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Differential transcriptomic landscapes of multiple organs from SARS-CoV-2 early infected rhesus macaques

Protein & Cell 2022年第12期13卷 920-939页

作者： chun-chun Gao Man Li Wei Deng chun-Hui Ma yu-Sheng Chen Yong-Qiao Sun Tingfu Du Qian-Lan Liu Wen-Jie Li Bing Zhang Lihong Sun Si-Meng Liu Fengli Li Feifei Qi Yajin Qu Xinyang Ge Jiangning Liu Peng Wang Yamei Niu Zhiyong Liang Yong-Liang Zhao Bo Huang Xiao-Zhong Peng Ying Yang Chuan Qin Wei-Min Tong yun-Gui Yang CAS Key Laboratory of Genomic and Precision Medicine Collaborative Innovation Center of Genetics and DevelopmentCollege of Future TechnologyBeijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China China National Center for Bioinformation Beijing 100101China Sino-Danish College University of Chinese Academy of SciencesBeijing 101408China Department of Pathology Beijing Ditan HospitalCapital Medical UniversityBeijing 100000China Department of Pathology Institute of Basic Medical SciencesMolecular Pathology Research CenterChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100005China NHC Key Laboratory of Human Disease Comparative Medicine Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious DiseasesInstitute of Laboratory Animal ScienceChinese Academy of Medical Sciences and Comparative Medicine CenterPeking Union Medical CollegeBeijing 100021China Institute of Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical CollegeKunming 650031China Center for Experimental Animal Research Institute of Basic Medical Sciences Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100005China Department of Pathology Peking Union Medical College HospitalMolecular Pathology Research CenterChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100005China Department of Immunology&National Key Laboratory of Medical Molecular Biology Institute of Basic Medical SciencesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100005China Clinical Immunology Center Chinese Academy of Medical SciencesBeijing 100005China Department of Biochemistry&Molecular Biology Tongji Medical CollegeHuazhong University of Science&TechnologyWuhan 430030China State Key Laboratory of Medical Molecular Biology Department of Molecular Biology and BiochemistryInstitute of Basic Med

SARS-CoV-2 infection causes complicated clinical manifestations with variable multi-organ injuries,how-ever,the underlying mechanism,in particular immune responses in different organs,remains *** this study,comprehensive transcriptomic alterations of 14 tissues from rhesus macaque infected with SARS-CoV-2 were *** to normal controls,SARS-CoV-2 infection resulted in dysregulation of genes involving diverse functions in various examined tissues/organs,with drastic transcriptomic changes in cerebral cortex and right ***,cerebral cortex exhibited a hyperinflammatory state evidenced by sig-nificant upregulation of inflammation response-related ***,expressions of coagulation,angio-genesis and fibrosis factors were also up-regulated in cerebral *** on our findings,neuropilin 1(NRP1),a receptor of SARS-CoV-2,was significantly elevated in cerebral cortex post infection,accompanied by active immune response releasing inflammatory factors and signal transmission among tissues,which enhanced infection of the central nervous system(CNS)in a positive feedback way,leading to viral ***,our study depicts a multi-tissue/organ tran-scriptomic landscapes of rhesus macaque with early infection of SARS-CoV-2,and provides important insights into the mechanistic basis for COVID-19-asso-ciated clinical complications.

关键词： SARS-CoV-2 NRP1 inflammation central nervous system viral encephalitis rhesus macaque

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Mechanistic insights into the key marine dimethylsulfoniopropionate synthesis enzyme DsyB/DSYB

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mLife 2022年第2期1卷 114-130页

作者： chun-Yang Li Jason C.Crack Simone Newton-Payne Andrew R.J.Murphy Xiu-Lan Chen benjamin J.Pinchbeck Shun Zhou Beth T.Williams Ming Peng Xiao-Hua Zhang Yin Chen Nick E.Le Brun Jonathan D.Todd yu-Zhong Zhang Frontiers Science Center for Deep Ocean Multispheres and Earth System College of Marine Life SciencesOcean University of ChinaQingdaoChina State Key Laboratory of Microbial Technology Marine Biotechnology Research CenterShandong UniversityQingdaoChina Laboratory for Marine Biology and Biotechnology Pilot National Laboratory for Marine Science and TechnologyQingdaoShandongChina School of Chemistry Centre for Molecular and Structural BiochemistryUniversity of East AngliaNorwich Research ParkNorwichUK School of Biological Sciences University of East AngliaNorwichUK School of Life Sciences University of WarwickCoventryUK

