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Optimizing water resources allocation in the Haihe River basin under groundwater sustainability constraints

Journal of Geographical Sciences 2019年第6期29卷 935-958页

作者： Grith MARTINSEN LIU Suxia MO Xingguo bauer-gottwein peter Key Laboratory of Water Cycle and Related Land Surface Processes Institute of Geographic Sciences and Natural Resources ResearchCAS Department of Environmental Engineering Technical University of Denmark College of Resources and Environment/Sino-Danish Center for Education and Research University of Chinese Academy of Sciences Sino-Danish Center for Education and Research

This study applies a hydroeconomic optimization method for water resources management in the highly water stressed Haihe River basin. A multi-objective, multi-temporal deterministic hydroeconomic optimization model has been built to quantify the economic trade-offs and reveal "minimum cost strategies" when reducing groundwater abstraction to sustainable levels. A complex basin representation, with ～140,000 decision variables is formulated where each decision variable represents a flow-path from a water source to a sink. Available water sources are runoff generated by the sub-basins upstream the nine major surface water reservoirs, the inter-basin transfers from Yellow River and South to North Water Transfer Project(SNWTP) and the natural groundwater recharge to the three main groundwater aquifers. Water demands, i.e. sinks, are aggregated for each model sub-basin in categories of the major agricultural users, domestic, industrial and ecological water demands. Each demand is associated with a curtailment cost and groundwater abstraction with a pumping cost. Groundwater overdraft is constrained in each model scenario, ranging from unlimited overdraft in the plain area groundwater aquifer to sustainable abstractions over an 8-year period. Inflow upstream Yuqiao reservoir, and the inter-basin transfers from SNWTP and Yellow River are identified as the water resources with the highest increase in average shadow prices when limiting groundwater overdraft. An increase in inflow shadow prices of 37.5% indicates that these water sources will be most valuable if sustainable groundwater abstraction should be achieved. The shadow prices of water sources reveal when and where in the Haihe River basin users are curtailed if water resources are managed in the most optimal way. Average shadow prices of 1.6 yuan/m3 for all surface water sources in the sustainable abstraction scenarios shows that overdraft can be avoided by curtailment of users with a willingness-to-pay ≤1.6 yuan/m3.

关键词： Haihe River China hydroeconomic optimization linear programming groundwater sustainability spatio-temporal economic trade-offs decision support

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基于水经济价值的长江口环境流量探讨

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自然资源学报 2018年第3期33卷 467-477页

作者：唐瑜宋献方 bauer-gottwein peter 卜红梅杨丽虎张应华韩冬梅马英 Davidsen Claus 中国科学院地理科学与资源研究所陆地水循环及地表过程重点实验室北京100101 中国科学院大学中丹学院北京100049 中国科学院大学资源与环境学院北京100190 Department of Environmental Engineering Technical University of Denmark2800 Kgs.LyngbyDenmark

适宜的环境流量对于维持河口生态系统稳定以及保障区域社会经济用水需求有着重要意义。论文以探讨水资源优化配置条件下长江口适宜环境流量为目的,基于水经济价值分析构建了长江中下游水资源优化配置模型,分析了区域缺水量以及环境流量... 详细信息

适宜的环境流量对于维持河口生态系统稳定以及保障区域社会经济用水需求有着重要意义。论文以探讨水资源优化配置条件下长江口适宜环境流量为目的,基于水经济价值分析构建了长江中下游水资源优化配置模型,分析了区域缺水量以及环境流量约束的影子成本随长江口环境流量约束的变化。结果表明:当环境流量约束超过临界值后,区域缺水量不断增加,且环境流量约束产生非零影子成本;通过区域供水目标和环境流量约束的影子成本图确定长江口适宜环境流量的上限和下限,得到20%、50%、75%及95%水资源保证率下,长江口适宜环境流量分别为27.10×10~9~29.65×10~9、25.50×10~9~27.12×10~9、23.08×10~9~24.62×10~9及17.72×10~9~19.65×10~9m^3/月;该环境流量标准可以满足一定目标下长江口的生态需求。

关键词：环境流量水资源配置水经济价值影子成本长江口

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Perioperative chemotherapy for advanced gastric cancer - results from a tertiary-care hospital in Germany

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World Journal of Gastrointestinal Oncology 2020年第5期12卷 559-568页

作者： Katrin bauer Giulia Manzini Doris Henne-Bruns peter Buechler Department for General VisceralThoracic and Paediatric SurgeryClinic of KemptenKempten 87439Germany Department of General and Visceral Surgery University Hospital of UlmUlm 89081Germany

