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ADAM12 is a costimulatory molecule that determines Th1 cell fate and mediates tissue inflammation

Cellular & Molecular Immunology 2021年第8期18卷 1904-1919页

作者： Yawei Liu Robert Bockermann Mahdieh Hadi Iman Safari belinda carrion Marie Kveiborg Shohreh Issazadeh-Navikas Neuroinflammation Unit Biotech Research&Innovation Centre(BRIC)Faculty of Health and Medical SciencesUniversity of CopenhagenOle Maaløes Vej 5DK-2200Copenhagen NDenmark BRIC Faculty of Health and Medical SciencesUniversity of CopenhagenOle Maaløes Vej 5DK-2200Copenhagen NDenmark

A disintegrin and metalloproteinase(ADAM)12 was previously found to be expressed in T cells in the inflamed ***,the function of ADAM12 in T-cell responses in general and in tissue inflammation has not been ***,we studied the role of ADAM12 in T-cell responses,fate determination on activation,and its functions in T cells to mediate tissue *** identified ADAM12 as a costimulatory molecule that is expressed on naive T cells and downregulated on ***12 mimics CD28 costimulatory signaling to activate and induce the proliferation of T-helper 1(Th1)*** ADAM12 Fab antibodies trigger T-cell activation by amplifying TCR signaling to stimulate T-bet-mediated IFNγ*** of genomic ADAM12 and its knockdown in T cells diminished T-bet and IFNγproduction in Th1 cells,whereas other T cells,including Th17 cells,were ***12 had similar functions in vivo on myelin antigen(MOG_(35-55))-induced T-cell *** found that genetic loss of ADAM12 profoundly alleviated Th1-mediated neuroinflammation and thus disease severity in experimental autoimmune encephalomyelitis,a model of multiple *** profiling of MOG_(35-55)-specific ADAM12^(−/−)T cells revealed differentially expressed genes that are important for T-cell activation,proliferation,and costimulatory signaling and Th1 pathogenicity,consistent with their inability to cause T-cell-mediated skin inflammation in a model of adoptive delayed-type *** conclude that ADAM12 is a T-cell costimulatory molecule that contributes to the pathogenesis of tissue inflammation and a potential target for the treatment of Th1-mediated diseases.

关键词： T cells T-bet Th17 EAE DTH GM-CSF

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Real-time hybrid simulation for structural control performance assessment

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Earthquake Engineering and Engineering Vibration 2009年第4期8卷 481-492页

作者： Juan E carrion BF Spencer Jr Brian M Phillips Skidmore Owings & Merrill LLP Civil and Environmental Engineering Department University of Illinois

Real-time hybrid simulation is an attractive method to evaluate the response of structures under earthquake loads. The method is a variation of the pseudodynamic testing technique in which the experiment is executed in real time, thus allowing investigation of structural systems with rate-dependent components. Real-time hybrid simulation is challenging because it requires performance of all calculations, application of displacements, and acquisition of measured forces, within a very small increment of time. Furthermore, unless appropriate compensation for actuator dynamics is implemented, stability problems are likely to occur during the experiment. This paper presents an approach for real-time hybrid simulation in which compensation for actuator dynamics is implemented using a model-based feedforward compensator. The method is used to evaluate the response of a semi-active control of a structure employing an MR damper. Experimental results show good agreement with the predicted responses, demonstrating the effectiveness of the method for structural control performance assessment.

关键词： real-time hybrid simulation MR damper semi-active control actuator dynamics

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Development and implementation of a validation protocol for crisis maps: reliability and consistency assessment of burnt area maps

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International Journal of Digital Earth 2011年第S1期4卷 8-24页

作者： C.Corbane D.carrion M.Broglia European Commission Joint Research CentreIspraItaly

Validation is an emerging topic in the field of geospatial information for emergency *** the framework of the Global Monitoring for Environment and Security initiative,the Services and Applications for Emergency Response project seeks to implement and validate the pre-operational version of Emergency Response Core *** that context,a dedicated effort has been made in the development and implementation of a comprehensive,productoriented validation protocol tailored to crisis maps and data *** paper presents the approach for validation of crisis maps and its application in the context of rapid mapping of forest fires in Corsica during the summer of *** also discusses the main challenges and the critical aspects of validation of geospatial information in emergency response services.

关键词： validation protocol crisis mapping remote sensing forest fires

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Ventral phalloplasty

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Asian Journal of Andrology 2008年第1期10卷 155-157页

作者： Jorge Caso Michael Keating Alejandro Miranda-Sousa Rafael carrion Division of Urology Department of Interdisciplinary Oncology University of South Florida Tampa FL 33612 USA

Aim： To present a simple technique during penile prosthesis implantation that promotes the perception of increased phallic length. Methods： The penoscrotal web is defined. A ＂check mark＂ incision is made with excision of scrotal tissue. Excellent exposure is provided for implantation of the cylinders, pump and reservoir. Wound closure is performed longitudinally. Results： This technique is a modified extension of surgeries described in the pediatric literature for webbed penis. Loss of penile length following penile implantation surgery is worrisome for patients suffering from erectile dysfunction （ED）. This technique helps with patient satisfaction, cosmetic results, and improves perception of penile length. Conclusion： Ventral phalloplasty is a safe, technically simple procedure that may be performed in concert with penile prosthesis implantation or as a stand alone procedure under＇certain circumstances.

