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肥厚型心肌病猝死危险因素分层

中华心血管病杂志 2009年第4期37卷 294-297页

作者： Paolo Spirito barry j maron Genoa 16128 Divisione di Cardiologia Ente Ospedaliem Ospedali GaUiera Minneapolis Heart Institute Foundation

肥厚型心肌病（HCM）是最常见的遗传性心脏病。普通人群患病率1／500，以自然病史差异极大为特征。很多患者终生无症状，寿命与常人并无不同。有些患者有心力衰竭（心衰）或心房颤动（房颤）的症状，某些患者猝死。猝死者常常先前没有... 详细信息

肥厚型心肌病（HCM）是最常见的遗传性心脏病。普通人群患病率1／500，以自然病史差异极大为特征。很多患者终生无症状，寿命与常人并无不同。有些患者有心力衰竭（心衰）或心房颤动（房颤）的症状，某些患者猝死。猝死者常常先前没有症状，年龄较轻。HCM是青年人和运动员最常见的猝死原因。因此对猝死危险进行分层，预防猝死是一个重要的临床问题。

关键词：肥厚型心肌病猝死原因危险因素遗传性心脏病心房颤动无症状普通人群自然病史

正电子发射断层成像术在肥厚型心肌病中的应用：发现微血管功能异常所致的心肌低灌注

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中华心血管病杂志 2009年第12期37卷 1069-1073页

作者： Franco Cecchi Iacopo Olivotto Massimo Baldi Martin S. maron barry j. maron Florence 50129 Dipartimento cuore e vasi-S. Lucavecchio Azienda Ospedaliera Universitaria Careggi Division of Cardiology Tufts-New England Medical Center Hypertrophic Cardiomyopathy Center Minneapolis Heart Institute Foundation

肥厚型心肌病是最常见的遗传性心脏疾病，其在人群中患病率约为2／1000，以表型表达和临床表现差异极大为特点——从完全无症状到猝死、疾病进展和心力衰竭相关并发症等。微血管水平的心肌缺血与疾病表达和临床后果密切相关，是一些致... 详细信息

肥厚型心肌病是最常见的遗传性心脏疾病，其在人群中患病率约为2／1000，以表型表达和临床表现差异极大为特点——从完全无症状到猝死、疾病进展和心力衰竭相关并发症等。微血管水平的心肌缺血与疾病表达和临床后果密切相关，是一些致命性并发症，如室性心律失常、猝死、左心室重构和收缩功能障碍的直接原因。至今，肥厚型心肌病患者心肌缺血的评估还存在一定技术和实际的困难，尚没有纳入到规范的临床实践中，亦没有列入肥厚型心肌病的诊疗指南。

关键词：肥厚型心肌病正电子发射断层成像术微血管功能异常遗传性心脏疾病低灌注相关并发症室性心律失常

肥厚型心肌病心房颤动：决定因素、临床进程与处理

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中华心血管病杂志 2009年第4期37卷 303-307页

作者： Iacopo Olivotto Paolo DiDonna Aurelio Sgalambro Massimo Baldi barry j maron Franco Cecchi Florence 50132 Referral Center for Myocardial Diseases Careggi University Hospital Division of Cardiology Cardinal Massaia Hospital Hypertrophic Cardiomyopathy Center Minneapolis Heart Institute Foundation

心房颤动（房颤）是一个全球性健康问题，东西方患病率相同，反映人群老化，心血管病负担加重。在肥厚型心肌病（HCM）患者中，房颤是最常见的持续性心律不齐，最常见的并发症之一，对临床病程与预后影响很大。房颤成为HCM治疗的棘手问... 详细信息

心房颤动（房颤）是一个全球性健康问题，东西方患病率相同，反映人群老化，心血管病负担加重。在肥厚型心肌病（HCM）患者中，房颤是最常见的持续性心律不齐，最常见的并发症之一，对临床病程与预后影响很大。房颤成为HCM治疗的棘手问题，特别年轻患者，需要一致的循证治疗策略。尽管HCM房颤的循证依据不多，近期证据提示，新的治疗方法给某些患者带来了希望。

关键词：肥厚型心肌病心房颤动临床病程全球性健康问题循证治疗心血管病心律不齐年轻患者

Investigation of HCAR2 antagonists as a potential strategy to modulate bovine leukocytes

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journal of Animal Science and Biotechnology 2024年第4期15卷 1567-1577页

