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t.e role of melat.nin recept.r 1B gene(Mt.R1B)in t.e suscept.bilit. t. depression and t.pe 2 diabet.s comorbidit.

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Genes & Diseases 2024年第3期11卷 113-115页

作者： Mut.z Amin benjamin Rafla Rongling Wu t.odor t.Post.lache Cclaudia Gragnoli INSERM US14-OrphanetParis 75014France Depart.ent.of Biochemist.y and Molecular Biology Faculty of MedicineAl-Neelain UniversityKhartoum 11121Sudan Division of Endocrinology Department of MedicineCreighton University School of MedicineOmahaNE 68124USA Depart.ent.of Public Healt. Sciences Penn State College of MedicineHersheyPA 17033USA Depart.ent.of St.t.st.cs Penn State College of MedicineHersheyPA 17033USA Mood and Anxiet. Program Department of PsychiatryUniversity of Maryland School of MedicineBaltimoreMD 21201USA Rocky Mount.in Ment.l llness Research Educat.on and Clinical Cent.r(MIRECC) Veterans Integrated Service Network(VISN)19Military and Veteran Microbiome:Consortium for Research and Education(MVM-CoRE)DenverCO 80246USA Ment.l Ilness Research Educat.on and Clinical Cent.r(MIRECC) Veterans Integrated Service Network(VISN)5VA Capitol Health Care NetworkBaltimoreMD 21090USA Molecular Biology Laborat.ry Bios Biotech Multi-Diagnostic Health CenterRome00197Italy

Melat.nin is an endogenous monoamine hormone secret.d by t.e pineal *** signaling has been shown t. play a role in circadian rhyt.m regulat.on,lipid and glucose met.bolism,and obesit.,and it.has ant.-inflammat.ry and ant.oxidant.*** melat.nin recept.r 1B gene(Mt.R1B)is expressed in,among ot.er t.ssues,t.e brain and pancreat.c bet. cells,and risk variant. for t.D have been report.d as impairing early insulin secret.on and increasing fast.ng glucose levels.^(1) Variant. in t.e Mt.R1B gene also have been report.d in pat.ent. wit. depression(MDD).

关键词： Mt.R1B met.bolism propert.es.

Impact. of mult.ple demand-side management.st.at.gies on microgrids planning: a lit.rat.re survey

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CLEAN ENERGY 2024年第1期8卷 36-54页

作者： Elazab, Rasha Abdelnaby, Ahmed t. Ali, A. A. Helwan Univ Fac Engn Elect Power & Machines Dept Cairo Egypt

Demand-side management.(DSM) schemes play a crucial role in managing renewable energy generat.on and load fluct.at.ons by ut.lizing demand-response programmes (DRPs). t.is paper aims t. provide a det.iled overview of DRPs t.at.help microgrid operat.rs t. keep cost. and reliabilit. wit.in accept.ble ranges. Addit.onally, t.is review paper provides a det.iled economic load model for DRPs based on init.al load, demand-response (DR) incent.ve, DR penalt. and elast.cit. coefficient.. t.is art.cle also aims t. guide researchers in ident.fying research gaps in DSM applicat.ons in microgrids by comparing various DSM schemes from different.count.ies and regions in t.rms of DSM st.at.gies, object.ve funct.ons and opt.mizat.on t.chniques. Furt.ermore, t.is st.dy analyses t.e impact.of DRPs on microgrid configurat.on from t.e perspect.ve of ut.lit.es and cust.mers, considering t.chnical and economic performance met.ics. As a result. it.can be concluded t.at.none of t.e st.died cases provides models or guidelines for choosing appropriat. DSM schemes t.at.consider different.consumer int.rest. or load-t.pe feat.res. Furt.ermore, a few researchers have addressed t.e feat.res of a modern price-based DR st.at.gy, renewable generat.on-based dynamic pricing DR, which offers higher cust.mer sat.sfact.on t.an t.adit.onal DRPs. [GRAPHICS] .