关键词： penile implantation impotence phalloplasty genital lengthening

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Patient satisfaction and penile morphology changes with postoperative penile rehabilitation 2 years after Coloplast Titan prosthesis

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Asian Journal of Andrology 2016年第5期18卷 754-758页

作者： Michael B Pryor Rafael carrion Run Wang Gerard Henry Regional Urology 255 Bert Kouns Industrial Loop Shreveport LA USA Department of Urology University of South Florida Tampa Florida USA Department ofUrology University of Texas School of Medicine at Houston and MD Anderson Cancer Center Houston TX USA.

A common complaint after inflatable penile prosthesis surgery is reduced penile length. We previously reported how using the Coloplast Titan inflatable penile prosthesis with aggressive new length measurement technique （NLMT） coupled with postoperative IPP rehabilitation of the implant for 1-year helped to improve patient satisfact on and erectile peni e measurements Th s is a 2 years follow-up of a prospective, three-center, study of 40 patients who underwent Titan prosthesis placement, With new length measurement technique for erectile dysfunction. Patient instructions were to inflate daily for 6 months and then inflate maximally for 1-2 h daily for 6-24 months. Fifteen penile measurements were taken before and immediately after surgery and at follow-up visits. Measurement changes were improved at 24 months as compared to immediately postoperative and at 12 months. 67.8% of subjects were satisfied with their length at 2 years, and 77% had perceived penile length that was longer （30.8%） or the same （46.2%） as prior to the surgery. 64.3% and 17.9% of subjects had increased and unchanged satisfaction, respectively, with penile length as compared to prior to penile implant surgery. All but one subject （96.5%） was satisfied with the overall function of his implant. This study suggests using the Coloplast Titan with aggressive cylinder sizing, and a postoperative penile rehabilitation inflation protocol can optimize patient satisfaction and erectile penile measurements at 2 years postimplant.

关键词： erectile dysfunction penile implant surgery penile prosthesis

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TopSTO:a 115-line code for topology optimization of structures under stationary stochastic dynamic loading

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Earthquake Engineering and Engineering Vibration 2023年第4期22卷 1081-1100页

作者： Sebastian Pozo Fernando Gomez Thomas Golecki Juan carrion Billie F.Spencer Jr. Civil and Environmental Engineering University of Illinois at Urbana-ChampaignUrbana 61801ILUSA College of Science and Engineering Universidad San Francisco de QuitoDiego de Robles y Vía InteroceanicaQuitoEcuador Skidmore Owings&MerrillLLPChicago 60604ILUSA Department of Civil Engineering University of CuencaCuencaEcuador

The use of topology optimization in structural design under dynamic excitation is becoming more prevalent in the *** many such applications utilize frequency or time domain formulations,relatively few consider stochastic dynamic *** paper presents an efficient and compact code called TopSTO for structural topology optimization considering stationary stochastic dynamic loading using a method derived from random vibration *** theory,described in conjunction with the implementation in the provided code,is illustrated for a seismically excited *** work demonstrates the efficiency of the approach in terms of both the computational resources and minimal amount of code *** code is intended to serve as a baseline for understanding the theory and implementation of this topology optimization approach and as a foundation for additional applications and developments.

关键词： topology optimization stochastic dynamics matlab python

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Validation of EO-derived information for crisis management: a Digital Earth perspective in the VALgEO expert community

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International Journal of Digital Earth 2011年第S1期4卷 1-7页

作者： Corbane, C. Pesaresi, M. carrion, D. European Commission Joint Research Centre Italy

New generation remote sensing technologies today open new application areas and demonstrate their effectiveness providing geo-information in support of disaster *** the same time,new challenges can be identified and among them the validation of geo-information under the new specific constraints dictated by the disaster management application area has a crucial *** the frame of the Digital Earth concept,geo-information is a sharable resource,and a resource is truly shareable not only if we know the formal code used to make itand then we can read itbut alsoand in particular during disasterif we know the reliability of this *** is crucial in order to avoid information overflow and time wasting during the decision-making process in support of disaster ***‘International workshop on validation of geo-information products for crisis management,’VALgEO 2009,was held at the Joint Research Centre,in Ispra,Italy on 2123 November *** purpose of this first workshop was to initiate a dialog between the main actors of Emergency Response Services around validation and to raise awareness of the necessity for an independent formal assessment of geoinformation for disaster *** special issue includes a collection of invited papers presented at the *** gathers interdisciplinary initiatives where the majority of the contributions either directly or implicitly address different aspects of validation of geo-information generated following a disaster,ranging from flood information to forest fires and earthquake damage assessments.

