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Exploring the interaction between the gut microbiota and cyclic adenosine monophosphate-protein kinase A signaling pathway:a potential therapeutic approach for neurodegenerative diseases

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Neural Regeneration Research 2025年第11期20卷 3095-3112页

作者： Fengcheng Deng Dan Yang Lingxi Qing Yifei Chen Jilian Zou Meiling jia Qian Wang Runda jiang Lihua Huang College of Pharmacy Chengdu University of Traditional Chinese MedicineChengduSichuan ProvinceChina State Key Laboratory of Southwestern Chinese Medicine Resources Chengdu University of Traditional Chinese MedicineChengduSichuan ProvinceChina

The interaction between the gut microbiota and cyclic adenosine monophosphate(cAMP)-protein kinase A(PKA)signaling pathway in the host's central nervous system plays a crucial role in neurological diseases and enhances communication along the gut–brain *** gut microbiota influences the cAMP-PKA signaling pathway through its metabolites,which activates the vagus nerve and modulates the immune and neuroendocrine ***,alterations in the cAMP-PKA signaling pathway can affect the composition of the gut microbiota,creating a dynamic network of microbial-host *** reciprocal regulation affects neurodevelopment,neurotransmitter control,and behavioral traits,thus playing a role in the modulation of neurological *** coordinated activity of the gut microbiota and the cAMP-PKA signaling pathway regulates processes such as amyloid-β protein aggregation,mitochondrial dysfunction,abnormal energy metabolism,microglial activation,oxidative stress,and neurotransmitter release,which collectively influence the onset and progression of neurological *** study explores the complex interplay between the gut microbiota and cAMP-PKA signaling pathway,along with its implications for potential therapeutic interventions in neurological *** pharmacological research has shown that restoring the balance between gut flora and cAMP-PKA signaling pathway may improve outcomes in neurodegenerative diseases and emotional *** can be achieved through various methods such as dietary modifications,probiotic supplements,Chinese herbal extracts,combinations of Chinese herbs,and innovative dosage *** findings suggest that regulating the gut microbiota and cAMP-PKA signaling pathway may provide valuable evidence for developing novel therapeutic approaches for neurodegenerative diseases.

关键词： cyclic adenosine monophosphate emotional disorders gut microbiota neurodegenerative diseases neurological diseases protein kinase A reciprocal regulation signaling pathway strategy therapies

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Multi-Source Characteristics of Atmospheric Deposition in nanjing,China,as Controlled by East Asia Monsoons and Urban Activities

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Pedosphere 2016年第3期26卷 374-385页

作者： LI Shanquan ZHANG Ganlin YANG Jinling jia nan State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil Science Chinese Academy of Sciences Nanjing 210008 (China) University of Chinese Academy of Sciences Beijing 100049 (China)

Atmospheric deposition, a major pathway of metals entering into soils, plays an important role in soil environment, especially in urban regions where a large amount of pollutants are emitted into atmosphere through various sources. In order to understand the characteristics of atmospheric deposition in urban area and its relation with natural and anthropogenic sources, a three-year study of atmospheric deposition at three typical sites, industrial zone(IN), urban residential area(RZ) and suburban forested scenic area(FA),was carried out in nanjing, a metropolitan city in eastern China from 2005 to 2007. The bulk deposition rate and element composition of atmospheric deposition varied spatio-temporally in the urban zones of nanjing. The concentrations of Cu, Zn, Pb and Ca in the atmospheric deposits were strongly enriched in the whole nanjing region; however, anthropogenic pollutants in atmospheric deposits were diluted by the input of external mineral dust transported from northwestern China. Source apportionment through principal component analysis(PCA) showed that the background atmospheric deposition at the FA site was the combination of external aerosol and local emission sources. The input of long-range transported Asian dust had an important influence on the urban background deposition, especially in spring when the continental dust from the northwestern China prevailed. Marine aerosol source was observed in summer and autumn, the seasons dominated by summer monsoon in nanjing. In contrast, the contribution of local anthropogenic emission source was constant regardless of seasons. At the RZ and IN sites, the atmospheric deposition was more significantly affected by the nearby human activities than at the FA site. In addition, different urban activities and both the winter and summer Asian monsoons had substantial impacts on the characteristics of dust deposition in urban nanjing.

