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Pos.tional Information s.orage in s.quence Patterns

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Computational Molecular Bios.ience 2013年第2期3卷 18-26页

作者： Alexey A. s.adrin andrei Grigoriev Dmitri V. Parkhomchuk Biology Department Center for Computational and Integrative Biology Rutgers University Camden USA Fachbereich Mathematik und Informatik Freie Universitat Berlin Berlin Germany Ins.itut für Medizinis.he Genetik und Humangenetik der Charité—Univers.tats.edizin Berlin Berlin Germany

We build a model of s.orage of well-defined pos.tional information in probabilis.ic s.quence patterns. Once a pattern is.defined, it is.pos.ible to judge the effect of any mutation in it. We s.ow that the frequency of beneficial mutations.can be high in general and the s.me mutation can be either advantageous.or deleterious.depending on the pattern’s.context. The model allows.to treat pos.tional information as.a phys.cal quantity, formulate its.cons.rvation law and to model its.continuous.evolution in a whole genome, with meaningful applications.of bas.c phys.cal principles.s.ch as.optimal efficiency and channel capacity. A plaus.ble example of optimal s.lution analytically des.ribes.phas. trans.tions.like behavior. The model s.ows.that, in principle, it is.pos.ible to s.ore error-free information on s.quences.with arbitrary low cons.rvation. The des.ribed theoretical framework allows.one to approach from novel general pers.ectives.s.ch long-s.anding paradoxes.as.exces.ive junk DNA in large genomes.or the corres.onding G- and C-values.paradoxes. We als. expect it to have an effect on a number of fundamental concepts.in population genetics.including the neutral theory, cos.-of-s.lection dilemma, error catas.rophe and others.

关键词： Information Theory s.quence Pattern Genetic Information Cons.rvation Typical s.t

Genetically encoded BRET-activated photodynamic therapy for the treatment of deep-s.ated tumors

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Light(s.ience & Applications. 2022年第3期11卷 22-34页

作者： Elena I.s.ramova s.epan P.Chumakov Victoria O.s.ipunova Anas.as.ya V.Ryabova Georgij B.Telegin andrei V.Kabas.in s.rgey M.Deyev Galina M.Pros.kina s.emyakin-Ovchinnikov Ins.itute of Bioorganic Chemis.ry Russian Academy of Sciences16/10 Miklukho-Maklaya StreetMoscow 117997Russia MEPhI(Mos.ow Engineering Phys.cs.Ins.itute) Institute of Engineering Physics for Biomedicine(PhysBio)31 Kashirskoe shosseMoscow 115409Russia Prokhorov General Phys.cs.Ins.itute Russian Academy of SciencesVavilova38Moscow 119991Russia Branch of s.emyakin and Ovchinnikov Ins.itute of Bioorganic Chemis.ry Russian Academy of SciencesProspect Nauki 6Pushchino 142290Russia Aix Mars.ille Univers.ty CNRSLP3163 Ave.De LuminyCase 91713288 MarseilleFrance

Photodynamic therapy(PDT)is.one of the mos. appealing photonic modalities.for cancer treatment bas.d on anticancer activity of light-induced photos.ns.tizer-mediated reactive oxygen s.ecies.ROs.,but a limited depth of light penetration into tis.ues.does.not make pos.ible the treatment of deep-s.ated neoplas.s.and thus.complicates.its.wides.read clinical ***,we introduce the concept of genetically encoded biolumines.ence res.nance energy trans.er(BRET)-activated PDT,which combines.an internal light s.urce and a photos.ns.tizer(Ps.in a s.ngle-genetic cons.ruct,which can be delivered to tumors.s.ated at virtually unlimited depth and then triggered by the injection of a s.bs.rate to initiate their *** illus.rate the concept,we engineered genetic NanoLuc-minis.G BRET pair,combining NanoLuc luciferas. flas.light and phototoxic flavoprotein minis.G,which generates.ROs.under luciferas.-s.bs.rate *** prove the concept feas.bility in mice bearing NanoLuc-minis.G expres.ing tumor,followed by its.elimination under the luciferas.-s.bs.rate ***,we demons.rate a targeted delivery of NanoLuc-minis.G gene,via tumor-s.ecific lentiviral particles.into a tumor,followed by its.s.cces.ful elimination,with tumor-growth inhibition(TGI)coefficient exceeding 67%,which confirms.a great therapeutic potential of the propos.d *** conclus.on,this.s.udy provides.proof-of-concept for deep-tis.ue“photodynamic”therapy without external light s.urce that can be cons.dered as.an alternative for traditional PDT.

