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Palcernuine, the first [5/6/6/6]-cernuane-type alkaloid from Palhinhaea cernua ***

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Chinese Chemical Letters 2016年第6期27卷 969-973页

作者： Yu Tang Juan Xiong Yike Zou bastien Nay Li-Jun Wang Jin-Feng Hu Department of Natural Products Chemistry School of PharmacyFudan UniversityShanghai 201203China Department of Chemistry University of PennsylvaniaPhiladelphia 19104-6323USA Unite Molecules de Communication et Adaptation des Micro-organismes Sorbonne UniversitesMuseum National d'Histoire NaturelleCentre National de la Recherche Scientifique(CNRS UMR 7245)Paris 75005France

One novel（named palcernuine, 1） and five known cernuane-type（2–6） alkaloids were isolated from the whole plant of Palhinhaea cernua f. sikkimensis. The structure of 1, possessing an unprecedented [5/6/6/6]-tetracyclic ring system containing two nitrogen atoms, was established on the basis of spectroscopic methods, and its absolute configuration was determined by comparison of the experimental and calculated electronic circular dichroism（ECD） spectra. A plausible biosynthetic pathway to 1 is proposed.

关键词： Palhinhaea cernua f.sikkimensis Lycopodiaceae Palcernuine Cernuane-type alkaloids Biosynthetic pathway

Potentiation of NETs release is novel characteristic of TREM-1 activation and the pharmacological inhibition of TREM-1 could prevent from the deleterious consequences of NETs release in sepsis

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Cellular & Molecular Immunology 2021年第2期18卷 452-460页

作者： Amir Boufenzer Kevin Carrasco Lucie Jolly Benjamin Brustolin Elisa Di-Pillo Marc Derive Sébastien Gibot INOTREM Vandœuvre-lès-NancyNancyFrance UMR-S 1116 Défaillance Cardiovasculaire Aigue et ChroniqueVandœuvre-lès-NancyNancyFrance CHRU Nancy Hôpital CentralService de Réanimation MédicaleNancyFrance

During sepsis,neutrophil activation induces endothelial cell(EC)dysfunction partly through neutrophil extracellular trap(NET)*** triggering receptor expressed on myeloid cell-1(TREM-1)is an orphan immune receptor that amplifies the inflammatory response mediated by Toll-like receptor-4(TLR4)*** the key role of TLR4 signaling in NETosis is known,the role of TREM-1 in this process has not yet been ***,we report that TREM-1 potentiates NET release by human and murine neutrophils and is a component of the NET *** contrast,pharmacologic inhibition or genetic ablation of TREM-1 decreased NETosis in vitro and during experimental septic shock in ***,isolated NETs were able to activate ECs and impair vascular reactivity,and these deleterious effects were dampened by TREM-1 ***-1 may,therefore,constitute a new therapeutic target to prevent NETosis and associated endothelial dysfunction.

关键词： TREM-1 NETs sepsis endothelial cell activation vascular dysfunction LR12

NGD Analysis of Defected Ground and SIW-Matched Structure

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Chinese Journal of Electronics 2023年第2期32卷 343-352页

作者： GU Taochen WAN Fayu GE Junxiang Lalléchère Sébastien Rahajandraibe Wenceslas Ravelo Blaise Nanjing University of Information Science & Technology (NUIST) Université Clermont Auvergne (UCA) CNRS SIGMA Clermont Aix-Marseille University CNRS University of Toulon

A bandpass negative group delay(NGD)passive circuit based on defect ground structure(DGS)and substrate integrated waveguide(SIW)-matched is developed in the paper. The NGD DGS topology is originally built with notched cells associated with self-matched substrate waveguide elements. The DGS design method is introduced as a function of the geometrical notched and SIW via elements. Then, parametric analyses based on full wave 3-D electromagnetic S-parameter simulations were considered to investigate the influence of DGS physical size effects. The design method feasibility study is validated with fully distributed microstrip circuit prototype. Significant bandpass NGD function performances were validated with 3-D simulations and measurements with-1.69 ns negative group delay value around 2 GHz center frequency over 33.7 MHz NGD bandwidth. Insertion loss is 4.37 d B, and reflection loss reaches 41.5 d B.

