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In vivo and ex vivo confocal endomicroscopy of pancreatic cystic lesions: A prospective study

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World Journal of Gastroenterology 2017年第18期23卷 3338-3348页

作者： Somashekar G Krishna rohan M Modi Amrit K Kamboj benjamin J Swanson Phil A Hart Mary E Dillhoff Andrei Manilchuk Carl r Schmidt Darwin L Conwell Division of Gastroenterology Hepatology and NutritionThe Ohio State University Wexner Medical Center Department of Internal Medicine The Ohio State University Wexner Medical Center College of Medicine The Ohio State University Wexner Medical Center Department of Pathology The Ohio State University Wexner Medical Center Division of Surgical Oncology The Ohio State University Wexner Medical Center Deparment of General Surgery The Ohio State University Wexner Medical Center

To investigate the reproducibility of the in vivo endoscopic ultrasound (EUS) - guided needle based confocal endomicroscopy (nCLE) image patterns in an ex vivo setting and compare these to surgical histopathology for characterizing pancreatic cystic lesions (PCLs).METHODSIn a prospective study evaluating EUS-nCLE for evaluation of PCLs, 10 subjects underwent an in vivo nCLE (AQ-Flex nCLE miniprobe; Cellvizio, MaunaKea, Paris, France) during EUS and ex vivo probe based CLE (pCLE) of the PCL (Gastroflex ultrahigh definition probe, Cellvizio) after surgical resection. Biopsies were obtained from ex vivo CLE-imaged areas for comparative histopathology. All subjects received intravenous fluorescein prior to EUS and pancreatic surgery for in vivo and ex vivo CLE imaging *** total of 10 subjects (mean age 53 ± 12 years; 5 female) with a mean PCL size of 34.8 ± 14.3 mm were enrolled. Surgical histopathology confirmed 2 intraductal papillary mucinous neoplasms (IPMNs), 3 mucinous cystic neoplasms (MCNs), 2 cystic neuroendocrine tumors (cystic-NETs), 1 serous cystadenoma (SCA), and 2 squamous lined PCLs. Characteristic in vivo nCLE image patterns included papillary projections for IPMNs, horizon-type epithelial bands for MCNs, nests and trabeculae of cells for cystic-NETs, and a “fern pattern” of vascularity for SCA. Identical image patterns were observed during ex vivo pCLE imaging of the surgically resected PCLs. Both in vivo and ex vivo CLE imaging findings correlated with surgical *** vivo nCLE patterns are reproducible in ex vivo pCLE for all major neoplastic PCLs. These findings add further support the application of EUS-nCLE as an imaging biomarker in the diagnosis of PCLs.

关键词： Confocal laser endomicroscopy Serous cystadenoma Pancreatic neuroendocrine tumor Intraductal papillary mucinous neoplasm Pancreatic cystic neoplasm

Gastrointestinal function testing model using a new laryngopharyngeal pH probe(restech)in patients after Ivor-Lewis esophagectomy

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World Journal of Gastrointestinal Oncology 2021年第6期13卷 612-624页

作者： benjamin Babic Dolores T Müller Florian Gebauer Lars Mortimer Schiffmann rabi r Datta WolfgangSchröder Christiane J Bruns Jessica M Leers Hans F Fuchs Department of General VisceralCancer and Transplant SurgeryUniversity of CologneCologne 50931Germany

