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The Sustainable Procedure Framework for Disaster Risk Management: Illustrated by the Case of the EU Floods Directive in Sweden

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International Journal of Disaster Risk Science 2016年第2期7卷 151-162页

作者： beatrice Hedelin Department of Environmental and Life Sciences Centre for Climate and Safety Karlstad University

How can the concrete meaning of the ambiguous and theoretical concept of sustainable development(SD) be defined and implemented, without losing sight of its fundamental principles? This study introduces a theoretical framework that supports studies of SD implementation in the context of strategic disaster risk management, by defining what SD implies with regard to planning procedures. The framework is based on the procedural SD principles of participation and integration. It was originally developed for,and has shown great value in, the field of water resource management. In-depth interviews with senior risk management researchers indicate that the framework is also applicable to and valuable for disaster risk management *** illustrate the application of the framework, a study of the EU Floods Directive in Sweden is summarized with the framework as the basis for the analysis.

关键词： Disaster risk management EU Floods Directive Planning Sustainable development Sustainable Procedure Framework Sweden

Shaping Small Bioactive Molecules to Untangle Their Biological Function： A Focus on Fluorescent Plant Hormones

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Molecular Plant 2016年第8期9卷 1099-1118页

作者： beatrice Lace Cristina Prandi Department of Chemistry University of Turin Via P. Giuria 7 10125 Torino Italy

Modern biology overlaps with chemistry in explaining the structure and function of all cellular processes at the molecular level. Plant hormone research is perfectly located at the interface between these two disciplines, taking advantage of synthetic and computational chemistry as a tool to decipher the complex biological mechanisms regulating the action of plant hormones. These small signaling molecules regulate a wide range of developmental processes, adapting plant growth to ever changing environmental conditions. The synthesis of small bioactive molecules mimicking the activity of endogenous hormones allows us to unveil many molec- ular features of their functioning, giving rise to a new field, plant chemical biology. In this framework, fluores- cence labeling of plant hormones is emerging as a successful strategy to track the fate of these challenging molecules inside living organisms. Thanks to the increasing availability of new fluorescent probes as well as advanced and innovative imaging technologies, we are now in a position to investigate many of the dynamic mechanisms through which plant hormones exert their action. Such a deep and detailed comprehension is mandatory for the development of new green technologies for practical applications. In this review, we sum- marize the results obtained so far concerning the fluorescent labeling of plant hormones, highlighting the basic steps leading to the design and synthesis of these compelling molecular tools and their applications.

关键词： plant hormones fluorescent labeling fluorescent strigolactone analogs labeled bioactive com-pounds fluorescence imaging

The Hsp90 chaperone complex-A potential target for cancer therapy?

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World Journal of Gastroenterology 1999年第3期5卷 195-198页

作者： beatrice D. Darimont University of California 美国

ORIGINAL ARTICLEDown-regulation of Hsp90 could change cell cycle distribution and increase drug sensitivity of tumor cells..

关键词： SGC ADP The Hsp90 chaperone complex-A potential target for cancer therapy

The ＂narrative sincerity＂ in museums, architectural and archaeolosical restoration of Franco Minissi

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Frontiers of Architectural Research 2015年第3期4卷 202-211页

作者： beatrice A. Vivio Deportment of Architectural History Survey and Conservotion 'Supienza' University of Rome Rome 00185 Italy

The Italian historiography of the architecture of the second half of the Twentieth century has not given due weight to the dialectic qualities of work of Franco Minissi on ancient structures. He became known for the debate on the use of innovative materials in archaeological sites and not for the extent of his contributions. The world do not know his museums, Italian and not, his many conservation and restoration projects, his archaeological parks, redevelopments of historic centres, new buildings, interior design projects, shops and exhibitions. A reading of his museological works alongside of his experiments on archaeological sites, can help highlight the conceptual congruence with which Minissi tried to meet the needs of the present and the preservation of antiquities, as a dialogue with the past, of refined sensibility and intended to a reversibility respectful of preexistence. This places him among the key figures of the origins of the critical restoration, as an inspiration that continues to offer fruitful ideas to the new generations.

关键词： Critical restoration virtual reintegration Ancient architecture Museology Archaeological arrangement Museum design Critical conservation theory

Programmed cell death and natural killer cells in multiple sclerosis: new potential therapeutic targets?

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Neural Regeneration Research 2016年第5期11卷 733-734页

作者： beatrice Macchi Antonio Mastino Department of Systems Medicine University of Rome "Tor Vergata" Department of Chemical Biological Pharmaceutical and Environmental Sciences University of Messina The Institute of Translational Pharmacology CNR

Multiple sclerosis（MS）is a chronic,severe and complex disease of still uncertain etiopathogenesis,with lesions in the cerebral white matter and spinal *** disease is heterogeneous,but is characterized by neuroinflammatory and neurodegenerative processes,usually associated with altered activation of the immune system following presumable stimulation by still unknown autoantigens.