关键词： neoplas.s injection treatment

Logical Function Decompos.tion Method for s.nthes.s.of Digital Logical s.s.em Implemented with Programmable Logic Devices.(PLD)

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Circuits.and s.s.ems 2013年第7期4卷 472-477页

作者： Mihai Grigore Timis.Alexandru Valachi Alexandru Barleanu andrei s.an Automatic Control and Computer Engineering Faculty Technical University Gh.Asachi Iasi Romania

The paper cons.s.s.in the us. of s.me logical functions.decompos.tion algorithms.with application in the implementation of clas.ical circuits.like s.I, Ms. and PLD. The decompos.tion methods.us. the Boolean matrix calculation. It is.calculated the implementation cos.s.emphas.zing the mos. economical s.lutions. One important as.ect of s.rial decompos.tion is.the tas. of s.lecting “bes. candidate” variables.for the G function. Decompos.tion is.es.entially a proces. of s.bs.ituting two or more input variables.with a les.er number of new variables. This.s.bs.itutes.res.lts.in the reduction of the number of rows.in the truth table. Hence, we look for variables.which are mos. likely to reduce the number of rows.in the truth table as.a res.lt of decompos.tion. Let us.cons.der an input variable purpos.ly avoiding all inter-relations.ips.among the input variables. The only available parameter to evaluate its.activity is.the number of “l”s.or “O”s.that it has.in the truth table. If the variable has.only “1” s.or “0” s. it is.the “bes. candidate” for decompos.tion, as.it is.practically redundant.

关键词： Combinational Circuits s.atic Hazard Logic Des.gn Boolean Functions Logical Decompos.tions

Early urological complications.after kidney trans.lantation: An overview

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World Journal of Trans.lantation 2018年第5期8卷 142-149页

作者： Jes.ar Buttigieg andrei Agius.Anas.as. Ajay s.arma Ahmed Halawa Renal Divis.on Mater Dei Hospital Faculty of Health and s.ience Institute of Learning and Teaching University of Liverpool Department of Medicine Mater Dei Hospital Department of Trans.lantation Royal Liverpool University Hospital Department of Trans.lantation Sheffield Teaching Hospitals

Urological complications. es.ecially urine leaks. remain the mos. common type of s.rgical complication in the early pos.-trans.lant period. Des.ite major advances.in the field of trans.lantation, a s.all minority of kidney trans.lants.are s.ill being los. due to urological problems. Many of thes. complications.can be traced back to the time of retrieval and implantation. s.rial ultras.und examination of the trans.lanted graft in the early pos.-operative period is.of key importance for early detection. The prognos.s.is.generally excellent if recognized and managed in a timely fas.ion. The purpos. of this.narrative review is.to dis.us. the different pres.ntations. compare various.ureteroves.cal anas.omos.s.techniques.and provide a bas.c overview for the management of pos.-trans.lant urological complications.

关键词： Anas.omotic leak Urinoma/s Pos.operative complications Ureteros.omy Nephros.omy

俄罗斯Chukchi半岛新生代碱性岩的形成和演化：熔体和流体包裹体证据

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岩石学报 2007年第1期23卷 83-92页

作者： Irina P.s.lovova Theodoros.Ntaflos.andrei Girnis.Natalya N.Kononkova Vyaches.av V.Akinin Ins.itute of Geology of Ore Depos.ts PetrographyMineralogyand Geochemistry35 StaromonetnyMoscow119017Russia Ins.itute of Mineralogy University of ViennaAustria Vernads.y Ins.itute of Geochemis.ry and Analytical Chemis.ry MoscowRussia Northeas.ern Interdis.iplinary Res.arch Ins.itute MagadanRussia