BACKGrOUND There is no established correlation between 24-h esophageal pH-metry(Eso-pH)and the new laryngopharyngeal pH-monitoring system(restech)as only small case series ***-pH was not designed to detect laryngopharyngeal reflux(LPr)and restech may detect LPr *** have previously published a dataset using the two techniques in a large patient collective with gastroesophageal reflux ***,patients after esophagectomy were reported to represent an ideal human reflux model as no reflux barrier *** To use a human reflux model to examine our previously published correlation in these *** Patients after Ivor Lewis esophagectomy underwent our routine follow-up program with surveillance endoscopies,computed tomography scans and further exams following *** patients with a complete check-up program and reflux symptoms were offered inclusion into this prospective study and evaluated using restech and simultaneous ***,the relationship between the two techniques was evaluated rESULTS A total of 43 patients from May 2016-November 2018 were *** patients presented with mainly typical reflux symptoms such as heartburn(74%),regurgitation(84%),chest pain(58%),and dysphagia(47%).Extraesophageal symptoms such as cough,hoarseness,asthma symptoms,and globus sensation were also *** 24-hour pH-metry was abnormal in 88%of patients with a mean DeMeester Score of 229.45[range 26.4-319.5].restech evaluation was abnormal in 61%of cases in this highly selective patient *** patients with abnormal supine LPr were also abnormal for supine esophageal reflux measured by conventional *** Patients following esophagectomy and reconstruction with gastric interposition can ideally serve as a human reflux ***,laryngopharyngeal reflux phases occur mainly in the upright *** this human volume-reflux model,results of simultaneous esophageal and laryngopharyngeal(restech)pH

关键词： Gastroesophageal reflux disease Laryngopharyngeal reflux Minimally invasive esophagectomy Surgical technology restech Esophageal pH-metry

A chromosome-level genome assembly reveals that a bipartite gene cluster formed via an inverted duplication controls monoterpenoid biosynthesis in Schizonepeta tenuifolia

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Molecular Plant 2023年第3期16卷 533-548页

作者： Chanchan Liu Samuel J.Smit Jingjie Dang Peina Zhou Grant T.Godden Zheng Jiang Wukun Liu Licheng Liui Wei Lin Jinao Duan Qinan Wu benjamin r.Lichman School of Pharmacy Nanjing University of Chinese MedicineNanjingChina Jiangsu Collaborative Innovation Center of Chinese Medicinal resources Industrialization Nanjing University of Chinese MedicineNanjingChina Centre for Novel Agricultural Products Department of BiologyUniversity of YorkYork YO105DDUK Florida Museum of Natural History University of FloridaGainesileFLUSA Department of Pathogen Biology School of Medicine and Holistic Integrative MedicineNanjing University of Chinese MedicineNanjngChina

Biosynthetic gene clusters(BGCs)are regions of a genome where genes involved in a biosynthetic pathway are in *** origin and evolution of plant BGCs as well as their role in specialized metabolism remain largely *** this study,we have assembled a chromosome-scale genome of Japanese catnip(Schizonepeta tenuifolia)and discovered a BGC that contains multiple copies of genes involved in four adjacent steps in the biosynthesis of p-menthane *** BGC has an unprecedented bipartite structure,with mirrored biosynthetic regions separated by 260 *** bipartite BGC includes identical copies of a gene encoding an old yellow enzyme,a type of flavin-dependent *** vitro assays and virus-induced gene silencing revealed that this gene encodes the missing isopiperitenone *** enzyme evolved from a completely different enzyme family to isopiperitenone reductase from closely related Mentha spp.,indicating convergent evolution of this pathway *** analysis revealed that this bipartite BGC has emerged uniquely in the *** lineage and through insertion of pathway genes into a region rich in monoterpene *** cluster gained its bipartite structure via an inverted *** discovered bipartite BGC for p-menthane biosynthesis in *** has similarities to the recently described duplicated p-menthane biosynthesis gene pairs in the Mentha longifolia genome,providing an example of the convergent evolution of gene *** work expands our understanding of plant BGCs with respect to both form and evolution,and highlights the power of BGCs for gene discovery in plant biosynthetic pathways.

关键词： specialized metabolism monoterpenoids biosynthetic gene cluster Lamiaceae biosynthesis chromosomal inversion

文化差异及其对广告诉求的影响:基于中美比较的视角(英文)

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中国市场 2013年第45期 7-16页

作者： Charles emery Guang r.Tian Erskine College Medaille College

全球营销获得成功的首要条件是理解不同文化之间的价值观的相似性和差异性。由于缺乏以研究为基础获得的信息,这一任务对于试图与中国做生意的公司而言尤为艰巨。本研究采用霍夫斯塔德文化模型中的最新价值观来比较中美之间波莱广告诉... 详细信息

