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Investigation of Extracts from Tunisian Ethnomedicinal Plants as Antioxidants,Cytotoxins,and Antimicrobials

Biomedical and Environmental Sciences 2017年第11期30卷 811-824页

作者： Guesmi Fatma ben hadj ahmed sami Landoulsi ahmed Laboratory of Biochemistry and Molecular Biology Faculty of Sciences of BizerteUniversity of CarthageZarzouna 7021Tunisia Laboratory of Protein Engineering and Bioactive Molecules(LIP-MB) National Institute of Applied Sciences and Technology(INSA T)BP 6761080 Tunis CedexTunisia

Objective To determine the medicinal potential of various plants and their parts extracted with different solvents. Methods The total phenolic content of acetonitrile/water（60%-40%）（ACN/W） and aqueous（W） extract fractions was determined by high-performance liquid chromatography（HPLC）, and terpenic compounds were detected by gas chromatography/mass spectrometry（GC/MS）. Antioxidant activity of the samples was evaluated using 2,2-diphenyl-1-picrylhydrazyl（DPPH） assay and β-carotene bleaching method. Cell viability was investigated by thiazolyl blue tetrazolium bromide [3-（4,5-dimethylthiazol）-2-yl 2,5-diphenyltetrazolium bromide]（MTT） assay. The mechanisms involved in cytotoxic activity were investigated in a murine macrophage cell line（RAW 264.7） and cancer lines. Results Our findings show that 11 plant species exhibited biological activity. In addition, moderate antibacterial activity was reported against one or more of the tested bacterial strains at two concentrations： 300 μg and 3 mg/disc. Furthermore, our data reveal that among all plants investigated, some extract and hydrophobic fractions were potent scavengers of the DPPH radical（6.78 μg/m L 〈 EC50 〈 8.55 μg/mL）. Taken together, our results show that Nerium oleander（NOACN/W） and Pituranthos tortuosus（PTACN/W） were highly cytotoxic against RAW 264.7 cells with IC80 values of 0.36, and 1.55 μg/mL, respectively. In contrast, murine macrophage cell lines had low growth and were significantly sensitive to water extracts of Thymus hirtus sp. algeriensis（THW）, Lavandula multifida（LMW）, and ACN/W extract of Erica multiflora（EMACN/W） at doses 〉 400, 47.20, and 116.74 μg/m L, respectively. The current work demonstrates that RAW 264.7 cell proliferation was inhibited by samples in a dose-dependent manner. Conclusion Our findings, validated through free radical scavenging activity, agar diffusion assay, and cytotoxicity of essential oils towards cancer cells, show that ethnomedicinal plants used in this work have a novel

关键词： Phenolic compounds Cytotoxicity Antioxidant Antibacterial

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Metastatic Colorectal Cancer: Evolution of the Response Rate and Survival with Therapeutic Progress

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Open Journal of Gastroenterology 2016年第5期6卷 127-135页

作者： Amira Daldoul Olfa Gharbi Laila ben Fatma Imene Chabchoub Sonia Zaied Khaled ben ahmed Faten Ezzairi Makrem Hochlef Imtinene Belaid sami Limem Slim ben ahmed Oncological Medical Department of the University Hospital of Sousse Sousse Tunisia Oncological Medical department of the University Hospital of Monastir Monastir Tunisia

Introduction: The therapeutic strategy for metastatic colorectal cancer (mCRC) has evolved greatly in the last two decades. This study aimed to compare patients with mCRC treated at the University Hospital of Sousse (Tunisia) through three periods, in terms of treatment strategy;objective response rate (ORR) to chemotherapy;median overall survival (OS) and prognostic factors conditioning OS. Methods: This was a retrospective study covering the period from January 1994 to December 2011. It involved 401 patients with mCRC divided into three groups: group 1 (G1) including patients treated in the period 1994-1998, group 2 (G2) including patients treated in the period 1999-2005 and group 3 (G3) including patients treated in the period 2006-2011. Results: The ORR after 3 cycles of first line chemotherapy was 33%, 50% and 57.8% for G1, G2 and G3 respectively. The median OS was 13.8 months for G1, 19 months for G2 and 23 months for G3. The prognostic factors associated with a better OS for G3 were absence of initial tumor complication, normal initial level of carcinoembryonic antigen, normal liver function tests, surgery of the primary tumor, surgery of liver metastases and the ORR after three cycles of first line chemotherapy. Conclusion: The development of the therapeutic strategy, whatever of medical or surgical nature, has led to improved response rates and survival of patients treated for mCRC.

