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Delayed referral for liver transplant evaluation worsens outcomes in chronic liver disease patients requiring inpatient transplant evaluation

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World journal of Transplantation 2023年第4期13卷 169-182页

作者： Katherine m Cooper Alessandro Colletta Nicholas j Hathaway Diana Liu Daniella gonzalez Arslan Talat Curtis Barry Anita Krishnarao Savant mehta Babak movahedi Paulo N martins Deepika Devuni Department of medicine UMass Chan Medical SchoolWorcesterMA 01605United States Department of medicine Division of GastroenterologyUMass Chan Medical SchoolWorcesterMA 01605United States Department of Surgery Transplant DivisionUMass Chan Medical SchoolWorcesterMA 01605United States

BACKGROUND Indications to refer patients with cirrhosis for liver transplant evaluation(LTE)include hepatic decompensation or a model for end stage liver disease(mELDNa)score≥*** studies have evaluated how delaying referral beyond these criteria affects patient *** To evaluate clinical characteristics of patients undergoing inpatient LTE and to assess the effects of delayed LTE on patient outcomes(death,transplantation).mETHODS This is a single center retrospective cohort study assessing all patients undergoing inpatient LTE(n=159)at a large quaternary care and liver transplant center between 10/23/2017-7/31/*** referral was defined as having prior indication(decompensation,mELD-Na≥15)for LTE without *** referral was defined as referrals made within 3 mo of having an indication based on practice *** regression and Cox Hazard Regression were used to evaluate the relationship between delayed referral and patient *** many patients who require expedited inpatient LTE had delayed *** regarding transplant candidacy were a leading cause of delayed ***,delayed referrals negatively affected overall patient outcome and an independent predictor of both death and not receiving a *** referral was associated with a 2.5 hazard risk of *** Beyond initial access to an liver transplant(LT)center,delaying LTE increases risk of death and reduces risk of LT in patients with chronic liver *** is substantial opportunity to increase the percentage of patients undergoing LTE when first clinically *** is crucial for providers to remain informed about the latest guidelines on liver transplant candidacy and the transplant referral process.

关键词： Liver transplantation Liver transplant evaluation Liver transplant referral Patient access Equity Patient outcomes

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Atrazine Sorption by Biochar, Tire Chips, and Steel Slag as media for Blind Inlets: A Kinetic and Isotherm Sorption Approach

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journal of Water Resource and Protection 2016年第13期8卷 1266-1282页

作者： javier m. gonzalez martin j. Shipitalo Douglas R. Smith Elizabeth Warnemuende-Pappas Stanley j. Livingston USDA-ARS National Soil Erosion Research Laboratory West Lafayette IN USA USDA-ARS National Laboratory for Agriculture and the Environment Ames IA USA USDA-ARS Grassland Soil and Water Research Laboratory Temple TX USA

Surface inlets are installed in subsurface drainage systems to reduce ponding duration and surface runoff, but can contribute to water quality concerns by allowing water to directly enter buried drains. Blind inlets consist of perforated pipes covered with gravel and are separated from an overlying sand layer by a geotextile membrane and have been shown to be more effective in reducing losses of sediment, nutrients, and pesticides than typical tile line risers. In this study, we investigated whether the effectiveness of blind inlets to sorb pollutants, with emphasis on the herbicide atrazine, could be further improved by amended them with materials other than limestone. The media, shredded tires (tire chips), electric arc steel furnace slag (steel slag), and oak-derived biochar were chosen because they are readily available, inexpensive, and do not present environmental concerns. Kinetic sorption and isotherms were determined to ascertain atrazine sorption by these materials, in addition to testing for potential metal leaching using the Synthetic Precipitation Leaching Procedure (SPLP) and the Toxicity Characteristic Leaching Procedure (TCLP). The kinetic data were fitted using pseudo first- and second-order reaction equations and indicated that atrazine sorption rate was 38 times faster and equilibrium was reached 5 times earlier for biochar than tire chips. The 24-h sorption isotherm data were fitted to the Freundlich sorption equation. The sorption coefficient for biochar was higher than for tire chips, steel slag, and limestone. Per the SPLC and TLCP tests, there was no leaching of heavy metals at levels of environmental concern. Our results suggested that the effectiveness of blind inlets as well as other conservation practices that include filter media such as rain gardens and filter socks could be improved by incorporating more reactive materials than sand and gravel with biochar being a particularly effective alternative.

