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Warm Forged Medium Carbon V Steel

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Journal of Iron and Steel Research International 2011年第S1期18卷 822-826页

作者： Carlos Garcia-Mateo beatriz Lopez Jose Maria Rodriguez-Ibabe MATERALIA Research Group.Department of Physical Metallurgy Centro Nacional de Investigaciones Metalúrgicas (CENIM-CSIC)Avda.Gregorio del Amo 8.E-28040MadridSpain CEIT and TECNUM (University of Navarra) Po Manuel de Lardizabal 15San SebastianE-20018Basque ContrySpain

Nowadays there is a continuous demand,particularly from the automotive industry,for cheaper,lighter and more reliable *** is not surprising then that steel research has been focused during the last decades in new qualities and *** paper is dealing with the use of vanadium microalloyed steels on one of those new processes,warm *** its low precipitation temperature and its recognised ability to strengthen steel microstructures via austenite grain growth control,precipitation hardening and interference of the static recrystallization process,vanadium in microalloyed steels seem to be an appropriate candidate for warm forging.

关键词： warm forging vanadium microalloyed steels

Social Vulnerability to Natural Hazards in Brazil

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International Journal of Disaster Risk Science 2016年第2期7卷 111-122页

作者： beatriz Maria de Loyola Hummell Susan L.Cutter Christopher T.Emrich American Red Cross Southwest Washington ChapterHumanitarian Services Hazards & Vulnerability Research Institute Department of Geography University of South Carolina

Although social vulnerability has recently gained attention in academic studies, Brazil lacks frameworks and indicators to assess it for the entire *** vulnerability highlights differences in the human capacity to prepare for, respond to, and recover from disasters. It varies over space and time, and among and between social groups, largely due to differences in socioeconomic and demographic characteristics. This article provides a social vulnerability index(SoVI~) replication study for Brazil and shows how SoVI~concepts and indicators were adapted to the country. SoVI~Brazil follows the place-based framework adopted in the Social Vulnerability Index initially developed for the United States. Using a principal component analysis(PCA), 45city-level indicators were reduced to 10 factors that explain about 67 % of the variance in the data. Clearly identified spatial patterns showed a concentration of the most socially vulnerable cities in the North and Northeast regions of Brazil, as well as the social vulnerability of metropolitan areas and state capitals in the South and Southeast *** least vulnerable cities are mainly concentrated in the inland regions of the Southeast. Although different factors contribute to the social vulnerability in each city, the overall results confirm the social and economic disparities among Brazilian’s regions and reflect a differential vulnerability to natural hazards at local to regional scales.

关键词： Brazil Natural hazards Social vulnerability Social vulnerability index(SoVI)

Lupeol:An antioxidant triterpene in Ficus pseudopalma Blanco(Moraceae)

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Asian Pacific Journal of Tropical Biomedicine 2014年第2期4卷 109-118页

作者： Librado A Santiago Anna beatriz R.Mayor Research Center for the Natural and Applied Sciences.University of Santo Tomas Manila.Philippines Department of Biochemistry Faculty of Pharmacy.University of Santo TomasManila.Philippines The Graduate School.University of Santo Tomas Manila.Philippines

Objective:To assess the antioxidant activity of Ficus pseudopalma Blanco(Moraceae)(***) and characterize the active components present in ***:Column chromatography of crude ethanol leaf extract of *** was performed and seven fractions were obtained,labeled as Ft.F2,F3,F4.F5,F6,***,Criess,Kenton and superoxide radical scavenging assays were performed to assess the antioxidant ability of the *** layer chromatography(TLC),high performance liquid chromatography and Fourier transfer infrared spectroscopy(FTIR) were performed to identify and characterize the bioactive component present in each fractions of ***:DPPH and FRAP assay showed that F5.F6 and F7 exhibited the good proton accepting ability and reducing power as compared to the other *** fractions exhibited a good nitric oxide radical scavenging activity wherein F1,F2 and F3 showed the highest ***,all of the fractions exhibited a stimulatory activity on hydroxyl and superoxide *** matched one of the spots on the thin layer chromatography chromatogram of the *** gradient high performance liquid chromatography and spiking of lupeol with the fraction revealed the presence of 5.84 mg/L lupeol in *** spectra of the fractions revealed the presence of C-C,OH,aromatic C=C and C=O ***:The identified lupeol in *** may be responsible for the exhibited antioxidant property of the ***,knowing the antioxidant capability of the plant,*** can be developed into products which can help prevent the occurrence of oxidative stress related diseases.

