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Circulating Levels of Hypoxia-regulating microRNAs in Systemic Lupus Erythematosus Patients with Hemolytic Anemia

Current medical Science 2022年第6期42卷 1231-1239页

作者： Amira m.Gamal-Eldeen Cinderella A.Fahmy bassem m.raafat Fayez Althobaiti Iman H.Bassyouni Roba m.Talaat Clinical Laboratory Sciences Department College of Applied Medical SciencesTaif UniversityTaif21944Saudi Arabia High Altitude Research Center Prince Sultan Medical ComplexAl-HawiyahTaif UniversityTaif21944Saudi Arabia Cancer Biology and Genetics Laboratory Centre of Excellence for Advanced SciencesNational Research CentreCairo12622Egypt Biochemistry Department National Research CentreCairo12622Egypt Radiological Sciences Department College of Applied Medical SciencesTaif UniversityTaif21944Saudi Arabia Biotechnology Department Faculty of ScienceTaif UniversityTaif21944Saudi Arabia Department of Rheumatology and Rehabilitation Faculty of MedicineCairo UniversityEl-Kasr El-Aini HospitalCairo12613Egypt molecular Biology Department Genetic Engineering and Biotechnology Research Institute(GEBRI)Sadat City UniversitySadat City32897Egypt

Objective microRNAs are fine regulators for gene expression during the post-transcriptional stage in many autoimmune ***(miR-210 and miR-21)play an important role in hypoxia and in inflammation-associated *** lupus erythematosus(SLE)is a chronic systemic autoimmune disease that would potentiate many pathological complications,including hemolytic *** study aimed to investigate the role of hypoxamiRs in SLE/hemolytic anemia *** This work was designed to analyze the circulating levels of↱the miR-210 and miR-21 expressions and hypoxia-inducible factor-1α(HIF-α)in SLE/hemolytic anemia *** activity was evaluated for all patients by SLE Disease Activity Index(SLEDAI).Clinical manifestations/complications and serological/hematological investigations were ***-αconcentration was assayed by ELISA and expression of miR-21 and miR-210 was analyzed by *** The results indicated that the fold change of the miR-210/miR-21 expressions in plasma was significantly elevated in SLE/hemolytic anemia patients.A strong positive correlation between the miR-210 and miR-21 expression levels was also *** the associated-disease complications,hypertension,arthritis,oral ulcers,and serositis were associated with a high circulating miR-210 expression,while the occurrence of renal disorders was associated with the increased miR-21 ***,the HIF-αlevel was remarkably elevated in SLE/hemolytic anemia patients.A high positive correlation was recorded between the HIF-αconcentration and miR-210/miR-21 expression *** occurrence of oral ulcers,arthritis,and hypertension was associated with the increased HIF-α*** the other hand,SLEDAI and white blood cell count were positively correlated with miR-21/*** erythrocyte sedimentation rate was positively correlated with *** The dysregulation of the circulating miR-210/miR-210/HIF-1αlevels in SLE/hemolytic anemia pat

关键词： circulating hypoxamiRs miR-210 and miR-21 hypoxia-inducing factor-1α hemolytic anemia systemic lupus erythematosus

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