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Asian Journal of Andrology 2021年第2期23卷 135-139页

作者： Daniel J Wu Odgerel Badamjav Vikrant V Reddy Michael Eisenberg barry behr Department of Computer Science Stanford UniversityStanfordCA 94305USA Department of Urology University of Utah HealthSalt Lake CityUT 84108USA Department of Obstetrics and Gynecology Stanford Children’s HealthStanfordCA 94305USA Department of Urology Stanford University School of MedicineStanfordCA 94305USA

Sperm identification and selection is an essential task when processing human testicular samples for in vitro *** and identifying sperm cell(s)in human testicular biopsy samples is labor intensive and time *** developed a new computer-aided sperm analysis(CASA)system,which utilizes deep learning for near human-level performance on testicular sperm extraction(TESE),trained on a custom *** system automates the identification of sperm in testicular biopsy samples.A dataset of 702 de-identified images from testicular biopsy samples of 30 patients was *** image was normalized and passed through glare filters and diffraction *** data were split 80%,10%,and 10%into training,validation,and test sets,***,a deep object detection network,composed of a feature extraction network and object detection network,was trained on this *** model was benchmarked against embryologists’performance on the detection *** deep learning CASA system achieved a mean average precision(mAP)of 0.741,with an average recall(AR)of 0.376 on our *** proposed method can work in real time;its speed is effectively limited only by the imaging speed of the *** results indicate that deep learning-based technologies can improve the efficiency of finding sperm in testicular biopsy samples.

关键词： artificial intelligence computer vision male infertility microdissection testicular sperm extraction sperm

Ecotoxicological assessment of diffuse pollution using biomonitoring tool for sustainable land use in Thailand

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Journal of Environmental Sciences 2010年第6期22卷 858-863页

作者： Chuleemas Boonthai Iwai barry Noller Department of Plant Sciences and Agricultural Resources Land Resourcesand Environment SectionFaculty of AgricultureKhon Kaen University The University of Queensland Centre for Mined Land Rehabilitation (CMLR)

As a developing country, Thailand has a significant issue with diffuse pollution of the soil ecosystem due to an indiscriminate use of agrichemicals and poorly regulated disposal of a wide variety of hazardous wastes. Practical risk assessment tools based on locallyoccurring species are needed to assess the effects of diffuse pollutants on the soil ecosystem in Thailand because reliance on soil criteria developed for overseas conditions may provide inadequate protection. Native soil organisms in Thailand may be more or less sensitive to contaminants compared to overseas test species. This article described a biological indicator approach for ecological risk assessment of diffuse pollution in the soil ecosystem of Thailand from pesticide application with the aim of developing standardized protocols using native species and locally generated data to better evaluate the ecological risks of non-point source soil pollution. It was found that ecotoxicological assessment provided a better understanding of the ecological impacts that diffuse pollution induced on Thai environmental conditions. Thai soil biota species were more sensitive to soil contaminants than similar species overseas. Soil series also had an influence on the ecotoxicology of contaminants to soil biota. Collembolan, Cyphoderus sp., was demonstrated as a useful alternative test species to Folsomia candida （international test species） for terrestrial ecotoxicological testing of Thai soils. In addition, the soil biota activities such as soil respiration and earthworm avoidance including soil biodiversity and the litter bag decomposition technique are also good tools to assess the effects of diffuse pollution by pesticides on the soil ecosystem of Thailand.

关键词： ecotoxicological assessments diffuse pollution biomonitoring soil ecosystem

Non-Uniformity and Generalised Sacks Splitting

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Acta Mathematica Sinica,English Series 2002年第2期18卷 327-334页

作者： COOPER S.barry Department of Pure Mathematics School of Mathematics University of Leeds Leeds UK Institute of Software Chines Academy of Sciences Beijing P. R. China

We show that there do not exist computable fimetions f_1(e,i).f_2(e,i).g_1(e,i),g_2(e,i)such that for all e,i ∈ω, (1)(W_(f_1)(e,i)-W_(f_2)(e,i))≤T(W_e-W_1): (2)(W_(g_1)(e,i)-W_(g_2)(e,i))≤T(W_e-W_i): (3)(W_w-W_i)≤T(W_(f_1)(e,i)-W_(f_2)(e,i))⊕(W_(g_1)(e,i)-W_(g_2)(e,i)): (4)(W_e-W_i)T(W_(f_1)(e,i)-W_(f_2)(e,i))uuless(W_e-W_i)≤T:and (5)(W_e-W_i)T(E_(g_1)(e,i)-W_(g_2)(e,i))unless(W_w-W_i)≤T. It follows that the splitting theorems of Sacks and Cooper cannot be combined uniformly.

关键词： Computably enumerable(c.e.) Difference of computably enumerable sets(d.c.e.,or 2-c.e.) Turing degrees Splitting and nonsplitting

WHAT I LEARNED FROM BRITTON CHANCE

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Journal of Innovative Optical Health Sciences 2011年第3期4卷 223-226页

作者： barry R.MASTERS Department of the History of Science Harvard UniversityCambridgeMA 02138USA Department of Biological Engineering Massachusetts Institute of Technology CambridgeMA 02139USA

In this personal and reflective article,I honor the memory of Britton Chance and explain how his mentorship during my tenure at the Johnson Research Foundation greatly impacted my scientific career.I emphasize the critical role of mentors on the development of scientists and present some wonderful and remarkable attributes that characterized Britton Chance's scientific and personal style.