关键词： new potential therapeutic targets cell MS

Physical artificial intelligence(PAI):the next-generation artificial intelligence

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Frontiers of Information Technology & Electronic Engineering 2023年第8期24卷 1231-1238页

作者： Yingbo LI Zhao LI Yucong DUAN Anamaria-beatrice SPULBER School of Computer Science and Technology Hainan UniversityHaikou570228China Zhejiang Lab Hangzhou311121China

Artificial intelligence(AI)has been a driving force for innovation and social progress in various domains(Pan,2017).However,most of its industrial applications have focused on the signal processing domain,which relies... 详细信息

关键词： artificial domains intelligence

A Discontinuous Galerkin Method for Blood Flow and Solute Transport in One-Dimensional Vessel Networks

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Communications on Applied Mathematics and Computation 2022年第2期4卷 500-529页

作者： Rami Masri Charles Puelz beatrice Riviere Department of Computational and Applied Mathematics Rice UniversityHoustonTX 77005USA Department of Pediatrics-Cardiology Baylor College of MedicineHoustonTX 77030USA

This paper formulates an efficient numerical method for solving the convection diffusion solute transport equations coupled to blood flow equations in vessel *** reduced coupled model describes the variations of vessel cross-sectional area,radially averaged blood momentum and solute concentration in large vessel *** the discretization of the reduced transport equation,we combine an interior penalty discontinuous Galerkin method in space with a novel locally implicit time stepping *** stability and the convergence are *** results show the impact of the choice for the steady-state axial velocity profile on the numerical solutions in a fifty-five vessel network with physiological boundary data.

关键词： Reduced models Blood flow Solute transport Coriolis coefficient Vessel networks Junction conditions Locally implicit

Anti-Saccharomyces cerevisiae antibody titers are stable over time in Crohn's patients and are not inducible in murine models of colitis

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World Journal of Gastroenterology 2005年第44期11卷 6988-6994页

作者： Stefan Müller Maya Styner beatrice Seibold-Schmid beatrice Flogerzi Michael M(a|¨)hler Astrid Konrad Frank Seibold Division of Gastroenterology Central Animal Facility and Institute for Laboratory Animal Science

AIM： To investigate ASCA production over time in CD and murine colitis in order to further our understanding of their etiology. MATERIALS AND METHODS： Sixty-six CD patients were compared to ulcerative colitis （UC） and irritable bowel syndrome patients with respect to ASCA production as measured by ELISA. ASCA IgG or IgA positivity as well as change in titers over a period of up to 3 years （△tgG/A） was correlated with clinical parameters such as CD activity index （CDM） and C-reactive protein levels （CRP）. Moreover, two murine models of colitis （DSS and IL-10 knock out） were compared to control animals with respect to ASCA titers after oral yeast exposure. RESULTS： ASCA IgG and IgA titers are stable over time in CD and non-CD patients. Fistular disease was associated with a higher rate of ASCA IgA positivity （P = 0.014）. Ileal disease was found to have a significant influence on the △tgG of ASCA （P = 0.032）. There was no correlation found between ASCA positivity or △tgG/A and clinical parameters of CD： CDAI and CRP. In mice, neither healthy animals nor animals with DSS-induced or spontaneous colitis exhibited a marked increase in ASCA titers after high-dose yeast exposure. On the other hand, mice immunized intraperitoneally with mannan plus adjuvant showed a marked and significant increase in ASCA titers compared to adjuvant-only immunized controls （P = 0.014）. CONCLUSION： The propensity to produce ASCA in a subgroup of CD patients is largely genetically predetermined as evidenced by their stability and lack of correlation with clinical disease activity parameters. Furthermore, in animal models of colitis, mere oral exposure of mice to yeast does not lead to the induction of marked ASCA titers irrespective of concomitant colonic inflammation. Hence, environment may play only a minor role in inducing ASCA.

关键词： Crohn's disease Anti-Saccharomyces cerevisiae antibodies Colitis

Rapid correction of chronic hyperglycemia and bone remodeling,warning against overdoing

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World Journal of Diabetes 2024年第9期15卷 1858-1861页

作者： Dured Dardari beatrice Segurens Department of Diabetology Centre Hospitalier Sud FrancilienCorbeil Essonne 91100France UniversitéParis-Saclay CEACentre National de Recherche en Génomique Humaine(CNRGH)Evry CourcouronnesFrance

It is widely recognized that chronic hyperglycemia decreases bone quality,although little is known about the impact of the rapid correction of chronic hyperglycemia on the quality of bone *** spotlight article explore... 详细信息

关键词： Bone remodeling Chronic hyperglycemia Intensive hyperglycemia treatment Diabetes complication Rapid correction of hyperglycemia