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Ostrich Antibody and Its Application to Skin Diseases, a Review and Case Report

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Health 2018年第10期10卷 1357-1370页

作者： Yasuhiro Tsukamoto Osamu Maeda Genshi Shigekawa Stuart Greenberg barry Hendler Department of Animal Sciences Graduate School of Environmental & Biological Sciences Kyoto Prefecture University Kyoto Japan Clinical Studies Zeal Cosmetics Osaka Japan bioresearch Section Maz World Hong Kong Science Park Hong Kong S.A.R. China Clinical Studies Ostri Gen Holdings West Newton MA USA Microfollicular Hair Transplantation Ambler PA USA

Antibodies are immunoglobulins produced by b cells when antigens such as allergens or pathogens invade an animal’s body. The antibodies remove and inactivate antigens. Antibodies are distributed in internal body and mucosal membrane to protect living animals, but they are excellent proteins that can exert their functions, “antigen-antibody reactions,” even when removed from the body. For that reason, antibodies are being put to practical use in diagnostic kits for conditions such as pregnancy and influenza infection, and as anticancer drugs targeting specific tumor markers. The result has been an increasing use of antibodies for research, diagnosis, and therapeutic purposes. Unfortunately, antibodies from experimental mammals such as mice, rats, and rabbits, are not suited to industrial use because of their high production cost. Moreover, handling of these antibodies is difficult due to their vulnerability to heat, acids and alkalis. Accordingly, there is no adaptability to mass production. Recently, we developed a convenient method for the low-cost, mass-production of antibodies using egg-laying hen ostriches. The ostrich egg is an excellent source of antibodies for industrial purposes. The present report shows that the ostrich antibodies have therapeutic effects in ailments such as atopic dermatitis, acne, pyoderma, and pollen allergies. We have successfully produced and purified ostrich immunoglobulin yolk (IgY) against pollen allergens (Cryj1, Cryj2, Chao1, Chao2) and found that allergic reactions were alleviated in skin patch tests of allergic patients by using the ostrich IgY. In addition, we produced ostrich IgY against the homogenates of Staphylococcus aureus and Propionibacterium acnes, and applied to dermal lesions of atopic dermatitis and acne patients, and then observed the therapeutic effects on the dermatitis of volunteer subjects. Antibody against S. aureus also had the therapeutic effect on canine pyoderma caused by MRSA. A particular advantage in us

关键词： Ostrich Antibody Cosmetics Atopic Dermatitis Acne Pollen Allergy Pyoderma

Analysis of core protein clusters identifies candidate variable sites conferring metronidazole resistance in Helicobacter pylori

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Gastroenterology Report 2019年第1期7卷 42-49,I0002页

作者： Eng-Guan Chua Aleksandra W.Debowski KMary Webberley Fanny Peters binit Lamichhane Mun-Fai Loke Jamuna Vadivelu Chin-Yen Tay barry J.Marshall Michael J.Wise The Marshall Centre for Infectious Diseases Research and Training University of Western AustraliaPerthWestern AustraliaAustralia School of biomedical Sciences Faculty of Health and Medical SciencesUniversity of Western AustraliaPerthWestern AustraliaAustralia Department of Medical Microbiology University of MalayaKuala LumpurWilayah PersekutuanMalaysia Shenzhen Dapeng New District Kuichong People Hospital ShenzhenGuangdongChina UM Marshall Centre University of MalayaKuala LumpurWilayah PersekutuanMalaysia School of Computer Science and Software Engineering University of Western AustraliaPerthWestern AustraliaAustralia

background:Metronidazole is one of the first-line drugs of choice in the standard triple therapy used to eradicate Helicobacter pylori ***,the global emergence of metronidazole resistance in Hp poses a major challenge to health *** of RdxA is known to be a major mechanism of conferring metronidazole resistance in ***,metronidazole resistance can also arise in *** strains expressing functional RdxA protein,suggesting that there are other mechanisms that may confer resistance to this ***:We performed whole-genome sequencing on 121 *** clinical strains,among which 73 were ***-alignment analysis of core protein clusters derived from clinical strains containing full-length RdxA was *** sites in each alignment were statistically compared between the resistant and susceptible groups to determine candidate genes along with their respective amino-acid changes that may account for the development of metronidazole resistance in ***:Resistance due to RdxA truncation was identified in 34%of metronidazole-resistant *** of core protein clusters derived from the remaining 48 metronidazole-resistant strains and 48 metronidazole-susceptible identified four variable sites significantly associated with metronidazole *** sites included R16H/C in RdxA,D85N in the inner-membrane protein RclC(HP0565),V265I in a biotin carboxylase protein(HP0370)and A51V/T in a putative threonylcarbamoyl–AMP synthase(HP0918).Conclusions:Our approach identified new potential mechanisms for metronidazole resistance in *** that merit further investigation.

