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What Have We Learned from Design of Function in Large Proteins?

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BioDesign Research 2022年第1期2022卷 358-368页

作者： Olga Khersonsky Sarel j.Fleishman Department of Biomolecular Sciences Weizmann Institute of ScienceRehovot 7610001Israel

The overarching goal of computational protein design is to gain complete control over protein structure and *** majority of sophisticated binders and enzymes,however,are large and exhibit diverse and complex folds that defy atomistic design ***,recent strategies that combine evolutionary constraints from natural homologs with atomistic calculations have significantly improved design *** these approaches,evolutionary constraints mitigate the risk from misfolding and aggregation,focusing atomistic design calculations on a small but highly enriched sequence *** methods have dramatically optimized diverse proteins,including vaccine immunogens,enzymes for sustainable chemistry,and proteins with therapeutic *** new generation of deep learning-based ab initio structure predictors can be combined with these methods to extend the scope of protein design,in principle,to any natural protein of known *** envision that protein engineering will come to rely on completely computational methods to efficiently discover and optimize biomolecular activities.

关键词： vaccine constraints aggregation

COMPOSITE SOFT SWITCHING CONFIGURATION FOR INVERTERS USING BRIDGE LEG MODULES

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journal of Electronics(China) 2001年第1期18卷 61-69页

作者： He Xiangning Yang Yuwen (Dept of Electrical Eng., Zhejiang University, Hangzhou 310027)Kuang Sheng(Department of Engineering, University of Cambridge, Cambridge, U.K.)barry W. Williams Stephen j. Finney(Dept. of Computing & Electrical Eng., Heriot-Watt University, Edinburgh EH14 4AS, U.K.) Dept of Electrical Eng. Zhejiang University Hangzhou 310027Kuang ShengDepartment of Engineering University of Cambridge Cambridge U.K.Barry W. Williams Stephen J. Finney Dept. of Computing & Electrical Eng. Heriot-Watt University Edinburgh EH14 4AS Department of Engineering University of Cambridge Cambridge U.K. Dept. of Computing & Electrical Eng. Heriot-Watt University Edinburgh EH14 4AS U.K.

The use of either lossless snubbers or resonant zero voltage switching (ZVS) and zero current switching (ZCS) techniques can increase efficiency and reduce electromagnetic inter ference (EMI) and noise of industrial power equipment at high switching frequencies. This paper presents an adaptive composite soft switching configuration which combines snubber functions and resonant ZCS circuits for switches in inverters using power bridge leg modules. Simulation and experimental results are included.

关键词： Inverter Snubber Soft switching IGBT modules

CCS Research Development and Deployment in a Clean Energy Future： Lessons from Australia over the Past Two Decades

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Engineering 2017年第4期3卷 477-484页

作者： Peter j. Cook CO2CRC Ltd.& Peter Cook Centre for Carbon Capture and Storage Research The University of Melbourne Melbourne VIC 2010 Australia

There is widespread, though by no means universal, recognition of the importance of carbon capture and storage （CCS） as a carbon mitigation technology. However, the rate of deployment does not match what is required for global temperatures to stay well below 2℃. Although some consider the hurdles to achieving the widespread application of CCS to he almost insurmountable, a more optimistic view is that a great deal is now known about CCS through research, demonstration, and deployment. We know how to do it; we are confident it can be done safely and effectively; we know what it costs; and we know that costs are decreasing and will continue to do so. We also know that the world will need CCS as long as countries, companies, and communities continue to use fossil fuels for energy and industrial processes. What is lacking are the necessary policy drivers, along with a technology-neutral approach to decrease carbon emissions in a cost-effective and timely manner while retaining the undoubted benefits of ready access to reliable and secure electricity and energy-intensive industrial products. In this paper, Australia is used as an example of what has been undertaken in CCS over the past 20 years, particularly in research and demonstration, hut also in international collaboration. Progress in the large-scale deployment of CCS in Australia has been too slow. However, the world＇s largest storage project will soon be operational in Australia as part of the Gorgon liquefied natural gas （LNG） project, and investigations are underway into several large-scale CCS Flagship program opportunities. The organization and progress of the Cooperative Research Centre for Greenhouse Gas Technologies （CO2CRC） Otway Project, which is currently Australia＇s only operational storage project, is discussed in some detail because of its relevance to the commercial deployment of CCS. The point is made that there is scope for building on this Otway activity to investigate more broadly （through the p

关键词： Carbon dioxide Carbon capture and storage Otway Australia

An Earth-mass planet in a time of COVID-19:KMT-2020-BLG-0414Lb

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Research in Astronomy and Astrophysics 2021年第9期21卷 243-261页