BACKGROUND Neoadjuvant/perioperative chemotherapy is the recommended treatment for advanced stages of gastric cancer(>T2,N+)before tumour resection in many European ***,there is no consensus as to whether perioperative chemotherapy is as effective in distal as in proximal tumours,in addition to a relevant uncertainty concerning appropriate treatment modalities for elderly *** To investigate the role of perioperative chemotherapy in advanced gastric cancer in patients from a German tertiary clinic with respect to efficacy,localisation,and *** We performed a retrospective analysis of 158 patients from our clinic with adenocarcinoma of the stomach or the gastroesophageal junction who underwent resection between 2008 and *** data were evaluated particularly in relation to patient age,tumour site,and perioperative *** Administration of perioperative chemotherapy did not lead to a significant survival advantage in our study *** 5-year survival rates were 40%for patients who received perioperative chemotherapy and 29%for the group without perioperative chemotherapy(P=0.125).Our patients were on average distinctly older than patients in most of the published randomised controlled *** elder than 75 years received perioperative chemotherapy far less *** with a proximal tumour received perioperative chemotherapy much more *** This analysis reconfirms our previous data concerning the effectiveness of perioperative chemotherapy for advanced gastric *** is reasonable doubt that the quality of the existing randomized controlled trials is sufficient to generally justify perioperative chemotherapy in patients with advanced gastric cancer independent of tumour localization or age.

关键词： Gastric cancer Perioperative Chemotherapy Tumour localisation Age distribution Validity

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Neurological consequences of systemic inflammation in the premature neonate

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Neural Regeneration Research 2017年第6期12卷 890-896页

作者： Aparna Patra Hong Huang John A.bauer peter J.Giannone OMNI Academic Service Line and Division of Neonatology Department of Pediatrics Kentucky Children's Hospital College of MedicineUniversity of Kentucky

Despite substantial progress in neonatal care over the past two decades leading to improved survival of extremely premature infants, extreme prematurity continues to be associated with long term neurodevelopmental impairments. Cerebral white matter injury is the predominant form of insult in preterm brain leading to adverse neurological consequences. Such brain injury pattern and unfavorable neurologic sequelae is commonly encountered in premature infants exposed to systemic inflammatory states such as clinical or culture proven sepsis with or without evidence of meningitis, prolonged mechanical ventilation, bronchopulmonary dysplasia, necrotizing enterocolitis and chorioamnionitis. Underlying mechanisms may include cytokine mediated processes without direct entry of pathogens into the brain, developmental differences in immune response and complex neurovascular barrier system that play a critical role in regulating the cerebral response to various systemic inflammatory insults in premature infants. Understanding of these pathologic mechanisms and clinical correlates of such injury based on serum biomarkers or brain imaging findings on magnetic resonance imaging will pave way for future research and translational therapeutic opportunities for the developing brain.

关键词： premature consequences inflammation prematurity extremely translational dysplasia sepsis necrotizing neurological

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Crystal structures and constitution of the binary system iridium-boron

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Science China Materials 2015年第8期58卷 649-668,594页

作者： Isolde Zeiringer 程曦月陈星秋 Ernest bauer Gerald Giester peter Franz Rogl Institute of Materials Chemistry and Research University of Vienna Shenyang National Laboratory for Materials Science (SYNL) Institute of Metal Research (IMR) Chinese Academy of Sciences (CAS) Institute of Solid State Physics Vienna University of Technology Institute of Mineralogy and Crystallography University of Vienna

The constitution of the binary system Ir-B has been established between 10 and 70 at.% boron for temperatures above 700°C based on differential scanning calorimetry, electron probe microanalysis, and isothermal low temperature annealing experiments(≤1000°C). Four binary phases have been found, namely Ir4B5+x, Ir5B4+x and the high and low temperature modification of Ir4B3-x. X-ray structure analyses were performed on single crystals of Ir4B5+x(x = 0, Ir4B5 type; space group C2/m; a = 1.05200(2), b = 0.289564(6) and c = 0.60958(1) nm, β = 91.156(2)°), Ir5B4+x(x=0, Ir5B4 type; space group I41/a; a = 0.62777(1) and b = 1.02599(2) nm) and on the low temperature modification of Ir4B3-x(x=0, Ir B0.9 type; space group Cmc21; a = 0.27728(1), b = 0.75742(2) and c = 0.73152(2) nm). The high temperature modification of Ir4B3-x(WC type; space group P6-m2; a = 0.28137(5) and c = 0.2828(1) nm) has been confirmed by X-ray powder diffraction. By means of the first-principle calculations, in combination with the evolutionary structural search algorithm, the compositions, structures and enthalpies of the Ir-B system have been investigated theoretically. Confirming the experimental observations on Ir4B5, Ir5B4 and Ir4B3, we have investigated several metastable phases at other stoichiometries, such as Ir B, Ir B2 and Ir3B2. We also proposed three thermodynamically and dynamically stable new structures of o F28-Ir4B3, o C8-Ir B and m C10-Ir3B2, which may be synthesized under certain conditions.

