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Chinese Science Bulletin 2008年第5期53卷 642-651页

作者： SUN jingHua barry j S Gale Derryck T Reid Ultrafast Optics Group School of Engineering and Physical Sciences Heriot-Watt University Edinburgh EH14 4AS UK Laboratory of Optical Physics Institute of Physics Chinese Academy of Sciences Beijing 100080 China

The intrinsic synchronization, multi-color outputs and related carrier-envelope phases (CEP) among pulses bring advantages to synchronously pumped femtosecond optical parametric oscillators and the pumping sources for broadband frequency comb generation and ultrashort waveform coherent syn-thesis. In this paper, we discuss our latest research results in this field, which cover the following as-pects: the phase relationship and energy conservation law in an OPO and related experimental verifi-cation; control of the pumping Ti:sapphire femtosecond laser's CEP by self-referencing technology, and its repetition-rate locking by piezoelectric transducer (PZT); CEP locking of the pulses from the OPO by beating the non-phase-matched visible outputs against pump supercontinuum to obtain a driving signal for a fast PZT on the OPO end mirror; the generation of a broadband frequency comb spanning from 400 nm to 2.4 μm with 1.2 kHz bandwidth; and the realization of coherent interference between phase controlled pump pulses and signal second harmonic pulses.

关键词：光学参数振荡器载波包络相同步控制超短光脉冲

A preliminary study of sperm identification in microdissection testicular sperm extraction samples with deep convolutional neural networks

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Asian journal of Andrology 2021年第2期23卷 135-139页

作者： Daniel j Wu Odgerel Badamjav Vikrant V Reddy Michael Eisenberg barry Behr Department of Computer Science Stanford UniversityStanfordCA 94305USA Department of Urology University of Utah HealthSalt Lake CityUT 84108USA Department of Obstetrics and Gynecology Stanford Children’s HealthStanfordCA 94305USA Department of Urology Stanford University School of MedicineStanfordCA 94305USA

Sperm identification and selection is an essential task when processing human testicular samples for in vitro *** and identifying sperm cell(s)in human testicular biopsy samples is labor intensive and time *** developed a new computer-aided sperm analysis(CASA)system,which utilizes deep learning for near human-level performance on testicular sperm extraction(TESE),trained on a custom *** system automates the identification of sperm in testicular biopsy samples.A dataset of 702 de-identified images from testicular biopsy samples of 30 patients was *** image was normalized and passed through glare filters and diffraction *** data were split 80%,10%,and 10%into training,validation,and test sets,***,a deep object detection network,composed of a feature extraction network and object detection network,was trained on this *** model was benchmarked against embryologists’performance on the detection *** deep learning CASA system achieved a mean average precision(mAP)of 0.741,with an average recall(AR)of 0.376 on our *** proposed method can work in real time;its speed is effectively limited only by the imaging speed of the *** results indicate that deep learning-based technologies can improve the efficiency of finding sperm in testicular biopsy samples.

关键词： artificial intelligence computer vision male infertility microdissection testicular sperm extraction sperm

A History of Fischer-Tropsch Wax Upgrading at BP-from Catalyst Screening Studies to Full Scale Demonstration in Alaska

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journal of Natural Gas Chemistry 2006年第1期15卷 1-10页

作者： john P. Collins joep j. H. M. Font Freide barry Nay BP Exploration America Inc. BP Exploration Operating Company

Conversion of Fischer-Tropsch wax into high quality synthetic crude or finished transportation fuels such as premium diesel has been studied over the past 15 years within BP. Catalyst screening and selection was carried out in dedicated micro-reactors and pilot plants, whose designs are critical to the performance selection. Variation in catalyst composition and defining the gas to oil feed ratios with the operating temperature are a few of the parameters studied. Product selection and maximizing diesel yield combined with stability （catalyst life） were the ultimate drivers. The selected catalyst was then tested under commercial conditions in a dedicated 300 barrel per day demonstration plant. The products were also tested in engines to assess their combustion characteristics.