关键词： Atrazine Biochar Shredded Tires Sorption Water Quality

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Office Furniture Design for Wheelchair User

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journal of Civil Engineering and Architecture 2012年第11期6卷 1482-1491页

作者： Francisca jose Castillo Rueda Oscar David de Cozar macias maria del Carmen Ladron de Guevara munoz jose Ignacio jimenez gonzalez Elidia beatriz Blazquez Parra Escuela Polit~cnica Superior University of M6laga Mflaga 29071 Spain

There are an estimated 1.19 million wheelchair users in Spain. People use wheelchairs for a variety of reasons, the most common one is paralysis from spinal cord injuries. Current estimates indicate there are around 504,000 people alive in Spain with spinal cord injuries. Among other reasons for using wheelchairs are： fatigue from multiple sclerosis, muscle weakness from muscular dystrophy, lower limb spasticity from cerebral palsy, and missing limbs due to amputation. People who use wheelchairs may encounter a variety of obstacles at their workstations depending on their limitations. Some possible accommodations could be adjustable height desk or table for a person who cannot work comfortably at an existing desk, accessible filing system or office supplies, and frequently used materials on most accessible shelves or drawers for a person who cannot reach upper and lower shelves and drawers. This paper presents the graphical design of a workstation for wheelchair users, in this case, technical, anthropometric, ergonomic, aesthetics and scientists aspects have been analyzed. The design of composite structure conduct to explicit safety constraints applied to office furniture requirements kept continuously current and updated as part of innovation. Finally, results are showed in a three-dimensional model.

关键词： Computers graphics furniture design wheelchair users ergonomic

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Acoustic contamination assessment during the transition between the COVID-19 restrictions and reactivation:A exploratory analysis in Guayaquil

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Geography and Sustainability 2023年第2期4卷 138-149页

作者： Andrés Velastegui-montoya Geancarlo Guerrero-Cabrera Sandra gonzalez-Camba Yadira jaramillo-Lindao Ricardo murillo-Portillo j.Hidalgo-Crespo Luis Encalada-Abarca Centro de Investigación y Proyectos Aplicados a las Ciencias de la Tierra(CIPAT) ESPOL Polytechnic UniversityP.O.Box 09-01-5863GuayaquilEcuador Facultad de Ingeniería en Ciencias de la Tierra(FICT) ESPOL Polytechnic UniversityP.O.Box 09-01-5863GuayaquilEcuador Geoscience Institute Federal University of Pará66075-110BelémBrazil Facultad de Ciencias Naturales y matemáticas(FCNm) ESPOL Polytechnic UniversityP.O.Box 09-01-5863GuayaquilEcuador Sciences pour la Conception l’Optimisation et la Production(G-SCOP)Centre National de la Recherche Scientifique(CNRS)UniversitéGrenoble Alpes38000GrenobleFrance Facultad de Ingeniería Industrial Universidad de Guayaquil090150GuayaquilEcuador Centre of Geographical Studies Institute of Geography and Spatial PlanningUniversity of Lisbon1600-276LisbonPortugal Universidad Espíritu Santo SamborondónEcuador

Noise pollution is becoming a critical health risk for city *** 2020,the COVID-19 pandemic forced many cities to implement several mobility *** restrictions changed human activity patterns and decreased the noise levels and noise pollution that often affect urban *** the number of infections decreased,so did the outdoor activities,influencing the population’s perception of *** paper aims to evaluate the changes in noise levels associated with mobility restrictions between 2020 and 2021 in Guayaquil,*** study used crowdsourcing with the help of smartphones and mobile applications to collect geo-referenced environmental noise *** data was used to generate noise maps in different time ***,noise level maps were created using GIS-based tools to identify the urban areas that experienced the highest noise level variation during the study *** results show that the most significant noise increase occurred at ***,when analyzing noise level changes in different urban areas,the western area of Guayaquil was the one that experienced the most significant noise level *** inform the perception of noise pollution and could potentially serve as a reference for decision-makers during the proposal of public policies that ensure a better quality of life for its citizens.