Marine algae and bacteria produce approximately eight billion tonnes of the organosulfur molecule dimethylsulfoniopropionate(DMSP)in Earth's surface oceans *** is an antistress compound and,once released into the environment,a major nutrient,signaling molecule,and source of climate-active *** methionine transamination pathway for DMSP synthesis is used by most known DMSP-producing algae and *** S-directed S-adenosylmethionine(SAM)-dependent 4-methylthio-2-hydroxybutyrate(MTHB)S-methyltransferase,encoded by the dsyB/DSYB gene,is the key enzyme of this pathway,generating S-adenosylhomocysteine(SAH)and 4-dimethylsulfonio-2-hydroxybutyrate(DMSHB).DsyB/DSYB,present in most haptophyte and dinoflagellate algae with the highest known intracellular DMSP concentrations,is shown to be far more abundant and transcribed in marine environments than any other known S-methyltransferase gene in DMSP synthesis ***,we demonstrate in vitro activity of the bacterial DsyB enzyme from Nisaea denitrificans and provide its crystal structure in complex with SAM and SAH-MTHB,which together provide the first important mechanistic insights into a DMSP synthesis *** and mutational analyses imply that DsyB adopts a proximity and desolvation mechanism for the methyl transfer *** analysis suggests that this mechanism may be common to all bacterial DsyB enzymes and also,importantly,eukaryotic DSYB enzymes from e.g.,algae that are the major DMSP producers in Earth's surface oceans.

关键词： catalytic mechanism DMSP synthesis marine sulfur cycle S-methyltransferase

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高温条件下混凝土爆裂机理研究进展

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建筑材料学报 2006年第3期9卷 323-329页

作者：傅宇方黄玉龙潘智生唐春安交通部公路科学研究院道桥部北京100088 香港理工大学土木与结构工程系大连理工大学土木水利学院辽宁大连116024

对高温条件下混凝土爆裂的研究进行了全面综述,总结了混凝土爆裂发生的影响因素、成因机理及实验和理论研究的进展状况.提出了热开裂和孔隙水(汽)压力的耦合作用是产生混凝土爆裂和不确定性的主要原因.温升诱致混凝土爆裂是一个复杂的... 详细信息

对高温条件下混凝土爆裂的研究进行了全面综述,总结了混凝土爆裂发生的影响因素、成因机理及实验和理论研究的进展状况.提出了热开裂和孔隙水(汽)压力的耦合作用是产生混凝土爆裂和不确定性的主要原因.温升诱致混凝土爆裂是一个复杂的非线性问题,建立一个兼顾材料科学和力学的理论体系是全面理解混凝土温升爆裂的根本途径.

关键词：混凝土高温爆裂热开裂温度梯度

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Hif-1α/Hsf1/Hsp70 signaling pathway regulates redox homeostasis and apoptosis in large yellow croaker(Larimichthys crocea)under environmental hypoxia

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Zoological Research 2021年第6期42卷 746-760页

作者： Sheng-yu Luo Jing-Qian Wang Cheng Liu Xin-Ming Gao Yi-Bo Zhang Jie Ding Cong-Cong Hou Jun-Quan Zhu Bao Lou Wei-Liang Shen Xiong-Fei Wu chun-Dan Zhang Dao-Jun Tang Key Laboratory of Applied Marine Biotechnology by the Ministry of Education School of Marine SciencesNingbo UniversityNingboZhejiang 315211China Zhejiang Academy of Agricultural Sciences HangzhouZhejiang 310021China State Key Laboratory of Large Yellow Croaker Breeding Ningbo Academy of Oceanology and FisheryNingboZhejiang 315012China

