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Suppressive effect of Aurantii Fructus Immaturus and Atractylodis Macrocephalae Rhizoma on glutamic acid-induced autophagy of interstitial cells of Cajal

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Journal of Integrative Medicine 2020年第4期18卷 334-343页

作者： Shuai Yan Yin-zi Yue Ming-ming Sun ben-sheng wu Xiao-peng Wang Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica School of PharmacyNanjing University of Chinese MedicineNanjing 210023Jiangsu ProvinceChina Department of Anorectal Surgery Suzhou TCM HospitalNanjing University of Chinese MedicineSuzhou 215009Jiangsu ProvinceChina First Clinical Medical School Nanjing University of Chinese MedicineNanjing 210023Jiangsu ProvinceChina

Objective:To investigate the effects of Aurantii Fructus Immaturus(Zhishi,ZS)and Atractylodis Macrocephalae Rhizoma(Baizhu,BZ)-containing serum on glutamate-induced autophagy in rat colonic interstitial cells of Cajal(ICCs)and to analyze the underlying ***:Rat colonic ICCs cultured in vitro were identified by fluorescence and then stimulated with glutamic acid(5 mmol/L)for 24 h to establish a cell model of *** cells were then treated with different concentrations of ZSBZ-containing serum or rat *** viability of the ICCs was detected with cell counting kit-8 assays,and cell apoptosis rates were examined with flow *** ultrastructure and autophagosomes in the ICCs were observed using transmission electron *** effects of ZSBZ-containing serum on apoptosis-associated mediators were assessed by Western blotting and real-time quantitative polymerase chain *** addition,microtubule-associated protein light chain 3(LC3),p-phosphoinositide 3-kinase(p-PI3 K),p-Akt and p-mammalian target of rapamycin(pm TOR)expression was detected via Western blotting ***:Compared to those in the model group,ICC viability and apoptosis rates were significantly increased by ZSBZ-containing serum(Pbeneficial effect may be mediated by a reduction in autophagy via inhibition of the PI3 K/Akt/mTOR pathway.

关键词： Herbal medicine,Chinese Autophagy Phosphoinositide 3-kinase Signal pathway

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Plasmonic tandem heterojunctions enable high-efficiency charge transfer for broad spectrum photocatalytic hydrogen production

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Journal of Energy Chemistry 2025年第1期100卷 710-720页

作者： Wenxuan Chen Xiu-Qing Qiao Guo Hui Bojing Sun Dongfang Hou Meidi Wang Xueqian wu Tao wu Dong-sheng Li College of Materials and Chemical Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials China Three Gorges University Hubei Three Gorges Laboratory College of Chemistry and Materials Science and Guangdong Provincial Key Laboratory of Supramolecular Coordination Chemistry Jinan University

Rational engineering of semiconductor photocatalysts for efficient hydrogen production is of great significance but still challenging,primarily due to the limitations in charge transfer ***,a fascinating plasmonic tandem heterojunction with the hc-CdS/Mo2C@C heterostructure is aimfully prepared for effectively promoting the charge separation kinetics of the CdS photocatalyst via the synergistic strategy of phase junction,Schottky junction,and photothermal *** difference in atomic configuration between cubic-CdS （c-CdS） and hexagonal-CdS （h-CdS） leads to effective charge separation through a typical Ⅱ charge transfer mechanism,and plasmonic Schottky junction further extracts the electrons in the hc-CdS phase junction to realize gradient charge ***,the photothermal effect of Mo2C@C helps to expand the light absorption,accelerate charge transfer kinetics,and reduce the hydrogen evolution energy *** carbon layer provides a fast channel for charge transfer and protects the photocatalyst from *** a result,the optimized hc-CMC photocatalyst exhibits a significantly high photocatalytic H2production activity of 28.63 mmol/g/h and apparent quantum efficiency of 61.8%,surpassing most of the reported *** study provides a feasible strategy to enhance the charge transfer kinetics and photocatalytic activity of CdS by constructing plasmonic tandem heterogeneous junctions.