关键词： Acoustic contamination Crowdsourcing Data scrubbing Kriging Noise map

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Reversal of age-associated frailty by controlled physical exercise:The pre-clinical and clinical evidences

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Sports medicine and Health Science 2019年第1期1卷 33-39页

作者： C.Arc-Chagnaud F.millan A.Salvador-Pascual A.G.Correas G.Olaso-gonzalez A.De la Rosa A.Carretero m.C.Gomez-Cabrera j.Viña Freshage Research Group Department of PhysiologyFaculty of MedicineUniversity of Valencia and CIBERFESFundacion Investigacion Hospital Clínico Universitario/INCLIVAValenciaSpain INRA UMR866 Dynamique Musculaire et MetabolismeUniversite de MontpellierF-34060MontpellierFrance

Demographic aging is one of the most serious challenges facing our *** we live longer,we do not live better because it is considered that approximately 16–20%of our life is spent in late-life *** people have the greatest risk of developing frailty increasing the risk of presenting various adverse health events such as low quality of life,disability,hospitalization and even *** men and women over 65 years old have lower muscle quality and muscle mass and higher percentage of body fat than non-frail people of the same *** this review we will address the main physiological changes in the muscular and nervous system associated to *** specifically we will review the changes in muscle mass,quality,and strength relating them with the decrease in capillarization and muscular oxidative capacity as well as with the alterations in protein synthesis in the muscle with *** last section of the manuscript will be devoted to the animal models of frailty and the indexes developed to measure frailty in these *** will finally address the importance of exercise training as an intervention to delay or even reverse frailty.

关键词： Sarcopenia multicomponent exercise Disability Skeletal muscle Healthy aging

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Influence of laser polarization on collective electron dynamics in ultraintense laser-foil interactions

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High Power Laser Science and Engineering 2016年第3期4卷 120-126页

作者： Bruno gonzalez-Izquierdo Ross j.Gray martin King Robbie Wilson Rachel j.Dance Haydn Powell David A.mac Lellan john mcCreadie Nicholas m.H.Butler Steve Hawkes james S.Green Chris D.murphy Luca C.Stockhausen David C.Carroll Nicola Booth Graeme G.Scott marco Borghesi David Neely Paul mcKenna SUPA Department of Physics University of Strathclyde Central Laser Facility STFC Rutherford Appleton Laboratory Department of Physics University of York Centro de Láseres Pulsados (CLPU) Centre for Plasma Physics Queens University Belfast

The collective response of electrons in an ultrathin foil target irradiated by an ultraintense(~6×10^(20)W cm^(-2)) laser pulse is investigated experimentally and via 3D particle-in-cell simulations. It is shown that if the target is sufficiently thin that the laser induces significant radiation pressure, but not thin enough to become relativistically transparent to the laser light, the resulting relativistic electron beam is elliptical, with the major axis of the ellipse directed along the laser polarization axis. When the target thickness is decreased such that it becomes relativistically transparent early in the interaction with the laser pulse, diffraction of the transmitted laser light occurs through a so called ‘relativistic plasma aperture', inducing structure in the spatial-intensity profile of the beam of energetic electrons. It is shown that the electron beam profile can be modified by variation of the target thickness and degree of ellipticity in the laser polarization.

关键词： laser–plasmas interaction ultraintense ultrashort pulse laser interaction with matters

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Function of hepatocyte spheroids in bioactive microcapsules is enhanced by endogenous and exogenous hepatocyte growth factor

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Bioactive materials 2023年第10期28卷 183-195页

作者： Kihak Gwon Daheui Choi jose mde Hoyos-Vega Harihara Baskaran Alan m.gonzalez-Suarez Seonhwa Lee Hye jin Hong Kianna m.Nguyen Ether Dharmesh Go Sugahara Yuji Ishida Takeshi Saito Gulnaz Stybayeva Alexander Revzin Department of Physiology and Biomedical Engineering Mayo ClinicRochesterMNUSA Department of Chemical and Biomolecular Engineering Case Western Reserve UniversityClevelandOHUSA Biomedical Engineering Saint Louis UniversitySt.LouisMOUSA University of Southern Californi1 Keck School of MedicineDepartment of MedicineDivision of Gastrointestinal and Liver DiseasesLos AngelesCAUSA Research and Development Department PhoenixBioCo.LtdKagamiyam1Higashi-Hiroshim1Hiroshim1Japan USC Research Center for Liver Diseases Los AngelesCAUSA