关键词： Fischer-Tropsch wax upgrading hydrocracking synthetic crude diesel naphtha engine emission

Pancreatic intraepithelial neoplasia arising from an ectopic pancreas in the small bowel

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Hepatobiliary & Pancreatic Diseases International 2014年第6期13卷 658-661页

作者： Francisco Igor Macedo Deepa Taggarshe Tafadzwa Makarawo barry Herschman Michael j jacobs Department of General Surgery Providence Hospital and Medical Centers Southfield MI 48075 USA Department of General Surgery Providence Hospital and Medical Centers Southfield MI 48075 USA Department of Pathology Providence Hospital and Medical Centers Southfield MI 48075 USA

BACKGROUND： Ectopic pancreatic tissue is relatively uncommon, and is characterized as pancreatic tissue with no contact with the normal pancreas, and with its own ductal system and blood supply. It is usually asymptomatic, and can be incidentally diagnosed by conventional imaging studies. METHOD： A 69-year-old woman with a prior history of bilateral breast carcinoma presented with ectopic pancreatic intraepithelial neoplasia （PanIN） that was identified incidentally in the small bowel during an oncological resection of a synchronous primary pancreatic adenocarcinoma, and renal cell carcinoma. RESULTS： The patient underwent subtotal pancreatectomy with splenectomy, regional lymphadenectomy, radical left nephrectomy, and small bowel resection with primary anastomosis of ectopic PanlN-2. She had an uneventful hospitalization and was discharged home on postoperative day 7. CONCLUSIONS： The occurrence of ectopic PanIN is extremely unusual with only few cases previously reported in the literature. The need for negative margins after surgical resection of ectopic PanIN lesions remains controversial.

关键词： ectopic pancreas pancreatic intraepithelial neoplasia PanIN pancreatic adenocarcinoma

Unifying the Software Process Spectrum

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软件学报 2006年第4期17卷 649-657页

作者： Mingshu Li barry W. Boehm Leon j. Osterweil State Key Lab of Computer Science and Lab. for Internet Software Technologies Institute of Software at Chinese Academy of Sciences Beijing 100080 China University of Southern California CA 90089-0781 USA University of Massachusetts Amherst Amherst MA 01003 USA

Software Process Workshop (SPW 2005) was held in Beijing on May 25-27, 2005. This paper introduces the motivation of organizing such a workshop, as well as its theme and paper gathering and review; and summarizes the main content and insights of 11 keynote speeches, 30 regular papers in five sessions of “Process Content”, “Process Tools and Metrics”, “Process Management”, “Process Representation and Analysis”, and “Experience Reports”, 8 software development support tools demonstration, and the ending panel “Where Are We Now? Where Should We Go Next?”.

关键词：软件处理微处理宏处理过程表征

Histone Acetylation, VERNALIZATION INSENSITIVE 3, FLOWERING LOCUS C, and the Vernalization Response

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Molecular Plant 2009年第4期2卷 724-737页

作者： Donna M. Bond Elizabeth S. Dennis barry j. Pogson E. jean Finnegan CSIRO Plant Industry Canberra Australia ARC Centre of Excellence in Plant Energy Biology School of Biochemistry and Molecular Biology Australian National University Canberra Australia

The quantitative induction of VIN3 by low temperatures is required for PRC2 repression of FLC and promotion of flowering （vernalization） in Arabidopsis. Histone acetylation, a chromatin modification commonly associated with gene transcription, increased on VIN3 chromatin in two spatially and temporally distinct phases in response to low temperatures. During short-term cold exposure, histone H3 acetylation at the transcription start site rapidly increased, implying that it is required for VlN3 induction. Subsequent changes in histone H3 and H4 acetylation occurred following continued VIN3 transcription during prolonged cold exposure. Members of the SAGA-like transcriptional adaptor complex, including the histone acetyltransferase GCNS, which induces expression of the cold acclimation pathway genes, do not regulate VlN3 induction during cold exposure, indicating that the cold acclimation pathway and the cold-induction of VlN3 are regulated by different transcriptional mechanisms. Mutations in the other 11 histone acetyltransferase genes did not affect VlN3 induction. However, nicotinamide, a histone deacetyiase inhibitor, induced VIN3 and altered histone acetylation at the VIN3 locus. VIN3 induction was proportional to the length of nicotinamide treatment, which was associated with an early-flowering phenotype and repression of FLC. However, unlike vernalization, the repression of FLC was independent of VIN3 activity. Nicotinamide treatment did not cause a change in the expression of any genes in the autonomous pathway or members of the PRC2 complex, the well characterized repressors of FLC. Our data suggest that FLC is repressed via a novel pathway involving the SIR2 class of histone deacetylases.

