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Edible Coatings Based on Apple Pectin,Cellulose Nanocrystals,and Essential Oil of Lemongrass:Improving the Quality and Shelf Life of Strawberries(Fragaria Ananassa)

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Journal of Renewable Materials 2019年第1期7卷 73-87页

作者： Ingrid Souza Vieira da Silva Natália Soares Prado Patrícia Gontijo de Melo Danilo Campion Arantes Mara Zeni andrade Harumi Otaguro Daniel Pasquini Instituto de Química Universidade Federal de UberlândiaCampus Santa MônicaAv.João Naves deÁvila2121Uberlândia-MG38400-902Brazil Instituto Federal do Triângulo Mineiro Campus Uberaba Rua João Batista Ribeiro4000Uberaba-MG38064-790Brazil Departamento de Ciências Naturais(DCNAT) Universidade Federal de São João Del-ReiPraça D.Helvécio74São João Del-Rei-MG36301-160Brazil Universidade de Caxias do Sul Rua Francisco Getúlio Vargas1130Caxias do Sul-RS95070-970Brazil

In this work,nine different types of edible coating based on pectin,cellulose nanocrystals,glycerol,and essential oil of lemongrass were prepared and used to coat strawberries with a film formed directly on the surface of the coated *** effects of the different edible coatings on refrigerated fruits in terms of weight loss,titratable acidity,total soluble solids,pH,and anthocyanin content was evaluated after 2 days,4 days,6 days,and 8 days of *** of the edible coatings reduced the weight loss of the coated strawberries and the anthocyanin *** total soluble solids content of or uncoated fruit increase more markedly than that of coated *** contrast,pH was maintained for both coated and uncoated *** edible coatings were effective in minimizing of the weight loss,without worsening the physical chemistry *** treatments T5 and T9 presented the best results.

关键词： Strawberry edible coating cellulose nanocrystals pectin shelf life

Distinct patterns of mucosal apoptosis in H pylori-associated gastric ulcer are associated with altered FasL and perforin cytotoxic pathways

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World Journal of Gastroenterology 2006年第38期12卷 6133-6141页

作者： Heitor SP Souza Marcelo S Neves Celeste CS Elia Claudio JA Tortori Ilana Dines Cesonia A Martinusso Kalil Madi Leonardo andrade Morgana TL Castelo-Branco Departamento de Clínica Médica Instituto de Ciências Biomédicas Universidade Federal do Rio de Janeiro 21941-590 Brazil Laboratório Multidisciplinar de Pesquisa e Departamento de Anatomia Patologica Instituto de Ciências Biomédicas Universidade Federal do Rio de Janeiro 21941-590 Brazil Hospital Universitário Clementino Fraga Filho Departamento de Histologia e Embriologia Instituto de Ciências Biomédicas Universidade Federal do Rio de Janeiro 21941-590 Brazil Laboratório de Imunologia Celular Instituto de Ciências Biomédicas Universidade Federal do Rio de Janeiro 21941-590 Brazil

AIM: To analyze the level of apoptosis in different mucosal compartments and the differential expression of Fas/Fas-ligand and perforin in H pylori-associated gastric ulcer. METHODS: Antral specimens from patients with H pylori-related active gastric ulcer (GU), H pylori-related gastritis, and non-infected controls were analysed for densities and distribution of apoptotic cells determined by the TdT-mediated dUDP-biotin nick-end-labelling method. GU patients were submitted to eradication therapy with follow-up biopsy after 60 d. Fas, FasL, and perforin-expressing cells were assessed by immunoper- oxidase, and with anti-CD3, anti-CD20 and anti-CD68 by double immunofluorescence and confocal microscopy. Quantitative analysis was performed using a computer- assisted image analyser. RESULTS: H pylori-infected antrum showed greater surface epithelial apoptosis which decreased after eradi- cation therapy. In the lamina propria, higher rates of mononuclear cell apoptosis were observed in H pylori- gastritis. Co-expression of Fas with T-cell and macro- phage markers was reduced in GU. FasL- and perforin-expressing cells were increased in H pylori-infection and correlated with epithelial apoptosis. Perforin-expressing cells were also increased in GU compared with H pylori- gastritis. CONCLUSION: Epithelial apoptosis is increased in H pylori-infection and correlates to FasL- and perforin- expression by T cells. Expression of perforin is correlated with the tissue damage, and may represent the enhance- ment of a distinct cytotoxic pathway in GU. Increased expression of FasL not paralleled by Fas on T-cells and macrophages may indicate a reduced susceptibility to the Fas/FasL-mediated apoptosis of lymphoid cells in H pylori-infection.

