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HEPATITIS B VIRUS DNA DETECTED BY PCR IN SERA AND LIVER TISSUES OF CHINESE PATIENTS WITH CHRONIC LIVER DISEASES

中华医学杂志(英文版) 1993年第1期106卷 7-12页

作者：张永源郭林生李淋张永东郝连杰 bengt goran hansson Erik Nordenfelt Clinical Immunology Research Unit Tongji Hospital Tongji Medical University Wuhan 430030 Department of Medical Microbiology Section of Virology University of Lund Malmo General Hospital S-21401 Malmo Sweden

To investigate the HBV infection and its replication in Chinese patients with chronic liver disease, polymerase chain reaction (PCR) was employed to detect hepatitis B virus DNA in sera of 410 patients with chronic liver disease and liver samples from 188 patients. The HBV DNA detectability in all serum samples was 58%. Among them 100% HBeAg-positive and 58% anti-HBe cases were HBV DNA detectable respectively. However, HBV DNA was also found in 23% HBsAg-negative/anti-HBc postitive chronic cases. Furthermore, 30% anti-HBs positive chronic cases who had neutralizing antibody against HBV infection, continued to contain HBV DNA. Our findings indicate that HBV infection and its replication are dominant cause of chronic liver disease and some HBV variants may escape from the protective antibody to induce chronic liver disease, even anti-HBs antibody circulated.

关键词： POLYMERASE CHAIN-REACTION E-ANTIGEN ENZYMATIC AMPLIFICATION SURFACE-ANTIGEN CARRIERS REPLICATION INFECTION SEQUENCES HBE

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Randomized Controlled Trial Of Hpv Testing In Primary Cervical Screening

Randomized Controlled Trial Of Hpv Testing In Primary Cervic...

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24th International Papillomavirus Conference and Clinical Workshop

作者： Pontus Naucler Walter Ryd Sven Tomberg Anders Strand goran Wadell Kristina Elfgren Thomas Rodberg Born Strander Ola Forslund bengt-goran hansson Eva Rylander Joakim Dillner Lund University MalmoSweden Sahlgrenska University Hospital GothenburgSweden Karolinska University Hospital StockholmSweden University Hospital UppsalaSweden University of Northern Sweden UmeoSweden Karolinska University Hospital StockholmSweden Sahlgrenska University Hospital GothenburgSweden Sahlgrenska University Hospital GothenburgSweden Lund University MalmoSweden Lund University MalmoSweden Karolinska University Hospital StockholmSweden Lund University MalmoSweden

＜正＞Background:Human papillomavirus（HPV）-based cervical screening is known to increase sensitivity for detection of high- grade cervical intraepithelial neoplasia（CIN）.Randomized trials of longitudinal efficacy ...

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Assessment of voluntary rhythmic muscle contraction-induced exercising blood flow variability measured by Doppler ultrasound

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Open Journal of Molecular and Integrative Physiology 2013年第4期3卷 158-165页

作者： Takuya Osada bengt Saltin goran Radegran Department of Sports Medicine for Health Promotion Tokyo Medical UniversityTokyoJapan The Copenhagen Muscle Research Centre RigshospitaletUniversity of CopenhagenCopenhagenDenmark The Clinic for Heart Failure and Valvular Disease Skane University HospitalLundSweden Department of Cardiology Clinical SciencesLund UniversityLundSweden

Given recent technological developments, ultrasound Doppler can provide valuable measurements of blood velocity/flow in the conduit artery with high temporal resolution. In human-applied science such as exercise physiology, hemodynamic measurements in the conduit artery is commonly performed by blood flow feeding the exercising muscle, as the increase in oxygen uptake (calculated as a product of arterial blood flow to the exercising limb and the arterio-venous oxygen difference) is directly proportional to the work performed. The increased oxygen demand with physical activity is met through a central mechanism, an increase in cardiac output and blood pressure, as well as a peripheral mechanism, an increase in vascular conductance and oxygen extraction (a major part of the whole exercising muscles) from the blood. The increase in exercising muscle blood flow in relation to the target workload (quantitative response) may be one indicator in circulatory adjustment for the ac- tivity of muscle metabolism. Therefore, the determination of local blood flow dynamics (potential oxygen supply) feeding repeated (rhythmic) muscle contractions can contribute to the understanding of the factors limiting work capacity including, for instance, muscle metabolism, substance utilization and magnitude of vasodilatation in the exercising muscle. Using non-invasive measures of pulsed Doppler ultrasound, the validity of blood velocity/flow in the forearm or lower limb conduit artery feeding to the muscle has been previously demonstrated during rhythmic muscle exercise. For the evaluation of exercising blood flow, not only muscle contraction induced internal physiological variability, or fluctuations in the magnitude of blood velocity due to spontaneous muscle contraction and relaxation induced changes in force curve intensity, superimposed in cardiac beat-by-beat, but also the alterations in the blood velocity (external variability) due to a temporary sudden change in the achieved workloa

关键词： Exercising Blood Flow Doppler Ultrasound Muscle Contraction Blood Flow Alterations

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Measurement of the exercising blood flow during rhythmical muscle contractions assessed by Doppler ultrasound:Methodological considerations

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Journal of Biomedical Science and Engineering 2012年第12期5卷 779-788页

作者： Takuya Osada bengt Saltin Stefan P.Mortensen goran Radegran Department of Sports Medicine for Health Promotion Tokyo Medical UniversityTokyoJapan Cardiac Rehabilitation Center Tokyo Medical University HospitalTokyoJapan The Copenhagen Muscle Research Centre RigshospitaletUniversity of CopenhagenCopenhagenDenmark The Clinic for Heart Failure and Valvular Disease Skane University Hospitaland Department of CardiologyIKVLLund UniversityLundSweden

Given the recent technological developments, ultra-sound Doppler can provide valuable measurements of arterial blood flow with high temporal resolution. In a clinical setting, measurements of hemodynamics is used to monitor, diagnose and manage changes in blood velocity profile for cardiac valve disease, relatively large vessel stenosis and other cardiovascular diseases. In health science and preventive medicine for cardiovascular disease with exercise therapy, evaluation of cardiac and vascular function is a useful indicator not only at rest but also during exercise, leading to improved exercise tolerance as well as physical activity. During exercise, the increase in oxygen uptake (calculated as product of arterial blood flow to the exercising limb and the arteriovenous oxygen difference) is directly proportional to the work performed. The increased oxygen demand is met through a central mechanism, an increase in cardiac output and blood pressure, as well as a peripheral mechanism, an increase in vascular conductance and oxygen extraction (major part in the whole exercising muscles) from the blood. Therefore, the determination of the local blood flow dynamics (potential oxygen supply) feeding to rhythmic muscle contractions can contribute to the understanding of the factors limiting the work capacity including, for instance the muscle metabolism, substance utilization and vasodilatation in the exercising muscle. Using non-invasive measures of pulsed Doppler ultrasound the validity of evaluating blood velocity/flow in the fore- arm or lower limb conduit artery feeding to the mus- cle is demonstrated during rhythmic muscle exercise;however the exercising blood velocity profile (fast Fourier transformation) due to muscle contractions is always seen as a physiological variability or fluctuations in the magnitude in blood velocity due to the spontaneous muscle contraction and relaxation induced changes in force curve intensity. Considering the above mentioned variation

关键词： Exercising Blood Flow Doppler Ultrasound Muscle Contraction Physiological Flow Variations

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