检索结果-南通市图书馆

Fine Mapping of a Deafness Mutation hml on Mouse Chromosome 10

在线全文

学校读者我要写书评

暂无评论

Journal of Pharmaceutical Analysis 2004年第1期16卷 91-91页

作者： belinda s harris Patricia F Ward-Bailey Roderick T Bronson Muriel T Davisson Kenneth R Johnson The Jackson Laboratory The Jackson LaboratoryThe Jackson LaboratoryThe Jackson LaboratoryThe Jackson Laboratory Bar Harbor Maine 04609 USA Bar Harbor Maine 04609 USA Bar Harbor Maine 04609 USA Bar Harbor Maine 04609 USA Bar Harbor Maine 04609 USA

Objective To map a mouse deafness gene, identify the underlying mutation and develop a mouse model for human deafness. Methods Genetic linkage cross and genome scan were used to map a novel mutation named hypoplasia of the membranous labyrinth (hml), which causes hearing loss in mutant mice. Results ① hml was mapped on mouse Chr 10 (～43 cM from the centromere) suggests that the homologous human gene is on 12q22-q24, which was defined on the basis of known mouse-human homologies (OMIM, 2004). ② This study has generated 25 polymorphic microsatellite markers, placed 3 known human genes in the correct order in a high-resolution mouse map and narrowed the hml candidate gene region to a 500 kb area.

关键词： mouse deafness mutation

A review of progress on nano-aperture VCsEL Invited Paper

在线全文

学校读者我要写书评

暂无评论

Chinese Optics Letters 2008年第10期6卷 748-754页

作者： sonny Vo James s.harris solid state and Photonics Laboratory Stanford UniversityStanfordCalifornia94305USA

This paper reviews the progress on nano-aperture vertical-cavity surface-emitting lasers （VCsELs）. The design, fabrication, and polarization control of nano-aperture VCsELs are reviewed. With the nanoaperture evolving from conventional circular and square aperture to unique C-shaped, H-shaped, I-shaped, and bowtie-shaped aperture, both the near-field intensity and near-field beam confinement from nanoaperture VCsELs are significantly improved. As a high-intensity compact light source with sub-100- nm spot size, nano-aperture VCsELs are promising to realize many new near-field optical systems and applications.

关键词： VCsEL view A review of progress on nano-aperture VCsEL Invited Paper

Xyloglucans of Monocotyledons Have Diverse structures

在线全文

学校读者我要写书评

暂无评论

Molecular Plant 2009年第5期2卷 943-965页

作者： Yves s.Y. Hsieh Philip J. harris school of Biological sciences The University of Auckland Private Bag 92019 Auckland New Zealand

Except in the Poaceae, little is known about the structures of the xyloglucans in the primary walls of monocotyledons. Xyloglucan structures in a range of monocotyledon species were examined. Wall preparations were isolated, extracted with 6 M sodium hydroxide, and the extracts treated with a xyloglucan-specific endo-（1→4）-β-glucanase preparation. The oligosaccharides released were analyzed by high-performance anion-exchange chromatography and by matrix-assisted laser-desorption ionization time-of-flight mass spectrometry. Oligosaccharide profiles of the non-commelinid monocotyledons were similar to those of most eudicotyledons, indicating the xyloglucans were fucogalactoxyloglucans, with a XXXG a core motif and the fucosylated units XXFG and XLFG. An exception was Lemna minor （Araceae）, which yielded no fucosylated oligosaccharides and had both XXXG and XXGn core motifs. Except for the Arecales （palms） and the Dasypogonaceae, which had fucogalactoxyloglucans, the xyloglucans of the commelinid monocotyledons were structurally different. The Zingiberales and Commelinales had xyloglucans with both XXGn and XXXG core motifs; small proportions of XXFG units, but no XLFG units, were present. In the Poales, the Poaceae had xyloglucans with a XXGn core motif and no fucosylated units. In the other Poales families, some had both XXXG and XXGn core motifs, others had only XXXG; XXFG units were present, but XLFG units were not.

