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Developing green super rice varieties with high nutrient use efficiency by phenotypic selection under varied nutrient conditions

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The Crop journal 2019年第3期7卷 368-377页

作者： Zilhas Ahmed jewel jauhar Ali Yunlong Pang Anumalla Mahender bart Acero jose Hernandez jianlong Xu Zhikang Li Rice Breeding Platform International Rice Research Institute (IRRI)Los BanosLaguna 4031Philippines Institute of Crop Sciences Chinese Academy of Agricultural ScienceBeijing 100081China Institute of Crop Science College of Agriculture and Food ScienceUniversity of the PhilippinesLos BanosLaguna 4031Philippines

The development of green super rice varieties with improved nutrient use efficiency(NuUE)is a vital target area to increase yield and make it more stable under rainfed *** the present study, we followed an early backcross(BC) breeding approach by using a highyielding and widely adapted Xian variety, Weed Tolerant Rice 1(WTR-1), as a recipient and a Geng variety, Hao-An-Nong(HAN), as a *** from the BC1F2 generation, the BC population went through one generation of selection under irrigated, low-input, and rainfed conditions, followed by four consecutive generations of screening and selection for high grain yield(GY) under six different nutrient conditions(NPK, 75 N,-N,-P,-NP, and-NPK), leading to the development of 230 BC1F6 introgression lines(ILs).These 230 ILs were evaluated under the same six nutrient conditions for 13 agro-morphological and grain yield component traits in comparison to four checks and *** trait variations were observed between the treatments and *** correlations were identified for GY with biomass, panicle length, flag-leaf area, flag-leaf width, filled grain number per panicle,1000-grain weight, and tiller number under-N,-P,-NP, and-NPK *** of 230 ILs,12 were identified as promising under two or more nutrient deficiency *** results demonstrated an efficient inter-subspecific BC breeding procedure with a first round of selection under rainfed-drought conditions, followed by four generations of progeny testing for yield performance under six nutrient *** promising ILs can be useful resources for molecular genetic dissection and understanding the physiological mechanisms of NuUE.

关键词： Nutrient use efficiency Grain yield Nitrogen Phosphorus Green super rice

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Nonalcoholic fatty liver disease: An overview of current insights in pathogenesis, diagnosis and treatment

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World journal of Gastroenterology 2008年第16期14卷 2474-2486页

作者： Tim CMA Schreuder bart j Verwer Carin Mj van Nieuwkerk Chris jj Mulder Department of Gastroenterology and Hepatology VU University Medical Center

Estimates of people suffering from overweight (one billion) and obesity (300 million) are increasing. The accumulation of triglycerides in the liver, in the absence of excess alcohol intake, has been described in the early sixties. It was not until 1980, however, that Ludwig et al named this condition nonalcoholic steatohepatitis (NASH). Subsequently, nonalcoholic fatty liver disease (NAFLD) has been used as a general name for conditions ranging from simple steatosis through steatohepatitis to end-stage liver disease (cirrhosis). Many studies have demonstrated the significant correlation with obesity and insulin resistance. Other studies have revealed a signifi- cant correlation between hepatic steatosis, cardiovascu- lar disease and increased intima-media thickness. WHO estimated that at least two million patients will develop cirrhosis due to hepatic steatosis in the years to come. Longitudinal cohort studies have demonstrated that those patients with cirrhosis have a similar risk to devel- op hepatocellular carcinoma as those with other causes of cirrhosis. Taken all together, NAFLD has become the third most important indication for liver transplantation. There- fore, training programmes in internal medicine, gastroen- terology and hepatology should stress the importance of diagnosing this entity and treat properly those at risk for developing complications of portal hypertension and con- comittant cardiovascular disease. This review will focus on the clinical characteristics, pathophysiology, imaging tech- niques and the readily available therapeutic options.