作者： Weicheng Zang Cheongho Han Iona Kondo jennifer C.Yee Chung-Uk Lee Andrew Gould Shude Mao Leandro de Almeida Yossi Shvartzvald Xiangyu Zhang Michael D.Albrow Sun-ju Chung Kyu-Ha Hwang Youn Kil jung Yoon-Hyun Ryu In-Gu Shin Sang-Mok Cha Dong-jin Kim Hyoun-Woo Kim Seung-Lee Kim Dong-joo Lee Yongseok Lee Byeong-Gon Park Richard W.Pogge john Drummond Thiam-Guan Tan joséDias do Nascimento júnior Dan Maoz Matthew T.Penny Wei Zhu Ian A.Bond Fumio Abe Richard barry David P.Bennett Aparna Bhattacharya Martin Donachie Hirosane Fujii Akihiko Fukui Yuki Hirao Yoshitaka Itow Rintaro Kirikawa Naoki Koshimoto Man Cheung Alex Li Yutaka Matsubara Yasushi Muraki Shota Miyazaki Greg Olmschenk Clément Ranc Nicholas j.Rattenbury Yuki Satoh Hikaru Shoji Stela Ishitani Silva Takahiro Sumi Daisuke Suzuki Yuzuru Tanaka Paul j.Tristram Tsubasa Yamawaki Atsunori Yonehara Andreea Petric Todd Burdullis Pascal Fouqué Department of Astronomy Tsinghua UniversityBeijing 100084China Department of Physics Chungbuk National UniversityCheongju 28644Republic of Korea Department of Earth and Space Science Graduate School of ScienceOsaka UniversityToyonakaOsaka 560-0043Japan Center for Astrophysics j Harvard&Smithsonian 60 Garden St.CambridgeMA 02138USA Korea Astronomy and Space Science Institute Daejon 34055Republic of Korea University of Science and Technology Korea(UST)217 Gajeong-ro Yuseong-guDaejeon 34113Republic of Korea Max-Planck-Institute for Astronomy Königstuhl 1769117 HeidelbergGermany Department of Astronomy Ohio State University140 W.18th Ave.ColumbusOH 43210USA National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Universidade Federal do Rio Grande do Norte(UFRN) Departamento de F´1sica59078-970NatalRNBrazil Department of Particle Physics and Astrophysics Weizmann Institute of ScienceRehovot 76100Israel University of Canterbury Department of Physics and AstronomyPrivate Bag 4800Christchurch 8020New Zealand School of Space Research Kyung Hee UniversityYonginKyeonggi 17104Republic of Korea Possum Observatory PatutahiGisbourneNew Zealand Perth Exoplanet Survey Telescope PerthAustralia School of Physics and Astronomy Tel-Aviv UniversityTel-Aviv 6997801Israel Department of Physics and Astronomy Louisiana State UniversityBaton RougeLA 70803 USA Canadian Institute for Theoretical Astrophysics University of Toronto60 St George StreetTorontoON M5S 3H8Canada Institute of Natural and Mathematical Sciences Massey UniversityAuckland 0745New Zealand Institute for Space-Earth Environmental Research Nagoya UniversityNagoya 464-8601Japan Code 667 NASA Goddard Space Flight CenterGreenbeltMD 20771USA Department of Astronomy University of MarylandCollege ParkMD 20742USA Department of Physics University of AucklandPrivate Bag 92019AucklandNew Zealand Department of Earth and Planetary Science Graduate School of ScienceThe University of Tokyo7-3-1 Hongo

We report the discovery of KMT-2020-BLG-0414 Lb,with a planet-to-host mass ratio q2=0.9-1.2×10-5=3-4 q⊕at 1σ,which is the lowest mass-ratio microlensing planet to *** with two other recent discoveries(4?q/q⊕?6),it fills out the previous empty sector at the bottom of the triangular(log s,log q)diagram,where s is the planet-host separation in units of the angular Einstein radiusθ***,these discoveries call into question the existence,or at least the strength,of the break in the mass-ratio function that was previously suggested to account for the paucity of very low-q *** to the extreme magnification of the event,Amax~1450 for the underlying single-lens event,its light curve revealed a second companion with q3~0.05 and|log s3|~1,i.e.,a factor~10 closer to or farther from the host in *** measurements of the microlens parallaxπE and the angular Einstein radiusθE allow estimates of the host,planet and second companion masses,(M1,M2,M3)~(0.3 M⊙,1.0 M⊕,17 Mj),the planet and second companion projected separations,(a⊥,2,a⊥,3)~(1.5,0.15 or 15)au,and system distance DL~1 *** lens could account for most or all of the blended light(I~19.3)and so can be studied immediately with high-resolution photometric and spectroscopic observations that can further clarify the nature of the *** planet was found as part of a new program of high-cadence follow-up observations of high-magnification *** detection of this planet,despite the considerable difficulties imposed by COVID-19(two KMT sites and OGLE were shut down),illustrates the potential utility of this program.