关键词： demand-side management opt.mal sizing demand-response st.at.gies renewable generat.on-based dynamic pricing t.ME-OF-USE ENERGY MANAGEMENt RENEWABLE ENERGY RESPONSE PROGRAM RELIABILIt. PARt.CIPAt.ON t.CHNOLOGY CHALLENGES OPERAt.ON SYSt.MS

Basis for t.e diversit. and ext.nt.in loss of digest.ble nut.ient. creat.d by diet.ry phyt.n: Emphasis on fowl and swine

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动物营养学报 2024年第1期16卷 422-428页

作者： Edwin t. Moran Michael R. Bedford Poult.y Science Depart.ent Auburn University AL 36830-5416 USA AB Vist. Woodstock Court Blenheim Road Marlborough Wiltshire SN8 4AN UK

Phyt.n is t.e Ca 2+ -Mg 2+ -K + salt.of phyt.c acid t.at.is creat.d and deposit.d in t.e aleurone layer and/or germ of grains and legumes. It. high presence in feedst.ffs for fowl and swine diet. result. in it.being a universal and significant.impediment.t. opt.mum performance. Phyt.n impairs gast.oint.st.nal recovery of a wide array of nut.ient., t.e effect.varying wit. t.e nut.ient.concerned. On exposure t. low pH during gast.ic digest.on, phyt.n dissociat.s int. phyt.c acid and solubilized Ca 2+ . Even at.low gast.ic pH, phyt.c acid is negat.vely charged which forms t.e basis of it. ant.-nut.it.ve behavior. Pepsinogen has ext.nsive basic amino acids on it. act.vat.on pept.de t.at.are present.d as cat.ons at.low pH which are t.rget.d by pepsin for act.vat.on. Part.ally cryst.lized Ca 2+ near t.e enzyme's act.ve sit. furt.er st.bilizes it. newly formed st.uct.re. t.us, phyt.c acid appears t. int.rfere wit. gast.ic digest.on by several mechanisms; int.rfering wit. pepsinogen act.vat.on by binding t. t.e polypept.de's basic amino acids; coordinat.ng free Ca 2+ , dest.bilizing pepsin; binding some diet.ry prot.ins direct.y, furt.er compromising gast.ic prot.olysis. Upon digest. at.aining neut.alit. in t.e duodenum, Ca 2+ and ot.er cat.ons re-bind wit. accessible anions, phyt.c acid being a significant.cont.nder. Phyt.t. not.only binds free cat.ons but.can also st.ip t.em from enzymes (e.g. Ca 2+ , Zn 2+ ) which reduces t.eir st.uct.ral resist.nce t. aut.lysis and abilit. as co-fact.rs (e.g. Zn 2+ ) t. increase enzyme act.vit.. Goblet.cells init.ally employ Ca 2+ as an elect.onic shield bet.een mucin layers enabling granule format.on and cell st.rage. Aft.r mucin granule release, Ca 2+ is progressively displaced by Na + t. free t.e viscous mucins enabling it. t.anslocat.on. Mucin ent.ngles wit. t.e glycocalyx of adjacent.ent.rocyt.s t.ereby const.uct.ng t.e unst.rred wat.r layer (USWL). Excessive removal of Ca 2+ from mucin by phyt.c acid increases it. fluidit. facilit

关键词： Digest.ve enzyme Calcium Endogenous prot.in Mucin Phyt.n

SARS-CoV-2 and innat. immunit.:t.e good,t.e bad,and t.e"goldilocks"

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Cellular & Molecular Immunology 2024年第2期21卷 171-183页

作者： benjamin L.Sievers Mark t.K.Cheng Kat. Csiba Bo Meng Ravindra K.Gupt. Depart.ent.of Medicine University of CambridgeCambridgeUK Cambridge Inst.t.t. of t.erapeut.c Immunology&Infect.ous Disease(CIt.D) Department of MedicineUniversity of CambridgeCambridgeUk

An ancient.conflict.bet.een host. and pat.ogens has driven t.e innat. and adapt.ve arms of *** about.t.is int.rplay can not.only help us ident.fy biological mechanisms but.also reveal pat.ogen vulnerabilit.es t.at.can be leveraged *** humoral response t. SARS-CoV-2 infect.on has been t.e focus of int.nse research,and t.e role of t.e innat. immune syst.m has received significant.y less ***,we review current.knowledge of t.e innat. immune response t. SARS-CoV-2 infect.on and t.e various means SARS-CoV-2 employs t. evade innat. defense *** also consider t.e role of innat. immunit. in SARS-CoV-2 vaccines and in t.e phenomenon of long COVID.

关键词： SARS-CoV-2 Innat. immune response Int.rferon Cyt.kines Inflammat.on Ant.viral t.rget.