关键词： Solid modeling Prototypes Electromagnetic waveguides Reflection Passive circuits Delays Frequency measurement

Electrochemical ageing study of mixed lanthanum/praseodymium nickelates La2-xPrxNiO4+δ as oxygen electrodes for solid oxide fuel or electrolysis cells

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Journal of Energy Chemistry 2020年第7期29卷 62-70,I0003页

作者： Vaibhav Vibhu Aurélien Flura Aline Rougier Clément Nicollet Sébastien Fourcade Teresa Hungria Jean-Claude Grenier Jean-Marc Bassat CNRS Univ.BordeauxBordeaux INPICMCBUMR 5026F-33600 PessacFrance Centre de Microcaractérisation Raimond CASTAING Universitéde ToulouseCNRSUT3–Paul SabatierINPINSAEspace Clément Ader3 rue Caroline AigleToulouse 31400France

The chemical and electrochemical stability of lanthanide nickelates La2 NiO4+δ(LNO),Pr2 NiO4+δ(PNO)and their mixed compounds La(2-x)PrxNiO4+δ(LPNOs)with x=0.5,1 or 1.5 is *** aim is to promote these materials as efficient electrodes for solid oxide fuel cell(SOFC)and/or solid oxide electrolysis cell(SOEC).La2 NiO4+δand La1.5Pr0.5NiO4+δcompounds are chemically very stable as powders over one month in the temperature range 600-800℃,while the other materials rich in praseodymium progressively decompose into various perovskite-deriving components with additional Pr6 *** their uneven properties,all these materials are quite efficient and sustainable as electrodes on top of gadolinium doped ceria(GDCBL)//yttrium doped zirconia(8 YSZ)electrolyte,for one month at 700℃without *** polarization(300 mA·cm-2),the electrochemical performances of LNO,PNO and La1.5Pr0.5NiO4+δ(LP5 NO)quickly degrade in SOFC mode,*** the oxygen reduction reaction,while they show durability in SOEC mode,*** the oxide oxidation reaction.

关键词： Lanthanide nickelates SOFC cathode SOEC anode Stability Inductive loop Degradation

Structure-Thermal Conductivity Tentative Correlation for Hybrid Aerogels Based on Nanofibrillated Cellulose-Mesoporous Silica Nanocomposite

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Journal of Renewable Materials 2018年第3期6卷 299-313页

作者： Dounia Bendahou Abdelkader Bendahou bastien Seantier Benedicte Lebeau Yves Grohens Hamid Kaddami University of Southern Brittany Dupuy de Lôme Research InstituteFRE-CNRS 3744BP 9211656321 Lorient CedexFrance Cadi Ayyad University Faculty of Sciences and TechnologiesAvenue Abdelkrim ElkhattabiB.P.549MarrakechMorocco University of Upper Alsace Institute of Materials Science of Mulhouse(IS2M)68057 Mulhouse CedexFrance

Hybrid aerogels have been prepared by freeze-drying technique after mixing water dispersions of cellulose microfibers or cellulose nanofibers and silica(SiO2)of type SBA-15(2D-hexagonal).The prepared composites were characterized by different analysis techniques such as SEM,hot-filament,DMA,*** composites are compared to those previously prepared using nanozeolites(NZs)as mineral *** morphology studied by SEM indicated that both systems have different structures,i.e.,individual fibers for cellulose microfibers WP-based aerogels and films for nanofibrillated cellulose NFC-based ones....These differences seem to be driven by the charge of the particles,their aspect ratio and *** hybrid materials exhibit tunable thermal conductivity and mechanical *** thermal conductivity values range between^18 to 28 mW.m^-1.K^-1 and confirm the superinsulation ability of these fibrous *** on the thermal insulation properties and mechanical properties was shown by adjunction of mineral particles to both cellulose-based aerogels by reaching pore size lower than 100 *** significantly reduces the thermal conductivity of the hybrid aerogels as predicted by Knudsen et ***,the addition of mineral fillers to aerogels based on cellulose microfibers induced a significant increase in stiffness.

关键词： Aerogels cellulose microfibers WP TEMPO-oxidized NFC silica lyophilization porosity superinsulation mechanical properties

Local atomic structure evolution of liquid gadolinium and yttrium during solidification:An ab initio study

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Journal of Rare Earths 2023年第8期41卷 1265-1271,I0006页

作者： Qinghe Zheng Tao Hu Sébastien Le Roux Musen Li Chaoyue Chen Jianbo Yu Jiang Wang Wei Ren Zhongming Ren State Key Laboratory of Advanced Special Steels School of Materials Science and EngineeringDepartment of PhysicsInternational Center of Quantum and Molecular StructuresShanghai UniversityShanghai200444China University of Strasbourg Institut de Physique et Chimie des Matériaux de StrasbourgCNRSUMR 750423 rue du LoessStrasbourgF-67034France

Local atomic structure evolution of pure gadolinium(Gd)and yttrium(Y)during solidification was investigated by using ab initio molecular dynamics(AIMD)*** calculated results indicate that the local short-range order(SRO)in liquid Gd and Y is similar to some transitional metals with an asymmetric shape of the second peak in static structure ***,the formation of icosahedral local motifs as a function of temperature decreases the diffusivity,which explains the connection between structure evolution and dynamic *** examining the topological structures of both systems,we demonstrate that small atomic displacement leads to two different types of topological sixfold rings in liquid and solid *** analyses yield a systematic study about rare earth metals Gd and Y at the atomic level.