关键词： gravitational lensing:micro

Parental involvement and gender differences in the psychological profile of freshmen collegiate athletes

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journal of Sport and Health Science 2013年第3期2卷 160-167页

作者： j.Gualberto Cremades Catherine j.Donlon Artur Poczwardowski Department of Sport and Exercise Sciences Barry University Cognoscenti Health Institute Graduate School of Professional Psychology University of Denver

Background： The parent-to-child influences can be adaptive and contribute to the optimal psychological well-being and positive perception of the athlete. Contrary to the healthy parental involvement, a family can also have negative effects on an athlete development. The purpose of this study was to determine gender, father involvement, and mother involvement differences in the psychological profiles of collegiate freshmen athletes as measured by perfectionism, physical self-concept, and psychological well-being. Methods： Eighty-two male and 73 female collegiate freshmen responded to self-reported measures of family involvement, perfectionism, physical self-concept, and psychological well-being. Three separate 2 x 2 x 2 （gender x mother involvement x father involvement） factorial multivariate analysis of variance （MANOVAs） were carried out on the respective subscales from the reported measures. Results： There were significant differences for gender as well as father involvement in perfectionism （p 〈 0.01）. Freshmen females had lower concern over mistakes, and greater levels of organization as well as planfulness than males. Furthermore, freshmen athletes with high involved fathers showed greater levels of high standards for others as well as organization. Conclusion： Father involvement and mother involvement impact perfectionism, physical self-concept, and psychological well-being. perspective. extends through the freshmen year in college as shown in the athletes＇ Future research should develop better measures and utilize a family systems Copyright @ 2012, Shanghai University of Sport. Production and hosting by Elsevier B.V. All rights reserved

关键词： Development Father involvement Mother involvement Perfectionism Physical self-concept Psychological well-being

股骨近端同种异体骨移植治疗全髋关节置换术后VancouverB3型股骨假体周围骨折手术技术

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中华骨科杂志 2008年第3期28卷 I0047-I0056页

作者： Catherine F. Kellett Petros j. Boscainos Anthony C. Maury Ari Pressman barry Cayen Paul Zalzal David Backstein Allan Gross 史占军(译) 郭予立(译) Investigation performed at Mount Sinai Hospital Toronto Ontario Canada The original scientific article in which the surgical technique was presented was published in jBjS Vol. 88-A pp. 953-958 May 2006 南方医科大学南方医院骨科广州510515

背景：全髋关节置换术后的股骨假体周围骨折的发生率日益增高，当股骨近端骨量不足并出现骨折时，能够选择的翻修手术方法则不多，其中一种方法就是股骨近端同种异体骨移植术。方法：我们回顾性评估采用股骨近端同种异体骨移植术治疗24... 详细信息

背景：全髋关节置换术后的股骨假体周围骨折的发生率日益增高，当股骨近端骨量不足并出现骨折时，能够选择的翻修手术方法则不多，其中一种方法就是股骨近端同种异体骨移植术。方法：我们回顾性评估采用股骨近端同种异体骨移植术治疗24例VancouverB，型假体周围骨折患者（25髋）的随访结果和并发症，平均随访时间为5．1年，临床效果采用Harris评分，放射学评估指标包括转子的融合程度、宿主骨和移植骨的融合程度、是否出现移植骨的吸收、是否出现假体的松动或断裂，以须行清除移植骨的翻修手术作为失败的标准。

关键词：股骨假体周围骨折同种异体骨移植术全髋关节置换术股骨近端移植治疗手术技术 Harris评分 3型

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家庭医生在家政服务人员培训中的作用

中国全科医学 2008年第23期11卷 2187-页

作者： Mark j·Yaffe barry j·jacobs 李井泉

在工业化国家,75%～80%的老年人接受家政服务人员提供的帮助.患有脑卒中、帕金森综合征、阿尔茨海默病的患者更需要家政服务人员提供各种各样的服务.许多文章探讨家政服务人员如何服务于痴呆患者,说明这种疾病呈上升趋势,给家政服务人... 详细信息

在工业化国家,75%～80%的老年人接受家政服务人员提供的帮助.患有脑卒中、帕金森综合征、阿尔茨海默病的患者更需要家政服务人员提供各种各样的服务.许多文章探讨家政服务人员如何服务于痴呆患者,说明这种疾病呈上升趋势,给家政服务人员带来了很大的压力.

关键词：家庭医生家政服务人员培训