关键词： Cold acclimation histone acetyltransferase histone deacetylase SIR2 nicotinamide.

Transcriptional Control of SET DOMAIN GROUP 8 and CAROTENOID ISOMERASE during Arabidopsis Development

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Molecular Plant 2010年第1期3卷 174-191页

作者： Christopher I. Cazzonelli Andrea C. Roberts Melanie E. Carmody barry j. Pogson Australian Research Council Centre of Excellence in Plant Energy Biology Research School of Biology The Australian National University Canberra ACT0200 Australia

Carotenoids are pigments required for photosynthesis, photoprotection and the production of carotenoid- derived hormones such as ABA and strigolactones. The carotenoid biosynthetic pathway bifurcates after lycopene to produce epsilon- and beta-carotenoids and this branch is critical for determining carotenoid composition. Here, we show how the branch point can be regulated by the chromatin-modifying histone methyltransferase, Set Domain Group 8 （SDG8） targeting the carotenoid isomerase （CRTISO）. SDG8 is required to maintain permissive expression of CRTISO during seedling development, in leaves, shoot apex, and some floral organs. The CRTISO and SDG8 promoters show overlapping tissue-specific patterns of reporter gene activity. Interestingly, CRTISO showed atypical reporter gene expression in terms of greater variability between different lines compared to the Cauliflower Mosaic Virus 35S promoter （CaMV35s） and ~LCY promoters, potentially due to chromosomal position effects. Regulation of the CRTISO promoter was dependent in part upon the presence or absence of SDG8. Knockouts of SDG8 （carotenoid and chloroplast regulation （ccrl）） and CRTISO （ccr2） result in altered carotenoid composition and this could be restored in ccr2 using the CaMV35s or CRTISO promoters. In contrast, varying degrees of GUS expression and carotenoid complementation by CRTISO overexpression using CaMV35S or CRTISO promoters in the ccrl background demonstrated that both the CRTISO promoter and open reading frame are necessary for SDG8-mediated expression of CRTISO.

关键词： Photosynthesis secondary metabolism--terpenoids, isoprenoids, and carotenoids chloroplast biology epigenetics gene expression gene regulation.

Restricted nutrient intake does not alter serum-mediated measures of implant response in cell culture

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journal of Animal Science and Biotechnology 2014年第1期5卷 80-87页

作者： Christopher D Reinhardt Tiffany L Lee Daniel U Thomson Laman K Mamedova barry j Bradford Department of Animal Sciences and Industry 232 Weber Hall Kansas State University Department of Clinical Sciences A-111 Mosier Hall Kansas State University

Background： During nutritional stress, reduced intake may reduce the efficacy of anabolic implants. This study was conducted to evaluate basic cellular responses to a growth promotant implant at two intake levels. Methods： Sixteen crossbred steers （293 ± 19.3 kg） were used to evaluate the impact of anabolic implants in either an adequate or a restricted nutritional state. Steers were trained to individual Calan gates, and then randomly assigned to 1 of 4 treatments in a 2 × 2 factorial arrangement. Treatments consisted off presence or absence of an anabolic growth implant （Revalor-XS, 200 mg TBA and 40 mg estradiol; IMPLANT or CONTROL） and a moderate energy, pelleted, starting cattle diet fed at either 2.0 × or 1.0 × maintenance energy （NEM） requirements （HIGH or LOW）. Serum （d O, 14, and 28） was used for application to bovine muscle satellite cells. After treatment with the serum （20% of total media） from the trial cattle, the satellite cells were incubated for 72 h. Protein abundance of myosin heavy chain （MHC）, phosphorylated extracellular signal-related kinase （phospho-ERK）, and phosphorylated mammalian target of rapamycin （phospho-mTOR） were analyzed to determine the effects of implant, intake, and their interaction （applied via the serum）. Results： Intake had no effect on MHC （P = 0.85） but IMPLANT increased （P 〈 0.01） MHC abundance vs. CONTROL. Implant status, intake status, and the interaction had no effect on the abundance of phospho-ERK （P〉0.23）. Implanting increased phospho-mTOR （P 〈 0.01） but there was no effect （P 〉 0.51） of intake or intake x implant. Conclusions： The nearly complete lack of interaction between implant and nutritional status indicates that the signaling molecules measured herein respond to implants and nutritional status independently. Furthermore, results suggest that the muscle hypertrophic effects of anabolic implants may not be mediated by circulating IGF-1.

