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Friction 2024年第6期12卷 1283-1298页

作者： Junhyeon SEO Prahalada RAO bart RAEYMAEKERS department of Mechanical Engineering Virginia TechBlacksburgVA 24061USA Grado department of Industrial and Systems Engineering Virginia TechBlacksburgVA 24061USA

Numerically generating synthetic surface topography that closely resembles the features and characteristics of experimental surface topography measurements reduces the need to perform these intricate and costly ***,existing algorithms to numerically generated surface topography are not well-suited to create the specific characteristics and geometric features of as-built surfaces that result from laser powder bed fusion(LPBF),such as partially melted metal particles,porosity,laser scan lines,and ***,we present a method to generate synthetic as-built LPBF surface topography maps using a progressively growing generative adversarial *** qualitatively and quantitatively demonstrate good agreement between synthetic and experimental as-built LPBF surface topography maps using areal and deterministic surface topography parameters,radially averaged power spectral density,and material ratio *** ability to accurately generate synthetic as-built LPBF surface topography maps reduces the experimental burden of performing a large number of surface topography ***,it facilitates combining experimental measurements with synthetic surface topography maps to create large data-sets that facilitate,*** as-built surface topography to LPBF process parameters,or implementing digital surface twins to monitor complex end-use LPBF parts,amongst other applications.

关键词： additive manufacturing surface topography synthetic surface topography generative adversarial networks

Guest editorial:Special Issue on Artificial Intelligence and Emerging Computational Approaches for Tribology

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Friction 2024年第6期12卷 1057-1059页

作者： Zhinan ZHANG Shuaihang PAN bart RAEYMAEKERS State Key Laboratory of Mechanical System and Vibration Shanghai Jiao Tong UniversityShanghai 200240China department of Mechanical Engineering University of UtahSalt Lake CityUT 84112USA department of Mechanical Engineering Virginia TechBlacksburgVA 24061USA

Tribo-behavior is a complex system-based time-dependent process,and it is difficult to accurately model a tribo-system and predict its ***,tribology research,in most cases,has relied on extensive *** by the artificial intelligence(AI)-for-science revolution,AI and other emerging computational approaches provide opportunities to explore the complex processes in tribo-systems and the physical mechanisms of tribo-behavior in an efficient way,significantly pushing the boundaries of tribology research.

关键词： behavior editorial artificial

Numerical modeling techniques for noise emission of free railway wheels

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Railway Engineering Science 2024年第2期32卷 144-161页

作者： Linus Taenzer Urs Pachale bart Van Damme Andrea Bergamini Domenico Tallarico Laboratory of Acoustics/Noise Control EmpaÜberlandstrasse 129DübendorfSwitzerland

In this article,we consider the numerical prediction of the noise emission from a wheelset in laboratory *** focus on the fluid-structure interaction leading to sound emission in the fluid domain by analyzing three different methods to account for acoustic *** are a discretized baffled piston using the discrete calculation method(DCM),a closed cylindrical volume using the boundary element method(BEM)and radiating elastic disks in a cubic enclosure solved with the finite element method(FEM).We provide the validation of the baffled piston and the BEM using measurements of the noise emission of a railway wheel by considering ground reflections in the numerical *** space-resolved waveforms are compared with experimental results as well as with a fluid-structure interaction finite element *** computational advantage of a discretized disk mounted on a baffle and BEM compared to FEM is highlighted,and the baffled pistons limitations caused by a lack of edge radiation effects are investigated.

关键词： Discretized baffled piston Finite element Boundary element Railway noise Acoustic emission Vibrations

The Changes of Histone Methylation Induced by Adolescent Social Stress Regulate the Resting-State Activity in mPFC

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Research 2024年第3期2023卷 273-283页

作者： Jiesi Wang Wei Zhang Hang Xu bart Ellenbroek Jiajie Dai Li Wang Chaogan Yan Weiwen Wang CAS Key Laboratory of Mental Health Institute of PsychologyChinese Academy of SciencesBeijing.China department of Psychology University of Chinese Academy of SciencesBeijingChina School of Psychology Victoria University of WellingtonKelburnWellington 6012New Zealand CAS Key Laboratory of Behavioral Science Institute of PsychologyChinese Academy of SciencesBeijingChina.