关键词： Commelinid monocotyledons non-commelinid monocotyledons plant cell walls Poaceae xyloglucans xyloglucan-specific endo-(1→4)-β-glucanase.

1.3~1.55μm GAInNAssb Lasers

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

光学学报 2003年第S1期23卷 313-314页

作者： James s. harris solid state and Photonics Lab Stanford University Stanford CA 94305-4075

The realization of long wavelength lasers on GaAs provides the opportunity to produce both much lower cost vertical cavity lasers and high power lasers. Results of work on the GaInNAssb system to realize such lasers a... 详细信息

关键词： GaAs very as In that m GAInNAssb Lasers been from for of in with sb

Geochemical and Pb-sr-Nd isotopic compositions of granitoids from western Qinling belt: Constraints on basement nature and tectonic affinity

在线全文

学校读者我要写书评

暂无评论

science China Earth sciences 2007年第2期50卷 184-196页

作者： Nigel harris Department of Earth sciences The Open University Milton Keynes MK7 6AA UK

Geochemical and Pb-sr-Nd isotopic compositions of five Indosinian granitoid intrusions from the western Qinling belt provide insights into basement nature and tectonic affinity. The results show that the western Qinling granitoids incline towards basic in their bulk chemical composition. The granitoids belong to high-K to shoshonitic series with K2O/Na2O=1.04-1.86 and are dominantly metaluminous with A/CNK=0.90-1.05 (most samples have A/CNK of similar trace elemental compo- sitional patterns. In sr-Nd isotopic compositions, they display some extent heterogeneity with Isr=0.70682-0.70845, εNd(t)=?4.85 to ?9.17 and TDM=1.26-1.66 Ga. They are characterized by high ra- diogenic Pb isotopic compositions. Their initial Pb isotopic ratios are 206Pb/204Pb=17.996-18.468, 207Pb/204Pb=15.565-15.677 and 208Pb/204Pb=38.082-38.587. Geochemical and sr-Nd isotopic composi- tions reveal that magma for the granitoids was derived from partial melting of high-K (Rb) basaltic rocks, which might be formed in 900-1400 Ma. It is suggested that a large amount of the Proterozoic high-K (Rb) basaltic rocks, which underlie the Phanerozoic sedimentary cover, constitute the crustal basement of the western Qinling belt. Pb-sr-Nd isotopic compositional comparison between the east- ern Qinling and the western Qinling Indosinian granitoids indicates that the crustal basement of the western Qinling is distinct from that of the eastern Qinling. The Baoji-Chengdu railway close to south-north orientation can be taken as an approximate boundary between both basements. The Pb-Nd isotopic compositional characteristics of the western Qinling granitoids suggest that the basement of the western Qinling belt has an affinity with the Yangtze block.

关键词： granitoid geochemistry basement nature tectonic affinity West Qinling

Management of ejaculatory disorders in infertile men

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2012年第4期14卷 525-529页

作者： Yagil Barazani Peter J stahl harris M Nagler Doron s stember Beth Israel Medical Center and the Albert Einstein College of Medicine of Yeshiva University New YorkNew York 10003USA Department of Urology Columbia University Medical CenterNew YorkNY 10003USA

Ejaculatory dysfunction is a highly prevalent clinical condition that may be classified along a continuum that ranges from premature ejaculation （PE）, through retarded or delayed ejaculation （DE）, to complete anejaculation （AE）. Retrograde ejaculation （RE） represents a distinct entity in which ejaculate is expelled either partially or completely into the bladder. While DE and PE are significant sources of sexual dissatisfaction among men and their partners, patients with these disorders retain normal fertility in most cases. Conversely, men with AE and RE are unable to deliver sperm into the female genital tract and are therefore rendered subfertile. Therefore, in reviewing ejaculatory disorders as they relate to fertility, this paper will primarily focus on the diagnosis and management of AE and RE. Physiology, diagnostic strategies, pharmacological treatments, and procedural interventions relevant to AE and RE are discussed.