关键词： Gastric ulcer H pylori Apoptosis Fas receptor Fas ligand Perforin

Perspectives of nano-carrier drug delivery systems to overcome cancer drug resistance in the clinics

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Cancer Drug Resistance 2021年第1期4卷 44-68页

作者： Anna Ulldemolins Joaquin Seras-Franzoso Fernanda andrade Diana Rafael Ibane Abasolo Petra Gener Simo Schwartz Jr Drug Delivery and Targeting Group Molecular Biology and Biochemistry Research Centre for Nanomedicine(CIBBIM-Nanomedicine)Vall d’Hebron Institut de RecercaUniversitat Autonoma de BarcelonaBarcelona 08035Spain Networking Research Centre for Bioengineering Biomaterialsand Nanomedicine(CIBER-BBN)Instituto de Salud Carlos IIIZaragoza 50009Spain

Advanced cancer is still considered an incurable disease because of its metastatic spread to distal organs and progressive gain of *** though considerable treatment progress and more effective therapies have been achieved over the past years,recurrence in the long-term and undesired side effects are still the main drawbacks of current clinical ***,a majority of chemotherapeutic drugs are highly hydrophobic and need to be diluted in organic solvents,which cause high toxicity,in order to reach effective therapeutic *** limitations of conventional cancer therapies prompted the use of nanomedicine,the medical application of nanotechnology,to provide more effective and safer cancer *** of nanomedicines to overcome resistance,ameliorate solubility,improve pharmacological profile,and reduce adverse effects of chemotherapeutical drugs is thus highly *** use in the clinical setting has increased over the last *** the various existing nanosystems,nanoparticles have the ability to transform conventional medicine by reducing the adverse effects and providing a controlled release of therapeutic ***,their small size facilitates the intracellular ***,we provide a closer review of clinical prospects and mechanisms of action of nanomedicines to overcome drug *** significance of specific targeting towards cancer cells is debated as well.

关键词： Drug delivery systems resistance nanomedicine cancer treatment

Analgesic-like activity of perillyl acetate:In vivo and in silico studies

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Asian Pacific Journal of Tropical Biomedicine 2022年第4期12卷 156-163页

作者： Renan Braga Humberto andrade Ryldene Cruz Mayara Maia Carolina Lima Anderson Santos AndréMiranda Allana Duarte Marcus Scotti Reinaldo Almeida Damião Sousa Postgraduate Program in Natural and Synthetic Bioactive Products Federal University of Paraíba58051-970João PessoaPBBrazil Research Institute for Drugs and Medicines Federal University of ParaíbaCP 5009João Pessoa58051-900PBBrazil Department of Pharmaceutical Sciences Federal University of Paraíba58051-970João PessoaPBBrazil

Objective:To evaluate the antinociceptive activity of perillyl acetate in mice and in silico ***:The vehicle,perillyl acetate(100,150 and/or 200 mg/kg,i.p.),diazepam(2 mg/kg,i.p.)or morphine(6 mg/kg,i.p.)was administered to mice,*** test,acetic acidinduced abdominal writhing,formalin-induced nociception,hot plate test,and tail-flick test were *** receptorsinvolvement in perillyl acetate antinociceptive effect was also ***:Perillyl acetate did not affect the motor coordination of ***,it reduced the number of acetic acid-induced abdominal twitches and licking times in the formalin *** was an increase of latency time in the tail-flick test of 30 and *** with naloxone reversed the antinociceptive effect of perillyl acetate(200 mg/kg).In silico analysis demonstrated that perillyl acetate could bind toμ-opioid ***:Perillyl acetate has antinociceptive effect at the spinal level in animal nociception models,without affecting the locomotor integrity and possibly throughμ-opioid *** silico studies have suggested that perillyl acetate can act as aμ-opioid receptor agonist.

