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BIOCELL 2019年第1期43卷 29-35页

作者： Odin RAMIREZ-FERNANDEZ Ludovika CACOPARDO benjamin leon-mancilla Joana COSTA Research Centre“E.Piaggio”Department of Information Engineering University of PisaItaly Departamento de Cirugia Facultad de MedicinaUniversidad nacional Autonoma de Mexico Departamento de Ciencias Basicas Instituto Tecnologico de TlalnepantlaTecnologicos de MexicoMexico

We present a bioreactor system which combines a semi permeable membrane that simulates the osmotic nutrients interchange in the small intestine circulation and rhythmic peristaltic *** custom-designed presents a semipermeable membrane bioreactor,with peristaltic flow and compression variation that allows adjustment of luminal flow *** addition,this system is also capable of achieving the drug distribution in the small intestine model from the apical compartment to the basal compartment by the semipermeable *** dynamic bioreactor can mimic the human small intestine with increased accuracy to overcome many of the limitations and accuracy with the previously described in vitro small intestinal models,providing a more representative model of the small intestine.

关键词： Bioreactor Flow Simulation Permeability 3D Print Small Intestine

Comparative study of the effect of solvents on the efficacy of neonicotinoid insecticides against malaria vector populations across Africa

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Infectious Diseases of Poverty 2022年第2期11卷 23-31页

作者： Magellan Tchouakui Tatiane Assatse leon M.J.Mugenzi benjamin D.Menze Daniel Nguifo-Nguete Williams Tchapga Jonathan Kayondo Francis Watsenga Emile Zola Manzambi Michael Osae Charles S.Wondji Centre for Research in Infectious Diseases(CRID) P.O.Box 13501YaoundeCameroon Parasitology and Ecology Laboratory Department of Animal Biology and PhysiologyFaculty of ScienceUniversity of Yaounde 1P.O.Box 812YaoundeCameroon Institut National de Recherche Biomedicale KinshasaDemocratic Republic of Congo Radiation Entomology and Pest Management Centre Biotechnology and Nuclear Agriculture Research InstituteGhana Atomic Energy CommissionP.O.Box LG80Legon-AccraGhana Department of Vector Biology Liverpool School of Tropical MedicinePembroke PlaceLiverpool L35QAUK International Institute of Tropical Agriculture(IITA) P.O.Box 2008YaoundeCameroon Entomology Department Uganda Virus Research Institute(UVRI)P.O.Box 49EntebbeUganda.

Background:New insecticides with a novel mode of action such as neonicotinoids have recently been recommended for public health by *** monitoring of such novel insecticides requires a robust protocol to monitor the development of resistance in natural *** this study,we comparatively used three different solvents to assess the susceptibility of malaria vectors to neonicotinoids across ***:Mosquitoes were collected from May to July 2021 from three agricultural settings in Cameroon(Njombe-Penja,Nkolondom,and Mangoum),the Democratic Republic of Congo(Ndjili-Brasserie),Ghana(Obuasi),and Uganda(Mayuge).Using the CDC bottle test,we compared the effect of three different solvents(ethanol,acetone,MERO)on the efficacy of neonicotinoids againstAnopheles gambiae *** addition,TaqMan assays were used to genotype key pyrethroid-resistant markers *** and odds ratio based on Fisher exact test were used to evaluate potential cross-resistance between pyrethroids and ***:Lower mortality was observed when using absolute ethanol or acetone alone as solvent for clothianidin(11.4-51.9% mortality in Nkolondom,31.7-48.2% in Mangoum,34.6-56.1% in Mayuge,39.4-45.6% in Obuasi,83.7-89.3% in Congo and 71.1-95.9% in Njombe pendja)compared to acetone+MERO for which 100% mortality were observed for all the *** observations were done for imidacloprid and *** assays(PBO,DEM and DEF)with clothianidin revealed a significant increase of mortality suggesting that metabolic resistance mechanisms are contributing to the reduced susceptibility.A negative association was observed between the L1014F-kdr mutation and clothianidin resistance with a greater frequency of homozygote resistant mosquitoes among the dead than among survivors(OR=0.5;P=0.02).However,the I114T-GSTe2 was in contrast significantly associated with a greater ability to survive clothianidin with a higher frequency of homozygote resistant among surv

