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Preparing lipid nanoparticles with tunable drug loading capacity and morphology via improved sequential nanoprecipitation

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Science China Chemistry 2024年第5期67卷 1373-1374页

作者： Haoran Wang ben Zhong tang Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction Department of Chemistry.Institute of Molecular Functional MaterialsState Key Laboratory of NeuroscienceDivision of Biomedical Engineering and Division of Life ScienceThe Hong Kong University of Science and TechnologyHong Kong 999077China School of Science and Engineering Shenzhen Institute of Aggregate Science and Technology The Chinese University of Hong KongShenzhen(CUHK-Shenzhen)Shenzhen 518172China

Nanotechnology hailed as a revolutionary new technology of the 21st century, has ignited a wave of innovation across diverse fields spanning chemistry, physics, materials science,medicine, engineering, and electronics. In 2016, Nature published an article titled “The nanolight revolution is coming”, underscoring that “virus-sized particles that emit light in every color could transform applications ranging from television displays to cancer treatment”.

关键词： sized loading treatment

A Holistic View of Polymer Aggregate

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Chinese Journal of Polymer Science 2022年第3期40卷 231-232,I0004页

作者： ben Zhong tang Shenzhen Institute of Aggregate Science and Technology School of Science and EngineeringThe Chinese University of Hong KongShenzhenChina

Polymers are *** living kingdom is full of natural polymers or biological macromolecules(e.g.,polysaccharides,polynucleotides and proteins),while the modern society is alive with synthetic polymers or manmade macromol... 详细信息

关键词： rubber fibers

AIEgens in cell-based multiplex fluorescence imaging

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Science China Chemistry 2019年第10期62卷 1312-1332页

作者： Yabin Zhou Jin Hua ben Zhong tang Youhong tang Faculty of Biological Engineering Sichuan University of Science and EngineeringYibin 644000China Institute for NanoScale Science and Technology Medical Device Research InstituteCollege of Science and EngineeringFlinders UniversityTonsleySouth Australia 5042Australia Discipline of Medical Biochemistry College of Medicine and Public HealthFlinders UniversityBedford ParkSouth Australia 5042Australia Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Centre for Tissue Restoration and ReconstructionDivision of Biomedical EngineeringThe Hong Kong University of Science and TechnologyHong KongChina

Fluorescence imaging is an important branch of *** is non-invasive and provides superior spatial and temporal resolution during the real-time monitoring of biological samples of *** the spatial resolution limit of optical microscopes is about 200 nm,due to the diffraction limit,with the application of super-resolution fluorescence microscopy technologies this limit has been pushed below 30 *** makes it feasible to visualize biological structures in subcellular levels and to monitor subcellular biological processes in real ***,due to the complexity of the biological structure and components within cells,simultaneous staining and monitoring multiple intracellular components with different coloured fluorophores is often needed during multiplex imaging,to better understand biological ***-induced emission luminogens(AIEgen)and AIEgen based nanoparticles(NPs)have presented many advantages in fluorescence imaging,with strong potential for biological science and *** this review,we focus on the advantages of AIEgen and AIEgen NP in cell-based fluorescence imaging,and the latest advances of AIEgens in cell-based multiplex imaging are summarized and *** future perspectives are proposed.

关键词： aggregation induced emission cell imaging multiplex

Green Monomer of CO_(2) and Alkyne-based Four-component Tandem Polymerization toward Regio-and Stereoregular Poly(aminoacrylate)s

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Chinese Journal of Polymer Science 2021年第1期39卷 51-59,I0006页

作者： Bo Song An-Jun Qin ben Zhong tang State Key Laboratory of Luminescent Materials and Devices Guangdong Provincial Key Laboratory of Luminescence from Molecular AggregatesCenter for Aggregation-Induced EmissionSouth China University of TechnologyGuangzhou 510640China Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Centre for Tissue Restoration and ReconstructionInstitute for Advanced StudyDepartment of Chemical and Biological EngineeringThe Hong Kong University of Science&TechnologyHong KongChina

Green monomers, such as carbon dioxide(CO_(2)), are closely related to our daily life and highly desirable to be transferred to functional polymers with diverse structures and versatile properties because they are abundant, cheap, nontoxic, renewable, and sustainable. However, the polymerizations based on these green monomers are to be further developed. In this work, a facile CO_(2) and alkyne-based one-pot, two-step, fourcomponent tandem polymerization was successfully established. The polymerization of CO_(2), diynes, alkyl dihalides, and primary/secondary amines can proceed under mild reaction conditions and regio-and stereoregular poly(aminoacrylate)s with good solubility and thermal stability were obtained in high yields(up to 95%). Notably, distinctly different stereoregularity of resultant poly(aminoacrylate)s was realized via using primary or secondary amines. Using the former would readily generate polymers with 100% Z-isomers, whereas the latter furnished products with over 95% E-isomers. Through different monomer combination, the polymers with tunable structures and properties were ***, the tetraphenylethene units containing poly(aminoacrylate)s, showing the unique aggregation-induced emission characteristics,could function as a fluorescent probe for sensitive explosive detection. Thus, this work not only develops a facile CO_(2) and alkyne-based multicomponent tandem polymerization but also provides a valuable strategy to fine-tune the polymer structures and properties, which could be potentially applied in diverse areas.