Food poisoning due t. money t.ee seeds: A case report.of t.xic encephalopat.y

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Emergency and Crit.cal Care Medicine 2024年第3期4卷 126-129页

作者： Zhao Y. Quan X. Wang t. Depart.ent.of Emergency Medicine Hainan Hospital of Chinese PLA General Hospital Sanya Hainan China t.e Cent.r of Heat.St.oke Prevent.on and t.eat.ent.of Peoples' Liberat.on Army Sanya Hainan China

Background t.e money t.ee is a favored indoor pot.ed plant.in China. It. seeds resemble chest.ut. in bot. shape and flavor when cooked, which are generally considered non-t.xic and safe for consumpt.on. Case present.t.on t.is report.present. t.e first.published case of food poisoning due t. t.e ingest.on of large amount. of money t.ee seeds. A 67-year-old man exhibit.d t.xic encephalopat.y sympt.ms and dyspnea aft.r consuming t.e seeds for approximat.ly 6 mont.s. Aft.r empirical mechanical vent.lat.on, t.erapeut.c plasma exchange, and ot.er medical int.rvent.ons, t.e pat.ent.s clinical st.t.s improved significant.y. He was subsequent.y discharged from t.e hospit.l. Conclusion Consuming a subst.nt.al quant.t. of money t.ee seeds wit.in a limit.d t.meframe can lead t. poisoning, result.ng in adverse out.omes, part.cularly t.xic encephalopat.y. Moreover, plasma exchange may have some t.erapeut.c effect. © Wolt.rs Kluwer Healt., Inc. All right. reserved.

关键词： Case report Money t.ee Pachira macrocarpa Respirat.ry failure t.xic encephalopat.y

Development.validat.on,and t.ansport.bilit. of several machine-learned,non-exercise-based VO_(2max)predict.on models for older adult.

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Journal of Sport.and Healt. Science 2024年第5期13卷 611-620页

作者： benjamin t.Schumacher Michael J.LaMont. Andrea Z.LaCroix Eleanor M.Simonsick St.ven P.Hooker Humbert. Parada Jr. John Bellet.iere Arun Kumar Herbert.Wert.eim School of Public Healt. and Human Longevit. Science University of California San DiegoLa JollaCA 92093USA Depart.ent.of Epidemiology and Environment.l Healt. School of Public Health and Health ProfessionsUniversity at BuffaloState University of New YorkBuffaloNY 14214USA t.anslat.onal Geront.logy Branch Intramural Research ProgramNational Institute on AgingNational Institutes of HealthBaltimoreMD 21225USA College of Healt. and Human Services San Diego State UniversitySan DiegoCA 92182USA Division of Epidemiology and Biost.t.st.cs School of Public HealthSan Diego State UniversitySan DiegoCA 92182USA Universit. of California San Diego Moores Cancer Cent.r La JollaCA 92093USA Comput.r Science and Engineering and Halicioglu Dat. Science Inst.t.t. University of California San DiegoLa JollaCA 92093USA

Background:t.ere exist.few maximal oxygen upt.ke(VO_(2max))non-exercise-based predict.on equat.ons,fewer using machine learning(ML),and none specifically for older *** direct.measurement.of VO_(2max)is infeasible in large epidemiologic cohort.st.dies,we sought.t. develop,validat.,compare,and assess t.e t.ansport.bilit. of several ML VO_(2max)predict.on ***:t.e Balt.more Longit.dinal St.dy of Aging(BLSA)part.cipant. wit. valid VO2_(max)t.st. were included(n=1080).Least.absolut. shrinkage and select.on operat.r,linear-and t.ee-boost.d ext.eme gradient.boost.ng,random forest.and support.vect.r machine(SVM)algorit.ms were t.ained t. predict.VO_(2max)*** developed t.ese algorit.ms for:(a)t.e overall BLSA,(b)by sex,(c)using all BLSA variables,and(d)variables common in aging ***,we quant.fied t.e associat.ons bet.een measured and predict.d VO_(2max)and ***:t.e age was 69.0±10.4 years(mean±SD)and t.e measured VO_(2max)was 21.6±5.9 mL/kg/*** absolut. shrinkage and select.on operat.r,linear-and t.ee-boost.d ext.eme gradient.boost.ng,random forest.and support.vect.r machine yielded root.mean squared errors of 3.4 mL/kg/min,3.6 mL/kg/min,3.4 mL/kg/min,3.6 mL/kg/min,and 3.5 mL/kg/min,*** quart.les of measured VO_(2max)showed an inverse gradient.in mort.lit. *** VO_(2max)variables yielded similar effect.est.mat.s but.were not.robust.t. ***:Measured VO_(2max)is a st.ong predict.r of *** ML can improve t.e accuracy of predict.on as compared t. simpler approaches but.est.mat.s of associat.on wit. mort.lit. remain sensit.ve t. *** st.dies should seek t. reproduce t.ese result. so t.at.VO_(2max),an import.nt.vit.l sign,can be more broadly st.died as a modifiable t.rget.for promot.ng funct.onal resiliency and healt.y aging.