关键词： anejaculation delayed ejaculation ejaculatory dysfunction electroejaculation penile vibratory stimulation prematureejaculation retrograde ejaculation

sexual medicine disparities between Asia and North America： commentary on male sexual dysfunction in Asia

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2011年第4期13卷 605-606页

作者： Benjamin F Katz Doron s stember harris M Nagler Beth Israel Medical Center and the Albert Einstein College of Medicine of Yeshiva University 1300 Morris Park Avenue Bronx NY 10461 USA

In a recently published article in Asian Journal of Andrology, Ho et al.1 examine prevalence, attitudes, and treatment patterns related to sexual dysfunction in Asia and contrast them with those of Western society. They highlight the relative paucity of data with respect to erectile dysfunction （ED）, premature ejaculation, and hypogonadism in the Asian population.

关键词： sexual North America

Advances in targeted nanotherapeutics： From bioconjugation to biomimicry

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2018年第10期11卷 4999-5016页

作者： Danielle M. Valcourt Jenna harris Rachel s. Riley Megan Dang Jianxin Wang Emily s. Day 161 Colburn L ab Department of Biomedical Engineering University of Delaware Newark DE 19716 USA 201 DuPont Hall Department of Materials Science & Engineering University o f Delaware Newark DE 79716 USA 4701 Ogletown stanton Road Helen F. Graham Cancer Center & Research Institute Newark DE 19713 USA

since the emergence of cancer nanomedicine, researchers have had intense interest in developing nanoparticles （NPs） that can specifically target diseased sites while avoiding healthy tissue to mitigate the off-target effects seen with conventional treatments like chemotherapy. Initial endeavors focused on the bioconjugation of targeting agents to NPs, and more recently, researchers have begun to develop biomimetic NP platforms that can avoid immune recognition to maximally accumulate in tumors. In this review, we describe the advantages and limitations of each of these targeting strategies. First, we review developments in bioconjugation strategies, where NPs are coated with biomolecules such as antibodies, aptamers, peptides, and small molecules to enable cell-specific binding. While bioconjugated NPs offer many exciting features and have improved pharmacokinetics and biodistribution relative to unmodified NPs, they are still recognized by the body as ＂foreign＂, resulting in their clearance by the mononuclear phagocytic system （MPs）. To overcome this limitation, researchers have recently begun to investigate biomimetic approaches that can hide NPs from immune recognition and reduce clearance by the MPs. These biomimetic NPs fall into two distinct categories： synthetic NPs that present naturally occurring structures, and NPs that are completely disguised by natural structures. Overall bioconjugated and biomimetic NPs have substantial potential to improve upon conventional treatments by reducing off-target effects through site-specific delivery. and they show great promise for future standards of care. Here, we provide a summary of each strategy, discuss considerations for their design moving forward, and highlight their potential clinical impact on cancer therapy.

关键词： targeting nanoparticles cancer biomimicry bioconjugation delivery

A New semi-Lagrangian Finite Volume Advection scheme Combines the Best of Both Worlds

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Atmospheric sciences 2021年第9期38卷 1608-1609页

作者： Lucas harris NOAA/Geophysical Fluid Dynamics Laboratory Princeton University Forrestal Campus201 Forrestal RoadPrincetonNJ 08540-6649USA

Advection,or transport by wind,is fundamental to numerical weather and climate *** is especially important to solve the equations governing the distribution of heat,moisture,pollutants,and so *** classes of advection schemes have become dominant in recent ***-Lagrangian (sL;Diamantakis,2013) methods form the advection equation in its"Lagrangian"or flow-following form and use the winds (either prescribed or predicted) to trace trajectories backwards from a grid point to their original location on the previous time step.

关键词： prescribed backward Finite