作者： Laman K.Mamedova Kirby C.Krogstad Paiton O.McDonald Laxman Pokhrel Duy H.Hua Evan C.Titgemeyer barry j.Bradford Department of Animal Science Michigan State UniversityEast LansingMichigan 48824USA Department of Animal Sciences and Industry Kansas State UniversityManhattanKS 66506USA Comparative Medicine and Integrative Biology East LansingMI 48824USA Department of Chemistry Kansas State UniversityManhattanKS 66506USA

Background Dairy cows experiencing ketosis after calving suffer greater disease incidence and are at greater risk of leaving the herd. In vitro administration of beta-hydroxybutyric acid(BHBA;the primary blood ketone) has inhibitory effects on the function of bovine leukocytes. BHBA is a ligand of HCAR2 and the activation of these receptors promotes an anti-inflammatory response which may be related with immunosuppression observed in transition dairy cattle. The objective of this study was to identify and test antagonists for HCAR2 in bovine immune cells cultured with *** We observed expression of HCAR2 at the protein level within lymphocytes, monocytes, and granulocytes. The proportion of cells expressing HCAR2 tended to be greater in mid-lactation compared to early lactation cows;the increase was a result of increased proportion of T and B cells expressing HCAR2. Stimulation of HCAR2 with niacin or BHBA promoted Ca^(2+) mobilization in neutrophils and mononuclear cells. Mononuclear cells treated with BHBA had diminished intracellular Ca^(2+) responses when HCAR2 was knocked down by si RNA silencing, indicating Ca^(2+) mobilization was mediated by HCAR2 signaling. Two candidate antagonists for HCAR2, synthesized from niacin(NA-1 and NA-5), were tested;monocytes and neutrophils pre-treated with NA-1 and NA-5 had reduced Ca^(2+) mobilization after incubation with BHBA. Furthermore, NA-5 but not NA-1 prevented BHBA-associated reductions in cyclic *** We demonstrated that HCAR2 is present on bovine leukocytes and has greater expression later in lactation. We confirmed that BHBA and niacin derived HCAR2 antagonists alter bovine leukocyte activity. Our results demonstrate that both BHBA and niacin affect bovine leukocyte Ca^(2+) mobilization in a HCAR2-dependent manner.

关键词： Flow cytometry GPR109A HM74A Ketosis

Fetal Head Compression: Its Possible Role in Neurologic Injury

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Open journal of Obstetrics and Gynecology 2024年第1期14卷 124-143页

作者： barry S. Schifrin Brian j. Koos Wayne R. Cohen Department of Obstetrics and Gynecology The Western University of Health Sciences Pomona USA The David Geffen School of Medicine at UCLA Los Angeles USA The University of Arizona College of Medicine Tucson USA

It is widely assumed that fetal ischemic brain injury during labor derives almost exclusively from severe, systemic hypoxemia with marked neonatal depression and acidemia. Severe asphyxia, however, is one of several causes of perinatal neurological injury and may not be the most common;most neonates diagnosed with hypoxic-ischemic encephalopathy do not have evidence of severe asphyxia. Sepsis, direct brain trauma, and drug or toxin exposure account for some cases, while mechanical forces of labor and delivery that increase fetal intracranial pressure sufficiently to impair brain perfusion may also contribute. Because of bony compliance and mobile suture lines, the fetal skull changes shape and redistributes cerebrospinal fluid during labor according to constraints imposed by contractions, and bony and soft tissue elements of the birth canal as the head descends. These accommodations, including the increase in intracranial pressure, are adaptive and necessary for efficient descent of the head while safeguarding cerebral blood flow. Autonomic reflexes mediated through central receptors normally provide ample protection of the brain from the considerable pressure exerted on the skull. On occasion, those forces, which are transmitted intracranially, may overcome the various adaptive anatomical, cardiovascular, metabolic, and neurological mechanisms that maintain cerebral perfusion and oxygen availability, resulting in ischemic brain injury. Accepting the notion of a potentially adverse impact of fetal head compression suggests that avoidance of excessive uterine activity and of relentless pushing without steady progress in descent may offer protection for the fetal brain during parturition. Excessive head compression should be considered in the differential diagnosis of ischemic encephalopathy.

