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美国2000年的卫生政策

国外医学（医院管理分册） 1989年第4期6卷 169-172页

作者： beaufort b.longest Jr. 沈杰

政策总是为达到政策目标而制定的。美国卫生政策目标是就医可能性及方便性;医疗质量和成本效益。目前在美国推行的法规和市场机制相结合的循序渐进的卫生政策将谋求同时达到以上三组目标,对卫生系统产生了前所未有的影响。未来的卫生政... 详细信息

政策总是为达到政策目标而制定的。美国卫生政策目标是就医可能性及方便性;医疗质量和成本效益。目前在美国推行的法规和市场机制相结合的循序渐进的卫生政策将谋求同时达到以上三组目标,对卫生系统产生了前所未有的影响。未来的卫生政策不会有巨大的变化,而修正部分政策如在老人医疗保险中增加灾难保险,依靠国家和私人共同解决无保险者的问题等是可能的。90年代不会有新的主要卫生目标,到2000 年,卫生政策的改变也只会是局部的,非根本性的。

关键词：卫生政策美国

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Vanadium mineralization at Los Chihuidos sediment-hosted Cu-V deposit,Neuquén basin,Argentina:An approach to vanadium ore forming processes

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Geoscience Frontiers 2024年第1期15卷 225-246页

作者： Ana L.Rainoldi Daniel beaufort Marta b.Franchini Adolfo Giusiano Sabine Petit Patricia Patrier M.Josefina Pons Dpto.de Geología Universidad Nacional del Sur(UNS)8000 Bahía BlancaArgentina Consejo Nacional de Investigaciones Científicas y Técnicas Centro Patagónico de Estudios MetalogenéticosArgentina Universitéde Poitiers IC2MPCNRS-UMR 7285HydrasaF-86022 Poitiers CedexFrance Universidad Nacional del Comahue Facultad de IngenieríaDepartamento de Geología y Petróleo8300 NeuquénArgentina Consultant Geologist 8300 NeuquénArgentina Universidad Nacional de Río Negro Instituto de Investigación en Paleobiología y GeologíaRío NegroArgentina

Vanadium mineralization at Los Chihuidos deposit of the Neuquén basin is linked to the development of a redox front system related to the inflow of hydrocarbons into the red sandstone of the Huincul *** of hydrocarbons with oxidized red beds and connate water generated redox reactions where hematite was dissolved due to iron reduction resulting in the discoloration of the red *** the contact between oxidized red sandstone and reduced white sandstone,precipitation of specific mineral phases resulted in the V ore with minor amounts of *** the implementation of the redox interface,abundant V-montmorillonite and V-hematite precipitated at the more oxidizing conditions and Cu-V-corrensite-type at the more reducing conditions of the redox *** the redox front advanced with fluids constantly migrating into the reservoir,more reducing conditions were stablished,promoting chloritization and minor illitization with V-Cu incorporation and continuous upgrading of the *** ore mineralogy consists of clay minerals including V-bearing montmorillonite,Cu-V-corrensite-type,V-di-trioctahedral chlorite and Cu-tri-trioctahedral chlorite with minor V-illite-smectite mixed-layer minerals and associated secondary *** over illitization was favored due to high amounts of Fe and Mg in detrital clasts and in connate fluids and by low K availability related to low amounts of detrital *** spatial transition of V and/or Cu bearing clay minerals observed through the mineralized redox front at Los Chihuidos deposit(kaolinite→smectite→illite/smectite→corrensite-type→di-trioctahedral-chlorite→tri-trioctahedral-chlorite)and the related variation of V-Cu concentrations in bulk rock are indicative of increasing pH and decreasing Eh of resident solutions from red to white sandstones during the hypogene mineralization *** influx of Cu-rich oxidized basinal brines precipitated main copper ore with Cu-sulfides in the white sandst

关键词： Clay minerals V-chlorite Redox front bleaching Hydrocarbons

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IKKβ binds NLRP3 providing a shortcut to inflammasome activation for rapid immune responses

