoven University of TechnologyPO Box 5135600 MB EindhovenThe Netherlands Department of Mechanical Engineering Eindhoven University of TechnologyP.O.Box 5135600 MB EindhovenThe Netherlands Canon Production Printing Netherlands B.V. P.O.Box 1015900 MA VenloThe Netherlands

the immersed boundary method has emerged as an efficient approach for the simulation of finite-sized solid particles in complex fluid ***,one of the well known shortcomings of the method is the limited support for the simulation of light particles,*** with a density lower than that of the surrounding fluid,both in terms of accuracy and numerical *** a broad literature exists,with several authors reporting different approaches for improving the stability of the method,most of these attempts introduce extra complexities and are very costly from a computational point of *** this work,we introduce an effective force stabilizing technique,allowing to extend the stability range of the method by filtering spurious oscillations arising when dealing with light-particles,pushing down the particle-to-fluid density ratio as low as *** thoroughly validate the method comparing with both experimental and numerical data available in literature.

关键词： Immersed boundary method lattice Boltzmann method light particle force stabilization added mass effect

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