Oxygen is an essential molecule for animal respiration,growth,and *** in terrestrial environments,contamination and climate change have led to the frequent occurrence of hypoxia in aquatic environments,thus impacting aquatic animal ***,the adaptative mechanisms underlying fish responses to environmental hypoxia remain largely ***,we used large yellow croaker(Larimichthys crocea)and large yellow croaker fry(LYCF)cells to investigate the roles of the Hif-1α/Hsf1/Hsp70 signaling pathway in the regulation of cellular redox homeostasis,and *** confirmed that hypoxia induced the expression of Hif-1α,Hsf1,and Hsp70 in vivo and in *** Hsp70 knockdown/overexpression indicated that Hsp70 was required for maintaining redox homeostasis and resisting oxidative stress in LYCF cells under hypoxic ***70 inhibited caspase-dependent intrinsic apoptosis by maintaining normal mitochondrial membrane potential,enhancing Bcl-2 mRNA and protein expression,inhibiting Bax and caspase3 mRNA expression,and suppressing caspase-3 and caspase-9 ***70 suppressed caspaseindependent intrinsic apoptosis by inhibiting nuclear translocation of apoptosis-inducing factor(AIF)and disturbed extrinsic apoptosis by inactivating *** knockdown/overexpression of Hif-1αand dual-luciferase reporter assay indicated that Hif-1αactivated the Hsf1 DNA promoter and enhanced Hsf1 mRNA ***1 enhanced Hsp70 mRNA transcription in a similar *** summary,the Hif-1α/Hsf1/Hsp70 signaling pathway plays an important role in regulating redox homeostasis and anti-apoptosis in *** under hypoxic stress.

关键词： Hypoxia Larimichthys crocea Apoptosis Redox homeostasis Hif-1α/Hsf1/Hsp70

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Atomically flat surface preparation for surface-sensitive technologies

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Chinese Physics B 2020年第2期29卷 438-441页

作者： Cen-Yao Tang Zhi-Cheng Rao Qian-Qian yuan Shang-Jie Tian Hang Li Yao-Bo Huang He-Chang Lei Shao-chun Li Tian Qian yu-Jie Sun Hong Ding Beijing National Laboratory for Condensed Matter Physics and Institute of Physics Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China National Laboratory of Solid State Microstructures School of PhysicsNanjing UniversityNanjing 210093China Collaborative Innovation Center of Advanced Microstructures Nanjing UniversityNanjing 210093China Department of Physics and Beijing Key Laboratory of Opto-electronic Functional Materials and Micro-nano Devices Renmin University of ChinaBeijing 100872China Shanghai Synchrotron Radiation Facility Shanghai Institute of Applied PhysicsChinese Academy of SciencesShanghai 201800China Songshan Lake Materials Laboratory Dongguan 250100China

Surface-sensitive measurements are crucial to many types of researches in condensed matter ***,it is difficult to obtain atomically flat surfaces of many single crystals by the commonly used mechanical *** demonstrate that the grind-polish-sputter-anneal method can be used to obtain atomically flat surfaces on topological *** types of surface-sensitive measurements are performed on CoSi(001)surface with dramatically improved quality of *** method extends the research area of surface-sensitive measurements to hard-to-cleave alloys,and can be applied to irregular single crystals with selective crystalline *** may become a routine process of preparing atomically flat surfaces for surface-sensitive technologies.

关键词： grind-polish-sputter-anneal atomically flat single crystal surface topological materials

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Correction to:Aryl hydrocarbon receptor signaling promotes ORMDL3-dependent generation of sphingosine-1-phosphate by inhibiting sphingosine-1-phosphate lyase

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Cellular & Molecular Immunology 2018年第9期15卷 870-870页

作者： Hsueh-chun Wang Tzu-Hsuan wong Li-Ting Wang Hsiang-Han Su Hsiu-yueh yu Ai-Hsuan Wu yu-chun Lin Hua-Ling Chen Jau-Ling Suen Shih-Hsien Hsu Li-Chen Chen yufeng Zhou Shau-Ku Huang Department of Medical Research China Medical University HospitalChina Medical UniversityTaichung 40402 TaiwanChina Graduate Institute of Medicine College of MedicineKaohsiung Medical University KaohsiungTaiwan China Division of Allergy Asthrma and RheumatolayDepartment of Pediatrics Chang Gung Memorial Hospital TaoyuanTaiwan China National Institute of Environmental Health Sciences National Helath Research InstitutesMiaoli TaiwanChina Research Center of Envionmental Medicine Kaohsiung Medical University KaohsiungTaiwan China Center for Research Resources and Development kaosiung Medical University Kaohsiung Taiwan China Community Medicine Research Center Chang Gung Memorial Hospital at KeelungKeelung TaiwanChina Department of Oediatrics Xiamen Chang Gung Hospital XiamenChina Johns Hopkins University school of Medicine BaltimoreMDUSA Children's Hospital and Institute of Biomedical Sciences Fudan Universitykey Labortory of Neonatal DiseaseMinistry of Health201102 ShanghaiChina Lou-Hu Hospital Shen-Zhen UniversityShen-ZhenChina