关键词： Analgesic Biological products Opioid Essential oil Pain Monoterpene Perillyl acetate

Constructal Law of Institutions within Social Organizations

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Open Journal of Applied Sciences 2018年第3期8卷 103-125页

作者： Luciano Ondir Freire Delvonei Alves de andrade Instituto de Pesquisas Energéticas e Nucleares (IPEN-CNEN/SP) S&atilde o Paulo Brazil

This work looked for a unifying theory between physical-biological domain and social sciences. Constructal law unified physical and biological domain by telling the general sense in which flow systems tend to evolve. Management theory looks for relations between institutions and human agency. Although being state of mind entities, institutions follow constructal law. This work proposed the main organization flows are information and credit. Biologic instincts derived from Darwinian natural selection are the driving or blocking forces of such flows. Once biologic instincts systematically block information and credit flows in large numbers, this work proposed every human organization must have institutions to inhibit some behaviors. Those institutions need to be present, at least partially, in formal rules of social groups. This way it is possible to predict expansion or downfall of human groups using objective and quantifiable data. Therefore, further studies may employ classical history to confirm this theory. This work analyzed some case studies to show qualitatively the application of proposed theory. Concluding, this work gave physically-biologically grounded guidance for institutional changes.

关键词： Institutional Theory Institutional Entrepreneurship Unifying Theory Constructal Law Management Theory Social Systems

Evaluation of inflammatory activity in Crohn's disease and ulcerative colitis

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World Journal of Gastroenterology 2012年第9期18卷 872-881页

作者： Eduardo Garcia Vilela Henrique Osvaldo da Gama Torres Fabiana Paiva Martins Maria de Lourdes de Abreu Ferrari Marcella Menezes andrade Aloísio Sales da Cunha Internal Medicine Department Faculty of MedicineFederal University of Minas Gerais Gastroenterology Alfa Institute Clinic HospitalFederal University of Minas Gerais Complementary Propedeutic Department Faculty of MedicineFederal University of Minas Gerais Faculty of Medicine Federal University of Minas Gerais

Crohn's disease and ulcerative colitis evolve with a relapsing and remitting *** of inflammatory state is crucial for the assessment of disease activity and for tailoring ***,no simple diagnostic test for monitoring intestinal inflammation is *** markers give only indirect assessments of disease *** or endoscopical examinations accurately assess inflammatory activity,but they are invasive,time consuming and expensive and therefore are unsuitable for routine *** procedures are not applicable for ulcerative *** usefulness of ultrasound and Doppler imag-ing in assessing disease activity is still a matter of discussion for Crohn's disease,and an increased interest in computed tomography enterograph (CTE) has been seen,mainly because it can delineate the extent and severity of bowel wall inflammation,besides detecting extraluminal *** now,the available data concerning the accuracy of magnetic resonance enterography in detecting disease activity is less than *** to this,clinical activity indices are still commonly used for both diseases.

关键词： Crohn's disease Ulcerative colitis Inflamma-tory bowel disease Diagnostic test Therapy Inflamma-tory markers

Trace element geochemistry and Sr-Nd characteristics of Mesoproterozoic mafic intrusive rocks from Rondonia, Brazil, SW Amazonian Craton： Petrogenetic and tectonic inferences

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Episodes 2008年第4期31卷 392-400页

作者： Girardi, V.A. V. Teixeira, W. Bettencourt, J.S. andrade, S. Navarro, M.S. Sato, K. Instituto de Geociencias Universidade de Sao Paulo Rua do Lago 562. CEP 05508-080 Cidade Universitada S. Paulo Brazil