关键词： Cardiorespirat.ry fit.ess Predict.on algorit.ms Epidemiology Mort.lit.

Forecast.ng of t.opical cyclones ASANI (2022) and MOCHA (2023) over t.e Bay of Bengal - real t.me challenges t. forecast.rs

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t.OPICAL CYCLONE RESEARCH AND REVIEW 2024年第2期13卷 88-112页

作者： Kot.l, S. D. Arulalan, t. Mohapat.a, M. Govt.India Minist Earth Sci India Meteorol Dept New Delhi India

t.is st.dy examines t.e t.ack and int.nsit. forecast. of t.o t.pical Bay of Bengal t.opical cyclones (t.) ASANI and MOCHA. t.e analysis of various Numerical Weat.er Predict.on (NWP) model forecast. [ECMWF (European Cent.e for Medium range Weat.er Forecast., NCEP (Nat.onal Cent.rs for Environment.l Predict.on), NCUM (Nat.onal Cent.e for Medium Range Weat.er Forecast.Unified Model), IMD (India Met.orological Depart.ent., HWRF (Hurricane Weat.er Research and Forecast.ng)], MME (Mult.-model Ensemble), SCIP (St.t.st.cal Cyclone Int.nsit. Predict.on) model, and OFCL (Official) forecast. shows t.at.int.nsit. forecast. of ASANI and t.ack forecast. of MOCHA were reasonably good, but.t.ere were large errors and wide variat.on in t.ack forecast. of ASANI and in int.nsit. forecast. of MOCHA. Among all model forecast., t.e t.ack forecast.errors of IMD model and MME were least.in general for ASANI and MOCHA respect.vely. Also, t.e landfall point.forecast.errors of IMD were least.for ASANI, and t.e MME and OFCL forecast.errors were least.for MOCHA. No model is found t. be consist.nt.y bet.er for landfall t.me forecast.for ASANI, and t.e errors of ECMWF, IMD and HWRF were least.and of same order for MOCHA. t.e int.nsit. forecast.errors of OFCL and SCIP were least.for ASANI, and t.e forecast.errors of HWRF, IMD, NCEP, SCIP and OFCL were comparable and least.for MOCHA up t. 48 h forecast.and HWRF errors were least.t.ereaft.r in general. t.e ECMWF model forecast.errors for int.nsit. were found t. be highest.for bot. t.e t.s. t.e result. also show t.at.alt.ough t.ere is significant.improvement.of t.ack forecast. and limit.d or no improvement.of int.nsit. forecast.in previous decades but.challenges st.ll persist. in real t.me forecast.ng of bot. t.ack and int.nsit. due t. wide variat.on and inconsist.ncy of model forecast. for different.t. cases. (c) 2024 t.e Shanghai t.phoon Inst.t.t. of China Met.orological Administ.at.on. Publishing services by Elsevier B.V. on behalf of KeAi Communi

关键词： t.opical cyclone t.ack forecast Int.nsit. forecast NWP model Bay of Bengal Nort. Indian Ocean NORt. INDIAN-OCEAN INt.NSIt. PREDICt.ON At.ANt.C BASIN t.ACK FORECASt LANDFALL PACIFIC MODEL EYE

CO_(2)capt.re cost. of chemical looping combust.on of biomass:A comparison of nat.ral and synt.et.c oxygen carrier

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Journal of Energy Chemist.y 2024年第5期92卷 296-310页

作者： benjamin Fleiß Juraj Priscak Mart.n Hammerschmid Josef Fuchs St.fan Müller Hermann Hofbauer Inst.t.t. of Chemical Environmental and Bioscience EngineeringTU WienVienna1060 ViennaAustria BESt.Bioenergy and Sust.inable t.chnologies GmbH Graz8010 StyriaAustria

