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Shoot-level biomass allocation is affected by shoot type in Fagus sylvatica

Journal of Plant Ecology 2012年第4期5卷 422-428页

作者： benjam.n jarcuska Ruben Milla Institute of Forest Ecology Slovak Academy of SciencesSturova 296053 ZvolenSlovakia Area de Biodiversidad y Conservacion Universidad Rey Juan Carlosc/Tulipan s/n.E-28933 Mostoles(Madrid)Spain

Aims The present study aims(i)to examine if recently reported interspecific shoot-level biomass allocational trade-offs,*** trade-offs between leaf mass(LM)and stem mass(SM)and between leaf size and leaf number,hold intraspecifically and(ii)to explore whether those scaling relationships are independent of shoot type(*** *** shoots).Methods In order to address our questions,we used Fagus sylvatica saplings growing under a broad light range that were sampled in theWestern Carpathians Mountains(Slovakia).Important Findings We found that:(i)intraspecific shoot-level biomass allocational trade-offs differ from those reported interspecifically and that(ii)long and short shoots differ in biomass allocation scaling *** relationships with slopes statistically smaller than 1.0 or higher than-1.0,were found between SM and LM and between mean leafing intensity and individual leaf mass,respectively,in long *** contrast,isometric scaling was found in short *** suggests that leaf mass in short shoots is unaffected by shoot stem mass,in contrast to long *** shoots also had a larger fraction of biomass allocated to *** shoots,as has been observed in other shoot dimorphic species,are specialized,with short shoots specializing in carbon gain and long shoots in space acquisition.A greater shift in LM than in SM among species during speciation shifting from allometric intraspecific relationships to an isometric interspecific scaling relationship between those traits could explain the discrepancies between the outputs of the present intraspecific study and others similar *** study draws attention to the importance of considering shoot types in future studies dealing with allocation rules in species with dimorphic shoots.

关键词： biomass allocation dimorphic shoots leaf size stem size scaling relationships

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R0 Liver Resection should be a First-line Treatment for Selected Patients with Intermediate Hepatocellular Cancer

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Journal of Clinical and Translational Hepatology 2023年第4期11卷 757-760页

作者： Martin Janicko Sylvia Drazilova Peter jarcuska Second Department of Internal Medicine PJ Safarik UniversityFaculty of Medicine and Pasteur University HospitalKosiceSlovakia

Introduction Hepatocellular cancer(HCC)is the sixth most common malignancy worldwide and the second most common cause of mortality among all *** HCCs occur in cirrhotic livers,but an increasing proportion of cases occur in livers without cirrhosis,particularly in Hepatitis B virus infection or in nonalcoholic fatty liver disease patients.^(1) Liver resection(LR)is the treatment of choice in most noncirrhotic patients,therefore most discussion is related to patients with *** survival(OS)depends on the stage at the time of *** Clinic Liver Cancer(BCLC)staging is the currently preferred staging system for HCC in Europe and north America^(2) Only a small proportion of patients with HCC are diagnosed at a very early or early stage(BCLC 0-A)when curative treatment,including LR,is generally recommended.

关键词： Liver Cancer mortality

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Pleiotropic effects of statins in the diseases of the liver

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World Journal of Gastroenterology 2016年第27期22卷 6201-6213页

作者： Martin Janicko Sylvia Drazilova Daniel Pella Jan Fedacko Peter jarcuska 1~(st) Department of Internal medicine Pavol Jozef Safarik University in Kosice Louis Pasteur University hospital Department of Internal Medicine Hospital Poprad

Statins are a class of molecules that inhibit HMG Co A reductase. They are usually prescribed as a lipid lowering medication. However, there is accumulating evidence that statins have multiple secondary effects both related and unrelated to their lipid-lowering effect. This narrative review of the literature aims to provide the reader with information from clinical studies related to the effect of statin and statins' potential use in patients with liver diseases. In patients with advanced liver disease due to any etiology, statins exhibit an antifibrotic effect possibly through the prevention of hepatic sinusoidal microthrombosis. Two randomized controlled trials confirmed that statins decrease hepatic vein pressure gradient in patients with portal hypertension and improve the survival of patients after variceal bleeding. Lower rates of infections were observed in patients with cirrhosis who received statin treatment. Statins decrease the risk of hepatocellular carcinoma(HCC) in patients with advanced liver disease in general but particularly in patients with chronic hepatitis B and C. Statins in patients with chronic hepatitis C likely increase the virological response to the treatment with pegylated interferon and ribavirin and have the potential to decrease the rate of fibrosis. Finally, data from randomized controlled trials also confirmed that the addition of statin prolongs the survival of patients with advanced HCC even more than sorafenib. Statins are a very promising group of drugs especially in patients with liver disease, where therapeutic options can often be limited. Some indications, such as the prevention of re-bleeding from esophageal varices and the palliative treatment of HCC have been proven through randomized controlled trials, while additional indications still need to be confirmed through prospective studies.

关键词： Statins Hepatitis Cirrhosis Esophageal varices Hepatocellular carcinoma

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Association between hepatitis B and metabolic syndrome:Current state of the art

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World Journal of Gastroenterology 2016年第1期22卷 155-164页

作者： Peter jarcuska Sylvia Drazilova Jan Fedacko Daniel Pella Martin Janicko 1st Department of Internal Medicine University Hospital and Pavol Jozef Šafárik University in Kosice04001 KošiceSlovakia Department of Internal Medicine Hospital Poprad A.S.05845 PopradSlovakia

Chronic hepatitis B(CHB)is a global health issue that increases the risk of liver cirrhosis and hepatocellular carcinoma in infected *** syndrome(Met S)is a disease endemic mostly to the developed *** is associated with high cardiovascular mortality and morbidity,diabetes mellitus as well as *** this manuscript,we systematically review the published data on the relationship between Met S and CHB *** studies have described highly variable correlations between CHB on one hand and Met S,non-alcoholic fatty liver disease and dyslipidemia on the *** association between CHB and diabetes mellitus or atherosclerosis has been described as of *** presence of Met S in patients infected with hepatitis B virus increases the risk of fibrosis,cirrhosis and hepatocellular *** lifestyle,but also pharmacological interventions are needed to prevent the development of these complications.

关键词： Hepatitis B nonalcoholic fatty liver disease Fibrosis Cirrhosis Metabolic syndrome Hepatocellularcarcinoma

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