关键词： Antioxidant Oxidative stress Free radical scavenging Reducing power Phenolic acids Ficus pseudopalma Blanco

Pressure-induced ferroelectric and anti-ferroelectric phase transitions in LaN

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Science China(Physics,Mechanics & Astronomy) 2023年第2期66卷 122-130页

作者： Chi Ding Jianan Yuan beatriz H.Cogollo-Olivo Yunlong Wang Xiaomeng Wang Jian Sun National Laboratory of Solid State Microstructures School of Physics and Collaborative Innovation Center of Advanced MicrostructuresNanjingUniversityNanjing 210093China Applied Math Institute University of CartagenaCartagena de Indias 130001Colombia

In this work,we focus on the structural and electronic properties of lanthanum mono-nitride s under high *** on firstprinciples calculations and crystal structure predictions,we identified an anti-ferroelectric orthogonal phase with space group *** is predicted to be thermodynamically stable from 20 to 60 GPa,above which the tetragonal phase without the antiferroelectric distortion will substitute ***,the anti-ferroelectric distortion can be enhancedby reducing the pressure,and a phase transition to a NiAs-type(B8,P63/mmc) structure occurs at about 20 *** calculated double-well potential for La atoms along the c direction in the B8 phase reveals that it should exhibit ferroelectric properties at low *** calculations well confirm their phase transition sequences under high *** properties calculations suggest that all the newly identified phases are semiconductors and the corresponding structural distortions can increase their *** increasing the pressure to 50 GPa,the tetragonal phase undergoes a semiconductor-to-semimetal *** the spin-orbit coupling into account,the semimetal phase becomes a topological insulator with a small ***,given the similarities between the ionic compounds LaN and BaO,we predict that the most stable phase for BaO at about 25 GPa should also be the anti-ferroelectric orthogonal phase instead of the tetragonal phase.

关键词： ferroelectric phase distortion

Erlotinib inhibits progression to dysplasia in a colitis-associated colon cancer model

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World Journal of Gastroenterology 2011年第44期17卷 4858-4866页

作者： beatriz Pagán Angel A Isidro Myrella L Cruz Domenico Coppola Caroline B Appleyard Department of Physiology and Pharmacology Ponce School of Medicine Department of Anatomic Pathology H.Lee Moffitt Cancer Center and Research Institute

AIM:To investigate the role of epidermal growth factor receptor(EGFR) in colitis-associated dysplasia using the EGFR tyrosine kinase inhibitor ***:Sprague-Dawley rats received trinitrobenzene sulfonic acid(TNBS;30 mg in 50% ethanol,ic),followed 6 wk later by reactivation with TNBS(5 mg/kg,iv) for 3 *** induce colitis-associated dysplasia,rats then received TNBS(iv) twice a week for 10 *** group received erlotinib(10 mg/kg,ip) for 1 wk before the start of the reactivation of the colitis and 2 wk after(21 d);the rest received the *** rats were euthanized,the colons were removed and analyzed for damage and expression of the EGFR downstream effectors Erk1/2 and ***:Ninety percent of the vehicle-treated animals had dysplasia in any region of the ***-treated animals had a significant decrease in the incidence of dysplasia compared to vehicle-treated animals in all regions of the colon(50.00% ± 11.47% vs 90.00% ± 10.00% in proximal,P < 0.05;15.00% ± 8.19% vs 50.00% ± 16.67% in mid,P < 0.05;and 20.00% ± 9.17% vs 70.00% ± 15.28% in distal,P < 0.01).Erlotinib-treated animals also had reduced cell proliferation,reduced active Erk1/2,and reduced c-Myc in colon epithelium compared with the vehicle-treated *** vitro,erlotinib treatment was shown to markedly decrease c-Myc and pErk1/2 levels in rat epithelial *** of rat epithelial cells was stimulated by epidermal growth factor and inhibited by erlotinib(P < 0.05).CONCLUSION:Erlotinib can decrease the development of colitis-associated dysplasia,suggesting a potential therapeutic use for erlotinib in patients with long-standing colitis.