Early-life stress can lead to sustained alterations in regional resting-state brain functions, but the underlying molecular mechanism remains unclear. Stress can also induce sustained changes in epigenetic modifications across brain regions, which are not limited to a few genes;rather, they often tend to produce global levels of change. The functional implication of these changes also remains to be elucidated. We hypothesize that global epigenetic changes may partly modulate the resting-state functions of brain regions to influence behavior. To test this hypothesis, we used an adolescent social stress (ASS) model in mice and examined the relationship between epigenetic modifications and regional resting-state brain activity using resting-state functional magnetic resonance imaging (rs-fMRI). The results showed that, compared to the control mice, the stressed mice showed increased anxiety and social avoidance behaviors and greater levels of dimethylation of histone H3 at lysine 9 (H3K9me2) in the medial prefrontal cortex (mPFC). In addition, the resting-state activity represented by the amplitude of low-frequency fluctuation (ALFF) was significantly lower in the mPFC of stressed mice. To verify the relationship of H3K9me2 and ALFF, the specific inhibition of H3Kme2 was performed by using the drug UNC0642, which reversed the anxiety behavior induced by ASS and significantly increase the ALFF value of mPFC in both normal and ASS animals. Our study is the first to report an association between histone modifications and rs-fMRI findings, providing a new perspective for understanding of the significance of regional brain epigenetic changes and a possible molecular explanation for rs-fMRI findings.

关键词： sustained mPFC alterations

Surface modification of HKUST-1 for enhanced activity of immobilized formate dehydrogenase used in CO_(2)hydrogenation

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Carbon Resources Conversion 2024年第1期7卷 89-102,F0004页

作者： Shadeera Rouf Yaser E.Greish bart Van der Bruggen Sulaiman Al-Zuhair department of Chemical and Petroleum Engineering UAE University15551 Al AinUnited Arab Emirates department of Chemistry UAE University15551 Al AinUnited Arab Emirates department of Chemical Engineering KU Leuven3000 LeuvenBelgium

Post synthetic modification of a hydrophilic metal-organic framework(MOF),HKUST-1,with stearic acid(SA)was carried out to enhance the stability of HKUST-1 in aqueous solution to be used as a support for formate dehydrogenase(FDH)used for CO_(2)conversion to *** modification improved the hydrophobicity without affecting the morphology and crystal structure of *** of FDH on the modified MOF(SA@HKUST-1)was compared to that of the native HKUST-1 and *** adsorption kinetics on all MOFs was found to follow pseudo-second order kinetics and the isotherm was best described by Freundlich *** high stability of SA@HKUST-1 and enhanced hydrophobic interaction between support and CO_(2)resulted in high catalytic efficiency and stability of FDH@SA@*** immobilized enzyme retained 95.1%of its initial activity after 4 cycles of repeated *** was also shown that FDH@SA@HKUST-1 retained morphology and crystal structure after repeated *** of the present work provide novel insight into the influence of hydrophobic MOFs on the activity and stability of immobilized *** findings are expected to assist in developing highly active and stable biocatalysts for CO_(2)hydrogenation at commercial level.