关键词： aerosol anthropogenic pollutants Asian dust metals source apportionment urban environment

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H_∞ Robust Control of DC-AC Interfaced Microsource in Microgrids

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International Journal of Automation and computing 2013年第1期10卷 73-78页

作者： Chun-Xia Dou Fang Zhao Xing-bei jia Dong-Le Liu Institute of Electrical Engineering Yanshan University

This paper focuses on the direct current-alternating current （DC-AC） interfaced microsource based H∞ robust control strategies in microgrids. It presents detail of a DC-AC interfaced microsource model which is connected to the power grid through a controllable switch. A double loop current-regulated voltage control scheme for the DC-AC interface is designed. In the case of the load disturbance and the model uncertainties, the inner voltage and current loop are produced based on the H∞ robust control strategies. The outer power loop uses the droop characteristic controller. Finally, the scheme is simulated using the Matlab/Simulink. The simulation results demonstrate that DC-AC interfaced microsource system can supply high quality power. Also, the proposed control scheme can make the system switch smoothly between the isolated mode and grid-connected mode. 更多

关键词： Microgrid DC-AC interfaced microsource H∞ robust control f-v droop characteristic smooth switching

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An investigation of flow characteristics and critical heat flux in vertical upward round tube

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Nuclear Science and Techniques 2006年第3期17卷 170-176页

作者： FAN Pu QIU Sui-Zheng jia Dou-nan State Key Laboratory of Multiphase Flow in Power Engineering Xi＇an Jiaotong University Xi＇an 710049 China

Prediction of critical heat flux (CHF) in annular flow is important for the safety of once - through steam generator and the reactor core under accident conditions. The dryout in annular flow occurs at the point where the film is depleted due to entrainment, deposition, and evaporation. The film thickness, film mass flow rate along axial distribution, and CHF are calculated in vertical upward round tube on the basis of a separated flow model of annular flow. The theoretical CHF values are higher than those derived from experimental data, with error being within 30%.

关键词：环流临界热通量沉积挟带核反应堆工程

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Chiral Anomaly-Enhanced Casimir Interaction between Weyl Semimetals

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Chinese Physics Letters 2021年第8期38卷 57-61页

作者： jia-nan Rong Liang Chen Kai Chang SKLSM Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China School of Mathematics and Physics North China Electric Power UniversityBeijing 102206China CAS Center for Excellence in Topological Quantum Computation University of Chinese Academy of SciencesBeijing 100190China

We theoretically study the Casimir interaction between Weyl *** the distance a between semiinfinite Weyl semimetals is in the micrometer regime,the Casimir attraction can be enhanced by the chiral *** Casimir attraction depends sensitively on the relative orientations between the separations(b1,b2)of Weyl nodes in the Brillouin zone and show anisotropic behavior for the relative orientation of these separations(b1,b2)when they orient parallel to the *** anisotropy is quite larger than that in conventional birefringent *** Casimir force can be repulsive in the micrometer regime if the Weyl semimetal slabs are sufficiently thin and the direction of Weyl nodes separations(b1,b2)is perpendicular to the *** Casimir attraction between Weyl semimetal slabs decays slower than 1/a4 when the Weyl nodes separations b1 and b2 are both parallel to the interface.

关键词： materials separation attraction

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Influence of Shear Banding on the Formation of Brass-type Textures in Polycrystalline fcc Metals with Low Stacking Fault Energy

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Journal of Materials Science & Technology 2014年第4期30卷 408-416页

作者： Haile Yan Xiang Zhao nan jia Yiran Zheng Tong He Key Laboratory for Anisotropy and Texture of Materials(MOE) Northeastern University Northeastern University Research Academy

Texture evolution in nickel, copper and α-brass that are representative of face-centered-cubic （fcc） materials with different stacking fault energy （SFE） during cold rolling was systematically investigated. X-ray diffraction, scanning electron microscopy and electron backscatter diffraction techniques were employed to characterize microstructures and local orientation distributions of specimens at different thickness reductions. Besides, Taylor and Schmid factors of the {111} 〈110〉 slip systems and {111} 〈112〉 twin systems for some typical orientations were utilized to explore the relationship between texture evolution and deformation microstructures. It was found that in fcc metals with low SFE at large deformations, the copper-oriented grains rotated around the 〈110〉 crystallographic axis through the brass-R orientation to the Goss orientation, and finally toward the brass orientation. The initiation of shear banding was the dominant mechanism for the above-mentioned texture transition.