关键词： Atomic structure evolution Rare earth Ab initio molecular dynamics Solidification

Is aberrant CD8+ T cell activation by hypertension associated with cardiac injury in severe cases of COVID-19?

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Cellular & Molecular Immunology 2020年第6期17卷 675-676页

作者： Chao Zhang Fu-Sheng Wang Jean-Sébastien Silvestre Fernando Arenzana-Seisdedos Hong Tang Treatment and Research Center for Infectious Diseases The Fifth Medical Center of PLA General HospitalNational Clinical Research Center for Infectious DiseasesBeijingChina Inserm UMRS 970 Paris Centre de Recherche Cardiovasculaire(PARCC)75737 Paris cedex 15CedexFrance CAS Key Laboratory of Molecular Virology and Immunology COVID-19 Response TeamInstitut Pasteur of ShanghaiChinese Academy of SciencesShanghaiChina

COVID-19 global pandemic,caused by severe acute respiratory syndrome coronavirus type 2(SARS-CoV-2),1 has swept 185 countries and regions with more than 2,824,728 confirmed cases,and 197,667 death as on April 25,2020 according the Coronavirus Resource Center at Johns Hopkins *** data suggest that hypertension,diabetes,and cardiovascular diseases are the most frequent comorbidities in COVID-19 patients,and case mortality rates tended to be high in these individuals.

关键词： hypertension cases Hopkins

Functional responses to deforestation in fish communities inhabiting neotropical streams and rivers

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Ecological Processes 2023年第1期12卷 716-732页

作者： Isabel Cantera Céline Jézéquel Tony Dejean Jérôme Murienne Régis Vigouroux Alice Valentini Sébastien Brosse Department of Environmental Science and Policy Universitàdegli Studi di MilanoVia Celoria 2620133 MilanItaly Laboratoire Evolution et DiversitéBiologique UMR5174-UniversitéPaul SabatierCNRSIRD118 Route de Narbonne31062 ToulouseFrance SPYGEN Savoie Technolac-BP 27417 Rue du Lac Saint-André73375 Le Bourget-du-Lac CedexFrance HYDRECO Laboratoire Environnement de Petit SautB.P 82397388 Kourou CedexFrench GuianaFrance

Background Deforestation is a widespread disturbance for neotropical freshwater *** biodiversity declines have been associated with deforestation,its functional consequences for stream and river fish faunas remain poorly *** this study,we explored how deforestation affects the different facets of the functional structure of fish communities inventoried using environmental DNA metabarcoding in 64 river and 35 stream sites of French ***,we investigated how functional richness,divergence,evenness and identity of fish faunas are affected by *** We showed that anthropogenic disturbances in French Guiana are modifying the functional diversity of freshwater fish *** disturbances not only affected the amount of functional traits held by the communities but also the identity of the traits and the internal structure of the functional ***,different facets of the functional diversity supported by fish assemblages were *** streams,deforestation did not affect the overall diversity of traits but reduced functional redundancy,underlined by a shift in functional identity towards assemblages dominated by pelagic *** contrast,river fish faunas experienced a decline in functional richness,paired with shifts in functional identity and a loss of fish species with extreme *** The response to deforestation differed between streams and rivers,but it supports the hypothesis that deforestation is linked to functional changes in fish *** diminishing the range of the functions in rivers or by jeopardizing the redundancy of functions in streams,deforestation could severely hamper the functioning and stability of neotropical freshwater ecosystems.

关键词： eDNA Traits Functional space Richness Divergence Evenness Identity Gold mining

Supramolecular PS-P4VP diblock copolymer thin films slowly dip-coated from chloroform solutions

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Science China Chemistry 2013年第1期56卷 33-39页

作者： ROLAND Sébastien PRUD'HOMME Robert E. BAZUIN C. Geraldine Département de Chimie Centre de Recherche sur les Matériaux Auto-assemblés (CRMAA/CSACS)Université de MontréalC.P.6128 Succ.Centre-villeMontréal (QC) H3C 3J7Canada

This contribution shows the strong influence of using chloroform instead of THF on the characteristics of thin films of supramolecular block copolymers of poly(styrene-b-4-vinyl pyridine) dip-coated in the so-called "capillarity" regime from solutions containing 1-naphthol or 1-naphthoic *** small molecule content in the dip-coated films was investigated by infrared spectroscopy and the film morphology by atomic force *** was found that the small molecule content in the films is constant with dip-coating rate in the range investigated,but it is higher for 1-naphthoic acid than for *** main morphology observed was in the form of "islands" and "holes",which is typical of flat-on *** findings are related to hydrogen-bonding between the small molecule and pyridine being conserved in chloroform and to the good solubility of both blocks in this solvent,with differences between the two small molecules related to their differing H-bond *** findings contrast strongly with what was observed previously using THF as a solvent,for which the SM content increases with dip-coating rate and the morphologies are mainly spherical and cylindrical in the same parameter range.

关键词： dip-coating block copolymer thin films supramolecular polymers