关键词： Non-alcoholic fatty liver disease Non-alcoholicsteatohepatitis Insulin resistance Liver Obesity Steatosis

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Cantharellus(Cantharellales,Basidiomycota)revisited in Europe through a multigene phylogeny

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Fungal Diversity 2017年第2期83卷 263-292页

作者： Ibai Olariaga Gabriel Moreno jose Luis Manjon Isabel Salcedo Valerie Hofstetter Diego Rodrıguez bart Buyck Department of Life Sciences(Botany) University of Alcala28805 Alcalade HenaresMadridSpain Department of Plant Biology and Ecology(Botany) University of the Basque Country(UPV/EHU)Apdo 64448080 BilbaoSpain Department of Plant Protection Agroscope ChanginsWadenswil Research StationACWRte de Duiller1260 NyonSwitzerland Kherdzmari St.Microdistrict 11.Block 58 Flat 69TemkaTbilisiGeorgia Departement Systematique et Evolution CP 39ISYEBUMR 7205 CNRS MNHN UPMC EPHEMuseum National d’Histoire Naturelle12 Rue Buffon75005 ParisFrance

Resolving species delimitation issues of European Cantharellus is crucial to correctly name chanterelles around the *** names referring to Cantharellus *** been described in Europe,some of which are used in other *** on combined analyses of ITS2,LSU,RPB2 and TEF-1,merely eight species are here recognized in Europe applying the genealogical concordance phylogenetic species recognition criteria,one of which,***,is described as ***logical characters used in species delimitation are mapped and their variability *** colour of the hymenophore in young specimens is found to be a rather constant morphological character of taxonomic *** species of Cantharellus are morphologically distinguished by unique combinations of characters,such as the presence of a pink pileal coating,pileus and hymenophore colour when young,and in some cases,the mean spore length and *** type specimens from Europe are *** on revised species concepts sixteen novel taxonomic synonyms are here proposed for European chanterelles:***(=***,***,***),***(=*** ***,*** ***,***),***(=*** ***,***),***(=*** ***),***(=***),***(=*** ***,*** ***,***),and ***sianus(=***,***,***nesianus ***).The type of Cantharellus,***,is ***,colour illustrations and a key to all European species are provided.

关键词： Cantharelloid clade Cantharellaceae Epitype Edible fungi Genealogical concordance Species delimitation

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Inhibiting WNT secretion reduces high bone mass caused by Sost loss-of-function or gain-of-function mutations in Lrp5

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骨研究:英文版 2023年第3期11卷 595-606页

作者： Cassandra R.Diegel Ina Kramer Charles Moes Gabrielle E.Foxa Mitchell j.McDonald Zachary B.Madaj Sabine Guth jun Liu jennifer L.Harris Michaela Kneissel bart O.Williams Department of Cell Biology Van Andel Institute333 Bostwick Ave.NEGrand RapidsMI 49503USA Diseases of Aging and Regenerative Medicine Novartis Institutes for Biomedical ResearchCH-4002 BaselSwitzerland Bioinformatics and Biostatistics Core Van Andel Institute333 Bostwick Ave.NEGrand RapidsMI 49503USA Oncology Novartis Institutes for Biomedical ResearchSan DiegoCA 92121USA

Proper regulation of Wnt signaling is critical for normal bone development and *** in several Wnt signaling components,which increase the activity of the pathway in the skeleton,cause high bone mass in human subjects and mouse *** bone mass is often accompanied by severe headaches from increased intracranial pressure,which can lead to fatality and loss of vision or hearing due to the entrapment of cranial *** addition,progressive forehead bossing and mandibular overgrowth occur in almost all *** that would provide symptomatic relief in these subjects are ***-mediated palmitoylation is necessary for Wnt secretion and binding to the frizzled *** inhibition of porcupine is a highly selective method of Wnt signaling *** treated three different mouse models of high bone mass caused by aberrant Wnt signaling,including homozygosity for loss-of-function in Sost,which models sclerosteosis,and two strains of mice carrying different point mutations in Lrp5(equivalent to human G171V and A214V),at 3 months of age with porcupine inhibitors for 5–6 *** significantly reduced both trabecular and cortical bone mass in all three *** demonstrates that porcupine inhibition is potentially therapeutic for symptomatic relief in subjects who suffer from these disorders and further establishes that the continued production of Wnts is necessary for sustaining high bone mass in these models.