关键词： Face-centered-cubic ahoy Texture Rolling Shear band

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联合FOD-sCARS的土壤有机质高光谱机器学习估测模型

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光谱学与光谱分析 2025年第1期45卷 204-212页

作者：吴梦红窦森林楠姜然哲陈思李佳璇付佳伟梅显军吉林农业大学资源与环境学院吉林长春130118 吉林建筑大学测绘与勘查工程学院吉林长春130118 吉林大学生物与农业工程学院吉林长春130115

土壤有机质(SOM)含量是表征土壤质量的关键指标,在全球碳循环系统中发挥重大作用。快速准确的SOM估算和空间制图对土壤碳库估算、作物生长监测和耕地规划管理具有重要意义。利用传统方法监测区域性SOM含量耗时费力,基于高光谱遥感影像建... 详细信息

土壤有机质(SOM)含量是表征土壤质量的关键指标,在全球碳循环系统中发挥重大作用。快速准确的SOM估算和空间制图对土壤碳库估算、作物生长监测和耕地规划管理具有重要意义。利用传统方法监测区域性SOM含量耗时费力,基于高光谱遥感影像建立SOM估测模型是现在较为合理有效的方法。为探索解决目前高光谱遥感影像建立SOM含量估测模型存在光谱数据冗余、光谱数据特征提取精度低、小样本模型泛化能力不强的问题,选择位于青海省湟中县的研究区,共采集67个土壤样本。获取资源1号02D(ZY1-02D)高光谱遥感影像并进行预处理得到样点像元光谱数据,采用分数阶微分变换(FOD)方法挖掘与SOM含量具有响应关系的敏感波段,以0.2为一个步长,利用相关性阈值法对比分析不同阶次微分处理数据挖掘能力;运用稳定性竞争性自适应重加权采样算法(sCARS)去除高光谱冗余数据获取建模特征波段,选择随机森林(RF)、极端梯度提升树、极限学习机和岭回归机器学习作为建模算法,以全波段和特征波段光谱数据分别作为模型输入变量构建SOM估测模型进行高光谱反演研究工作;最后根据最优特征变量和建模算法,基于ZY1-02D遥感影像进行了SOM空间分布制图。结果表明:采用FOD变换相比整数阶可以大大提高波段与SOM含量间的相关性,挖掘出更多细微的与SOM含量产生响应关系的光谱波段,其中0.8阶微分变换效果最优,较原始波段相比相关系数最大值提高了0.546;相较于全波段光谱数据,采用sCARS特征提取方法获取特征波段构建模型的估测精度得到较大提升,说明sCARS可以有效提升建模数据的质量,提升模型预测精度。建模算法中RF表现最优,R_(p)^(2)(模型决定系数)达到0.766,RPD达到1.86,较全波段建模结果R_(p)^(2)提升约7.58%;基于FOD-sCARS和RF实现了区域SOM含量估测制图。研究进一步验证利用星载高光谱遥感影像是实现区域SOM估测制图的可靠途径,研究结果可为估测区域SOM含量提供新思路,为利用星载高光谱遥感影像绘制SOM含量空间分布图提供了数据支持。

关键词：高光谱遥感影像分数阶微分变换稳定性竞争性自适应重加权采样算法土壤有机质随机森林

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Achieving ultralow leakage current in Schottky-MIS cascode anode lateral field-effect diode based on AlGaN/GaN HEMT

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Science China(Information Sciences) 2025年第1期68卷 379-385页

作者： Fangzhou WANG Changhong GAO Guojian DING Cheng YU Zhuocheng WANG Xiaohui WANG Qi FENG Ping YU Peng ZUO Wanjun CHEN Yang WANG Haiqiang jia Hong CHEN Bo ZHANG Zeheng WANG Songshan Lake Materials Laboratory School of Microelectronics Southern University of Science and Technology State Key Laboratory of Electronic Thin Films and Integrated Devices University of Electronic Science and Technology of China Manufacturing Commonwealth Scientific and Industrial Research Organisation

In this paper,we design and fabricate a Schottky-metal-insulator-semiconductor（MIS） cascode anode GaN lateral field-effect diode（CA-LFED） to achieve ultralow reverse leakage current(ILEAK).The device based on AlGaN/GaN highelectron-mobility-transistor（HEMT） includes a normally-off MIS-controlled channel that is cascoded with a high barrier height Schottky *** reverse bias,the high electric-field is effectively prevented by the normally-off MIS-controlled channel *** with the high barrier height Schottky contact,this feature significantly suppresses the *** by the device fabrication,the CA-LFED with high breakdown voltage（BV）>600 V shows an ultralow ILEAKof 3.6×10-9A/mm as well as a low forward voltage drop（VF） of 2.2 *** performance suggests that the CA-LFED can be a promising candidate for ultralow ILEAKand better VF-ILEAKtrade-off GaN power diode applications.