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Signal Transduction and Targeted Therapy 2022年第11期7卷 4022-4024页

作者： Yaw Asare Margarita Shnipova LukaŽivković Christina Schlegl Federica Tosato Arailym Aronova Markus brandhofer Laura Strohm Nathalie beaufort Rainer Malik Christian Weber Jürgen bernhagen Martin Dichgans Institute for Stroke and Dementia Research(ISD) University HospitalLudwig-Maximilians-University(LMU)MunichGermany Munich Cluster for Systems Neurology(SyNergy) MunichGermany Institute for Cardiovascular Prevention(IPEK) LMUMunichGermany

Dear Editor,A rapid immune response to signals released from pathogens and injuries is critical for maintaining tissue integrity and restoring *** response is largely mediated by the concerted action of pattern recognition receptors(PRRs).Such cooperativity has been described for Toll-like receptors(TLRs)and NACHT,LRR,and pyrin domain-containing protein 3(NLRP3),but the underlying molecular mechanisms remain incompletely *** are multi-protein complexes defined by a cytosolic innate immune sensor,usually a PRR,which recruits the adaptor molecule apoptosis-associated speck-like protein containing a caspase-recruitment domain(ASC)to activate the effector caspase-1 leading to the release of matured IL-1βand *** caspase-1 further cleaves gasdermin D(GSDMD)allowing the N-terminal domain of GSDMD(GSDMD-N)to form pores in the plasma membrane,thus facilitating the release of matured IL-1βand ***-forming GSDMD-N further induces pyroptosis,an inflammatory form of cell death.

关键词： NLRP3 release activation

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Evaluating indicators of human well-being for ecosystem-based management

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Ecosystem Health and Sustainability 2017年第12期3卷 2-19页

作者： Sara Jo breslow Margaret Allen Danielle Holstein brit Sojka Raz barnea Xavier basurto Courtney Carothers Susan Charnley arah Coulthard Nives Dolsak Jamie Donatuto Carlos Garcia-Quijano Christina C.Hicks Arielle Levine Michael b.Masci Karma Norman Melissa Poe Terre Satterfield Kevin St.Martin Phillip S.Levin Center for Creative Conservation University of WashingtonSeattleWAUSA School of Marine and Environmental Affairs University of WashingtonSeattleWAUSA Nicholas School of the Environment Duke UniversityBeaufortNCUSA College of Fisheries and Ocean Sciences University of Alaska FairbanksAnchorageAKUSA Pacific Northwest Research Station USDA Forest ServicePortlandORUSA Department of Social Sciences and Languages Northumbria UniversityNewcastle upon TyneUK Community Environmental Health Program Swinomish Indian Tribal CommunityLa ConnerWAUSA Department of Sociology and Anthropology The University of Rhode IslandKingstonRI USA Center for Ocean Solutions Stanford UniversityMontereyCAUSA Lancaster Environment Center Lancaster UniversityLancasterUK Department of Geography San Diego State UniversitySan DiegoCAUSA Moore Center for Science Conservation InternationalArlingtonVAUS Northwest Fisheries Science Center National Oceanic and Atmospheric AdministrationSeattleWAUSA Washington Sea Grant University of WashingtonSeattleWAUSA Institute for Resources Environment and SustainabilityUniversity of British ColumbiaVancouverBCCanada Department of Geography RutgersThe State University of New JerseyPiscatawayNJUSA School of Environmental and Forest Sciences University of WashingtonSeattleWAUSA