关键词： CO_(2)hydrogenation Formate dehydrogenase Metal organic frameworks Hydrophobic MOFs Formate

Tree species identity and interaction determine vertical forest structure in young planted forests measured by terrestrial laser scanning

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Forest Ecosystems 2024年第3期11卷 266-275页

作者： Mengxi Wang Lander Baeten Frieke Van Coillie Kim Calders Kris Verheyen Quentin Ponette Haben Blondeel bart Muys John Armston Hans Verbeeck Q-ForestLab Department of EnvironmentFaculty of Bioscience EngineeringGhent UniversityBelgium Forest&Nature Lab Department of EnvironmentFaculty of Bioscience EngineeringGhent UniversityBelgium Earth and Life Institute Université Catholique de Louvain(UCLouvain)Louvain-la-NeuveBelgium department of Earth&Environmental Sciences KU LeuvenBelgium department of Geographical Sciences University of MarylandCollege ParkMDUSA

Vertical forest structure is closely linked to multiple ecosystem characteristics,such as biodiversity,habitat,and *** tree species in planted forests has the potential to create diverse vertical forest structures due to the different physiological and morphological traits of the composing tree ***,the relative importance of species richness,species identity and species interactions for the variation in vertical forest structure remains unclear,mainly because traditional forest inventories do not observe vertical stand structure in *** laser scanning(TLS),however,allows to study vertical forest structure in an unprecedented ***,we used TLS single scan data from 126 plots across three experimental planted forests of a largescale tree diversity experiment in Belgium to study the drivers of vertical forest *** plots were 9–11years old young pure and mixed forests,characterized by four levels of tree species richness ranging from monocultures to four-species mixtures,across twenty composition *** generated vertical plant profiles from the TLS data and derived six stand structural *** mixed models were used to test the effect of species richness on structural *** a hierarchical diversity interaction modelling framework,we further assessed species identity effect and various species interaction effects on the six stand structural *** results showed that species richness did not significantly influence most of the stand structure variables,except for canopy height and foliage height *** identity on the other hand exhibited a significant impact on vertical forest structure across all *** interaction effects were observed to be site-dependent due to varying site conditions and species pools,and rapidly growing tree species tend to dominate these ***,our results highlighted the importance of considering both species identity an

关键词： TreeDivNet FORBIO Stand structural complexity Terrestrial laser scanning Vertical forest structure Tree diversity Planted forests

Implementation of a single quad MS detector in routine QC analysis of peptide drugs

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Journal of Pharmaceutical Analysis 2016年第1期6卷 24-31页

作者： Matthias D'Hondt Bert Gevaert Evelien Wynendaele bart de.spiegeleer Drug Quality and Registration (Dru Qua R) Group Faculty of Pharmaceutical Sciences Ghent University

A newly developed single quad mass spectrometry （MS） detector was coupled to a ultra-high perfor- mance liquid chromatography （UPLC） system and implemented in the routine quality control （QC） and impurity analysis of four therapeutic peptides, namely bleomycin sulfate, tyrothricin, vancomycin HCl and bacitracin, which were selected given their multi-component drug nature and their closely struc- turally related impurity profiles. The QC and impurity profiling results obtained using the ultra-high performance liquid chromatography ultraviolet/mass spectrometry （UPLC-UV/MS） detection system were analyzed against the results obtained using traditional high performance liquid chromatography- ultraviolet detection （HPLC-UV） methods derived from pharmacopoeial methods. In general, the used stationary phases of sub-2 μm particle （UPLC） technology resulted in lower limits of detection and higher resolution separations, which resulted in more detected impurities and shorter overall run times con- trasting the traditional HPLC columns. Moreover, online coupling with a single quad MS detector allowed direct peak identification of the main compounds as well as small impurities, hereby increasing the information content without the need of reference standards.

关键词： Quality control Peptide Impurity profiling Single quad MS detector

N-alkylamide profiling of Achillea ptarmica and Achillea millefolium extracts by liquid and gas chromatography–mass spectrometry

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Journal of Pharmaceutical Analysis 2017年第1期7卷 34-47页

作者： Lieselotte Veryser Lien Taevernier Evelien Wynendaele Yannick Verheust Ann Dumoulin bart de.spiegeleer Drug Quality and Registration (DruQuaR) group Faculty of Pharmaceutical Sciences Ghent University Ottergemsesteenweg 460 B-9000 Ghent Belgium LIWET Department of Industrial Biological Sciences Ghent University Campus Kortrijk Graaf Karel de Goedelaan 5 B-8500 Kortrijk Belgium