关键词： Animal model Epidermal growth factor receptor Colitis Dysplasia Erlotinib

Building health monitoring in the old town of Madrid:applicability of SAR Imagery to the monitoring of underground works through classification indexes

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International Journal of Digital Earth 2021年第3期14卷 271-287页

作者： Adrian Jesus Garcia beatriz González-Rodrigo Sara Martinez Ruben Martinez Miguel Marchamalo Topography and Geomatics Lab ETSI CaminosCanales y PuertosUniversidad Politécnica de MadridMadridSpain ETS de Ingeniería Civil Universidad Politécnica de MadridMadridSpain

The old city centers of many major cities represent a great challenge from a constructive point of view since the foundations of the buildings consist of an aggregation of previous *** endorses thorough monitoring activities during any underground *** capabilities of the persistent scatterer interferometry(PSI)can be exploited to cope with these monitoring ***,the old city centers represent a very challenging urban scenario since the rooftops are usually filled with air conditioning systems and due to the fact that the streets are usually *** work assesses the applicability of the PSI technique under this challenging ***,it proposes a set of novel classification indexes that allow an objective assessment of the building’s health and the impact derived from any *** can be applied in deformation monitoring and risk evaluation in urban *** applicability of the technique and the proposed indexes is validated in the monitoring of underground construction works in the old city center of Madrid comparing the results against on-ground measurements and identifying the potential and the limitation of the technique.

关键词： Satellite-based monitoring historical city center building health monitoring persistent scatterer interferometry urban planning

Functions of NKG2D in CD8^(+) T cells: an opportunity for immunotherapy

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Cellular & Molecular Immunology 2018年第5期15卷 470-479页

作者： Kushal Prajapati Cynthia Perez Lourdes beatriz Plaza Rojas Brianna Burke Jose A Guevara-Patino Loyola University Chicago Oncology InstituteMaywoodIL 60153USA

Natural killer group 2 member D(NKG2D)is a type II transmembrane ***2D is present on NK cells in both mice and humans,whereas it is constitutively expressed on CD8+T cells in humans but only expressed upon T-cell activation in ***2D is a promiscuous receptor that recognizes stress-induced surface *** NK cells,NKG2D signaling is sufficient to unleash the killing response;in CD8+T cells,this requires concurrent activation of the T-cell receptor(TCR).In this case,the function of NKG2D is to authenticate the recognition of a stressed target and enhance TCR ***28 has been established as an archetype provider of costimulation during T-cell *** has become apparent,however,that signals from other costimulatory receptors,such as NKG2D,are required for optimal T-cell function outside the priming *** review will focus on the similarities and differences between NKG2D and CD28;less well-described characteristics of NKG2D,such as the potential role of NKG2D in CD8+T-cell memory formation,cancer immunity and autoimmunity;and the opportunities for targeting NKG2D in immunotherapy.

关键词： NKG2D CD28 CD8+T Cell Cancer Immunity Auto-immunity Memory Immunotherapy

Severe Acute Hepatitis of Unknown Origin in Children: What Do We Know Today?