关键词： Cadmium sulfide

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Overview of in-situ oxygen production technologies for lunar resources

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 233-255页

作者： Youpeng Xu sheng Pang Liangwei Cong Guoyu Qian Dong Wang Laishi Li Yusheng wu Zhi Wang College of Materials Science and Engineering Shenyang University of TechnologyShenyang 110870China CAS Key Laboratory of Green Process and Engineering National Engineering Research Center for Green Recycling of Strategic Metal ResourcesInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China Innovation Academy for Green Manufacture Chinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China

The rich resources and unique environment of the Moon make it an ideal location for human expansion and the utilization of extraterrestrial ***,crucial for supporting human life on the Moon,can be extracted from lunar regolith,which is highly rich in oxygen and contains polymetallic *** oxygen and metal extraction can be achieved using existing metallurgical ***,the ample reserves of water ice on the Moon offer another means for oxygen *** paper offers a detailed overview of the leading technologies for achieving oxygen production on the Moon,drawing from an analysis of lunar resources and environmental *** delves into the principles,processes,advantages,and drawbacks of water-ice electrolysis,two-step oxygen production from lunar regolith,and one-step oxygen production from lunar *** two-step methods involve hydrogen reduction,carbothermal reduction,and hydrometallurgy,while the one-step methods encompass fluorination/chlorination,high-temperature decomposition,molten salt electrolysis,and molten regolith electrolysis(MOE).Following a thorough comparison of raw materials,equipment,technology,and economic viability,MOE is identified as the most promising approach for future in-situ oxygen production on the *** the corrosion characteristics of molten lunar regolith at high temperatures,along with the Moon's low-gravity environment,the development of inexpensive and stable inert anodes and electrolysis devices that can easily collect oxygen is critical for promoting MOE technology on the *** review significantly contributes to our understanding of in-situ oxygen production technologies on the Moon and supports upcoming lunar exploration initiatives.

关键词： lunar resources in-situ oxygen production space metallurgy molten lunar regolith electrolysis

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Modeling tactile perceived intensity for vibration from a coin eccentric rotating mass motor

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Science China Technological Sciences 2025年

作者： Yun FANG Jingchen HUANG Yujun wu Jiaqi DONG Weichao GUO Xinjun sheng State Key Laboratory of Mechanical System and Vibration School of Mechanical Engineering Shanghai Jiao Tong University Meta Robotics Institute Shanghai Jiao Tong University

Establishing the relationship between vibrotactile parameters and perceived intensity（PI） is of great significance in the regulation of desired sensations, which contribute to haptic interfaces in practical applications. Coin eccentric rotating mass（ERM） motors are routinely utilized due to their lightweight design and efficient ability to evoke strong tactile sensations. By adjusting input voltages, ERMs can yield different stimuli, but the effects of their physical properties on PI remain ***, we developed the physical model of the ERM-skin system and optimized the parameters affecting PI. Moreover, the relationship between stimulus and perception was derived based on Fechner?s law. Three experiments were conducted on fifteen subjects（ten males and five females, aged 24.40 ± 2.87 years） to identify the vibration parameters and corresponding PI to verify the proposed PI model. ERMs in this study were attached to phantom skin/forearm with slim adhesive tape to minimize the interference. Experiment 1 performed vibration calibration with ERM attached to the skin phantom to simulate the actual configuration. Then, the relative and absolute PI of subjects on specific stimuli were acquired in Experiments 2 and *** fitting reliability of the proposed PI model was evaluated on fifteen subjects with R2of 0.73 ± 0.07 and root mean squared error（RMSE） of 1.35 ± 0.28. Overall, the proposed PI model established the quantitative relationship between stimulus parameters（vibration parameters and physical parameters） and subjective PI, which provided theoretical support for ERM optimization and vibrotactile modulation.