Achillea millefolium and Achillea ptarmica are both plants belonging to the Asteracea family and are traditionally used for their medicinal properties. It has already been shown that some N-alkylamides(NAAs)are responsible for these pharmacological actions. Therefore, in the present study, the NAA content of the two plants was analytically characterised. Different extracts were prepared from the roots, the leaves, the stems and the flowers. The structures of NAAs have been assigned in ethanolic extracts of Achillea millefolium and Achillea ptarmica using high performance liquid chromatography – electrospray ionisation – mass spectrometry(HPLC–ESI–MS) and gas chromatography – electron impact – mass spectrometry(GC–EI–MS). Using both analytical techniques, the structures of 14 and 15 NAAs have been assigned in Achillea ptarmica and Achillea millefolium, respectively. Structures of two new NAAs, previously never observed in Achillea ptarmica,were assigned: deca-2E,6Z,8E-trienoic acid 2-methylbutylamide(homospilanthol) or a related isomeric compound and deca-2E,4E-dienoic acid N-methyl isobutylamide. The structure of homospilanthol or a related isomeric compound was also assigned in Achillea millefolium for the first time.

关键词： N-alkylamides Achillea millefolium Achillea ptarmica HPLC–ESI–MS GC–EI–MS

The Role of Age as a Risk Factor for Pickleball-Related Injuries

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Health 2024年第1期16卷 87-91页

作者： Ches Jones bart Hammig department of Health Human Performance and Recreation University of Arkansas Fayetteville USA

Pickleball is a popular sport that includes players from many different demographics. The popularity has resulted in not only increases in participation but also in activity related injuries. The purpose of this study was to identify risk factors along with potential mechanisms for injuries related to pickleball and identify effective countermeasures. Methods included the identification of pickleball related injuries from a US National Emergency Room database (NEISS). A narrative section of the database was used to identify and categorize potential mechanisms of injury. Results indicated that the types and mechanisms of injury relate to three specific age groups: younger, middle age, and older players. Injuries to younger players under the age of 26 are likely the result of misuse of sport equipment. Middle aged players from 26 to 50 sustained injuries more related activity overuse. However, there were more concerns with players over 50 years of age with a great percentage resulting in cardia arrest or symptoms leading to more severe cardiovascular conditions. While pickleball activity should be encouraged as it is a beneficial form of physical activity, there should be specific age-group interventions to reduce injury. It should be highly recommended that doctors approve the activity for individual at risk for heart conditions and supervision for adults in that age group.

关键词： Physical Activity Cardiac Arrest Epidemiology Pickleball Injury

Supramolecular Polymerization of Hydrogen-Bonded Trimers in Bulk and Aqueous Medium

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CCS Chemistry 2024年第6期6卷 1458-1465页

作者： Freek V.de Graaf Stef A.H.Jansen Sandra M.C.Schoenmakers Bas van Genabeek Marle E.J.Vleugels bart W.L.van den Bersselaar E.W.Meijer Ghislaine Vantomme Institute for Complex Molecular Systems Laboratory of Macromolecular and Organic ChemistryEindhoven University of Technology5600 MBEindhoven School of Chemistry and RNA Institute University of New South WalesSydneyNew South Wales 2052

Synthetic molecules that form functional noncovalent assemblies in water have received much attention for their potential applications as *** this work,we introduce a novel water-compatible monomer based on the phthalhydrazide moiety that assembles into hydrogen-bonded trimeric *** bulk,the material exhibits a cylindrical nanostructure in the liquid-crystalline phase at elevated temperatures,morphologically distinct from the crystalline lamellar *** water,these molecules effectively form cylinders in a one-dimensional fashion,yielding fibrous *** formation of these supramolecular polymers follows a cooperative mechanism,as evidenced by denaturation *** trimerized pattern represents a new category of aqueous su pramolecular polymers with future prospects for functional complex molecular systems.

关键词： noncovalent chemistry supramolecular polymers hydrogen bonding cooperativity nanostructure