Introduction:Interrelated social and ecological challenges demand an understanding of how environmental change and management decisions affect human *** paper out-lines a framework for measuring human well-being for ecosystem-based management(EbM).We present a prototype that can be adapted and developed for various scales and *** and managers use indicators to assess status and trends in integrated ecosystem assessments(IEAs).To improve the social science rigor and success of EbM,we developed a systematic and transparent approach for evaluating indicators of human well-being for an ***:Our process is based on a comprehensive conceptualization of human well-being,a scalable analysis of management priorities,and a set of indicator screening criteria tailored to the needs of *** tested our approach by evaluating more than 2000 existing social indicators related to ocean and coastal management of the US West *** focused on two foundational attributes of human well-being:resource access and *** and Discussion:Our results suggest that existing indicators and data are limited in their ability to reflect linkages between environmental change and human well-being,and extremely limited in their ability to assess social equity and *** reveal a critical need for new social indicators tailored to answer environmental questions and new data that are disaggregated by social variables to measure *** both,we stress the importance of collaborating with the people whose well-being is to be ***:Our framework is designed to encourage governments and communities to carefully assess the complex tradeoffs inherent in environmental decision-making.

关键词： Human well-being indicators ecosystem-based management integrated ecosystem assessment resource access self-determination

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儿童期基于单一SCN5A突变的3型长QT综合征和brugada综合征的发育特征

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世界核心医学期刊文摘（心脏病学分册） 2005年第12期1卷 56-56页

作者： beaufort-Krol G. C. M. Van Den berg M. P. Wilde A. A. M. M. Th. E. bink-boelkens 徐永城 beatrix Children's Hospital Department of Pediatric CardiologyHanzeplein 1 9700 RB Groningen Netherlands

ObJECTIVES: The aim was to investigate at what age electrocardiographic characteristics of long QT syndrome type 3(LQT3) and brugada syndrome(bS), based on a single SCN5A mutation, appear. bACKGROUND: The QT interval(QT) in LQT3 is prolonged during bradycardia. It is not clear yet if this is obvious in young children with a relative fast heart rate(HR). METHODS: Thirty-six children with an SCN5A gene mutation(1795insD) and 46 non-carrier siblings were investigated. In different age groups, HR, QT, QTc, and ST segment elevation on a 12-lead electrocardiogram(ECG), and HR, QT, QTc, and ΔQT after the longest pause in a Holter(recording) were evaluated. RESULTS: In all age groups, HR at rest tended to be lower in carriers than in non-carriers, and QT was longer in carriers than in non-carriers. The brugada phenotype was found >5 years. Gender specific differences were not identified. The QT at lower HR and ΔQT were longer in carriers than in non-carriers. A QTc ofbS show age-dependent penetrance. A QT prolongation and conduction disease were present from birth onwards,whereas ST-segment elevation only developed >5 years. Good tools for clinical diagnosis of LQT3 in this family are QTc at the lowest HR and ΔQT after a pause in a Holter, even at very young age.

关键词： brugada SCN5A 童期心电图特征携带者导联心电图基因突变外显率心动过缓年龄组

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基于Radarsat-1数据的北极海冰SAR图像自动分割研究

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唐山学院学报 2018年第6期31卷 13-17页

作者：赵庆平于力刚王耀张馨月淮北师范大学物理与电子信息学院安徽淮北235000 淮北师范大学实验室与设备管理处安徽淮北235000 塔斯马尼亚大学信息技术与系统学院

基于Radarsat-1数据提出了一种集成Gibbs采样标记步骤的北极海冰SAR图像分割算法,该算法综合考虑了斑点噪声、纹理特征等不确定因素,经由像素到区域再到大尺度区域这一途径,把区域化标识、Gibbs采样标记以及区域合并等操作组合起来,实... 详细信息

基于Radarsat-1数据提出了一种集成Gibbs采样标记步骤的北极海冰SAR图像分割算法,该算法综合考虑了斑点噪声、纹理特征等不确定因素,经由像素到区域再到大尺度区域这一途径,把区域化标识、Gibbs采样标记以及区域合并等操作组合起来,实现对海冰SAR图像的分割,针对*** bay和beaufort海冰图像的测试实验表明,与基于区域的MRF分割算法相比提出的算法可有效提高图像分割的准确性。

关键词： SAR海冰图像图像分割 Radarsat-1数据 Gibbs采样标记

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