关键词：晶格常数点阵参数 XPD nm

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利用飞秒双光子光电子发射研究GaAs(100)的自旋动力学过程

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物理学报 2005年第7期54卷 3200-3205页

作者：郭立俊 Jan-peter Wüstenberg Andreyev Oleksiy Michael bauer Martin Aeschlimann 凯泽斯劳腾大学物理系

超短激光技术的发展为研究材料中的超快光动方学过程提供了重要的实验手段,也使得人们能够更为深入地研究电子的自旋动力学行为.GaAs(100)表面由于费米钉扎而会导致能带弯曲,位于该区域的电子及其自旋特性将会明显不同于体相材料中的情... 详细信息

超短激光技术的发展为研究材料中的超快光动方学过程提供了重要的实验手段,也使得人们能够更为深入地研究电子的自旋动力学行为.GaAs(100)表面由于费米钉扎而会导致能带弯曲,位于该区域的电子及其自旋特性将会明显不同于体相材料中的情况.利用时间分辨和自旋分辨的双光子光电子发射技术研究了p型掺杂GaAs(100)表面的电子极化动力学过程.结果表明,由费米钉扎而引起的能带弯曲明显影响电子的自旋弛豫过程,从实验上观察到了GaAs(100)表面能带弯曲区域的电子自旋翻转时间存在近2个量级的差异(从几纳秒到几十皮秒),基于电子_自旋交换相互作用的BAP机理在自旋弛豫过程中起着主导作用.

关键词：动力学过程双光子光电子发射飞秒能带弯曲交换相互作用弛豫过程动力学行为实验手段激光技术电子极化 P型掺杂发射技术时间分辨电子自旋主导作用表面 BAP 材料钉扎费米

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How Do Stomata Sense Reductions in Atmospheric Relative Humidity？

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Molecular Plant 2013年第5期6卷 1703-1706页

作者： Hubert bauer peter Ache Florian Wohlfart Khaled A.S. Al-Rasheid Sophia Sonnewald Uwe Sonnewald Susanne Kneitz Alistair M. Hetherington Rainer Hedrich Julius-von-Sachs-Institut fur Biowissenschaften Biozentrum University of Wurzburg D-97082 Wurzburg Germany College of Science King Saud University Riyadh 11451 Saudi Arabia Department of Biology Friedrich-Alexander-University Erlangen- Nuremberg 91058 Erlangen Germany Theodor-Boveri-Institute of Biosciences University of Wurzburg D-97074 Wurzburg Germany School of Biological Sciences University of Bristol Bristol BS8 1UG UK

Dear Editor, It has been known since the work of Francis Darwin that, in response to a reduction in atmospheric relative humidity （rh）, stomatal aperture decreases. Screening for Arabidopsis mutants compromised in stomatal responses to reduced rh resulted in the identification of two genes, OST1 and ABA2, that are involved in stomatal response to low rh conditions. Interestingly both encode proteins previously known to be involved in ABA signaling （Xie et al., 2006, and references therein）. These findings strongly suggested that, at least in part, the stomatal response to low rh is mediated by ABA and the intracellular ABA signaling pathway. Our most recent data show that low rh-induced stomatal closure can pro- ceed by guard cell autonomous ABA synthesis （bauer et al., 2013）,

关键词： ABA signaling regulate SLAC1 ABA signaling pathway

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Helicobacter pylori upregulates prion protein expression in gastric mucosa: A possible link to prion disease

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World Journal of Gastroenterology 2005年第48期11卷 7651-7656页

作者： peter C Konturek Karolina Bazela Vitally Kukharskyy Michael bauer Eckhart G Hahn Detlef Schuppan Department of Medicine