关键词： Colorectal Neoplasms Prognosis Chemotherapy Metastasis

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Primary Synovial Sarcoma of the Kidney: A Case Report

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Journal of Cancer Therapy 2021年第10期12卷 579-584页

作者： Nouha Ammar Imene Chabchoub Rihab ben Jaafar Hiba Sboui Makram Hochlef Faten Ezzaairi sami Sfar Imtinane Belaid Leila ben Fatma Manel Njim Nadia Bouzid Mohsen Belguith Rzig ahmed Zakhama Abdelfateh Slim ben ahmed Medical Onocology Department University Hospital Farhat Hached Sousse Tunisia Pediatric Surgery Department University Hospital Fatouma Bourguiba Monastir Tunisia Anathomopathology Department University Hospital Fatouma Bourguiba Monastir Tunisia Radiotherapy Department University Hospital Farhat Hached Sousse Tunisia Radiology Department University Hospital Fatouma Bourguiba Monastir Tunisia

Synovial sarcoma originating from the kidney is extremely rare. A 13-year-old girl presented with a mild left flank pain of one-week duration, with no associated history of hematuria or any other systemic symptoms. Computed tomography (CT) demonstrated a 6 × 13 × 9 cm mass in the left kidney. No soft tissue or extrarenal masses were identified. The patient received a combined of treatment with doxorubicin and ifosfamide. A radical nephrectomy was performed in the left kidney with no complications. Postoperative pathology revealed post-chemotherapy residue of monophasic spindle cell synovialosarcoma of the left kidney. She received a combined treatment with doxorubicin and ifosfamide in concomittance with external radiation therapy. The patient was re-examined 4 months after surgery. An abdominal and pulmonary CT found no recurrence or metastasis.

关键词： Synovial Sarcoma Kidney

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Association of hepatitis C virus infection and diabetes in central Tunisia

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World Journal of Gastroenterology 2009年第22期15卷 2778-2781页

作者： Naoufel Kaabia Elhem ben Jazia Ines Slim Imen Fodha Wissem Hachfi Rafika Gaha Mabrouk Khalifa Aoutef hadj Kilani Halim Trabelsi ahmed Abdelaziz Fethi Bahri Amel Letaief Department of Internal Medicine and Infectious Disease Unit of Research:04/UR/08-21University Hospital Farhat Hached Microbiology Unit University Hospital Sahloul Epidemiology Unit University Hospital Farhat Hached Department of Medicine Msaken hospital

AIM：To investigate hepatitis C virus （HCV） seroprevalence in Tunisian patients with diabetes mellitus and in a control group. METHODS： A cross-sectional study was conducted to determine the HCV seroprevalence in 1269 patients with diabetes （452 male, 817 female） and 1315 nondiabetic patients, attending health centers in Sousse, Tunisia. HCV screening was performed in both groups using a fourth-generation enzyme immunoassay. RESULTS： In the diabetic group, 17 （1.3%） were found to be HCV-infected compared with eight （0.6%） in the control group, although the difference was not significant （P = 0.057）. Quantitative PCR was performed in 20 patients. Eleven patients were positive and showed HCV genotype lb in all cases. CONCLUSION： Frequency of HCV antibodies was low in patients with diabetes and in the control group in central Tunisia, with no significant difference between the groups.