The ability to maintain functional hepatocytes has important implications for bioartificial liver development,cell-based therapies,drug screening,and tissue *** approaches can be used to restore hepatocyte function in vitro,including coating a culture substrate with extracellular matrix(ECm),encapsulating cells within biomimetic gels(Collagen-or matrigel-based),or co-cultivation with other *** paper describes the use of bioactive heparin-based core-shell microcapsules to form and cultivate hepatocyte *** microcapsules are comprised of an aqueous core that facilitates hepatocyte aggregation into spheroids and a heparin hydrogel shell that binds and releases growth *** demonstrate that bioactive microcapsules retain and release endogenous signals thus enhancing the function of encapsulated *** also demonstrate that hepatic function may be further enhanced by loading exogenous hepatocyte growth factor(HGF)into microcapsules and inhibiting transforming growth factor(TGF)-β1 ***,bioactive microcapsules described here represent a promising new strategy for the encapsulation and maintenance of primary hepatocytes and will be beneficial for liver tissue engineering,regenerative medicine,and drug testing applications.

关键词： Droplet microfluidics Bioactive microcapsules Hepatocyte spheroid Heparin Hepatocyte growth factor

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Combining Ability in mixtures of Prairie Grass and Clovers

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American journal of Plant Sciences 2012年第10期3卷 1355-1360页

作者： miguel jacinto Arturi mónica beatriz Aulicino Oscar Ansín Gustavo Gallinger Rodolfo Signorio Facultad de Ciencias Agrarias y Forestales Universidad Nacional de La PlataCalle 60 y 119 S/NCC·31(1900)La PlataProvincia de Buenos AiresArgentina Instituto Fitotécnico de Santa Catalina FCAFUNLPGaribaldi 3400(1836)LlavallolProvincia de Buenos AiresArgentina Estación Experimental j.Hirschhorn FCAFUNLPCalle 66 y 166 S/NLos HornosProvincia de Buenos AiresArgentina

Our objective was to evaluate the combining ability among cultivars of forage species, commonly sown in temperate regions of Argentina using a short rotation system. Three genetically diverse cultivars of prairie brome grass (Bromus catharticus, cv Copetona, cv ?andú and cv Tango), a white clover cultivar (Trifolium repens, cv Lucero) and a red clover cultivar (T. pratense, cv Tropero) were evaluated. A randomized complete block design experiment was established in 2005. The treatments included five monocultures and ten binary mixtures. The experiment was harvested 6 times over an 18-month period. Cumulative dry matter yield (kg?ha–1) was calculated as the sum of the six individual harvests. Diallel analysis provided estimates of the general combining ability (GCA) and specific combining ability (SCA). Red clover in monoculture and mixtures produced the highest yields, with significant positive GCA effects (P P P P m nature of this study, we must limit our inference to short-term pastures (mbination with prairie brome grass.

关键词： Bromus catharticus Trifolium repens T. pretense Grass/Legume mixtures Dry matter Yield Argentina

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Fatty acid desaturation by stearoyl-CoA desaturase-1 controls regulatory T cell differentiation and autoimmunity

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Cellular & molecular Immunology 2023年第6期20卷 666-679页