关键词： Britton Chance mentorship scientific attributes and style

Functional dyspepsia:Are psychosocial factors of relevance?

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World Journal of Gastroenterology 2006年第17期12卷 2701-2707页

作者： Sandra barry Timothy G Dinan Department of Psychiatry and Alimentary Pharmacobiotic Centre University College Cork CorkIreland

The pathogenesis of Functional Dyspepsia （FD） remains unclear, appears diverse and is thus inadequately understood. Akin to other functional gastrointestinal disorders, research has demonstrated an association between this common diagnosis and psychosocial factors and psychiatric morbidity. Conceptualising the relevance of these factors within the syndrome of FD requires application of the biopsychosocial model of disease. Using this paradigm, dysregulation of the reciprocal communication between the brain and the gut is central to symptom generation, interpretation and exacerbation. Appreciation and understanding of the neurobiological correlates of various psychological states is also relevant. The view that psychosocial factors exert their influence in FD predominantly through motivation of health care seeking also persists. This appears too one-dimensional an assertion in light of the evidence available supporting a more intdnsic aetiological link. Evolving understanding of pathogenic mechanisms and the heterogeneous nature of the syndrome will facilitate effective management. Co-morbid psychiatric illness warrants treatment with conventional therapies. Acknowledging the relevance of psychosocial variables in FD, the degree of which is subject to vadation, has implications for assessment and management. Available evidence suggests psychological therapies may benefit FD patients particularly those with chronic symptoms. The rationale for use of psychotropic medications in FD is apparent but the evidence base to support the use of antidepressant pharmacotherapy is to date limited.

关键词： Functional dyspepsia Psychosocial factors Psychiatry Pathophysiology

Differences between lower extremity joint running kinetics captured by marker-based and markerless systems were speed dependent

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Journal of Sport and Health Science 2024年第4期13卷 569-578页

作者： Hui Tang barry Munkasy Li Li Department of Health Sciences and Kinesiology Georgia Southern UniversityStatesboroGA 30458USA Department of Kinesiology and Health Education University of Texas at AustinAustinTX 78712USA

Background:The development of computer vision technology has enabled the use of markerless movement tracking for biomechanical *** research has reported the feasibility of markerless systems in motion analysis but has yet to fully explore their utility for capturing faster movements,such as *** studies using markerless systems in clinical and sports settings are still ***,the present study compared running biomechanics estimated by marker-based and markerless *** running speed not only affects sports performance but is also associated with clinical injury prevention,diagnosis,and rehabilitation,we aimed to investigate the effects of speed on the comparison of estimated lower extremity joint moments and powers between markerless and marker-based technologies during treadmill running as a concurrent validating ***:Kinematic data from marker-based/markerless technologies were collected,along with ground reaction force data,from 16 young adults running on an instrumented treadmill at 3 speeds:2.24 m/s,2.91 m/s,and 3.58 m/s(5.0 miles/h,6.5 miles/h,and 8.0 miles/h).Sagittal plane moments and powers of the hip,knee,and ankle were calculated by inverse dynamic *** series analysis and statistical parametric mapping were used to determine system ***:Compared to the marker-based system,the markerless system estimated increased lower extremity joint kinetics with faster speed during the swing phase in most ***:Despite the promising application of markerless technology in clinical settings,systematic markerless overestimation requires focused *** on segment pose estimations,the centers of mass estimated by markerless technologies were farther away from the relevant distal joint centers,which led to greater joint moments and powers estimates by markerless ***-based *** differences were amplified by running speed.

关键词： Biomechanics Motion capture Gait Statistical parametric mapping

Application and evaluation of a pattern-based building energy model calibration method using public building datasets

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Building Simulation 2022年第8期15卷 1385-1400页

作者： Kaiyu Sun Tianzhen Hong Janghyun Kim barry Hooper Lawrence Berkeley National Laboratory BerkeleyCAUSA National Renewable Energy Laboratory GoldenCOUSA San Francisco Deportment of the Environment San FranciscoCAUSA

Building performance simulation has been adopted to support decision making in the building life *** essential issue is to ensure a building energy simulation model can capture the reality and complexity of buildings and their systems in both the static characteristics and dynamic *** energy model calibration is a technique that takes various types of measured performance data(e.g.,energy use)and tunes key model parameters to match the simulated results with the actual *** study performed an application and evaluation of an automated pattern-based calibration method on commercial building models that were generated based on characteristics of real buildings.A public building dataset that includes high-level building attributes(e.g.,building type,vintage,total floor area,number of stories,zip code)of 111 buildings in San Francisco,California,USA,was used to generate building models in *** level energy use calibrations were then conducted by comparing building model results against the actual buildings’monthly electricity and natural gas *** results showed 57 out of 111 buildings were successfully calibrated against actual buildings,while the remaining buildings showed opportunities for future calibration *** to the pattern-based model calibration method are identified to expand its use for:(1)central heating,ventilation and air conditioning(HVAC)systems with chillers,(2)space heating and hot water heating with electricity sources,(3)mixed-use building types,and(4)partially occupied buildings.