关键词： homeostasis function mass

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Quality evaluation of synthetic quorum sensing peptides used in R&D

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journal of Pharmaceutical Analysis 2015年第3期5卷 169-181页

作者： Frederick Verbeke Evelien Wynendaele Sarah Braet Matthias D'Hondt bart De Spiegeleer Drug Quality and Registration(DruQuaR) Group Faculty of Pharmaceutical SciencesGhent University

Peptides are becoming an important class of molecules in the pharmaceutical field. Closely related peptide-impurities in peptides are inherent to the synthesis approach and have demonstrated to potentially mask biomedical experimental results. Quorum sensing peptides are attracting high interest in R＆D and therefore a representative set of quorum sensing peptides, with a requested purity of at least 95.0%, was evaluated for their purity and nature of related impurities. In-house quality control （QC） revealed a large discrepancy between the purity levels as stated on the supplier＇s certificate of analysis and our QC results. By using our QC analysis flowchart, we demonstrated that only 44.0% of the peptides met the required purity. The main compound of one sample was even found to have a different structure compared to the desired peptide. We also found that the majority of the related impurities were lacking amino acid（s） in the desired peptide sequence. Relying on the certificates of analysis as provided by the supplier might have serious consequences for peptide research, and peptide-researchers should implement and maintain a thorough in-house QC.

关键词： Quorum sensing peptides Quality Impurity profiling

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Prehabilitation prior to intestinal resection in Crohn’s disease patients:An opinion review

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World journal of Gastroenterology 2022年第22期28卷 2403-2416页

作者： Michiel T j Bak Marit F E Ruiterkamp Oddeke van Ruler Marjo j E Campmans-Kuijpers bart C Bongers Nico L U van Meeteren C janneke van der Woude Laurents P S Stassen Annemarie C de Vries Department of Gastroenterology and Hepatology Erasmus University Medical Center RotterdamRotterdam 3015 GDNetherlands Department of Surgery IJsselland HospitalCapelle aan den IJssel 2906 ZCNetherlands Department of Surgery Erasmus University Medical Center RotterdamRotterdam 3015 GDNetherlands Department of Gastroenterology and Hepatology University Medical Center Groningen and University of GroningenGroningen 9713 GZNetherlands Department of Nutrition and Movement Sciences School of Nutrition and Translational Research in MetabolismMaastricht UniversityMaastricht 6200 MDNetherlands Department of Epidemiology Care and Public Health Research InstituteMaastricht UniversityMaastricht 6200 MDNetherlands Department of Anaesthesiology Erasmus MC University Medical Center RotterdamRotterdam 3015 GDNetherlands Department of Surgery Maastricht University Medical CenterMaastricht 6229 HXNetherlands

Patients with Crohn’s disease(CD)are at a considerable risk for intestinal *** 25%of patients with CD will undergo an intestinal resection within 10 years of *** complications after CD surgery have been reported in 20%-47%of the *** general and CD-related risk factors are associated with postoperative complications,and comprise non-modifiable(e.g.,age)and potentially modifiable risk factors(e.g.,malnutrition).Prehabilitation focuses on the preoperative period with strategies designed to optimize modifiable risk factors concerning the physical and mental condition of the individual *** aim of prehabilitation is to enhance postoperative recovery and return to or even improve preoperative functional *** improvement of nutritional status,physical fitness,cessation of smoking,psychological support,and critical revision of preoperative use of CD medication are important *** of the effect on postoperative outcome in CD patients are scarce,and guidelines lack recommendations on tailored *** this opinion review,we review the current evidence on the impact of screening and management of nutritional status,physical fitness,CD medication and laboratory values on the postoperative course following an intestinal resection in CD *** addition,we aim to provide guidance for individualized multimodal prehabilitation in clinical practice concerning these modifiable factors.

关键词： Crohn’s disease Prehabilitation strategies Nutrition Physical fitness Medication Laboratory values

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Randomized Trial of Ciclosporin with 2-h Monitoring *** with Trough Monitoring in Liver Transplantation:DELTA Study

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journal of Clinical and Translational Hepatology 2023年第4期11卷 839-849页