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Single-cell transcriptomic profiling reveals ZEB1-mediated regulation in microglial subtypes and the impact of exercise on neuroinflammatory responses

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Traditional Medicine Research 2025年第2期10卷 55-64页

作者： Jin-Fang wu Yi-sheng Chen Yu-Chun Xie Department of Rehabilitation Medicine Jiangsu Province Geriatric HospitalNanjing 210024China Fujian Key Laboratory of Toxicant and Drug Toxicology Medical CollegeNingde Normal UniversityNingde 352100China Central Laboratory Jiangsu Province Geriatric HospitalNanjing 210024China

Background:This study aims to identify distinct cellular subtypes within brain tissue using single-cell transcriptomic analysis,focusing on specific biomarkers that differentiate cell types and the effects of traditional and exercise ***:Four samples were analyzed:older control(OC),older exercise(OE),younger control(YC),and younger exercise(YE).Single-cell RNA sequencing was used to distinguish cellular subtypes through their biomarker *** visualization included violin and t-SNE plots to illustrate biomarker expression across cell clusters such as oligodendrocytes,microglia,and ***,BV2 cells were exposed to amyloid-beta fragments to simulate Alzheimer’s disease,assessing the impact of exercise-induced cellular ***:Distinct cellular subtypes were identified:oligodendrocytes(MBP,St18),microglia(Dock8),and astrocytes(Aqp4,Gpc5).Sample OE was predominantly oligodendrocytes,while YE had more astrocytes,inhibitory neurons,and Canal-Retzius *** showed a significant presence of Olfm3+ganglion ***1 gene knockout revealed changes in SMAD family gene expression,which regulate *** stress levels were also ***:This profiling enhances our understanding of brain cellular functions and interactions,potentially informing targeted therapies in neurological *** may influence brain cell immune responses and cell death pathways by regulating specific gene expressions,offering new insights for treating neuroinflammation and degeneration.

关键词： single-cell transcriptomics brain tissue cellular subtypes biomarker expression neuronal diversity

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高管限薪方式与国有企业高质量发展

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经济问题 2025年第1期 70-78页

作者：吴秋生郑玥臻山西财经大学会计学院山西太原030012

2009年和2015年中华人民共和国人力资源和社会保障部和国务院国有资产监督管理委员会先后出台了国有企业高管限薪规定,采取了绝对限薪和相对限薪两种不同方式,因此,有必要明晰哪一种方式更有利于促进国有企业高质量发展。以2010—2023年... 详细信息

2009年和2015年中华人民共和国人力资源和社会保障部和国务院国有资产监督管理委员会先后出台了国有企业高管限薪规定,采取了绝对限薪和相对限薪两种不同方式,因此,有必要明晰哪一种方式更有利于促进国有企业高质量发展。以2010—2023年的A股国有企业为样本进行研究,结果表明:与绝对限薪相比,相对限薪更能够促进国有企业高质量发展,且相对限薪程度越高、内部控制质量越高,上述关系越明显。进一步研究发现,相对限薪促进国有企业发展质量提高是通过降低盈余管理、提高创新效率等路径实现的,且这种作用路径在产品市场竞争度高的国有企业和实体国有企业中更明显。研究结论对合理制定和有效实施限薪政策及提高企业内部控制质量,促进国有企业高质量发展具有启示意义。

关键词：绝对限薪相对限薪全要素生产率内部控制质量

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Hierarchical Human Action Recognition with Self-Selection Classifiers via Skeleton Data

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Communications in Theoretical Physics 2018年第11期69卷 633-640页

作者： ben-Yue Su Huang wu Min sheng Chuan-sheng Shen School of Computer and Information Anqing Normal UniversityAnqing 246133China The Key Laboratory of Intelligent Perception and Computing of Anhui Province Anqing 246133China School of Mathematics and Computational Science Anqing Normal UniversityAnqing 246133China

Human action recognition has become one of the most active research topics in human-computer interaction and artificial intelligence, and has attracted much attention. Here, we employ a low-cost optical sensor Kinect to capture the action information of the human skeleton. We then propose a two-level hierarchical human action recognition model with self-selection classifiers via skeleton data. Especially different optimal classifiers are selected by probability voting mechanism and 10 times 10-fold cross validation at different coarse grained levels. Extensive simulations on a well-known open dataset and results demonstrate that our proposed method is efficient in human action recognition, achieving 94.19%the average recognition rate and 95.61% the best rate.