关键词： Helicobacter pylori metronidazole antibiotic resistance whole-genome sequencing core protein clusters sequence alignment

Self-Assembly and Ordering of C60 on the WO2/W（110） Surface

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Nano Research 2011年第2期4卷 194-203页

作者： Sergey A. Krasnikov Sergey I. bozhko Kevin Radican Olaf Lübben barry E. Murphy Sundar-Raja Vadapoo Han-Chun Wu Mohamed Abid Valery N. Semenov lgor V. Shvets Centre tbr Research on Adaptive Nanostrucmres and Nanodevices （CRANN） School of Physics Trinity College Dublin Dublin 2 Ireland Institute of Solid State Physics Russian Academy of Sciences Chernogolovka Russian Federation King Abdullah Institute for Nanoteclmology College of Science King Saud University Riyadh 1145l Saudi Arabia

The growth and ordering of C60 molecules on the WO2/W（110） surface have been studied by low-temperature scanning tunnelling microscopy and spectroscopy （STM and STS）, low-energy electron diffraction （LEED）, and density functional theory （DFT） calculations. The results indicate the growth of a well-ordered C60 layer on the WO2/W（110） surface in which the molecules form a close-packed hexagonal structure with a unit cell parameter equal to 0.95 nm. The nucleation of the C60 layer starts at the substrate＇s inner step edges. Low-temperature STM of C60 molecules performed at 78 K demonstrates well-resolved molecular orbitals within individual molecules. In the C60 monolayer on the WO2/W（110） surface, the molecules are aligned in one direction due to intermolecular interaction, as shown by the ordered molecular orbitals of individual C60. STS data obtained from the C60 monolayer on the WO2/W（110） surface are in good agreement with DFT calculations.

关键词： Fullerenes self-assembly tungsten oxide low-temperature scanning tunnelling microscopy scanning tunnellingspectroscopy W(110)

皮下注射超声造影剂观察前哨淋巴结的实验研究

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苏州医学 2009年第2期32卷 89-92页

作者：邓学东刘吉斌 barry b.goldb.rg 苏州市立医院超声中心 215002 美国Thomas Jefferson大学医院

目的在肿瘤周围皮下注射超声造影剂．观察是否能够探测淋巴管和前哨淋巴结（SLN），是否能够探测SLN内的转移灶。方法用普通超声、彩色多普勒和反向灰阶二次谐波超声对6头猪，17个黑色素瘤进行了研究。在肿瘤周边皮下注射超声造影剂Sona... 详细信息

目的在肿瘤周围皮下注射超声造影剂．观察是否能够探测淋巴管和前哨淋巴结（SLN），是否能够探测SLN内的转移灶。方法用普通超声、彩色多普勒和反向灰阶二次谐波超声对6头猪，17个黑色素瘤进行了研究。在肿瘤周边皮下注射超声造影剂Sonazoid（总量1ml）。淋巴超声造影后，进行^99mTc硫化物胶体皮下注射，然后由两位医生来判断超声造影时是否SLN有转移。结果超声造影发现28个SLN，而淋巴系闪烁造影检出27个热点（hotspots），可能为SLN（2个假阳性）。蓝色染料注射后的手术切除检出31个SLN。超声探测SLN无假阳性；淋巴系闪烁造影漏诊6个SLN；这其中5个SLN，皮下注射超声造影剂后都能清晰显示。皮下超声造影探测SLN的准确性为90％（28／31），而淋巴系闪烁造影为81％（P=0．29）。皮下注射超声造影剂在20个发生转移的SLN中，成功检出19个；在8个无转移的SLN中，成功检出5个，准确性86％（k=0．62）。结论皮下注射超声造影剂后都能显示SLN，并可显示SLN内的转移灶。皮下超声造影比淋巴系闪烁造影更有效。

关键词：超声造影剂前哨淋巴结

Splitting and cone avoidance in the D.C.E. degrees

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Science China Mathematics 2002年第9期45卷 1135-1146页

作者：李昂生 S.b.Cooper Department of Pure Mathematics School of Mathematics University of Leeds Leeds LS2 9JT United Kingdom Institute of Software Chinese Academy of Sciences Beijing 100080 China

It is shown that the Cooper splitting theorem for the n-c.e. degrees is not compatible with cone avoidance: For any n > 1, there exist n-c.e. degree a, c.e. degree b such that 0 < b < a and such that for any n-c.e. de... 详细信息

It is shown that the Cooper splitting theorem for the n-c.e. degrees is not compatible with cone avoidance: For any n > 1, there exist n-c.e. degree a, c.e. degree b such that 0 b b ≤ x or b ≤ y. This provides a new type of elementary difference between the classes of c.e. and d.c.e. degrees, implementable at lower levels of the high/low hierarchy.