作者： Bastian N.Ruijter Akin Inderson Aad Pvan den Berg Herold j.Metselaar jeroen Dubbeld Maarten E.Tushuizen Robert j.Porte Wojciech Polak Danny van der Helm Marjolein van Reeven Mar Rodriguez-Girondo bart van Hoek Department of Gastroenterology and Hepatology LUMC Transplantation CenterLeiden University Medical CenterLeidenThe Netherlands Department of Gastroenterology and Hepatology University Medical Center GroningenGroningenThe Netherlands Department of Gastroenterology and Hepatology Erasmus MC Transplant InstituteErasmus Medical CenterRotterdamThe Netherlands Department of Surgery LUMC Transplantation CenterLeiden University Medical CenterLeidenThe Netherlands Department of Surgery Section HPB Surgery and Liver TransplantationUniversity of GroningenUniversity Medical Center GroningenGroningenThe Netherlands Department of Surgery Division of HPB and Transplant SurgeryErasmus MC Transplant InstituteErasmus Medical CenterRotterdamThe Netherlands Department of Biomedical Data Sciences Leiden University Medical CenterLeidenThe Netherlands.

Background and Aims:Previous trials comparing cyclosporine and tacrolimus after liver transplantation(LT)showed conflicting *** used trough monitoring for cyclosporine(C0),leading to less accurate dosing than with 2-h monitoring(C2).Only one larger trial compared C2 with tacrolimus based on trough level(T0)after LT,with similar treated biopsy-proven acute rejection(tBPAR)and graft loss,while a smaller trial had less tBPAR with C2 compared to ***,it is still unclear which calcineurin inhibitor is preferred after *** aimed to demonstrate superior efficacy(tBPAR),tolerability,and safety of C2 or T0 after first ***:Patients after first LT were randomized to C2 or ***,patient-and graft survival,safety and tolerability were the main endpoints,with analysis by Fisher test,Kaplan-Meier survival analysis and log-rank ***:In intention-totreat analysis 84 patients on C2 and 85 on T0 were *** incidence of tBPAR C2 vs.T0 was 17.7%vs.8.4%at 3 months(p=0.104),and 21.9%vs.9.7%at 6 and 12 months(p=0.049).One-year cumulative mortality C2 vs.T0 was 15.5%vs.5.9%(p=0.049)and graft loss 23.8%vs.9.4%(p=0.015).Serum triglyceride and LDL-cholesterol was lower with T0 than with *** of diarrhea in T0 vs,C2 was 64%vs.31%(p≤0.001),with no other differences in safety and ***:In the first year after LT immunosuppression with T0 leads to less tBPAR and better patient-/re-transplant-free survival as compared to C2.

关键词： Adverse effects Ciclosporin Liver transplantation Outcome Randomized controlled trial Rejection Survival Renal function Tacrolimus

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Derringer desirability and kinetic plot LC-column comparison approach for MS-compatible lipopeptide analysis

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journal of Pharmaceutical Analysis 2014年第3期4卷 173-182页

作者： Matthias D’Hondt Frederick Verbeke Sofie Stalmans Bert Gevaert Evelien Wynendaele bart De Spiegeleer Drug Quality and Registration (DruQuaR) Group Faculty of Pharmaceutical SciencesGhent University

Lipopeptides are currently re-emerging as an interesting subgroup in the peptide research field, having historical applications as antibacterial and antifungal agents and new potential applications as antiviral, antitumor, immune-modulating and cell-penetrating compounds. However, due to their specific structure, chromatographic analysis often requires special buffer systems or the use of trifluoroacetic acid, limiting mass spectrometry detection. Therefore, we used a traditional aqueous/acetonitrile based gradient system, containing 0.1% （m/v） formic acid, to separate four pharmaceutically relevant lipopeptides （polymyxin B1, caspofungin, daptomycin and gramicidin A1）, which were selected based upon hierarchical cluster analysis （HCA） and principal component analysis （PCA）.In total, the performance of four different C18 columns, including one UPLC column, were evaluated using two parallel approaches. First, a Derringer desirability function was used, whereby six single and multiple chromatographic response values were rescaled into one overall D-value per column. Using this approach, the YMC Pack Pro C18 column was ranked as the best column for general MS-compatible lipopeptide separation. Secondly, the kinetic plot approach was used to compare the different columns at different flow rate ranges. As the optimal kinetic column performance is obtained at its maximal pressure, the length elongation factor λ（Pmax/Pexp） was used to transform the obtained experimental data （retention times and peak capacities） and construct kinetic performance limit （KPL） curves, allowing a direct visual and unbiased comparison of the selected columns, whereby the YMC Triart C18 UPLC and ACE C18 columns performed as best. Finally, differences in column performance and the （dis）advantages of both approaches are discussed.

