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Advanced glycation end product:A potential biomarker for risk stratification of non-alcoholic fatty liver disease in ELSA-Brasil study

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World Journal of Gastroenterology 2021年第29期27卷 4913-4928页

作者： Evelyn Nunes Goulart da Silva Pereira Daniela Polessa Paula beatriz peres de araujo Maria de Jesus Mendes da Fonseca Maria de Fátima Haueisen Sander Diniz Anissa Daliry Rosane Harter Griep Laboratory of Cardiovascular Investigation Oswaldo Cruz FoundationRio de Janeiro 21040-360Brazil National School of Statistical Sciences Brazilian Institute of Geography and StatisticsRio de Janeiro 20231-050Brazil department of Epidemiology and Quantitative Methods in Health Oswaldo Cruz FoundationRio de Janeiro 21040-360Brazil Faculty of Medicine Universidade Federal de Minas GeraisMinas Gerais 31270-901Brazil Laboratory of Health and Environment Education Oswaldo Cruz FoundationRio de Janeiro 21040-360Brazil

BACKGROUND Liver diseases are associated with the excess formation of advanced glycation end products(AGEs),which induce tissue inflammation and oxidative ***,the trend of oxidative marker levels according to the steatosis grade in non-alcoholic fatty liver disease(NAFLD)is *** To compare serum AGE levels between participants with NAFLD accordingly to steatosis severity in the baseline ELSA-Brasil *** In 305 individuals at baseline ELSA-Brasil,NAFLD-associated steatosis was classified by ultrasound hepatic *** participants were grouped according to the severity of steatosis:mild and moderate/severe *** measurement of serum fluorescent AGE concentrations was based on spectrofluorimetric *** AGE content and clinical and laboratory characteristics of the participants were compared between *** correlation between serum AGE levels and the grade of steatosis was *** regression analysis was used to investigate the relationship between serum AGE levels and steatosis severity.A P valuedered statistically *** According to the steatosis severity spectrum in NAFLD,from mild to moderate/severe,individuals with the most severe steatosis grade had a higher incidence of metabolic syndrome(63%vs 34%,P≤0.001),diabetes mellitus(37%vs 14%,P≤0.001),and high cholesterol levels(51%vs 33%,Pdex,systolic and diastolic blood pressure,fasting blood glucose,glycated hemoglobin,insulin,triglycerides,alanine aminotransferase,gamma-glutamyl transferase,C-reactive protein,and uric acid levels and lower high-density *** serum AGE content was present in the moderate/severe group of individuals than in the mild group(P=0.008).In addition,the serum AGE levels were correlated with the steatosis grade in the overall sample(rho=0.146,P=0.010).Logistic regres

关键词： Advanced glycation end products Non-alcoholic fatty liver disease Steatosis ELSA-Brasil study Spectroscopy

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Zoning Map of Favorable Areas for the Major Occurrence of Thaumastocoris peregrinus in Brazil

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Journal of Agricultural Science and Technology(A) 2021年第2期11卷 84-92页

作者： Rafael Mingoti Maria Conceicao peres Young Pessoa Catarina de araujo Siqueira Jeanne Scardini Marinho-Prado Embrapa Territorial Campinas/SP13070-115Brazil Embrapa Environment Jaguariuna/SP13918-110Brazil Intern at Embrapa Territorial/PUC-Campinas Campinas/SP13087-571Brazil

Native of Australia,Thaumastocoris peregrinus(Eucalyptus bronze bug)is a Eucalyptus insect pest which was firstly detected in Brazil in June *** studies have shown favorable areas for *** population outbreaks in Brazil,based on georeferenced-crossing information using geographical information system(GIS).despite that,it is crucial to both enhance the precision of methods used on georeferenced crossings and update information,in order to enable greater precision toward the identification of propitious areas for the occurrence of the *** objective of this study was to identify areas with favorable conditions to occurrence of Thaumastocoris peregrinus in Brazil,in at least one month in the year,based on national information of this *** conditions to the occurrence of the insect,the average climatic data from weather stations(2009-2018)and Eucalyptus crop areas in 2018 were *** information was used in GIS to obtain a zoning map indicating the favorable areas to the insect in at least one month in the *** georeferenced-crossing technique used considered both spatial interpolation by Cokriging methods and by Inverse Distance Weighted(IDW).Results indicated the presence of propitious outbreaks for *** occurring in differentiated months in the Southern,Southeastern,Midwestern and Northeastern geographic regions of the country,with lowest monthly aptitude noticed for the Northern *** sequential periods of favorability for occurrences from very high to medium intensities were identified.

关键词： Eucalyptus bronze bug forest geostatistical spatial analysis

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