关键词： Fetal Brain Injury Fetal Head Compression Ischemic Encephalopathy Neonatal Encephalopathy

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现今的心肌病定义和分类

放射学实践 2010年第G期25卷 8-11页

作者： barry j. maron jeffrey A. Towbin Gaetano Thiene Charles Antzelevitch Domenico Corrado Donna Arnett Arthur j. Moss Christine E. Seidman james B. Young 黄璐汤翔宇

心肌病是一类重要而复杂的疾病。以往提出了许多分类系统，它们在一定程度上相互矛盾。心肌病分类最近一次达成共识是11年前WHO分类标准。但在过去10年里，诊断上的巨大进步和病因的准确认识，一些新的疾病，导到认识，

关键词：分类系统心肌病分类标准 WHO 疾病

Multi-Institutional US Experience of the Occlutech AFR Device in Congenital and Acquired Heart Disease

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Congenital Heart Disease 2022年第1期17卷 107-116页

作者： barry O’Callaghan jenny Zablah joseph Vettukattil Daniel Levi Morris Salem Allison Cabalka jason Anderson Makram Ebeid Ryan Alexy Gareth j.Morgan The Heart Institute Children’s Hospital ColoradoAuroraUSA Pediatric Cardiology Helen DeVos Children’s HospitalGrand RapidsUSA Pediatric Cardiology UCLA HealthMattel Children’s HospitalLos AngelesUSA Pediatric Cardiology UCLA Medical CentreLos AngelesUSA Pediatric Cardiology Mayo ClinicRochesterUSA Pediatric Cardiology University of Mississippi Medical CenterJacksonUSA Pediatric Cardiology Riley Hospital for Children at Indiana University HealthIndianapolisUSA

Objectives:To detail the US multi-institutional experience with the Occlutech©(Occlutech International AB,Helsingborg,Sweden)atrial flow regulator(AFR)in children and adults with acquired or congenital heart ***:The creation of a long-term atrial communication is desirable in several cardiovascular disease phenotypes,most notably pulmonary arterial hypertension,disorders of increased left ventricular filling and increased cavopulmonary pressures in patients with a Fontan type ***:Patients were identified for inclusion from the AFR device manufacturer *** was collected using a RedCap database following IRB approval.8 weeks of follow up data was sought for each patient based on available *** was analyzed and summarized using ***:We report the experience of 6 US centers in the implantation of AFR devices in 15 patients,across a wide age range,with different disease phenotypes and a variety of *** was technically successful in all patients and improvement was noted in both clinical and hemodynamic *** were no immediate or intermediate term complications reported.3 patients died remote from *** deaths were not felt to be related to the AFR device or related procedural ***:Compassionate use of the AFR device in children and adults with congenital&acquired heart disease is technically feasible and produces beneficial short term hemodynamic and symptomatic *** uptake of this technique and treatment at specialist centers has the potential to provide significant benefits to a variety of complex patients with currently limited treatment options and indeterminate prognosis.

关键词： Congenital heart disease pulmonary hypertension left atrial hypertension single ventricle palliation diastolic heart failure

Robustness Assessment and Adaptive FDI for Car Engine

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International journal of Automation and computing 2008年第2期5卷 109-118页

作者： Mahavir Singh Sangha j.barry Gomm Control Systems Research Group School of EngineeringLiverpool John Moores University

A new on-line fault detection and isolation （FDI） scheme proposed for engines using an adaptive neural network classifier is evaluated for a wide range of operational modes to check the robustness of the scheme in this paper. The neural classifier is adaptive to cope with the significant parameter uncertainty, disturbances, and environment changes. The developed scheme is capable of diagnosing faults in on-line mode and the FDI for the closed-loop system with can be directly implemented in an on-board crankshaft speed feedback is investigated by diagnosis system （hardware）. The robustness of testing it for a wide range of operational modes including robustness against fixed and sinusoidal throttle angle inputs, change in load, change in an engine parameter, and all these changes occurring at the same time. The evaluations are performed using a mean value engine model （MVEM）, which is a widely used benchmark model for engine control system and FDI system design. The simulation results confirm the robustness of the proposed method for various uncertainties and disturbances.

关键词： On-board fault diagnosis automotive engines adaptive neural networks (ANNs) fault classification robustness assessment

COVID-19 has triggered a new century of vaccination and infection control for the benefit of all mankind

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Precision Clinical Medicine 2021年第2期4卷 77-79页

作者： barry j.Marshall Helicobacter pylori Research Laboratory School of Biomedical SciencesMarshall Centre for Infectious Disease Research and TrainingUniversity of Western AustraliaNedlands 6009Australia

Modern safe vaccinations were pioneered in 1796 by Edward jenner in England,when he noticed that milkmaids had beautiful complexions,clear of the blemishes from smallpox *** was attributed to their exposure to‘cowpox... 详细信息

关键词： vaccination infection attributed