关键词： Cooper splitting theorem, cone avoidance.

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闽江钻孔沉积物微量元素地球化学研究

海洋地质与第四纪地质 2015年第2期35卷 81-90页

作者：章桂芳郑卓 barry Rollet 黄康有乐远福朱光骐中山大学地球科学和地质工程学院广州510275 国土资源部海底矿产资源重点实验室广州海洋地质调查局广州510075 广东省地质工程与矿产资源探查重点实验室广州510275 Department of Anthropology University of Hawaii2424 Maile WayHonoluluHIUSA

河流沉积物微量元素特征对指示沉积演化历史、沉积环境及沉积物的物质来源具有十分重要的示踪作用。闽江福州段540cm的沉积物微量元素比值(Rb/Sr和Sr/ba)和稀土元素地球化学特征,敏锐地指示了沉积环境从河流快速转变为沼泽的突变点,同时... 详细信息

河流沉积物微量元素特征对指示沉积演化历史、沉积环境及沉积物的物质来源具有十分重要的示踪作用。闽江福州段540cm的沉积物微量元素比值(Rb/Sr和Sr/ba)和稀土元素地球化学特征,敏锐地指示了沉积环境从河流快速转变为沼泽的突变点,同时,也清楚地指示了不同沉积环境下的物源变化。受控于闽江流域丰富的岩浆岩和稀土资源以及呈酸性的福建土壤和闽江水体,闽江钻孔沉积物REE明显高于上地壳、长江和黄河,与福建土壤最为接近。经过球状陨石和北美页岩标准化之后,闽江钻孔沉积物稀土元素分配模式呈右倾型,与长江和黄河沉积相比具有更好的轻稀土富集。δEu负异常和δCe正异常非常显著,并且与∑REE密切相关,表明它们均受到源区环境变化和搬运作用的控制。

关键词：钻孔微量元素稀土元素地球化学闽江

软件成本估算 COCOMO II模型方法 4

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丛书名：软件工程技术丛书

2005年

作者：（美）barry W.boehm等李师贤等译

本书详细讲解如何利用COCOMO II进行软件开发项目管理中的有效估算，用大量实例说明COCOMO II的使用方法、涉及软件成本估算的各个方面。

ISBN: (纸本)711115777X

本书详细讲解如何利用COCOMO II进行软件开发项目管理中的有效估算，用大量实例说明COCOMO II的使用方法、涉及软件成本估算的各个方面。

关键词：成本计算数学模型软件开发

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JavaServer Pages开发指南

Does Ethanol Play a Pro-Oxidant Role during Oxidative Stress in the Liver?

丛书名：美国“高级开发工具”丛书

2002年

作者：（美）barry burd 何玉洁迟育强等译

今日电子:本书由浅入深，全面、系统的介绍了JavaServer Pages技术，全书分四个部分分别介绍了基本JSP脚本、Javabeans及其应用、使用数据库和Javabeans Pages，高级议题(描述一个完整的WEb应用的配置，以及创建定制的JSP标记的方法)等。

ISBN: (纸本)7505371053

关键词：互连网络程序设计

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Journal of biosciences and Medicines 2015年第8期3卷 1-9页

作者： Patience O. Obih Joseph S. Soblosky barry J. Potter College of Pharmacy Xavier University of Louisiana New Orleans USA The Alcohol Research Center LSU Health New Orleans USA The Department of Physiology at LSU Health New Orleans USA

Oxidative stress has been implicated in the pathophysiology of liver injury during xenobiotic and alcohol metabolism, ischemia/reperfusion injury. In this study we examined if ethanol acted as a pro-oxidant making cells become more sensitive to tert-butylhydroperoxide (tbH) killing. Cell viability was determined in a rat hepatoma cell line (FTO2b) and rat primary hepatocytes in culture in the presence or absence of ethanol pretreatment. To elucidate the contribution of labile iron, deferoxamine (DF, an iron chelator) or lipid free radicals, N,N-diphenyl-p-phenylenediamine (DPPD, a lipid scavenger) were added to the ethanol tbH co-treatment. The levels of glutathione (GSH) and glutathione disulfide (GSSG) in the hepatocytes were also measured. Ethanol treatment (both pretreatment and co-treatment during the 3-hr tbH exposure) increased cell killing dramatically in both FTO2b cells and primary rat hepatocytes. both DF and DPPD decreased ethanol-enhanced tbH cell killing in hepatocytes. These results demonstrated that co-treatment of FTO2b cells and primary rat hepatocytes with ethanol and tbH increased cell killing. The GSH level was dramatically reduced while GSSG level rose. both DFP and DPPD reversed or protected the cells from this insult, indicating that ethanol was a pro-oxidant.

关键词： Ethanol Liver Hepatocytes FTO2b Cells t-butyl Hydroperoxide