AIM： Pathological prion protein （PrP^sc） is responsible for the development of transmissible spongiform encephalopathies （TSE）. While PrPc enters the organism via the oral route, less data is available to know about its uptake and the role of gastrointestinal inflammation on the expression of priori precursor PrPc, which is constitutively expressed in the gastric ***： We studied PrPc expression in the gastric mucosa of 10 Helicobacter pylori-positive patients before and after successful H pylori eradication compared to non-infected controls using RT-PCR and Western blotting. The effect of central mediators of gastric inflammation, i.e., gastrin, prostaglandin E2 （PGE2）, tumor necrosis factor alpha （TNF-α） and interleukin 1 beta （IL-1β） on PrPc expression was analyzed in gastric cell ***： PrPc expression was increased in H pyloriinfection compared with non-infected controls and decreased to normal after successful eradication. Gastrin, PGE2, and IL-1β dose-dependently upregulated PrPc in gastric cells, while TNF-α had no ***： H pylori infection leads to the upregulation of gastric PrPc expression. This can be linked to H pylori induced hypergastrinemia and increased mucosal PGE2 and IL-1β synthesis. H pylori creates a milieu for enhanced propagation of prions in the gastrointestinal tract.

关键词： Prions Helicobacter pylori, Gastrin Proinflammatory cytokines

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VprBP mitigates TGF-β and Activin signaling by promoting Smurf1-mediated type Ⅰ receptor degradation

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Journal of Molecular Cell Biology 2020年第2期12卷 138-151页

作者： Yihao Li Chao Cui Feng Xie Szymon Kietbasa Hailiang Mei Maarten van Dinther Hans van Dam Andreas bauer Long Zhang peterten Dijke Department of Cell and Chemical Biology and Oncode Institute Leiden University Medical Center2300RC LeidenThe Netherlands MOE Laboratory of Biosystems Homeostasis and Protection and Innovation Center for Cell Signaling Network Life Sciences InstituteZhejiang UniversityHangzhou 310058China Department of Human Genetics Leiden Genome Technology CentreLeiden University Medical Center2300RC LeidenThe Netherlands Sequence Analysis Support Core Leiden University Medical Center2300RC LeidenThe Netherlands Novartis Institutes for BioMedical Research Inc.Novartis CampusForum 2.5.01.30CH-4056BaselSwitzerland

The transforming growth factor-β(TGF-β)family controls embryogenesis,stem cell differentiation,and tissue ***,how post-translation modifications contribute to fine-tuning of TGF-βfamily signaling responses is not well ***(I)-Smads can antagonize TGF-β/Smad signaling by recruiting Smurf E3 ubiquitin ligases to target the active TGF-βreceptor for proteasomal degradation.A proteomic interaction screen identified Vpr binding protein(VprBP)as novel binding partner of ***-expression studies revealed that VprBP negatively controls Smad2 phosphorylation,Smad2–Smad4 interaction,as well as TGF-βtarget gene *** was found to promote Smad7–Smurf1–TβRI complex formation and induce proteasomal degradation of TGF-βtype I receptor(TβRI).Moreover,VprBP appears to stabilize Smurf1 by suppressing Smurf1 *** multiple adult and mouse embryonic stem cells,depletion of VprBP promotes TGF-βor Activin-induced *** the mouse embryo VprBP expression negatively correlates with mesoderm marker expression,and VprBP attenuated mesoderm induction during zebrafish *** findings thereby uncover a novel regulatory mechanism by which Smurf1 controls the TGF-βand Activin cascade and identify VprBP as a critical determinant of embryonic mesoderm induction.

关键词： Smurfl TGF-βtype I receptor ubiquitination Activin mesoderm induction

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MRI-guided ablation of wide complex tachycardia in a univentricular heart

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World Journal of Cardiology 2012年第8期4卷 260-263页

作者： Theresa Reiter Oliver Ritter peter Nordbeck Meinrad Beer Wolfgang Rudolf bauer Department of Internal Medicine I University Hospital Wuerzburg97080 WuerzburgGermany Department of Radiology University Hospital Wuerzburg97080 WuerzburgGermany

Magnetic resonance imaging can be used for preprocedural assessment of complex anatomy for radiofrequency(RF) ablations,e.g.,in a univentricular *** case report features the treatment of a young patient with a functionally univentricular heart who suffered from persistent sudden onset tachycardia with wide complexes that required RF ablation as treatment.

关键词： Magnetic resonance imaging Ablation Univentricular heart Fontan’s Operation Ventricular tachycardia

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