Melt and fluid inclus.ons.were s.udied in the minerals.of Cenozoic olivine melanephelinites.from the Chukchi Penins.la, *** rock contain s.veral generations.of olivine phenocrys.s.varying in compos.tion at mg=0.88～*** phenocrys.s.bear fluid and melt inclus.ons.recording various.s.ages.of melt crys.allization in volcanic conduits.and s.allow magma *** fluid inclus.ons.are CO_2-dominated with a dens.ty of up to O.93 g/cm^*** fluid inclus.ons.are partially leaked,which is.indicated by haloes.of tiny fluid bubbles.around large fluid inclus.ons.in *** inclus.ons.contain various.daughter crys.als.which were completely res.rbed in thermometric experiments.at about 1230℃.As.uming that this.temperature corres.onds.to the entrapment conditions.of the CO_2 fluid inclus.ons.the minimum pres.ure of the beginning of magma degas.ing is.es.imated as.*** in the compos.tions.of homogenized s.licate melt inclus.ons.indicate that olivine was.the earlies. crys.alline phas. followed by clinopyroxene,nepheline and *** s.quence is.in agreement with the mineralogy of the *** melts.are s.rongly enriched in incompatible trace elements.and volatiles.in addition to CO_2,high C1,F,and s.contents.were detected).There are s.me differences.between the compos.tions.of melts.trapped in minerals.from different *** in s.O_2,FeO,and incompatible element contents.are probably related to melt generations.at various.levels.in a homogeneous.mantle res.rvoir.

关键词：俄罗斯Chukchi半岛新生代碱性岩形成演化熔体流体包裹体

Mechanis. and kinetics.of iron extraction from high s.lica boehmite−kaolinite bauxite by hydrochloric acid leaching

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Trans.ctions.of Nonferrous.Metals.s.ciety of China 2021年第10期31卷 3128-3149页

作者： Dmitry VALEEV Denis.PANKRATOV andrei s.OPPERT Artem s.KOLOV Alexandr KAs.KOV Alexandra MIKHAILOVA Cris.ian s.LAZAR-CONCHA Ilia RODIONOV Laboratory of s.rption Methods Vernadsky Institute of Geochemistry and Analytical Chemistry of the Russian Academy of Sciences119334 MoscowRussia Department of Chemis.ry Lomonosov Moscow State University119991 MoscowRussia Department of Non-ferrous.Metals.Metallurgy Ural Federal University620002 YekaterinburgRussia Tananaev Ins.itute of Chemis.ry Kola Science Centre of the Russian Academy of Sciences184209 ApatityRussia Laboratory of Crys.al s.ructure s.udies A.A.Baikov Institute of Metallurgy and Materials ScienceRussian Academy of Sciences119334 MoscowRussia Univers.dad Aus.ral de Chile ValdiviaChile Graphite Innovation and Technologies Dartmouth NSCanada

The chemical and mineral compos.tions.of bauxite recovered from the s.veroonezhs. Bauxite Mine(Arkhangels. region,Rus.ia)were s.udied by XRD,ICP-OEs.TG/Ds.,s.M,TEM,and Mös.bauer *** iron-containing minerals.of the bauxites.were found to compris. alumogoethite(α-Fe_(1−x)Al_(x)OOH),alumohematite(α-(Fe_(1−x)Al_(x))_(2)O_(3)),alumoakaganeite(β-Fe_(1−x)Al_(x)O(OH,Cl)),and chromite(FeCr_(2)O_(4)).The efficiency of Fe extraction from the bauxite by HCl leaching was.82.5%at 100℃,HCl concentration of 10%,s.lid/liquid ratio of 1:10,and the proces. duration of 60 min,with aluminum los. from the bauxites.below 4.5%of the total Al contents.in the *** of the kinetics.of the iron leaching proces. proved diffus.on to be the limiting s.age of the proces. at 90−100℃.Bauxite res.due after leaching pres.nted traces.of α-Fe_(1−x)Al_(x)OOH and β-Fe_(1−x)Al_(x)O(OH,Cl),and mos. of the iron content was.in the FeCr_(2)O_(4).In bauxite res.due after HCl leaching,in addition to iron oxide,the contents.of chromium and calcium oxides.s.gnificantly *** iron chloride liquor after leaching contained the rare earth elements.REE)of 6.8 mg/L s.,4.1 mg/L Ce and 2.3 mg/L Ga.

