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Early neonatal complications in pregnant women with gestational diabetes mellitus and the effects of glycemic control on neonatal infection

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World Journal of Diabetes 2023年第9期14卷 1393-1402页

作者： bei-bei wang Mei Xue Department of Neonatal Intensive Care Unit Taizhou People’s Hospital of Jiangsu ProvinceTaizhou 225300Jiangsu ProvinceChina

BACKGROUND Gestational diabetes mellitus(GDM)has become increasingly prevalent *** control in pregnant women with GDM has a critical role in neonatal *** To analyze the early neonatal complications in GDM,and examine the effect of blood glucose control level on neonatal *** The clinical data of 236 pregnant women with GDM and 240 healthy pregnant women and newborns during from March 2020 to December 2021 the same period were retrospectively analyzed,and the early complications in newborns in the two groups were *** patients were divided into the conforming glycemic control group(CGC group)and the non-conforming glycemic control group(NCGC group)based on whether glycemic control in the pregnant women with GDM conformed to *** data,immune function,infectionrelated markers,and infection rates in neonates were compared between the two *** The incidence of neonatal complications in the 236 neonates in the GDM group was significantly higher than that in the control group(P0.05).Additionally,the NCGC group had significantly decreased peripheral blood CD3^(+),CD4^(+),CD8^(+)T cell ratios,CD4/CD8 ratios and immunoglobulin G in neonates compared with the CGC group(P<0.05),while white blood cells,serum procalcitonin and C-reactive protein levels increased *** neonatal infection rate was also significantly increased in the NCGC group(P<0.05).CONCLUSION The risk of neonatal complications increased in pregnant women with *** glycemic control decreased neonatal immune function,and increased the incidence of neonatal infections.

关键词： Gestational diabetes mellitus Early neonatal complications Glycemic control Neonatal infection

High-Speed Friction Stir Welding of SiC_p/Al–Mg–Si–Cu Composite

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Acta Metallurgica Sinica(English Letters) 2019年第6期32卷 677-683页

作者： Chen wang bei-bei wang Dong wang Peng Xue Quan-Zhao wang Bo-Lv Xiao Li-Qing Chen Zong-Yi Ma State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819China Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China

A 17 vol%SiCp/Al–Mg–Si–Cu composite plate with a thickness of 3 mm was successfully friction stir welded(FSWed)at a very high welding speed of 2000 mm/min for the first *** observation indicated that the coarsening of the precipitates was greatly inhibited in the heat-affected zone of the FSW joint at high welding speed,due to the significantly reduced peak temperature and duration at high ***,prominent enhancement of the hardness was achieved at the lowest hardness zone of the FSW joint at this high welding speed,which was similar to that of the nugget ***,the ultimate tensile strength of the joint was as high as 369 MPa,which was much higher than that obtained at low welding speed of 100 mm/min(298 MPa).This study provides an effective method to weld aluminum matrix composite with superior quality and high welding efficiency.

关键词： Friction stir welding Metal matrix composite High welding speed Microstructure Mechanical property

Gold nanoparticles-enhanced bisphenol A electrochemical biosensor based on tyrosinase immobilized onto self-assembled monolayers-modified gold electrode

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Chinese Chemical Letters 2014年第5期25卷 720-722页

作者： Na wang Hai-Yan Zhao Xue-Ping Ji Xian-Rui Li bei-bei wang Department of Medical Chemistry Hebei Medical University

A novel electrochemical sensor based on the immobilization of tyrosinase（tyr） onto gold nanoparticles（nano-Au） and thioctic acid amide（T-NH2） self-assembled monolayers（SAMs）-modified gold electrode has been developed for the determination of bisphenol A（BPA）.It was found that the nano-Au could significantly enhance the electrochemical response of tyr/nano-Au/T-NH2/Au electrode to BPA,and the enhancement effect of nano-Au on the current response was also related to the *** results indicated that the biosensor could be used as a detector for BPA determination with a linear range from3.99 ×10-7mol/L to 2.34 ×10-4mol/L and a detection limit of 1.33×10-7mol/*** addition,this biosensor showed good reproducibility.