In this article, published online 23 March 2018, the affiliation 10 of Zhou Y was incorrect. The affiliation should be "Children's Hospital and Institute of Biomedical Sciences, Fudan University. Key Laboratory of Neo...

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Global Pediatric Pulmonology Alliance recommendation to strengthen prevention of pediatric seasonal influenza under COVID-19 pandemic

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World Journal of Pediatrics 2020年第5期16卷 433-437页

作者： Kun-Ling Shen Leyla Namazova-Baranova Yong-Hong Yang Gary Wing Kin wong Lanny J.Rosenwasser Lance E.Rodewald Anne Eng Neo Goh Eitan Kerem Chris O'Callaghan T.Bernard Kinane Basil Elnazir Rina Triasih Rosemary Horne Anne B Chang Jim Buttery Ruth A.Etzel Kazunobu Ouchi Hilary Hoey Varinder Singh Genesis C.Rivera Spencer SLi yu Guan Ling Cao yue-Jie Zheng Lu-Zhao Feng Wu Zhong Zheng-De Xie Bao-Ping Xu Rong-Jun Lin Gen Lu Qiang Qin chun-Mei Zhu Su-yun Qian Gang Liu Cheng-Song Zhao Zhuang Wei yu-Hong Zhao Global Pediatric Pulmonology Alliance(GPPA)Expert Panel on Infectious Diseases&COVID-19 China National Clinical Research Center of Respiratory Diseases Department of Respiratory Medicine of Beijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijingChina Pediatrics and Child Health Research Institute Central Clinical HospitalRussian Academy of SciencesMoscowRussian Federation Department of Respiratory Shenzhen Children's HospitalShenzhenChina Chinese University of Hong Kong Hong Kong SARChina UMKC School of Medicine Kansas CityMOUSA National Immunization Program Chinese Center for Disease Control and PreventionBeijingChina K Women's and Children's Hospital SingaporeSingapore Department of Pediatrics Hadassah Hebrew University Medical CenterJerusalemIsrael UCL Great Ormond Street Institute of Child Health and Great Ormond Street Hospital(GOSH)BRC University College LondonLondonUK Massachusetts General Hospital for Children BostonMAUSA Children's Health Ireland and Trinity College Dublin DublinIreland Department of Paediatric Faculty of MedicinePublic Health and NursingUniversitas Gadjah Mada/Dr.Sardjito HospitalYogyakartaIndonesia Monash University MelbourneAustralia Queensland Children's Hospital BrisbaneAustralia Monash Children's Hospital Menzies School of Health ResearchMelbourneAustralia George Washington University WashingtonDCUSA Department of Pediatrics Kawasaki Medical SchoolKurashiki-CityJapan Department of Pediatrics University of Dublin Trinity CollegeDublinIreland Lady Hardinge Medical College and Assoc Kalawati Saran Children's Hospital New DelhiIndia Center for Medical and Allied Health Sciences New Era UniversityQuezon Citythe Philippines Global Pediatric Pulmonology Alliance Hong Kong SARChina Department of Respiratory the Children's Hospital Affiliated to the Capital Institute of PediatricsBeijingChina School of Population Medicine and Public Health Chinese Academy of Medical Sciences/Peking Union Medical CollegeBeijingChina National Engineering Research Center for the Emergency Drug BeijingChina Nati

The World Health Organization(WHO)announced COVID-19 as a global pandemic in March of 2020[1].The COVID-19 pandemic may persist for a long period of *** prevention and control becomes a complex and challenging task,and such efforts should be *** general measures,such as social distancing,face masks,respiratory hygiene and hand sanitization,will bear fruits for decreasing spread of other respiratory illnesses including influenza,the specific prevention through vaccination is a key focus especially in the upcoming winter and spring seasons[2].