全球营销获得成功的首要条件是理解不同文化之间的价值观的相似性和差异性。由于缺乏以研究为基础获得的信息,这一任务对于试图与中国做生意的公司而言尤为艰巨。本研究采用霍夫斯塔德文化模型中的最新价值观来比较中美之间波莱广告诉求的有效性。在以文化维度为基础预测有效诉求的20个假设中,有9个得到了支持。另外一个假设也非常显著,但是与预想的方向正好相反。这些研究发现意味着,采用霍夫斯塔德文化维度作为有效广告诉求的唯一预测指标是不明智的。霍夫斯塔德维度或许缺乏可以有效预测各种广告诉求成功度所必需的结构。此外,广告诉求的有效性还可能由于其他因素(例如,年龄、社会趋势、政治法律环境及产品用法)而有所调整。

关键词： China Cultural Differences Advertising Appeals

Focus on using nanopore technology for societal health,environmental,and energy challenges

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Nano research 2022年第11期15卷 9906-9920页

作者： Izadora Mayumi Fujinami Tanimoto benjamin Cressiot Sandra J.Greive Bruno Le Pioufle Laurent Bacri Juan Pelta LAMBE CNRSUniv EvryUniversitéParis-Saclay91025Evry-CourcouronnesFrance LuMIn CNRSInstitut d'AlembertENS Paris-SaclayUniversitéParis-Saclay91190Gif-sur-YvetteFrance LAMBE CNRSCY Cergy Paris Université95000CergyFrance DreamPore S.A.S. 33 Boulevard du Port 95000CergyFrance

With an increasing global population that is rapidly ageing,our society faces challenges that impact health,environment,and energy *** this ageing comes an accumulation of cellular changes that lead to the development of diseases and susceptibility to *** impacts not only the health system,but also the global *** the population increases,so does the demand for energy and the emission of pollutants,leading to a progressive degradation of our *** in turn impacts health through reduced access to arable land,clean water,and breathable *** monitoring approaches to assist in environmental control and minimize the impact on health are urgently needed,leading to the development of new sensor technologies that are highly sensitive,rapid,and *** sensing is a new technology that helps to meet this purpose,with the potential to provide rapid point-of-care medical diagnosis,real-time on-site pollutant monitoring systems to manage environmental health,as well as integrated sensors to increase the efficiency and storage capacity of renewable energy *** this review we discuss how the powerful approach of nanopore based single-molecule,or particle,electrical promises to overcome existing and emerging societal challenges,providing new opportunities and tools for personalized medicine,localized environmental monitoring,and improved energy production and storage systems.

关键词： electric sensor nanoparticles environment biomarkers energy storage

Enhancing Dehydration Performance of Isopropanol by Introducing Intermediate Layer into Sodium Alginate Nanofibrous Composite Pervaporation Membrane

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Advanced Fiber Materials 2019年第2期1卷 137-151页

作者： Peiyun Li Cheng Cheng Ke Shen Tonghui Zhang Xuefen Wang benjamin S.Hsiao State Key Lab for Modification of Chemical Fibers and Polymer Materials Donghua UniversityShanghai 201620People’s Republic of China Department of Chemistry Stony Brook UniversityStony BrookNY 11794USA

A novel three-tier composite membrane based on highly porous nanofibrous substrate was demonstrated for efficient iso-propanol dehydration by ***,polyethyleneimine(PEI)modified graphene oxide(GO)sheets were vacuum-assistant assembled onto porous electrospun polyacrylonitrile(PAN)nanofibrous substrate to achieve a smooth,hydrophilic and compact PEI-GO intermediate *** introduction of PEI chains endowed GO interlayer with sufficient interaction for bonding adjacent GO nanosheets to enhance stability in water/isopropanol mixture and also with the ascended inter-lamellar space to improve the water-sorption ability due to the abundant active amino *** from PEI-GO layer,a defect-free sodium alginate(SA)skin layer could be facilely manufactured with elaborately controlled thickness as thin as possible in order to reduce mass transfer resistant and enhance permeability ***,the interlayer would also contribute to enhance interfacial adhesion to promote the structure integrity of three-tier thin-film nanofibrous composite(TFNC)membrane in pervaporation dehydration *** fine-tuning of membrane preparation process,the SA/PEI(75)-GO-60/PAN TFNC membrane exhibited competitive pervaporation performance with the permeate flux of 2009 g/m2 h and the separation factor of 1276 operated at 70°C for dehydration of 90 wt%isopropanol *** unique three-tier composite membrane structure suggested an effective and facile approach to design novel membrane structure for further improvement of pervaporation performance.