关键词： Tyrosinase Gold nanoparticles Biosensor Bisphenol A Thioctic acid amide

Risk Factors Asscociated with Hypokalemia during Postanesthesia Recovery and Its Impact on Outcomes in Gynecological Patients:A Propensity Score Matching Study

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Current Medical Science 2024年第2期44卷 441-449页

作者： bei-bei wang Li HU Xin-yue HU Dong HAN Jing WU Department of Anesthesiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Institute of Anesthesia and Critical Care Medicine Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Key Laboratory of Anesthesiology and Resuscitation(Huazhong University of Science and Technology) Ministry of EducationWuhan430022China

Objective:This study aimed to explore the risk factors and outcomes of hypokalemia during the recovery period from anesthesia in the gynecological ***:This retrospective cohort study included 208 patients who underwent gynecological surgery at our institution between January 2021 and March *** were collected for each patient,including demographics,disease status,surgical data,and clinical *** bowel preparation,postoperative gastrointestinal function,and electrolyte levels were compared between the two groups using propensity score matching(PSM).Results:The incidence of hypokalemia(serum potassium level<3.5 mmol/L)during the recovery period from anesthesia was approximately 43.75%.After PSM,oral laxative use(96.4%vs.82.4%,P=0.005),the number of general enemas(P=0.014),and the rate of≥2 general enemas(92.9%vs.77.8%,P=0.004)were identified as risk factors for hypokalemia,which was accompanied by decreased PaCO_(2) and *** were no significant differences in postoperative gastrointestinal outcomes,such as the time to first flatus or feces,the I-FEED score(a scoring system was created to evaluate impaired postoperative gastrointestinal function),or postoperative recovery outcomes,between the hypokalemia group and the normal serum potassium ***:Hypokalemia during postanesthesia recovery period occurred in 43.75%of gynecological patients,which resulted from preoperative mechanical bowel preparation;however,it did not directly affect clinical outcomes,including postoperative gastrointestinal function,postoperative complications,and length of hospital stay.

关键词： hypokalemia gynecological surgery postanesthesia recovery perioperative electrolyte disturbances postoperative recovery

Blocking the Aryl Hydrocarbon Receptor Alleviates Myocardial Ischemia/Reperfusion Injury in Rats

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Current Medical Science 2022年第5期42卷 966-973页

作者： Jin-xu wang bei-bei wang Shu-zhang YUAN Ke XUE Jin-sheng ZHANG Ai-jun XU Department of Anesthesiology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Anesthesiology Huashan Hospital of Fudan UniversityShanghai 200040China Henan University of Traditional Chinese Medicine Zhengzhou 450000China

Objective Restoring the blood perfusion of ischemic heart tissues is the main treatment for myocardial ***,the accompanying myocardial ischemia reperfusion injury(IRI)would aggravate myocardial *** studies have confirmed that aryl hydrocarbon receptor(AhR)is closely correlated to kidney and intestinal *** present study aimed to explore the relationship between AhR and myocardial *** An oxygen glucose deprivation/reoxygenation(OGD/R)model of H9c2 cells and an ischemia/reperfusion(I/R)model of Sprague-Dawley rat myocardium were ***/R cells and myocardial IRI rats were treated with different concentrations of the AhR antagonist CH-223191 or agonist 6-formylindolo[3,2-b]carbazole(FICZ).Under the conditions of normoxia and hypoxia/reoxygenation,the activity of cardiomyocytes,lactate dehydrogenase(LDH)and cell reactive oxygen species(ROS)were *** rats,myocardial pathological damage and markers of myocardial injury were *** According to the results of the cell viability,LDH and ROS tests in vitro,both CH-223191 and FICZ showed no myocardial protection under OGD/R ***,the histological staining and analysis of myocardial injury marker LDH in vitro revealed that CH-223191 could significantly reduce the myocardial *** AhR exhibited a different effect on myocardial IRI in vitro and in *** vivo,CH-223191 could significantly alleviate the myocardial IRI,suggesting that inhibition of AhR may play a role in myocardial protection,and AhR may serve as a potential treatment target for myocardial IRI.