关键词： Carbon dioxide Multicomponent tandem polymerization Aggregation-induced emission Green monomer

Special topic on research frontier in polymer science in China

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Science China Chemistry 2016年第12期59卷 1529-1530页

作者： Anjun Qin ben Zhong tang State Key Laboratory of Luminescent Materials and Devices South China University of Technology Guangzhou 510640. China Department of Chemistry Hong Kong Branch of National Engineering Research Center for Tissue Restoration and Reconstruction The Hong Kong University of Science & Technology Clear Water Bay Kowloon Hong Kong China

Polymer science is a multiple discipline that studies synthe- sis, structure, function and application of macromolecules. It encompasses subdisciplines of polymer chemistry, phys- ics and engineering. Despite the fact... 详细信息

关键词： Special topic on research frontier in polymer science in China

Special topic on aggregation-induced emission

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Science China Chemistry 2018年第8期61卷 879-881页

作者： Anjun Qin ben Zhong tang State Key Laboratory of Luminescent Materials and Devices Center for Aggregation-Induced Emission Guangzhou International CampusSouth China University of Technology Department of Chemistry Hong Kong Branch of National Engineering Research Center for Tissue Restoration and Reconstruction Institute for Advanced Study and Department of Chemical and Biological Engineering The Hong Kong University of Science & Technology

Aggregation-induced emission（AIE）,conceptually termed in 2001 by our group at the Hong Kong University of Science＆Technology,refers to a unique phenomenon that a kind of nonemissive or weakly emissive molecules in ... 详细信息

关键词： AIE In BODIPY Special topic on aggregation-induced emission

Multicomponent Tandem Polymerization of Aromatic Alkynes, Carbonyl Chloride, and Fischer's Base toward Poly(diene merocyanine)s

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Chinese Journal of Chemistry 2019年第12期37卷 1264-1270页

作者： Xiaojuan tang Lihui Zhang Rongrong Hu ben Zhong tang State Key Laboratory of Luminescent Materials and Devices Center for Aggregation-Induced EmissionSouth China University of TechnologyGuangzhouGuangdong 510640China Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Centre for Tissue Restoration and ReconstructionThe Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina

Summary of main observation and conclusion Multicomponent polymerization(MCP)is a popular tool to construct polymers with diverse structure,simple operation,and high efficiency,which faces the challenges of limited product *** tandem polymerization(MCTP),combining two or multiple reactions in a one-pot fashion,could expand the scope of MCP and enrich the polymer ***,a one-pot three-component tandem polymerization of diynes,carbonyl chloride,and Fischer's base has been developed to afford conjugated poly(diene merocyanine)s with mild condition,satisfactory molecular weights(Mw up to 10900 g/mol)and yields(up to 81%).The polymers enjoy good solubility and high thermal *** unique emission behavior of the model compound and polymer show that they are aggregation-induced emission(AIE)-active,suggesting that the diene merocyanine moiety is a potential *** MCTP shows great potential in the preparation of functional polymer materials,which could build new AlE functional units directly from the polymerization,demonstrating its synthetic simplicity and elegance.

关键词： stability. cyanine polymerization

Signaling pathways of chronic kidney diseases,implications for therapeutics

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Signal Transduction and Targeted Therapy 2022年第7期7卷 2245-2271页

作者： Qian Yuan ben tang Chun Zhang Department of Nephrology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Chronic kidney disease(CKD)is a chronic renal dysfunction syndrome that is characterized by nephron loss,inflammation,myofibroblasts activation,and extracellular matrix(ECM)*** and oxidative stress are the driving force for the loss of nephron including tubules,glomerulus,and ***3 inflammasome signaling,MAPK signaling,PI3K/Akt signaling,and RAAS signaling involves in *** upregulated Nox expression and the decreased Nrf2 expression result in oxidative stress *** injured renal resident cells release proinflammatory cytokines and chemokines to recruit immune cells such as macrophages from bone ***-κB signaling,NLRP3 inflammasome signaling,JAK-STAT signaling,Toll-like receptor signaling,and cGAS-STING signaling are major signaling pathways that mediate inflammation in inflammatory cells including immune cells and injured renal resident *** inflammatory cells produce and secret a great number of profibrotic cytokines such as TGF-β1,Wnt ligands,and angiotensin ***-βsignaling,Wnt signaling,RAAS signaling,and Notch signaling evoke the activation of myofibroblasts and promote the generation of *** potential therapies targeted to these signaling pathways are also introduced *** this review,we update the key signaling pathways of lipotoxicity,oxidative stress,inflammation,and myofibroblasts activation in kidneys with chronic injury,and the targeted drugs based on the latest *** these pathways and the targeted therapies will be instrumental to advance further basic and clinical investigation in CKD.

关键词： NLRP3 inflammation kidney

A divergent and stereoselective synthetic strategy for tetraarylethylene-based AIEgens

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National Science Review 2021年第6期8卷 8-9页

作者： Zheng Zhao ben Zhong tang School of Chemistry and Chemical Engineering Southeast University Department of Chemistry The Hong Kong University of Science and Technology HKUST-Shenzhen Research Institute Center for Aggregation-Induced Emission State Key Laboratory of Luminescent Materials and DevicesSouth China University of Technology

Since the coinage of the concept of aggregation-induced emission (AIE)in 2001 [1], AIE molecules have been widely utilized as biological probes, chemical sensors, and optoelectronic and stimuli-response materials[2]. Tetraarylethylenes (TAEs) are archetype luminogens with an AIE attribute (AIEgens) and have been used as frameworks for further functionalizations, structure-property relationship studies and application explorations[3]. According to the aryl substituents,

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