关键词： human action recognition hierarchical architecture model self-selection classifiers optimal classification unit

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A study of a supersonic capsule/rigid disk-gap-band parachute system using large-eddy simulation

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Applied Mathematics and Mechanics(English Edition) 2021年第4期42卷 485-500页

作者： sheng GONG Chuijie wu School of Aeronautics and Astronautics Dalian University of TechnologyDalian 116024Liaoning ProvinceChina

The aerodynamic performances and flow features of the capsule/rigid disk-gap-band(DGB)parachute system from the Mach number 1.8 to 2.2 are *** use the adaptive mesh refinement(AMR),the hybrid tuned center-difference and weighted essentially non-oscillatory(TCD-WENO)scheme,and the large-eddy simulation(LES)with the stretched-vortex subgrid *** simulations reproduce complex interaction of the flow structures,including turbulent wakes and bow shocks,as well as bow shocks and expansion *** results show that the calculated aerodynamic drag coefficient agrees well with the previou *** the aerodynamic drag coefficient and the aerodynamic drag oscillation of the parachute system decrease with the increase of the initial Mach number of the *** is found that the position and angle of the bow shock ahead of the canopy change as the Mach number increases,which makes the flow inside the canopy and the turbulent wake behind the canopy more complex and unstable.

关键词： compressible flow adaptive mesh refinement(AMR) large-eddy simulation(LES) supersonic flow rigid disk-gap-band(DGB)parachute

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Numerical modeling of solute transport in deformable unsaturated layered soil

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Water Science and Engineering 2017年第3期10卷 184-196页

作者： sheng wu Dong-sheng Jeng Cities Research Institute Griffith School of EngineeringGriffith UniversitySouthport 4222Australia

The effect of soil stratification was studied through numerical investigation based on the coupled model of solute transport in deformable unsaturated soil. The theoretical model implied two-way coupled excess pore pressure and soil deformation based on Biot's consolidation theory as well as a one-way coupled volatile pollutant concentration field developed from the advection-diffusion theory. Embedded in the model, the degree of saturation, fluid compressibility, self-weight of the soil matrix, porosity variance, longitudinal dispersion, and linear sorption were computed. Based on simulation results of a proposed three-layer landfill model using the finite element method, the multi-layer effects are discussed with regard to the hydraulic conductivity, shear modulus, degree of saturation, molecular diffusion coefficient, and thickness of each layer. Generally speaking, contaminants spread faster in a stratified field with a soft and highly permeable top layer; soil parameters of the top layer are more critical than the lower layers but controlling soil thicknesses will alter the results. This numerical investigation showed noticeable impacts of stratified soil properties on solute migration results, demonstrating the importance of correctly modeling layered soil instead of simply assuming the averaged properties across the soil profile.

关键词： Solute transport Layered soil Consolidation Unsaturated soil Deformable media

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A latest Permian non-reef calcisponge fauna from Laibin,Guangxi,southern China and its significance

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Journal of Palaeogeography 2017年第1期6卷 60-68页

作者： Ya-sheng wu Key Laboratory of Petroleum Resource Research Chinese Academy of SciencesBeijing 100029China Institute of Geology and Geophysics Chinese Academy of SciencesBeijing 100029China University of Chinese Academy of Sciences Beijing 100049China

A calcisponge fauna occurs in uppermost Permian Conodont Clarkina meishanensis yini zone of the sequence exposed in the vicinity of Laibin, Guangxi Zhuang Autonomous Region, southern China. The fauna is dominated by one thalamid species, Arnblysiphonella vesiculosa de Koninck, 1863, and one new scterosponge genus and species, Radiofibrosclera laibinensis gen. et sp. nov. They are associated with a few other accessory species, including the thalamid sponges Amblysiphonella laibinensis Deng, 1981, Colospongia sp., Polvcystocoelia sp., and the inozoan sponge Acoelia discontinua sp. nov. Though the individuals are abundant, the species diversity is very low. Without common calcisponge components of Changhsingian reefal faunas, the assembtage is interpreted as not a reefal fauna. The water depth at which they dwelled was less than 105 m, and more probably tess than 40 m. Its occurrence indicates a significant sea-level drop at the end of Late Permian Changhsingian Age.

关键词： Upper Permian Calcisponge Laibin Palaeoecology Sclerosponge Tha[amid sponge Guangxi Southern China

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