关键词： aryl hydrocarbon receptor ischemia/reperfusion injury myocardial protection CH-223191 6-formylindolo[3,2-b]carbazole

Different positive end expiratory pressure and tidal volume controls on lung protection and inflammatory factors during surgical anesthesia

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World Journal of Clinical Cases 2022年第33期10卷 12146-12155页

作者： Yu wang Yi Yang Ding-Mu wang Jie Li Quan-Tang Bao bei-bei wang Shu-Jun Zhu Lu Zou Department of Anesthesia Xinghua City People's HospitalXinghua 225700Jiangsu ProvinceChina Department of Anesthesiology Suzhou High-Tech Zone People's HospitalSuzhou 215011Jiangsu ProvinceChina Naval Medical Center Naval Medical UniversityPLAShanghai 200433China Department of Anesthesiology Changzhou Hospital of Traditional Chinese MedicineChangzhou 213000Jiangsu ProvinceChina

BACKGROUND Mechanical ventilation can lead to the severe impairment of the metabolic pathway of alveolar surfactants,inactivating alveolar surfactants and significantly reducing lung-chest *** cardiopulmonary function of elderly patients usually reduced to a certain extent,and there are lung complications after surgical anesthesia,just like lung barotrauma caused by mechanical ventilation,atelectasis and postoperative *** To investigate the effects of different positive end expiratory pressures(PEEPs)and tidal volumes(VTs)on respiratory function,the degree of the inflammatory response and hemodynamic indexes in patients undergoing surgery under general *** A total of 120 patients undergoing surgery for gastric or colon cancer under general anesthesia in Xinghua People's Hospital from January 2017 to January 2021 were randomly divided into Group A and Group B,with 60 cases in each *** ventilation mode in Group A was VT(6.0 mL/kg)+PEEP(5.0 cmH_(2)O),while that in Group B was VT(6.0 mL/kg)+PEEP(8.0 cmH_(2)O).Blood gas parameters,respiratory mechanical parameters,inflammatory response indicators,hemodynamic indicators and related complications were compared between the two *** There were no significant differences in PaCO_(2),PaO_(2),oxygen or the examined indexes at T0 between group A and group B(P>0.05).The measured PaO_(2) value of patients in group A at T3 was higher than that in group B,and the difference was significant(P0.05).The measured P_(peak) value of patients in group A at T1 was higher than that in group B,and the difference was significant(P<0.05).The measured Cdyn value at T1 and T2 was greater than that in group B(P<0.05).Before surgery,there were no significant differences in tumor necrosis factor-α(TNF-α),interleukin(IL)-6 or IL-

关键词： General anesthesia Positive end expiratory pressure Tidal volume Respiratory function Inflammatory reactions Hemodynamics

Potential involvement of heat shock proteins in pancreaticduodenal homeobox-1-mediated effects on the genesis of gastric cancer: A 2D gel-based proteomic study

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World Journal of Gastroenterology 2018年第37期24卷 4263-4271页

作者： Juan Ma bei-bei wang Xiao-Yan Ma Wei-Ping Deng Li-Shu Xu Wei-Hong Sha Department of Gastroenterology and Hepatology Guangdong General Hospital (Guangdong Academy of Medical Sciences) Guangdong Geriatrics Institute Forensic Identification Institute Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes The Third Affiliated Hospital of Guangzhou Medical University