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Journal of Clinical and Translational Hepatology 2022年第4期10卷 711-717页

作者： María Teresa Pérez-Gracia Antonio Tarín-Pelló beatriz Suay-García Área de Microbiología.Departamento de Farmacia Universidad Cardenal Herrera-CEU.CEU UniversitiesAlfara del Patri-arca(Valencia)Spain ESI International Chair@CEU-UCH Departamento de MatemáticasFísica y Ciencias TecnológicasUniversidad Cardenal Herrera-CEUCEU UniversitiesAlfara del Patriarca(Valencia)Spain

In May 2022, the UK International Health Regulations National Focal Point notified World Health Organization of 176 cases of severe acute hepatitis of unknown etiology in children under 10 years of age. From that moment on, cases of severe acute hepatitis of unknown origin in children began to be reported in several countries. As of June 17, 2022, a total of 991 cases had been reported in 35 countries worldwide, 50 children needed a liver transplant and 28 patients died. According to information published by ECDC, 449 cases have been detected in 21 EU countries. The children were between 1 month and 16 years of age. Adenovirus was detected in 62.2% of the analyzed samples. So far, the cause of these cases is unknown and many hypotheses remain open, but hepatitis A-E viruses and COVID-19 vaccines have been ruled out. A possible hypothesis has been published to explain the cause of these cases of severe hepatitis, according to which it could be a consequence of adenovirus infection in the intestine in healthy children previously infected with SARS-CoV-2. No other clear epidemiological risk factors have been identified to date. Thus, at this time, the etiology of the current cases of hepatitis remains under active investigation.

关键词： Hepatitis Children Unknown origin SARS-CoV-2 Adenovirus

In vitro antioxidant,antilipoxygenase and antimicrobial activities of extracts from seven climbing plants belonging to the Bignoniaceae

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Journal of Integrative Medicine 2018年第4期16卷 255-262页

作者： Carola Analla Torres Cristina Marisel Perez Zamora Maria beatriz Nunez Ana Maria Gonzalez Laboratory of Microbiology and Pharmaceutical Technology Department of Basic and Applied SciencesNational University of Chaco AustralPresidencia Roque Saenz Pena 3700ChacoArgentina National Council for Scientific and Technical Research(CONICET) Godoy Cruz 2290Buenos Aires C1425FQBArgentina Institute of Botany of the Northeast(IBONE-CONICET) Sargento Juan Bautista Cabral 2131CorrientesArgentina

Objectives： This study aimed to evaluate the in vitro antioxidant capacity, to determine the anti-inflammatory effect due to lipoxygenase inhibition and to test the antimicrobial activity of ethanolic extracts from leaves of seven climbing species belonging to the Bignoniaceae family. These species are Adenocalyrnrna rnarginatum （Cham.） DC., Amphilophium vauthieri DC., Cuspidaria convoluta （VEIL） A. H. Gentry, Dolichandra dentata （K. Schum.） L. G. Lohmann, Fridericia caudigera （S. Moore） L. G. Lohmann, Fridericia chica （Bonpl.） L. G. Lohmann and Tanaecium selloi （Spreng.） L. G. Lohmann. Methods： The antioxidant activity was evaluated using three methods, 2,2＇-azino-bis（3-ethylbenzothiazo line-6-sulfonic acid）（ABTS）, 2,2-diphenyl-l-picrylhydrazyl （DPPH）, and ferric reducing antioxidant power. Lipoxygenase-inhibiting activity was assayed spectrophotometrically; the result was expressed as percent inhibition. The antimicrobial activity was assessed using the agar disk diffusion method. Minimal inhibitory concentration （MIC） and minimal bactericidal]fungicidal concentration were also determined for each extract against 12 pathogenic bacterial strains of Staphylococcus aureus and seven fungal strains of the Candida genus. The identification of the major compounds present in the most promising extract was established by high-performance liquid chromatography-tandem mass spectrometry. Results： C convoluta, F. caudigera, and F. chica exhibited the best antioxidant activity by scavenging DPPH and ABTS~ radicals and reducing Fe3＋ ion. These extracts showed a notable inhibition of lipnxygenase. F. caudigera was found to have the lower MIC value against S. aureus strains and six Candida species. The extracts of F. caudigera and C. convoluta were active even against methicillin-resistant S. aureus. C convoluta had higher total phenol content, better antioxidant activity and superior anti- inflammatory and antimicrobial activity. The main phenolic compounds found in this extract

关键词： Cuspidaria Fridericia Antioxidants Lipoxygenase Antimicrobials Herbal drugs Free radical scavengers