The Amazonian Craton comprises an Archean domain surrounded by four successively younger Proterozoic tectonic provinces. Within the Rio-Negro-Juruena province the Serra da Providencia Intrusive Suite （1.60 and 1.53 Ga） consists of A-type rapakivi gran- ites, charnockites and mangerites genetically associated with diabase dikes, gabbros and amphibolites. The original mafic melts were derived from a depleted mantle source （εN（T）＋2.5 to ＋2.8;εSr（T） -12.1）. Underplated mafic magma induced melting of a short-lived felsic crust, thus originating coeval felsic-mafic magmatism in a conti- nental intraplate setting. The Colorado Complex, assigned to the Rondonian-San Ignacio province, comprises 1.35-1.36 Ga intrusive bimodal magmatism represented by monzonite gneisses associated with amphibolite, gabbro and metadiabase dikes intercalated with metasediments with detrital zircon that yield U- Pb ages of 1.35 to 1.42 Ga. Mafic samples dis- play juvenile signatures （εNd（T） 0.0 to ＋5.2; εSr（T） --5.0 to --30.7） and are less contaminated than the Serra da Previdencia and Nova Brasilandia ones. The generation of the basaltic magma is related to the subduction of an oceanic slab below the peridotite wedge （intraoceanic arc setting）. Fluids and/or small melts from the slab impregnated the mantle. The Nova Brasilandia Sequence （Sunsas-Aguapef province） comprises a metasedimentary sequence intruded by 1.10-1.02 Ga metadia- bases, gabbros, meta-gabbros, and amphibolites associated with granitic plutons （bimodal mag- matism）. The original tholeiitic magmas, derived from a depleted source （εNd（T） = ＋3.1 to ＋5.0）, in a proto-oceanic setting, underwent subsequent contamination by the host rocks, as indicated by the isotopic and trace element data.

关键词：亚马逊河流域巴西 Sr-Nd特性地球化学

Techno-functionality of fisetin-enriched yoghurt fermented with Lactobacillus acidophilus bio-capsules produced via osmoporation

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Systems Microbiology and Biomanufacturing 2022年第4期2卷 743-749页

作者： Eduardo Wagner Vasconcelos de andrade Sebastien Dupont Laurent Beney Edilene Souza da Silva Roberta Targino Hoskin Márcia Regina da Silva Pedrini Bioprocess Laboratory Chemical Engineering DepartmentUniversidade Federal do Rio Grande do NorteLagoa NovaNatalRN 59078-900Brazil Laboratory of Bioactive Compounds Chemical Engineering DepartmentUniversidade Federal do Rio Grande do NorteLagoa NovaNatalRN 59078-900Brazil UMR Procédés Alimentaires et Microbiologiques(PAM UMR A 02.102)Univ.Bourgogne Franche-ComtéAgroSup Dijon21000 DijonFrance

Osmoporation is a novel encapsulation approach for bioactive compounds based on the osmoresistance mechanisms of microbial *** the best of our knowledge,this is the first study investigating the production of fisetin-enriched yoghurt using Lactobacillus acidophilus-based bio-capsules via osmoporation as the starter *** showed that the milk acidification with fisetin-loaded *** progressed at a slower pace due to complex mechanisms induced by osmopo-ration and internalized *** fermentation using fisetin bio-capsules reached a maximum acidification rate of 0.18 pH units/h after 23 h and pH 4.6 was achieved after 32 ***,the antioxidant activity of yoghurts produced with fisetin bio-capsules did not change during cold storage,while the antioxidant activity of yoghurt produced with non-encapsulated fisetin was reduced by 2.5-fold after 28 ***,this study shows that fisetin osmoporation using *** is a versatile encapsulation bioprocess that enables the delivery of preserved phytoactives into fermented foods like *** strategy has the potential to be extended to other applications in the dairy industry using lactic acid bacteria as both the encapsulation matrix and fermentation agent.

关键词： Cell-based carriers Probiotic bacteria Dairy fermented products Food biotechnology Functional foods

The Role of Nuclear Power from a System Engineering Standpoint

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World Journal of Nuclear Science and Technology 2017年第3期7卷 167-188页

作者： Luciano Ondir Freire Delvonei Alves de andrade Nuclear and Energy Research Institute Instituto de Pesquisas Energéticas e Nucleares S&atilde o Paulo Brazil

This work proposed the application of system engineering methods to identify organizations vital for society, seeking development and well-being. System engineering requires the identification of blocks (or systems), identification of their service functions, identification of states, identification of required quality and identification of constraints. Analyzing modern societies, vital functions were identified and countries behavior was modeled, identifying their states. In this context, nuclear power was found to be fundamental for development and defense because of its inherent advantages for military naval purposes at war. Another striking conclusion is that nuclear power is the best solution for country energy security, more than to avoid climate changes, but to help the nation to resist climate changes. A solution to mitigate the high overnight costs of nuclear power was also proposed. It was demonstrated qualitatively that the adoption of dual purpose mobile nuclear power plants military performances, economic development and risks management.

关键词： System Engineering Nuclear Energy Energy Security Climate Changes Constructal Law PWR