关键词： Polyethyleneimine modified graphene oxide Intermediate layer Thin-film nanofibrous composite membrane Pervaporation membrane

Multilocular thymic cysts-a diagnostic challenge on computed tomography

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World Journal of Clinical Cases 2025年第3期13卷 61-65页

作者： Nirmal Kumar reddy Onteddu Naga Sai rasagna Mareddy Sai Swarupa r Vulasala Jayabharath Onteddu Mayur Virarkar Department of Internal Medicine University of Florida College of MedicineJacksonvilleFL 32209United States Department of Diagnostic radiology University of AlabamaBirminghamAL 35294United States Department of Diagnostic radiology University of Florida College of MedicineJacksonvilleFL 32209United States Department of Public Health Sciences University of FloridaGainesvilleFL 32611United States

A recent case report provided a patient scenario,wherein,a 39-year-old male patient presented with occasional palpitations,headache,and *** of tumor markers did not show any abnormal ***,a computed tomography(CT)scan was undertaken,and its findings were affirmative of thymic ***,the postoperative histopathological assessment of the mass,after its resection,confirmed it as an anterior mediastinal multilocular thymic cyst(MTC),with concurrent acute upper respiratory tract infection and acute ***,this case report advocates the need for a preoperative histopathological examination with CT imaging to minimize the risk of confusing an MTC with a malignant thymic tumor.

关键词： Imaging findings Multilocular thymic cyst Histopathology Thymic cancer Mediastinal mass

FOrMATION OF MOLYBDENUM OXIDE NANOSTrUCTUrES CONTrOLLED BY POLY(ETHYLENE OXIDE)

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Chinese Journal of Polymer Science 2009年第1期27卷 11-22页

作者： Chirakkal V.Krishnan rafael Muoz-Espí Christian Burger benjamin Chu Department of Chemistry Stony Brook University

Polymeric systems have played an important role as structure-directing agents and in the control of nucleation and growth of *** article reviews the work of our research group in the field of the polymer-assisted crystallization of inorganic materials,mainly focused on the formation of highly ordered,porous molybdenum oxide *** experimental parameters including the influence of poly(ethylene oxide)-containing polymers on the morphology and structure of the products obtained fr...

关键词： Polymer-assisted crystallization Molybdenum oxide Peroxomolybdate Polyoxomolybdate

抗癌治疗后患者的存活期保健：全科医疗服务的作用

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中国全科医学 2014年第28期17卷 3283-3285页

作者： Jon emery 魏亚萌(译) 墨尔本大学全科与初级保健学术中心澳大利亚维多利亚州3010 中国全科医学杂志社

癌症检测、治疗手段的改进及人口老龄化进程的加快,癌症生存者的数量正在逐渐增加。目前以医院为中心的癌症随访模型主要针对癌症复发的检测,而癌症患者的一些重要需求,尤其是社会心理需求则未必能得到满足。全科医疗服务在癌症生存者... 详细信息

癌症检测、治疗手段的改进及人口老龄化进程的加快,癌症生存者的数量正在逐渐增加。目前以医院为中心的癌症随访模型主要针对癌症复发的检测,而癌症患者的一些重要需求,尤其是社会心理需求则未必能得到满足。全科医疗服务在癌症生存者的综合关护中担任着重要的角色,且在其随访过程中也发挥着一定的作用。目前我国各地区的社区卫生服务机构也正在开展癌症筛查、癌症幸存者的健康管理及晚期癌症患者的临终关怀等全科医疗服务,期望本文对社区卫生实践工作有所帮助和启发。

关键词：癌症初级保健全科医生治疗相关性癌症整体医学生存