关键词： Malaria Anopheles Insecticide resistance Neonicotinoids Clothianidin Cross-resistance

Hypersensitivity to Aspirin as a Factor for Poor Control in Hereditary Angioedema

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Journal of Biosciences and Medicines 2017年第3期5卷 39-54页

作者： Carlos Alberto Garcia-Lopez Maria Eugenia Vargas-Camano Emmanuel Alcazar-Casarin Guillermo Quintana Mexiac Pablo leon Gomez Mario Alberto Ynga-Durand benjamin Lopez-Velazquez Maria Isabel Castrejon-Vazquez Servicio Inmunologia Clinica y Alergia Centro Medico Nacional“20 de Noviembre”ISSSTEMexico CityMexico Laboratorio de Inmunidad de Mucosas Seccion de Investigacion y PosgradoEscuela Superior de MedicinaInstituto Politecnico NacionalMexico CityMexico

Background: Hereditary angioedema (HAE) is a primary immunodeficiency disorder characterized by C1 complement inhibitor deficiency and unregulated activation of complement. Aspirin hypersensitivity is related to an increase in the amount of leukotrienes with eosinophil and mast cell activation and increased levels of glandular kallikrein with upregulated local conversion of bradykinin. Both conditions can be present in the same patient. Objectives: We present five patients with HAE;they were all being treated in similar ways according to the therapeuthic options available in our institute (danazol). However, three of them had recurrent episodes of angioedema;in these cases, it was identified aspirin hypersensitivity as a cause of poor disease control. A review of the literature is included. Case Presentation: We present the cases of four females and one male (age range 21 - 58 years) with type I HAE. Subjects were all ISSSTE beneficiaries (state workers) treated at the National Medical Center “20 de Noviembre”. Aspirin hypersensitivity was identified in three patients. Elimination of NSAIDs along with dietary elimination of high salicylate-containing foods improved control of angioedema crisis (severe and/ or recurrent episodes). Discussion: Aspirin hypersensitivity was identified as a factor for poor control in our patients with HAE. Such cases improved with dietary elimination of high salicylate-containing foods and avoidance of NSAIDs. Conclusions: This is the first report of patients with HAE and aspirin hypersensitivity as a cause of poor control. We recommend a deliberate search of these comorbidities, especially in cases of poor disease control. Further studies are needed to continue the investigation on this topic.

关键词： Hereditary Angioedema Immunodeficiency Complement Salicylates

Diabetes and cardiovascular disease: Epidemiology, biological mechanisms, treatment recommendations and future research

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World Journal of Diabetes 2015年第13期6卷 1246-1258页

作者： benjamin M leon Thomas M Maddox Department of Education University of Colorado School of Medicine Cardiology 111b VA Eastern Colorado HCSDenver CO 80220 United States

The incidence of diabetes mellitus(DM) continues to rise and has quickly become one of the most prevalent and costly chronic diseases worldwide. A close link exists between DM and cardiovascular disease(CVD), which is the most prevalent cause of morbidity and mortality in diabetic patients. Cardiovascular(CV) risk factors such as obesity, hypertension and dyslipidemia are common in patients with DM, placing them at increased risk for cardiac events. In addition, many studies have found biological mechanisms associated with DM that independently increase the risk of CVD in diabetic patients. Therefore, targeting CV risk factors in patients with DM is critical to minimize the long-term CV complications of the disease. This paper summarizes the relationship between diabetes and CVD, examines possible mechanisms of disease progression, discusses current treatment recommendations, and outlines future research directions.

关键词： Diabetes mellitus Cardiovascular disease Mechanism

Bulk lateral shearing interferometry for spatiotemporal study of time-varying ultrashort optical vortices

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Photonics Research 2022年第4期10卷 922-931页

作者： Miguel Lopez-Ripa Inigo J.Sola benjamin Alonso Grupo de Aplicaciones del Laser y Fotonica(ALF) Departamento de Fisica AplicadaUniversidad de Salamanca37008 SalamancaSpain

The spatiotemporal measurement of ultrashort laser beams usually involves techniques with complex set-ups or limited by instabilities that are unable to accurately retrieve the frequency-resolved wavefront. Here, we solve these drawbacks by implementing a simple, compact, and ultra-stable spatiotemporal characterization technique based on bulk lateral shearing spectral interferometry using a birefringent uniaxial crystal. We apply it to retrieve complex spatiotemporal structures by characterizing ultrafast optical vortices with constant and time-varying orbital angular momentum. This technique can operate in all the transparency range of the anisotropic elements,enabling the characterization in different spectral ranges like infrared, visible, or ultraviolet.