关键词： Lipopeptide Hierarchical cluster analysis (HCA) Principal component analysis (PCA) LC-MS Kinetic plot Derringer desirability function

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Twenty years of experience with the rabbit model,a versatile model for tracheal transplantation research

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Plastic and Aesthetic Research 2016年第1期3卷 223-230页

作者： Margot Den Hondt bart M.Vanaudenaerde Pierre Delaere jan j.Vranckx Department of Plastic and Reconstructive Surgery KU Leuven University Hospitals3000 LeuvenBelgium Department of Clinical and Experimental Medicine Laboratory of PulmonologyLung Transplant UnitKU LeuvenUniversity of Leuven3000 LeuvenBelgium Department of Otolaryngology Head and Neck SurgeryKU Leuven University Hospitals3000 LeuvenBelgium

Pathologies comprising more than half the length of the trachea are a challenge to the reconstructive *** tracheal transplantation techniques aim to offer the patient a curative solution with a sustained improvement in quality of *** review summarizes the authors’experience with the rabbit as a versatile model for research regarding tracheal *** of the segmental blood supply of the trachea,it is not feasible to transplant the organ together with a well-defined vascular *** such,the key element of successful tracheal transplantation is the creation of a new blood *** vascularized construct is created by prelaminating the rabbit trachea heterotopically,within the lateral thoracic *** prelamination,the construct and its vascular pedicle are transferred to the orthotopic position in the *** model has become gold standard because of the advantages of working with rabbits,the anatomy of the rabbit trachea,and the reliability of the lateral thoracic artery *** this paper,the key elements of surgery in the rabbit are discussed,as well as the tracheal anastomosis and the harvest of the lateral thoracic artery *** tips and tricks are *** data described in this review represent the fundaments of ongoing translational research in the center over the past twenty years.

关键词： Trachea transplantation rabbit lateral thoracic artery flap prelamination prefabrication

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Haplotype of prostaglandin synthase 2/cyclooxygenase 2 is involved in the susceptibility to inflammatory bowel disease

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World journal of Gastroenterology 2005年第38期11卷 6003-6008页

作者： David G Cox j bart A Crusius Petra HM Peeters H Bas Bueno-de-Mesquita A Salvador Pe(n|~)a Federico Canzian International Agency for Research on Cancer Laboratory of Immunogenetics julius Center for Health Sciences and Primary Care Department of Epidemiology Laboratory of Immunogenetics and Department of Gastroenterology

AIM： Prostaglandin G/H synthase 2 （PTGS2 or COX2） is one of the key factors in the cellular response to inflammation. PTGS2 is expressed in the affected intestinal segments of patients with inflammatory bowel diseases （IBD）. In IBD patients, non-steroidal anti-inflammatory drugs, which have been shown to reduce both the production and activity of PTGS2, may activate IBD and aggravate the symptoms. We aimed at examining genetic variants of PTGS2 that may be risk factors for IBD. METHODS： We genotyped 291 individuals diagnosed with IBD and 367 controls from the Dutch population for the five most frequent polymorphisms of the PTG52 gene. Clinical data were collected on all patients. DNA was extracted via normal laboratory methods. Genotyping was carried out using multiplex PCR followed by the Invader Assay and the 5＇ exonuclease assay （TaqMan）. New polymorphism screening was performed by pre-screening with denaturing high-performance liquid chromatography, followed by fluorescent sequencing. RESULTS： Allele 5209G was weakly associated with Crohn＇s disease （odds ratio [OR] 1.63, 95% confidence interval [CI] 1.03-2.57）, and allele 8473T with ulcerativecolitis （OR 1.50, 95%CI 1.00-2.27）. The haplotype including both alleles showed a strong association with IBD （OR 13.15, 95%CI 3.17-116.15）. This haplotype, while rare （-0.3%） in the general population, is found more frequently in patients （3.5%）. CONCLUSION： Our data suggest that this haplotype of PTGS2 contributes to the susceptibility of IBD.

关键词： Inflammatory bowel disease Prostaglandin G/H synthase Cyclooxygenase SNP Haplotype

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