AIM To identify functional proteins involved in pancreaticduodenal homeobox-1(PDX1)-mediated effects on gastric *** A PDX1-overexpressed model was established by transfecting gastric cancer cell line SGC7901 with pcDNA3.1(+)-PDX1 vector(SGC-PDX1). Transfection with empty pcDNA3.1 vector(SGC-pcDNA) served as control. Comparative protein profiles of the two groups were analyzed by two-dimensional electrophoresis basedproteomics(2 DE gel-based proteomics). The differential proteins identified by 2 DE were further validated by qRTPCR and immunoblotting. Finally, co-immunoprecipitation was used to determine any direct interactions between PDX1 and the differential ***2 DE gel proteomics identified seven differential proteins in SGC-PDX1 when compared with those in SGC-pcDNA. These included four heat shock proteins(HSPs; HSP70 p1 B, HSP70 p8, HSP60, HSP27) and three other proteins(ER60, laminin receptor 1, similar to epsilon isoform of 14-3-3 protein). Immunoblotting validated the expression of the HSPs(HSP70, HSP60, HSP27). Furthermore, their expressions were lowered to 80%, 20% and 24%, respectively, in SGC-PDX1, while PDX1 exhibited a 9-fold increase, compared to SGC-pcDNA. However, qRT-PCR analysis revealed that mRNA levels of the HSP s were increased in SGC-PDX1, suggesting that the expression of the HSP s was post-translationally regulated by the PDX1 protein. Finally, co-immunoprecipitation failed to identify any direct interaction between PDX1 and HSP70 *** This study demonstrates the potential involvement of HSPs in PDX1-mediated effects on the genesis of gastric cancer.

关键词： Pancreatic-duodenal homeobox-1 Heat shock proteins Gastric cancer Proteomics Two-dimensional electrophoresis

Multisystem involvement Langerhans cell histiocytosis in an adult:A case report

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World Journal of Clinical Cases 2020年第20期8卷 4966-4974页

作者： bei-bei wang Jun-Ru Ye Yun-Lei Li Yi Jin Zhong-Wei Chen Jian-Min Li Yu-Ping Li Department of Pulmonary and Critical Care Medicine The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina Pathology Department The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina Radiology Department The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina

BACKGROUND Langerhans cell histiocytosis(LCH)is a rare condition wherein Langerhans cells proliferate abnormally,adversely impacting organs including lymph nodes,bones,skin,lungs,and pituitary *** LCH disease course varies widely among patients from a self-limiting condition to one that progresses rapidly and culminates in *** is uncommon for multisystem LCH to be observed in *** we describe a woman suffering from multi-system LCH *** SUMMARY A 37-year old Chinese woman was admitted to the hospital in June 2019 suffering from dyspnea that had progressed over the course of 5 *** medical history included:central diabetes insipidus(DI)that had been treated via radiotherapy,desmopressin acetate,and bromocriptine;bilateral pneumothorax with two surgeries having been performed to remove bullae;and autoimmune hepatitis that had been unsuccessfully treated using a combination of methylprednisolone and mycophenolate mofetil.A chest computed tomography(CT)scan revealed the presence of multiple pulmonary cysts of varying *** re-analyzed right pulmonary bullae samples that had been removed in 2014,performed a systematic 18 F-FDG PET/CT analysis,and convened a multidisciplinary medical team to diagnose and treat this *** a result,we were able to eventually diagnose this patient with LCH that was not associated with BRAF-V600 E *** We hope to emphasize the importance of systemic evaluation and of cooperation between multidisciplinary physicians with the goal of improving awareness and detection of this orphan disease.

关键词： Langerhans cell histiocytosis Lung Pituitary gland Liver Case report

基于固溶体短程序结构的团簇式合金成分设计方法

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物理学报 2017年第2期66卷 277-292页

作者：姜贝贝王清董闯大连理工大学材料科学与工程学院三束材料改性教育部重点实验室大连116024

合金成分设计对于研发高性能复杂合金材料至关重要,是实现新材料研发由经验指导实验的传统模式向理论预测、实验验证的新模式转变的关键环节.总结了合金研发中常用设计方法的应用领域及存在的局限性,包括Hume-Rothery规则、电子理论、... 详细信息

合金成分设计对于研发高性能复杂合金材料至关重要,是实现新材料研发由经验指导实验的传统模式向理论预测、实验验证的新模式转变的关键环节.总结了合金研发中常用设计方法的应用领域及存在的局限性,包括Hume-Rothery规则、电子理论、当量法、计算机模拟等.详细介绍了我们提出的基于固溶体局域短程序结构的团簇成分式设计方法.该方法建立在团簇加连接原子稳定固溶体结构模型基础上,其在不同复杂合金体系中的成功应用表明了该方法的普适性,为多元复杂合金成分设计提供了一种简单、精确的途径.

关键词：成分设计多组元合金团簇加连接原子结构模型固溶体