关键词： prevention influenza sustained

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溶瘤性新城疫病毒在头颈肿瘤中的治疗作用(英文)

溶瘤性新城疫病毒在头颈肿瘤中的治疗作用(英文)

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2010全国耳鼻咽喉头颈外科中青年学术会议

作者： Pingdong Li Danni Wang chun-Hao Chen Sen Li Babak Givi Zhenkun yu Dmitriy Zamarin Peter Palese yuman FongRichard J wong Department of Surgery Memorial Sloan-Kettering Department of Otolaryngology Head and Neck surgery Beijing Tongren HospitalCapital Medical UniversityKey laboratory of Otolaryngology Head and Neck surgery Department of Microbiology Mount Sinai School of Medicine Department of Medicine Mount Sinai School of Medicine

Therapies with novel mechanisms of activity are needed to improve outcomes for patients suffering from head and neck *** disease virus(NDV) is a paramyxovirus that is pathogenic in birds,but only causes mild flu-like ...

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应用数码图像精确描述性状特征在中药鉴定中的应用与展望

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时珍国医国药 2021年第3期32卷 631-636页

作者：梁之桃李丽媚陈亮俊黄丽丽邬家林陈玉婷香港卫生署政府中药检测中心中国香港

目的应用数码图像精确描述不同药用部位类别的中药性状特征,总结和展望应用数码图像精确描述性状特征在中药鉴定中的应用。方法采用先进仪器及景深合成技术对根及根茎类、花类、果实及种子类以及全草类中药的表面和横切面进行观察和拍... 详细信息

目的应用数码图像精确描述不同药用部位类别的中药性状特征,总结和展望应用数码图像精确描述性状特征在中药鉴定中的应用。方法采用先进仪器及景深合成技术对根及根茎类、花类、果实及种子类以及全草类中药的表面和横切面进行观察和拍摄数码图像,总结应用数码图像精确描述性状特征在不同药用部位类别中药中的现代鉴定优势。结果应用数码图像精确描述性状特征更能客观反映外观特征,并透过放大倍数观察性状特征可以看到肉眼不易察觉的特征,大大充实和丰富了现有的性状鉴别特征,提升中药鉴别的正确性。应用数码图像精确描述性状特征不仅可以作为中药真伪鉴定的重要依据,也可以用于相对质量评价。结论加强应用数码图像精确描述性状特征,并积极扩充至中药检测和标准中,对中药质量保证有重要意义及贡献。

关键词：性状特征数码图像中药鉴定质量评价

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Hydration process of rice husk ash cement paste and its corrosion resistance of embedded steel bar

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Journal of Central South University 2020年第11期27卷 3464-3476页

作者： WANG Hui ZHANG Ai-lian ZHANG Lin-chun WANG Qian HAN Yan LIU Jun-zhe GAO Xiao-jian SHI Fei-ting LIN Xue-yan FENG Li-yu School of Civil and Environmental Engineering Ningbo UniversityNingbo 315000China School of Civil Engineering Sichuan College of Architectural TechnologyDeyang 618000China School of Construction Engineering Qingdao Agricultural UniversityQingdao 266000China School of Civil Engineering Harbin Institute of TechnologyHarbin 150090China Civil Engineering Department Yancheng Institute of TechnologyYancheng 224051China

Thermogravimetric analysis and electrical resistivity were used to determine the hydration process of cement paste with rice husk ash(RHA)(0−15%)and water-cement ratio of 0.4 in this work.X-ray diffraction(XRD)method and scanning electron microscopy(SEM)were used to survey crystal composition and microstructures of specimens cured for 3 h,1 d,7 d and 28 ***,electrical parameters(electrical resistance and AC impedance spectroscopy)of steel bars reinforced cement paste were investigated to study the effect of RHA on the corrosion *** showed that RHA could affect the cement hydration by hydration promotion and pozzolanic *** evaluation function for electrical resistivity and curing ages fitted well with linear increasing *** addition of RHA higher than 5%demonstrated a decreasing role in the electrical resistivity of cement paste at earlier curing ages(3−7 d).Meanwhile,when at later curing ages(7−28 d)the result was the ***,RHA demonstrated positive effects on corrosion resistance of steel bars in cement paste.

关键词： rice husk ash thermogravimetric analysis electrical parameters X-ray diffraction corrosion resistance

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