关键词： ultrashort shearing interferometry

Insecticidal Activity and Physicochemical Characterization of Nanoparticles from Foliar Extract of Capsicum chinense

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Journal of Renewable Materials 2023年第11期11卷 3933-3943页

作者： Arnoldo E.Alfaro-Corres Daniel Gonzalez-Mendoza Esau Ruiz-Sanchez Carlos Ail-Catzin benjamin Valdez-Salas Federico Gutierrez-Miceli Arturo Reyes-Ramirez Jacques Fils Pierre Division of Postgraduate Studies and Research Tecnologico Nacional de MéxicoCampus ConkalConkalYucatán97345Mexico Institute of Agricultural Sciences Universidad Autonoma de Baja CaliforniaEjido Nuevo LeonMexicaliBaja California21705Mexico Instituto de Ingeniería Universidad Autónoma de Baja CaliforniaMexicaliBaja California21100Mexico Division of Postgraduate Studies and Research Tecnologico Nacional de MexicoCampus Tuxtla GutierrezTuxtla GutierrezChiapas29050Mexico

This work was carried out to evaluate the insecticidal effect of mono,bi and trimetallic nanoparticles(NPs)from leaf extract of habanero pepper(Capsicum chinense Jacq.)on the red flour beetle(Tribolium castaneum herbst.)and cotton mealybug(Phenacoccus solenopsis Tinsley).The results showed that Cu NPs,Cu/Mn NPs and Zn/Cu NPs had high insecticidal effect against ***(63%-80% mortality after 96 h).The Cu NPs and Zn/Cu NPs showed also insecticidal effect against ***,but to a lesser extent(20%–28% after 96 h).With regards to the physicochemical characterization,Cu NPs had a zeta potential of 21.1 mV,whereas Cu/Mn NPs and Zn/Cu NPs exhibited zeta potentials of 200 *** polydispersity index(PDI)values for Cu NPs,Cu/Mn NPs,and Zn/Cu NPs were 10.1,29.16,and 14.34,*** TF-IR spectra of the NPs varied from 600 to 4000 cm−*** EDX weight percentages showed the presence of Cu(0.29%–2.4%),Mn(1.4%),and Zn(2.6%)in Cu/Mn NPs and Zn/Cu NPs,respectively.

关键词： Phytonanoparticles botanical insecticide pest control agronanotechnology

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波形类震源定位方法的多尺度研究及应用进展

波形类震源定位方法的多尺度研究及应用进展

Risk perception and knowledge of COVID-19 in patients with celiac disease

2019年中国地球科学联合学术年会

作者：李磊谭静强 Franti?ek Staněk 施佩东 benjamin Schwarz Natalia Poiata leon Diekmann Leo Eisner Dirk Gajewski 中南大学 Czech Academy of Sciences Université Grenoble Alpes SAINT MARTIN D’ German Research Centre for Geosciences (GFZ) Institut de Physique du Globe de Paris Utrecht University Seismik s.r.o. Prague University of Hamburg

地震监测已广泛应用于地震、地球物理、声学和工程等领域。震源位置能提供断层/裂缝及其周围破坏区域的直接信息,是地震监测资料处理和解释的基础。作为经典的反演问题,震源定位在过去的一个世纪中取得了重大发展和进步。随着近年来非... 详细信息

地震监测已广泛应用于地震、地球物理、声学和工程等领域。震源位置能提供断层/裂缝及其周围破坏区域的直接信息,是地震监测资料处理和解释的基础。作为经典的反演问题,震源定位在过去的一个世纪中取得了重大发展和进步。随着近年来非常规油气和地热资源等开发的快速发展,水力压裂

关键词：震源定位全波形反演震源能量应用进展多尺度研究

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World Journal of Gastroenterology 2021年第12期27卷 1213-1225页