作者： Elien Grajchen melanie Loix Paulien Baeten beatriz F.Côrte-Real Ibrahim Hamad Sam Vanherle mansour Haidar jonas Dehairs jelle Y.Broos james m.Ntambi Robert Zimmermann Rolf Breinbauer Piet Stinissen Niels Hellings Sanne G.S.Verberk Gijs Kooij martin Giera johannes V.Swinnen Bieke Broux markus Kleinewietfeld jerome j.A.Hendriks jeroen F.j.Bogie Department of Immunology and Infection Biomedical Research InstituteHasselt UniversityDiepenbeekBelgium University mS Center Hasselt PeltBelgium Neuro-Immune Connections and Repair Lab Department of Immunology and InfectionBiomedical Research InstituteHasselt UniversityDiepenbeekBelgium VIB Laboratory of Translational Immunomodulation VIB Center for Inflammation ResearchHasselt UniversityDiepenbeekBelgium Department of Oncology Laboratory of Lipid Metabolism and CancerLKI–Leuven Cancer InstituteKU Leuven-University of LeuvenLeuvenBelgium Department of molecular Cell Biology and Immunology Amsterdam University Medical CenterVrije Universiteit AmsterdamAmsterdam NeuroscienceMS Center AmsterdamAmsterdamThe Netherlands Center for Proteomics and metabolomics Leiden University Medical CenterLeidenThe Netherlands Department of Biochemistry Department of Nutritional SciencesUniversity of Wisconsin-MadisonMadisonUSA Institute of molecular Biosciences University of GrazGrazAustria BioTechmed-Graz GrazAustria Institute of Organic Chemistry Graz University of TechnologyGrazAustria Cardiovascular Research Institute maastricht Department of Internal MedicineMaastricht UniversityMaastrichtThe Netherlands

The imbalance between pathogenic and protective T cell subsets is a cardinal feature of autoimmune disorders such as multiple sclerosis(mS).Emerging evidence indicates that endogenous and dietary-induced changes in fatty acid metabolism have a major impact on both T cell fate and *** date,however,the molecular mechanisms that underlie the impact of fatty acid metabolism on T cell physiology and autoimmunity remain poorly ***,we report that stearoyl-CoA desaturase-1(SCD1),an enzyme essential for the desaturation of fatty acids and highly regulated by dietary factors,acts as an endogenous brake on regulatory T-cell(Treg)differentiation and augments autoimmunity in an animal model of mS in a T cell-dependent *** by RNA sequencing and lipidomics analysis,we found that the absence of Scd1 in T cells promotes the hydrolysis of triglycerides and phosphatidylcholine through adipose triglyceride lipase(ATGL).ATGL-dependent release of docosahexaenoic acid enhanced Treg differentiation by activating the nuclear receptor peroxisome proliferator-activated receptor *** findings identify fatty acid desaturation by SCD1 as an essential determinant of Treg differentiation and autoimmunity,with potentially broad implications for the development of novel therapeutic strategies and dietary interventions for autoimmune disorders such as mS.

关键词： Regulatory T cells Autoimmunity Fatty acid metabolism Stearoyl-CoA desaturase-1 multiple sclerosis

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Corrosion Inhibition of Carbon Steel in Acidic mediaby Using Actinidia deliciosa(Kiwifruit)Extract

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Advances in materials Physics and Chemistry 2015年第11期5卷 447-457页

作者： m.I.Arias-montoya G.F.Dominguez-Patino j.G.gonzalez-Rodriguez j.A.Dominguez-Patino m.L.Dominguez-Patino Facultad de Ciencias Quimicas e Ingenieria Universidad Autonoma del Estado de MorelosCuernavacaMexico Facultad de Ciencias Biologicas Universidad Autonoma del Estado de MorelosCuernavacaMexico Universidad Autonoma del Estado de morelos CIICAPCuernavacaMexico

The corrosion inhibition of 1018 carbon steel in 0.5 m H2SO4 by using Actinidia deliciosa (Kiwifruit) peel extract has been investigated by using potentiodynamic polarization curves and electro-chemical impedance spectroscopy. Two kinds of extracts are investigated, one from the tender, and another one from ripe Actinidia deliciosa. Concentrations include 0, 25, 50, 75, and 100 ppm at room temperature. Results indicate that both kind of extracts acted as good corrosion inhibitors, is more efficient in the ripe extract. Corrosion inhibition efficiency increases with increasing its concentration for ripe extract, whereas for the tender Actinidia deliciosa, the higest inhibitor efficiency is obtained by adding 25 ppm and decresaing with a further increase in its concentration. Both extracts improve the passive film properties by decreasing the passive current density values. It is found that the corrosion inhibition is due to the presence of heteroatoms present in Actinidia deliciosa, mainly quercitine, which is physically adsorbed in the steel following a Frumkin type of adsorption isotherm which forms a protective film.

关键词： Green Inhibitor Acidic Corrosion Electrochemical Techniques

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