关键词： Beef cattle Implant Muscle Myosin heavy chain Nutrient restriction Satellite cells

Helicobacter pylori serology in a birth cohort of New Zealanders from age 11 to 26

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World journal of Gastroenterology 2005年第21期11卷 3273-3276页

作者： j.Paul Fawcett Gill O.Barbezat Richie Poulton barry j.Milne Harry H.X.Xia Nicholas j.Talley School of Pharmacy University of Otago DunedinNew Zealand Dunedin School of Medicine University of Otago DunedinNew Zealand Dunedin Multidisciplinary Health and Development Research Unit Dunedin School of Medicine University of Otago Dunedin New Zealand Department of Medicine The University of Hong Kong Queen Mary Hospital Hong Kong China Department of Medicine The University of Sydney Nepean HospitalNSW 2751Australia

AIM: To determine seroprevalence of Helicobacter pylori (Hpylori)in the Dunedin Multidisciplinary Health and Development Study (DMHDS) at age 26 in order to investigate seroconversion and seroreversion from age 11 to 26 and the association of seropositivity with risk factors for H pylori infection. METHODS: Participants in the DMHDS at age 26 and retrospectively at age 21 were tested for H pylori antibodies using two commercially available ELISA ***, socioeconomic status (SES), smoking,educational attainment and employment at age 26 were tested for association with H pylori seropositivity. RESULTS: At ages 21 and 26,seroprevalence of H pylori using one or other kit was 4.2% (n=795) and 6.3% (n=871) respectively, Seroreversion rate was lower than seroconversion rate (0.11% vs 0.53% per person-year) in contrast to the period from age 11 to 21 when seroreversion rate exceeded seroconversion rate (0.35% vs 0.11% per person-year). Serology in those tested at ages 11, 21, and 26 remained unchanged in 93.6% of the sample. Seroprevalence at age 26 was lower among those with a secondary school qualification (P=0.042) but was not associated with gender, SES, smoking or employment status. CONCLUSION: H pylori seroprevalence in a New Zealand birth cohort remains low between ages 11 and 26. H pylori infection remains stable from childhood to adulthood although seroreversion seems to be more common in the adolescent years than in young adults.

关键词： H pylori Seroprevalence Cohort

肥厚型心肌病猝死预防：肥厚型心肌病患者除颤器置入

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中华心血管病杂志 2009年第4期37卷 297-302页

作者： barry j Maron Paolo Spirito Minneapolis MN 55407 Hypertrophic Cardiomyopathy Center Minneapolis Heart Institute Foundation Division di Cardiologia Ente Ospedaliero Ospodali Galliera

从50年前认识到肥厚型心肌病（HCM）起，对HCM患者猝死危险已有了充分的认识和足够的重视。HCM是青年人（包括受训运动员）猝死最常见的原因。置入性心脏除颤器（ICD）起初用于治疗缺血性心脏病，近几年用于HCM心原性猝死的预防。临床IC... 详细信息

从50年前认识到肥厚型心肌病（HCM）起，对HCM患者猝死危险已有了充分的认识和足够的重视。HCM是青年人（包括受训运动员）猝死最常见的原因。置入性心脏除颤器（ICD）起初用于治疗缺血性心脏病，近几年用于HCM心原性猝死的预防。临床ICD置人增加很快，是改变HCM青年患者病程的主要治疗手段。

关键词：肥厚型心肌病心原性猝死心脏除颤器置入预防病患缺血性心脏病 HCM