关键词： disaster Earth flood

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First extensive and cost-effective quality check of Crisis Maps: presentation of assessment parameters and results

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International Journal of Digital Earth 2013年第S2期6卷 50-66页

作者： D.carrion C.Corbane M.Broglia M.Pesaresi Politecnico di Milano DIIARSurveyingMilanoItaly European Commission Joint Research CentreInstitute for the Protection and Security of the CitizenIspra(VA)Italy

The digital representation of disaster situations into maps,mainly based on remotely sensed observations,is becoming a widely used instrument for emergency *** of maps are being produced all over the world and big attention is paid by international institutions,such as the World Bank,the United Nations and the European Commission to these *** quality of crisis maps is a crucial element to ensure effectiveness in the disaster response chain,but it is often neglected with respect to the need for a rapid *** this paper a sample of crisis maps produced between 2005 and 2010 by world leader providers has been evaluated through around 40 parameters assessed by visual analysis and extracted from the validation protocol designed at the Joint Research Centre(JRC)of the European *** maps turned out to be in most cases clearly readable,but some gaps and inconsistencies have been singled out,due to the lack of international standard *** results are analysed in detail and some remarks are presented.

关键词： emergency maps quality assessment readability metadata cartographic standards

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Loss of Aβ-nerve endings associated with the Merkel cell-neurite complex in the lesional oral mucosa epithelium of lichen planus and hyperkeratosis

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International Journal of Oral Science 2016年第1期8卷 32-38页

作者： Daniela Calderon carrion Yiiksel Korkmaz Britta Cho Marion Kopp Wilhelm Bloch Klaus Addicks Wilhelm Niedermeier Department of Prosthetic Dentistry Dental SchoolUniversity of CologneCologneGermany Center for Biochemistry Institute for Experimental Dental Research and Oral Musculoskeletal BiologyMedical FacultyUniversity of CologneCologneGermany Department of Anatomy University of CologneCologneGermany Department of Molecular and Cellular Sport Medicine German Sport UniversityCologneGermany

The Merkel cell-neurite complex initiates the perception of touch and mediates Ap slowly adapting type I responses. Lichen planus is a chronic inflammatory autoimmune disease with T-cell-mediated inflammation, whereas hyperkeratosis is characterized with or without epithelial dysplasia in the oral mucosa. To determine the effects of lichen planus and hyperkeratosis on the Merkel cell-neurite complex, healthy oral mucosal epithelium and lesional oral mucosal epithelium of lichen planus and hyperkeratosis patients were stained by immunohistochemistry （the avidin-biotin-peroxidase complex and double immunofluorescence methods）using pan cytokeratin, cytokeratin 20 （K20, a Merkel cell marker）, and neurofilament 200 （NF200, a myelinated Aβ- and Aδ-nerve fibre marker） antibodies. N F200-immunoreactive （ir） nerve fibres in healthy tissues and in the lesional oral mucosa epithelium of lichen planus and hyperkeratosis were counted and statistically analysed. In the healthy oral mucosa, K20-positive Merkel cells with and without close association to the intraepithelial NF200-ir nerve fibres were detected. In the lesional oral mucosa of lichen planus and hyperkeratosis patients, extremely rare NF200-ir nerve fibres were detected only in the lamina propria. Compared with healthy tissues, lichen planus and hyperkeratosis tissues had significantly decreased numbers of NF200-ir nerve fibres in the oral mucosal epithelium. Lichen planus and hyperkeratosis were associated with the absence of Aβ-nerve endings in the oral mucosal epithelium. Thus, we conclude that mechanosensation mediated by the Merkel cell-neurite complex in the oral mucosal epithelium is impaired in lichen planus and hvperkeratosis.

关键词： Aβ-nerve fibres hyperkeratosis lichen planus mechanosensation Merkel cell-neurite complex

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The IgH 3′ regulatory region super-enhancer does not control IgA class switch recombination in the B1 lineage

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Cellular & Molecular Immunology 2018年第3期15卷 289-291页

作者： Hussein Issaoui Nour Ghazzaui Alexis Saintamand Claire carrion Christelle Oblet Yves Denizot CNRS UMR 7276 CRIBLUniversitéde LimogesLimogesFrance INSERM U1236 UniversitéRennes 1RennesFrance

The bone marrow-derived B2 population represents the vast majority of bone marrow,blood,lymph node and splenic *** B1 B-cells mostly originate during embryonic life in the liver and represent the main B-cell population in the pleural and peritoneal cavities.1,2,3,4,5 B1 and B2 B-cells differ in their origin,antigen specificity,cell surface markers,tissue distribution and capacity for class switch recombination(CSR).Schematically,B1 B-cells appear earlier than B2 B-cells during fetal development and maintain their self-renewal ability throughout their life.

关键词： maintain specificity mostly

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