关键词： model calibration building energy modeling EnergyPlus building performance simulation monthly energy use

Simulation of the deformable lateral boundaries in biaxial test using DEM

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Particuology 2024年第5期88卷 161-175页

作者： Ali Momeni barry Clarke Yong Sheng Ali Hassanpour WSP 3 Wellington PlaceLeedsLS1 4APUK Hull University HullHU6 7RXUK School of Civil Engineering University of LeedsLeedsLS2 9JTUK School of Computer Science University of HullHullHU6 7RXUK School of Chemical and Process Engineering University of LeedsLeedsLS2 9JTUK

Applying the discrete element method(DEM)in soil mechanics can provide abundant information at the particle-scale and facilitates illustration of the macro-mechanical behaviour of soils based on the inter-particle *** triaxial test is one of the most common laboratory methods to study the macro-mechanical behaviour of particulate materials such as ***,many problems in geotechnical design can be assumed and simplified as a plane strain *** a biaxial test can be conducted to reproduce the macro-mechanical behaviour of soil,where the sample is enclosed by two horizontal rigid platens and a vertical latex membrane,which is a deformable continuous element and allows the enclosed specimen to deform freely while maintaining confining stress during *** paper presents an algorithm to represent physical and mechanical characteristics of latex membrane in the 2D DEM simulation of biaxial test using the PFC^(2D) *** investigate the impact of the lateral boundary conditions on the micro-macro mechanical behaviours of soil samples,two sets of DEM biaxial tests are conducted,*** rigid and deformable lateral boundary *** DEM modeling results indicate that the lateral boundary conditions have a significant effect on the micro-scale fabric properties,thickness and inclination of the shear *** comparison between these two simulations also demonstrates that the lateral boundary conditions play a major role in the peak and post-peak stress-strain behaviours as well as the dilation and critical state behaviours of granular soils.

关键词： Discrete element method Biaxial test Deformable boundaries Shear band Critical state Fabric anisotropy Geometrical stability index

Bioinformatics advances in saliva diagnostics

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International Journal of Oral Science 2012年第2期4卷 85-87页

作者： barry Smith David TW Wong University of California at Los Angeles School of Dentistry and Dental Research Institute Center for Health SciencesUniversity of CaliforniaLos AngelesUSA Departmentof Philosophy University at BuffaloBuffaloUSA

There is a need recognized by the National Institute of Dental ＆ Craniofacial Research and the National Cancer Institute to advance basic, translational and clinical saliva research. The goal of the Salivaomics Knowledge Base （SKB） is to create a data management system and web resource constructed to support human salivaomics research. To maximize the utility of the SKB for retrieval, integration and analysis of data, we have developed the Saliva Ontology and SDxMart. This article reviews the informatics advances in saliva diagnostics made possible by the Saliva Ontology and SDxMart.

关键词： BioMart database ontology saliva

Coronaviruses in pregnant women in Saudi Arabia:A systematic comparative review of MERS-CoV and SARS-CoV-2

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Asian pacific Journal of Reproduction 2021年第3期10卷 97-101页

作者： Mazin barry Magdoleen A.barry Division of Infectious Diseases Department of MedicineCollege of MedicineKing Saud UniversityRiyadhSaudi Arabia Department of Obstetrics and Gynecology King Salman HospitalMinistry of HealthRiyadhSaudi Arabia

Objective:To compare the effects of coronaviruses,such as Middle East respiratory syndrome coronavirus(MERS-CoV)or coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus-2(SARS-CoV-2),on pregnant women in Saudi Arabia,and to understand the disease dynamics of these coronaviruses so as to konw how to provide care and management of infected pregnant women and ***:We conducted a systematic review of all published papers on MERS-CoV and SARS-CoV-2 infections in pregnant women in Saudi Arabia to identify knowledge *** and exclusion criteria were based on the PRISMA *** search included all papers which were published between September 1,2012 and November 29,2020 on pregnant women with MERS-CoV and/or COVID-19 in Saudi *** 26 papers screened,five were included in the ***:A total of 11 pregnant women with MERS-CoV and four with COVID-19 were reported in Saudi Arabia in the medical literature during the review *** mean ages of the women were 33 and 31 years old for MERS-CoV and COVID-19,*** and fetal mortality in cases of MERSCoV were 35%and 30%,respectively,while no maternal or fetal mortalities were reported in COVID-19 ***:Very limited data has emerged from Saudi Arabia on pregnant women MERS-CoV and *** such high mortality observed with MERS-CoV compared to COVID-19,there is a need for greater reporting of cases to truly grasp the extent of these infections in pregnant women in a country where both coronaviruses are circulating.

关键词： MERS-CoV SARS-CoV-2 COVID-19 Pregnant women