作者： Jamie Zhen Juan Pablo Stefanolo María de la Paz Temprano Caroline L Seiler Alberto Caminero Enrique de-Madaria Miguel Montoro Huguet Vivas Santiago Sonia Isabel Niveloni Edgardo Gustavo Smecuol Luis Uzcanga Dominguez Elena Trucco Virginia Lopez Carolina Olano Pasquale Mansueto Antonio Carroccio Peter H Green Donald Duerksen Andrew S Day Jason A Tye-Din Julio César Bai Carolina Ciacci Elena F Verdú benjamin Lebwohl M Ines Pinto-Sanchez Department of Medicine Farncombe Family Digestive Health Research InstituteMcMaster University Medical CenterHamilton Health SciencesHamilton L8S4K1ONCanada Department of Medicine Dr.C.Bonorino Udaondo Gastroenterology HospitalBuenos Aires 1264Argentina Department of Pancreatic Unit Hospital General Universitario de AlicanteAlicante 03010Spain Department of Medicine Instituto Aragonés de Ciencias de la Salud(IACS)Zaragoza 50009Spain Department of Medicine Hospital Universitario San Jorge.HuescaZaragoza 50004Spain Department of Gastroenterology Univ Hosp LeonGastroenterol UnitAltos de Nava S-NLeon 24071Spain Department of Medicine Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico DF 14080Mexico Department of Medicine Universidad de la RepublicMontevideo 11800Uruguay Department of Internal Medicine PROMISE DepartmentUniversity of PalermoPalermo 90127Italy Department of Internal Medicine V.Cervello HospitalPROMISE DepartmentUniversity of PalermoPalermo 90127Italy Celiac Disease Center Columbia University Medical CenterColumbia UnivCeliac Dis CtrDiv Digest and Liver DisNew YorkNY 10032United States Department of Medicine St Boniface Gen HospUniversity of ManitobaWinnipeg R2H 2A6Canada Department of Paediatrics University of Otago ChristchurchChristchurch 8041New Zealand Department of Gastroenterology Royal Melbourne HospitalImmunology DivisionWalter and Eliza Hall InstituteMelbourne 3052Australia Department of Medicine Surgery and DentryScuola Medica SalernitanaUniversity of SalernoCeliac Center at the University Hospital San Giovanni di Dio e Ruggi di AragonaSalerno 84131Italy Department of Medicine Farncombe Family Digestive Research InstituteMcMaster UniversityHamilton L8S4K1ONCanada The Celiac Disease Center Columbia UniversityNew YorkNY 10032United States

BACKGROUND We recently demonstrated that the odds of contracting coronavirus disease 2019(COVID-19)in patients with celiac disease(CeD)is similar to that of the general ***,how patients with CeD perceive their COVID-19 risk may differ from their actual *** To investigate risk perceptions of contracting COVID-19 in patients with CeD and determine the factors that may influence their *** We distributed a survey throughout 10 countries between March and June 2020 and collected data on demographics,diet,COVID-19 testing,and risk perceptions of COVID-19 in patients with *** were recruited through various celiac associations,clinic visits,and social *** perception was assessed by asking individuals whether they believe patients with CeD are at an increased risk of contracting COVID-19 when compared to the general *** regression was used to determine the influencing factors associated with COVID-19 risk perception,such as age,sex,adherence to a gluten-free diet(GFD),and comorbidities such as cardiac conditions,respiratory conditions,and *** was presented as adjusted odds ratios(aORs)RESULTS A total of 10737 participants with CeD completed the *** them,6019(56.1%)patients with CeD perceived they were at a higher risk or were unsure if they were at a higher risk of contracting COVID-19 compared to the non-CeD population.A greater proportion of patients with CeD perceived an increased risk of contracting COVID-19 when compared to infections in general due to their CeD(56.1%vs 26.7%,P<0.0001).Consequently,34.8%reported taking extra COVID-19 precautions as a result of their *** of celiac associations were less likely to perceive an increased risk of COVID-19 when compared to non-members(49.5%vs 57.4%,P<0.0001).Older age(aOR:0.99;95%CI:0.99 to 0.99,P<0.001),male sex(aOR:0.84;95%CI:0.76 to 0.93,P=0.001),and strict adherence to a GFD(aOR:0.89;95%CI:0.82 to 0.96,P=0.007)were associated

关键词： Celiac disease Gluten Risk Infection Knowledge Perception Coronavirus COVID-19