关键词： Schottky-MIS cascode anode lateral field-effect diode (LFED) ultralow reverse leakage current ($I_{\rm{LEAK}}$) forward drop and reverse leakage trade-off AlGaN/GaN HEMTs

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Phase-field numerical simulation of three-dimensional competitive growth of dendrites in a binary alloy

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China Foundry 2018年第1期15卷 44-50页

作者： Li Feng Ya-long Gao Chang-sheng Zhu Guo-sheng An Xin Deng bei-bei jia School of Materials and Engineering Lanzhou University of Technology State Key Laboratory of Advanced Processing and Recycling of Nonferrous Metals Lanzhou University of Technology School of Computer and Communication Lanzhou University of Technology

The normal vector of migration direction in the solid-liquid interface of dendrites was used to describe the phase-field governing equation. By using the three angles formed by the normal vector for the migration direction of the dendritic growth interface and the coordinate axes of the simulation region, the authors expressed the interfacial anisotropy equation, and built a phase-field model for the competitive growth of multiple grains. Taking a Al-2%mole-Cu binary alloy as an example, the competitive growth of multiple grains during isothermal solidification was simulated by applying parallel computing techniques. In addition, the phase field simulation results were verified by the experimental method. The simulation results show that the competitive growth of equiaxed dendrite is divided into two types: the first occurs during the process of competitive growth, the tips of primary dendrite on different grains taking part in the competition stop growing in their optimal growth direction; the second also occurs during competitive growth, the tips of primary dendrite which participate in the competition on different grains never stop growing in their optimal growth direction. The dendritic morphologies of the first competition growth type are divided into two types. Primary dendrites of grains taking part in the competition stop growing in their optimal growth direction and the competition plane enlarges when neither one wins the competition. However, when one wins the competition, the primary dendrites of grains with superiority go through the blocking grains and continue to grow in their optimal growth direction. The primary dendrites of inferior grains stop growing in their optimal growth direction and then instead grow in those areas without obstacles. The dendritic morphology of the second competition-growth type is shown to be the deformation of primary dendrites, which are mainly represented as the deflection and bending observed from different views. Compar

关键词： dendrite Al-Cu binary alloy competitive growth dendritic morphology

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Controllable synthesis of NiS and NiS2 nanoplates by chemical vapor deposition

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nano Research 2020年第9期13卷 2506-2511页

作者： Chen Dai Bo Li jia Li bei Zhao Ruixia Wu Huifang Ma Xidong Duan Hunan Key Laboratory of Two-Dimensional Materials and State Key Laboratory for Chemo/Biosensing and Chemometrics College of Chem istry and Chemical EngineeringHunan UniversityChangsha 410082China Hunan Key Laboratory of Two-Dimensional Materials Department of Applied PhysicsSchool of Physics and ElectronicsHunan UniversityChangsha 410082China

Mulitipe stoichiometric ratio of two-dimensional(2D)transition metal dichalcogenides(TMDCs)attracted considerable interest for their unique chemical and physical *** we developed a chemical vapor deposition(CVD)method to controllably synthesize ultrathin NiS and NiS2 *** tuning the growth temperature and the amounts of the sulfur powder,2D nonlayered NiS and NiS2 nanoplates can be selectively prepared with the thickness of 2.0 and 7.0 nm,respectively.X-ray diffraction(XRD)and transmission electron microscopy(TEM)characterization reveal that the 2D NiS and N1S2 nanoplates are high-quality single crystals in the hexagonal and cubic phase,*** transport studies show that electrical conductivities of the 2D NiS and N1S2 nanoplates are as high as 4.6 x 10^5 and 6.3 x 10^5 S·m^-1,*** electrical results demonstrate that the synthesized metallic NiS and NiS2 could serve as good electrodes in 2D electronics.

关键词： two-dimensional(2D)non-layerd materials multi stoichiometries chemical vapor deposition nickel sulfides high conductivity

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