关键词： Hepatitis C virus Diabetes mellitus Tunisia Epidemiology Autoantibodies Hepatitis

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Primary Prostatic Tuberculosis: A Rare Entity

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Open Journal of Urology 2022年第2期12卷 129-135页

作者： Tiéoulé Mamadou Traore Abdoul Kader Tapsoba Kays Chaker Amine Hermi Kheireddine Mrad Dali Mokhtar Bibi Yassine Ouanes ahmed Sellami sami ben Rhouma Yassine Nouira University of Ouahigouya Ouahigouya Burkina Faso Department of Urology La Rabta Hospital Tunis Tunisia University of Joseph Ki-Zerbo Ouagadougou Burkina Faso Faculty of Medicine of Tunis University Tunis Manar Tunis Tunisia

Objectives: To clarify the clinical, histological and therapeutic features of prostatic tuberculosis. Methods: We conducted a single-centre retrospective descriptive study of all patients presenting with prostatic tuberculosis between January 2002 and December 2020. Patients who were lost to follow-up, could not be reached by telephone or whose records were not usable were excluded from this study. Results: 240 patients were treated for urogenital tuberculosis, including 13 for isolated prostatic tuberculosis. The average age of the patients was 75 years. None of our patients had a history of tuberculosis. The average of international prostate symptom score (IPSS) was 27. Lower urinary tract symptoms in the filling phase were predominant. The digital rectal examination was suspicious in only one patient. The mean preoperative PSA was 9.24 ng/ml. 46.15% of patients underwent transurethral resection of the prostate and 53.85% underwent ultrasound-guided prostate biopsy. Histological examination showed epithelioid gigantocellular granuloma with isolated caseous necrosis in 61.53% of patients and associated adenomyomatous hyperplasia in 38.47% of patients. Antituberculosis treatment was given for 6 months. The average of follow up was 15 months. All patients reported an improvement in clinical signs with a mean post operative IPSS score of 17 and a normalisation of PSA levels. Conclusion: Isolated prostatic tuberculosis is a rare entity, it can simulate a cancer. In front of the symptoms of the lower urinary tract, the clinicians must think of it especially in the developing countries where tuberculosis still prevails in an endemic state.

关键词： Prostatic Tuberculosis Epithelioid Gigantocellular Granuloma Antituberculosis Treatment

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A comparative study of a direct and pulse electrodeposition method of TiO_(2)films and its effect on photoelectrocatalytic degradation of methyl orange dye

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Optoelectronics Letters 2021年第6期17卷 334-341页

作者： Khadidja hadj Larbi Farid Habelhames Meriem Lakhdari Farid bennabi Belkacem Nessark Mehdi Adjdir Abdelkader Echchergui Nebatti Bouhalouane Amrani Laboratoire d'électrochimie et matériaux(LEM) Facultéde TechnologieDépartement de génie des procédésUniversitéFerhat Abbas Sétif-1Sétif19000Algérie Laboratory of Applied Chemistry University ofAin-Temouchent Belhadj BouchaibAlgeria Laboratory of Applied Organic Synthesis Faculty of Exact and Applied SciencesUniversity Oran1 Ahmed Ben BellaBP 1524 El M'NaouerOran 31000Algeria Laboratory of Materials Sciences and Applications(LMSA) University of Ain-Temouchent Belhadj BouchaibAlgeria Electron Microscopy Center Faculty of Exact and Applied SciencesUniversity of Oran1 Ahmed Ben BellaOranAlgeria

The present study reports the titanium dioxide(TiO_(2))films synthesized from TiCl3 precursor on ITO glass substrates using two electrochemical techniques,namely direct electro-deposition(DE)and pulse electro-deposition(PE).The synthesis potential during the time-on(Ton)period was fixed at-1.5 ***,the open-circuit potential was applied during the time-off(Toff)*** effect of the technique of electro-deposition and Toff duration on the properties of TiO_(2)films and their photoelectron-catalytic activity were *** obtained films were investigated by X-ray diffraction(XRD),scanning electron microscopy(SEM),UV-VIS spectrometer,and photocurrent measurement *** is found that the use of the PE technique at different Toff improves the properties of TiO_(2)films compared to the DE *** XRD patterns show the anatase phase with a marked preferential orientation along the(101)direction for all *** the SEM analysis,it is seen a significant change from big multigrain agglomerates at DE to a dense film structure and small multigrain agglomerates at different *** the Toff decreases from 3 s to 1 s,the photocurrent response rises and reaches a high value of about 12 m A/cm^(2).Compared with DE,and under UV light the photocatalytic property of TiO_(2)film synthesis via PE has been improved in the degradation of methyl orange(MO).Finally,the films deposited at low Toff(Toff=1 s)show a faster degradation of MO.

关键词： films orange effect

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