Chemical looping combust.on has t.e pot.nt.al t. be an efficient.and low-cost.t.chnology capable of cont.ibut.ng t. t.e reduct.on of t.e at.ospheric concent.at.on of CO_(2) in order t. reach t.e 1.5/2°C goal and mit.gat. climat. *** t.is process,a met.l oxide is used as oxygen carrier in a dual fluidized bed t. generat. clean CO_(2) via combust.on of *** commonly,nat.ral ores or synt.et.c mat.rials are used as oxygen carrier whereas bot. must.meet.special requirement. for t.e conversion of solid *** oxygen carriers are charact.rized by higher react.vit. at.t.e expense of higher cost. versus t.e lower-cost.nat.ral *** det.rmine t.e viabilit. of bot. possibilit.es,a t.chno-economic comparison of a synt.et.c mat.rial based on manganese,iron,and copper t. t.e nat.ral ore ilmenit. was *** synt.et.c oxygen carrier was charact.rized and t.st.d in a pilot.plant.where high combust.on efficiencies up t. 98.4%and carbon capt.re rat.s up t. 98.5%were *** t.chno-economic assessment.result.d in CO_(2) capt.re cost. of 75 and 40€/t.O_(2) for t.e synt.et.c and nat.ral ore rout. respect.vely,whereas a sensit.vit. analysis showed t.e high impact.of product.on cost. and at.rit.on rat.s of t.e synt.et.c *** synt.et.c oxygen carrier could break even wit. t.e nat.ral ore in case of lower product.on cost. and at.rit.on rat.s,which could be reached by adapt.ng t.e product.on process and recycling *** comparison t. st.t.-of-t.e-art.t.chnologies,it.is demonst.at.d t.at.bot. rout.s are viable and t.e capt.re cost.of CO_(2) could be reduced by implement.ng t.e chemical looping combust.on t.chnology.

关键词： Chemical looping combust.on BECCS t.chno-economic assessment CO_(2)capt.re cost. Oxygen carrier development Synt.et.c mat.rials Ilmenit.

Virt.ally coupled t.ain set.cont.ol subject.t. space-t.me separat.on: A dist.ibut.d economic MPC approach wit. emergency braking configurat.on

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High-speed Railway 2024年第3期2卷 143-152页

作者： Luo X. t.ng t. Wang L. Liu H. St.t. Key Laborat.ry of Advanced Rail Aut.nomous Operat.on Beijing Jiaotong University Beijing 100044 China Depart.ent.of Elect.ical and Comput.r Engineering University of California Riverside 92521 CA United States Beijing Zongheng Elect.o-Mechanical t.chnology Development.Co. Ltd. Beijing 100081 China School of Aut.mat.on and Int.lligence Beijing Jiaotong University Beijing 100044 China Nat.onal Engineering Research Cent.r of Rail t.ansport.t.on Operat.on and Cont.ol Syst.m Beijing Jiaotong University Beijing 100044 China

t.e emerging virt.al coupling t.chnology aims t. operat. mult.ple t.ain unit. in a Virt.ally Coupled t.ain Set.(VCt.) at.a minimal but.safe dist.nce. t. guarant.e collision avoidance, t.e safet. dist.nce should be calculat.d using t.e st.t.-of-t.e-art.space-t.me separat.on principle t.at.separat.s t.e Emergency Braking (EB) t.aject.ries of t.o successive unit. during t.e whole EB process. In t.is case, t.e minimal safet. dist.nce is usually numerically calculat.d wit.out.an analyt.c formulat.on. t.us, t.e const.ained VCt. cont.ol problem is hard t. address wit. space-t.me separat.on, which is st.ll a gap in t.e exist.ng lit.rat.re. t. solve t.is problem, we propose a Dist.ibut.d Economic Model Predict.ve Cont.ol (DEMPC) approach wit. comput.t.on efficiency and t.eoret.cal guarant.e. Specifically, t. alleviat. t.e comput.t.on burden, we t.ansform implicit.safet. const.aint. int. explicit.y linear ones, such t.at.t.e opt.mal cont.ol problem in DEMPC is a quadrat.c programming problem t.at.can be solved efficient.y. For t.eoret.cal analysis, sufficient.condit.ons are derived t. guarant.e t.e recursive feasibilit. and st.bilit. of DEMPC, employing compat.bilit. const.aint., t.be t.chniques and t.rminal ingredient.t.ning. Moreover, we ext.nd our approach wit. globally opt.mal and dist.ibut.d online EB configurat.on met.ods t. short.n t.e minimal dist.nce among VCt.. Finally, experiment.l result. demonst.at. t.e performance and advant.ges of t.e proposed approaches. © 2024 Beijing Jiaot.ng Universit.

关键词： Dist.ibut.d model predict.ve cont.ol Economic model predict.ve cont.ol Emergency braking configurat.on Space-t.me separat.on Virt.ally coupled t.ain set