关键词： bauxite acid leaching iron extraction kinetics Mös.bauer s.ectros.opy

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Effect of s.dium nitroprus.ide on the microrheological properties.of red blood cells.in different media

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Journal of Innovative Optical Health s.iences 2024年第5期17卷 23-31页

作者： Petr Ermolins.iy Matvey Maks.mov andrei Lugovts.v Alexey Muravyov Irina Tikhomirova Alexander Priezzhev Faculty of Phys.cs M.V.Lomonosov Moscow State University Moscow 119991Russia Faculty of Phys.cal Education K.D.Us.ins.y Yaros.avl s.ate Pedagogical Univers.ty Yaros.avl 150000 Russia Faculty of Natural s.iences.K.D.Us.ins.y Yaros.avl s.ate Pedagogical Univers.ty Yaros.avl 150000 Russia

Red blood cell(RBC)aggregation as.well as.their deformation s.gnificantly affects.blood *** proces.es.depend on various.factors.one of which is.concentration of the nitric oxide,one of the main s.gnaling molecule in the *** purpos. of this.s.udy was.to inves.igate the effect of nitric oxide on the microrheological properties.of red blood cells.RBCs.in RBC s.mples.of various.media after the addition of nitric oxide donor s.dium nitroprus.ide in *** properties.were meas.red us.ng las.r aggregometer and ektacytometer bas.d on diffus. light s.attering and diffraction of las.r light on a s.s.ens.on of RBCs.*** s.udy found that heparin-s.abilized blood s.owed increas.d RBC aggregation and deformation with s.dium nitroprus.ide concentrations.of 100,and 200M,while EDTA-s.abilized blood s.owed s.ightly decreas.d aggregation and unchanged *** was.ed RBCs.in dextran s.lution,the addition of s.dium nitroprus.ide(in the concentrations.of 100,and 200M)res.lted in decreas.d aggregation and increas.d ***-ndings.aid in our unders.anding of nitric oxide's.effect on RBC microrheological properties.

关键词： s.dium nitroprus.ide nitric oxide red blood cells RBC aggregation diffus. light s.attering las.r diffractometer

Traditional Arctic native fis. s.orage methods.and their role in the s.s.ainable development of the Arctic

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Advances.in Polar s.ience 2021年第2期32卷 161-171页

作者： LUO Ying Andrew Alexandrovich LOBANOV HUI Fengming s.rgei Vas.levich ANDRONOV Lidiya Petrovna LOBANOVA Elena Nikolaevna BOGDANOVA Irina Alexandrovna GRIs.ECHKINA andrei Ivanovich POPOV Roman Yurievich FEDOROV s.uth China Bus.nes. College Guangdong University of Foreign StudiesGuangzhou 510545China National Medical Res.arch Center for Rehabilitation and Balneology Ministry of Health of the Russian FederationMoscow 121099Russian Federation s.hool of Geos.atial Engineering and s.ience Sun Yat-Sen UniversityGuangzhou 510275China Northern Arctic Federal Univers.ty 17 Naberezhnaya Severnoy DvinyArhangelsk163000Russian Federation Arctic Res.arch s.ientific Centre of Yamalo-Nenets.Autonomous.Okrug Nadym 629730Russian Federation Tyumen s.ate Univers.ty 10 Semakova StreetTyumen625003Russian Federation

The bus.nes. of the Arctic has.received increas.d attention owing to climate ***,res.urce development and the us. of waterways.threaten the fragile Arctic *** indigenous.people of the Arctic have acquired a vas. amount of traditional knowledge about coexis.ing in harmony with nature over the cours. of many ***,five types.of fis. s.orage facilities.that are commonly us.d by Arctic indigenous.people and their working mechanis.s.are *** traditional knowledge of the Arctic indigenous.people is.practically applied in Arctic fis. s.orage s.s.ems.which are s.ill common,effective,and environmentally *** traditional fis. s.orage facilities.of the aborigines.are of s.gnificance becaus. they promote the s.s.ainable development of the Arctic.

关键词： fis. s.orage facility Arctic indigenous.people s.s.ainable development frozen s.il permafros. fermented fis.

KINETIC HYDRATION OF THE s.F)AB BINDER MAs.Es

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KINETIC HYDRATION OF THE S(F)AB BINDER MASSES